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Zonulin,leaky gut and blood brain barrier articles

Discussion in 'Adrenal Rx and Leaky Gut Rx' started by chocolate, Apr 9, 2012.

  1. chocolate

    chocolate Silver

    http://somvweb.som.umaryland.edu/absolutenm/templates/?a=1445





    Its a protein made by celiacs whether they consume the stuff or not. Also, it appears elevated in folks that have had antibiotics. Certain probitics make it behave in a petrie dish. Petrie dishes aren't people, but people can take probiotics. I guess everyone could wait until a study was funded after rats were extensively studied and the finding were presented. Or we could just eat unpasteurized kraut.



    http://blog.cholesterol-and-health....r.http://www.ncbi.nlm.nih.gov/pubmed/21248165
     
  2. Jack Kruse

    Jack Kruse Administrator

    Look up Richard Anderson, Zonulin in primates and humans, and Parker Jr from Duke. When CT is over this is the new blog series I am going after. The leaky gut and all we dont know.
     
  3. chocolate

    chocolate Silver

    http://www.celiac.com/gluten-free/topic/47795-zonulin-leaky-gut-and-gluten-sensitivity/



    this is a link to forum that has been discussing it for a while. I know from reading about heavy metals, that aluminum supposedly specifically causes leaky bbb. I was taking that as a sort of positive for chelation, just to be able to get to the stuff. (Even though bad stuff can get in) If the info is accurate. I have to review sources, I am just pulling it out of my compromised compulsive reading head. Anyway, zonulin does seem to be the thread that ties all of the autoimmunes together . Darned if it isn't the old gut/ brain. I think we all have the same owner's manual.
     
  4. chocolate

    chocolate Silver

    http://blog.cholesterol-and-health.com/2011/04/new-genetics-part-v-is-intestinal.html



    genetics determine intestinal flora



    Epigenetics versus genetics? is genetics the wrong term used?



    http://coolinginflammation.blogspot.com/ lots of relevant gut flora articles that are easy to understand. The human gut biome has supposedly 150 different probiotics to manufacture all of the vitamins, but whats the point with a leaky gut? The flora maybe doesn't need to be so diverse. I read articles that said the flora was adaptive to the diet. I will try to find one and post or someone else could.:)
     
  5. Jack Kruse

    Jack Kruse Administrator

    Chocolate I disagree big with that.......epigenetics is the main determining factor of gut microflora and health
     
  6. chocolate

    chocolate Silver

    http://www.jbc.org/content/276/22/19160.full.pdf



    Zonula Occludens Toxin Structure-Function Analysis

    IDENTIFICATION OF THE FRAGMENT BIOLOGICALLY ACTIVE ON TIGHT JUNCTIONS AND OF THE

    ZONULIN RECEPTOR BINDING DOMAIN*



    Anderson has a huge body of work and I will find the good stuff. I'm not hitting it so easily.
     
  7. finnite@dccnet.com

    finnite@dccnet.com New Member

  8. chasee33

    chasee33 Silver

    Any research done by Dr. Vojdani relative to autoimmune, leaky gut, and the TH17 system is brilliant as well
     
  9. txritchies@att.net

    txritchies@att.net New Member


    Colleen, this is really interesting information. I have a nephew that is T1D and his younger sister has been diagnosed with Celiac. Add to that mix that my BIL is a doctor and my sister is a nurse. Thanks for sharing :)
     
  10. Jack Kruse

    Jack Kruse Administrator

    I have said for years I thought that T1 D is an epigenetic disease
     
  11. hellojtm

    hellojtm New Member

    Didn't see anyone mentioned the c-section link to gut health yet:



    http://www.ncbi.nlm.nih.gov/pubmed/9890463



    I discovered this after a casual poll at a small dinner, of the 4 people at the table I was the only non-cesarian birth and also the only one completely free of chronic digestive issues, the rest of the table had one of IBS, fructose malabsoprtion, ulcerative colitis or Crohn's-like symptoms which were never fully diagnosed even after colonoscopy etc... Then I got hunting around and found the link. There is also the NPR story about the lady who had the gut flora transplant from her husband to cure her gut.



    jesse
     
  12. chocolate

    chocolate Silver

    Thanks Jesse, I had a weird feeling for years because of such a sterile birth with my kid. The article concluded the same, you need cross-contaminated by your mother in the birthing process. My first born, I labored then c-sectioned. But then, you can have it right and a dose of antibiotics can screw everything up. But never having it right in the first place blows.



    http://www.wjgnet.com/2150-5349/full/v1/i1/36.htm this article talks of trying to vaccinate against gluten sensitivity. Il-15 is the player this time. http://www.ncbi.nlm.nih.gov/pubmed/17635814 IL- 15 is affiliated to Chagas, a South American (we thought) Lyme disease. Maybe we should go donate blood and see if it gets screened out. And get free breakfast, oops...not Paleo. It could be dormant for years this says.
     
  13. chocolate

    chocolate Silver

    http://en.wikipedia.org/wiki/Interleukin_15



    Il-15 is the most awesome of all it would seem. The zonulin needs to behave. This is what kills cancer. It starts with what you put in your mouth. Unbelievable. And to top it off, cancer likes the same things that zonulin allows to pass. Fructose, sugars, etc. Does cancer like gliadin? What is cancer good for...where is the evolutionary match? if you eat the things cancer likes , it grows. Someone shoot holes in this insanity quickly. Does fasting kill cancer?

    http://www.marksdailyapple.com/fasting-cancer/#axzz1rgdXMemJ http://www.nature.com/nm/journal/v4/n6/abs/nm0698-713.html



    gliadin specific t cells???? http://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=3&ved=0CDYQFjAC&url=http%3A%2F%2Fwww.msnbc.msn.com%2Fid%2F46905912%2Fns%2Flocal_news-detroit_mi%2Ft%2Fdog-discovers-breast-cancer-michigan-woman%2F&ei=tM-ET8zsHe7PiALFqKj2BA&usg=AFQjCNGiNyhTm3RJMKqETxHXRVgKD0daWQ&sig2=dhf78euJSrRQu4rkciZ5KA

    http://digitaljournal.com/article/267942

    http://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=9&ved=0CF8QFjAI&url=http%3A%2F%2Fwww.dailymail.co.uk%2Fnews%2Farticle-1381183%2FPet-dog-saves-owners-life-smelling-breast-cancer.html&ei=tM-ET8zsHe7PiALFqKj2BA&usg=AFQjCNGrxUF5ahwGphiJcQGGvHNck7O3Qw&sig2=LCKNoVbnXnvKeAgLqC9azw

    http://cancerres.aacrjournals.org/content/early/2011/06/10/0008-5472.CAN-10-3973 low carb high protein prevents cancers

    Its like the minute you put sugar in your mouth, you open the gates. The pancreas doesn't do its job, then it starts. Not to mention the stomach. Gliadin is the mystery.

    http://www.sciencedirect.com/science/article/pii/S0887233302000176



    Some of the above articles are about dogs detecting cancer. These are untrained dogs. I was going to follow up to see what they were smelling. I don't think the dogs feel threatened by the cancer, maybe its not a virus.



    http://www.mendeley.com/research/cy...t makes k2, without being exposed to the mom?
     
  14. chocolate

    chocolate Silver

  15. chocolate

    chocolate Silver

    So zonulin has the gates closed when it has the fermented veggies probiotic. The Lacto-bacillus. You put yourself in the fridge and cool off like yogurt and it slows down the lacto and opens the gates for the antifreeze. The lactic acidosis pickles you so you don't rot and feeds your brain. The IL-15 gets ready for sneaky little cancer and who knows where it comes from. Its looking like we are not supposed to be eating again...Fat seems off the table. Or at least I'm not finding anything. I don't know about the metals.* They cause the zonulin to open the gates also. I guess that would make it a winter need. Who knows anything about fat?



    *the metals come from deep water fish....what sea mammal eats deep water fish? Or what bacteria contains heavy metal?
     
  16. chocolate

    chocolate Silver

    http://www.springerlink.com/content/w63j14p154872837/ this talks about environmental clean up with the bacteria



    http://www.springerlink.com/content/3372815ut8252573/Mercury Microbiology: Resistance Systems, Environmental Aspects, Methylation, and Human Health



    Mercury has no beneficial biological role, and is highly toxic to all forms of life. Bacteria are involved in the global environmental cycling of mercury, both by reducing Hg2+ to metallic Hg0, which is less soluble in aqueous systems and therefore less bioavailable, and by oxidizing and methylating Hg species, and in the process making Hg more bioavailable and more highly toxic. The most thoroughly studied bacterial biotransformation of mercury is reduction by the widely distributed mer resistance operons found on plasmids and transposons in Gram-negative and -positive bacteria. The products of these resistance operons transport ionic Hg2+ from outside the cell to the cellular cytoplasm, where mercuric reductase reduces divalent Hg2+ to Hg0, which is less toxic than Hg2+. Metallic mercury vapor, Hg0, is volatile under aerobic conditions, leaves the cell by passive diffusion, and is volatilized from the growth environment.



    I guess if its volatile under aerobic conditions, we need it gone!
     
  17. chocolate

    chocolate Silver

  18. chocolate

    chocolate Silver

    http://en.wikipedia.org/wiki/Meconium



    Meconium, the first poop... or the poop inside the baby inside the mommy is already colonized with one of two floras. The Lacto or an E coli that makes K2. The babies are gestated with the right stuff. Maybe it gets killed with iv antibiotics or? or Epigenitics expects one bunch to have to hatch in the sun and cofactor with d or what? How about some factor x action here? I guess we need to know what temperature range the e coli works at.



    http://homepages.stmartin.edu/fac_staff/molney/website/SMU%20Bio%20Journal/Nguyen%202006.pdf

    The e coli is for warm weather and makes k2 from veggies. The cold weather diet eats k2 and the lacto is for making lactic acid in cooler temps. I guess it assumes different things. If you have no lacto. Those mercury barometers are looking better and better. It would be cool to know if cold weather cootie babies had more mercury. (weather/water HMMM.)
     
  19. agatha

    agatha New Member


    Oh yes, please.
     
  20. chocolate

    chocolate Silver

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