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Why sunlight always trumps food: The details.

Discussion in 'Educating Doctors' started by Jack Kruse, Jul 22, 2018.

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  1. Jack Kruse

    Jack Kruse Administrator

    Everyone knows that UV light is purple.....but few know how UV light acts in cells. It is the most variable frequency in a day and it acts in non-linear fashion 100% of the time with living systems. So as you watch the video and read the following words about how the sun builds its code you might begin to realize there is a lot you really do not know and there are many pieces you don't understand how they fit into the Quilt of your life. My website can change that for you.......Another possible explanation for why observations in a day on Earth don’t match predictions is that humans aren’t very observant about the mosaics of light around us.

    Watch the piano and the purple light and as you do imagine what you are seeing is the morse code in light instructing your cells how to make melatonin and dopamine using UV A light. Watch the keys and see the diurnal variation..........is there an order you failed to sense?

    Beautiful mosaics are made of broken or torn material. Your sight is made from broken down colors in light to bring you a unique reality. In every sound, the hidden silence sleeps. Life is a series of adversities: It's a strong wind tearing away from us all but the things that cannot be torn and ripped, so that we see ourselves as we are now. Food is also an electromagnetic mosaic of light but few humans realize it because of how they perceive food. They got this idea from food gurus. Food is an electromagnetic barcode mosaic of seasonal power densities. We're all mosaics of many things design to fall apart under the forces of nature so we do not come fully come undone. Pieces of light, love, history, stars; cemented together with love, music, and ideas.

    The key is transforming the environmental energies/information to something different and new..........

    We are all made up of broken pieces of sunlight, called food substrate, and our mitochondria were built by nature to collect the parts of this mosaic and make sense of the waveforms grown by the photosynthetic process of the sun. Mitochondria are the glue that makes life with mitochondria work with photosynthesis ..........and that is heteroplasmy in a nutshell...
  2. Jack Kruse

    Jack Kruse Administrator

    Bart Wolbers posted an interesting blog: https://www.naturebuildshealth.com/blog/iron

    My answer:

    Iron's toxicity is mediated by sunlight and few people seem aware of it. the first steps of heme synthesis begin in the mitochondria in humans. Simcox JA, Mitchell TC, Gao Y, et al. Dietary iron controls circadian hepatic glucose metabolism through heme synthesis. In a series of elegant studies, they show that higher iron intake, and consequently higher hepatic iron, was associated with the change in the circadian rhythm of glucose and gluconeogenesis mediated by the repression of key gluconeogenic enzymes, PEPCK, and glucose-6-phosphatase (G6Pase).

    The effects of iron were mediated by increased oxidative stress, resulting in increased peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) transcripts and protein levels; induction of aminolevulinic acid synthase 1 (ALAS1), the first enzyme for heme synthesis; and an increase in total heme and heme B in the liver. The mechanism of the repressive effect of iron was shown to be the requirement of heme for nuclear receptor subfamily 1 group d member 1 (Rev-Erbα) to bind nuclear receptor corepressor 1 (NCOR) to form a repressor complex without any change in its protein levels, instead of increasing hepatic heme by administering aminolevulinic acid, thus bypassing ALAS1 or by feeding heme repressed gluconeogenesis. Here is more food for thought: an endogenous ligand of Rev-erb is heme (the iron-binding element in red blood cells). RBC's have a serious diurnal cycle. Heme is degraded into bilirubin. Elevated levels of bilirubin cause jaundice in kids born from parents who germlines are blue light toxic. The older treatment for jaundice was exposure to UV light but today's treatment of neonatal jaundice is now exposure to blue light in NICU's. This has been associated with pigmented skin and higher risks of skin and ocular melanomas as the kids get older because of the stimulatory effect of blue light on melanocytes. Blue light is a major regulator of circadian rhythms and Rev-erb is an executive-level player in this game. When heme is degraded carbon monoxide (CO) is made. CO prevents Clock/Bmal1 from binding to DNA. This binding Inhibits this process and throws off numerous other circadian rhythms in the liver. This is why blue light exposure is causative in most cases of diabetes. When you add in the melanopsin issue it is no surprise why diabetes is now explosive globally. In humans, there is reciprocal regulation of carbon monoxide and the circadian clock mechanism. (Klemz et al., 2016)

    Bart seems very worried that eating more iron means more diabetes. That science has also been done and it is not true. The study by Simcox et al. underscored an important feature of chronobiology. A change in dietary iron did not perturb the periodicity of the chronome and it only impacted the amplitude of expression. The periodicity of expression of transferrin receptor, ferritin, PGC-1α, ALAS1, PEPCK, or G6Pase did not change and peaked at zeitgeber time (ZT) 10 and is likely related to activity and food intake. The key is the LIGHT that food was eaten under. If you eat that TOMAHAWK steak at 10 PM under LED light then being a carnivore could be an issue, not because of the steak but because of the effect of light. Most human-carnivore prior to 1879 never had to worry about this because we have no artificial light. I'm glad Bart post this because I hope he slays this dragon of bullshit because it once again shows my thesis light always trumps food nutrients in chronobiology always exists. Food is not the primary driver in anything. It just appears this way when you are missing the key data as this post points out.

    The sequence of peak expression of ALAS1 at ZT10, followed by heme concentration at ZT12 and of heme oxygenase 1 (HO1) at ∼ZT18 ensures the tight regulation of the cellular concentration of heme at the mitochondrial level. People keep forgetting that heme is a mitochondrial process and blue light causes melanopsin dysfunction and destroys iron-based photoreceptors. High dietary iron was associated with higher peak expression of PGC-1α, ALAS1, HO1, and the total heme in the liver, but it never causes a problem unless the toxic light is present. The antioxidants (SOD1 and catalase) peaked at ZT6. These data point to the exquisite regulation of diurnal rhythm by central oscillators tied to LIGHT, not the diet.

    What has Uncle Jack always said in his Leptin Rx?

    SUNLIGHT and food in the morning are most wise and let endogenously produced CO from heme breakdown rhythmically tune the clock in the evening. This is why ALAN has to be absent!!!!! ALAN = artificial light at night.
  3. Jack Kruse

    Jack Kruse Administrator

    Leland's premise is correct in this article. Let us dissect why: food is only needed as an electron and proton source to create the smallest current/force we need to remain alive to keep subatomic particles moving from cytochrome 1 to oxygen. For those how don't know death occurs when this motion STOPS. When it stops we die = what cyanide does to CCO (cytochrome 4). This is why I say mitochondria really are a Turing machine. Here is the real important point......This action is the see-saw of life. You need the quantize balance of both actions to get Optimal outcomes. Sunlight SLOWS the flow of ECT via UVA and UVB light - the VDR and NO actions on CCO.
    So what is nature saying? When you live in sun you'll need seasonal food but you won't need a lot of you are in my sun.......If you are not.....you'll eat a lot more out of the sun or further from the equator which is why I made uncoupled haplotypes.
    This is Mother Nature's message nobody seems to get in the food guru world. https://medium.com/@StillmanMD/who-will-win-the-diet-wars-aa7d16ec7de6
  4. Jack Kruse

    Jack Kruse Administrator

    Why isn't nutritional ketosis a panacea for man? Ketosis is what we do at night when we sleep. It is not designed to be a way we live chronically. WHY? Ketosis only provides us with a brisk flow of electrons from cytochrome 1 NAD+/NADH. The more electrons you have the more oxygen you need to capture them. What happens when you have more oxygen in a cell? You create more ROS. That ROS alters signaling and leads to problems. No human was built for 24/7 ketosis via food intake. This is especially true when you consider the colony of mitochondria's ability to tunnel electrons. What happens if they cannot and you keep feeding in massive amounts of electrons? The system breaks down.

    When the respiratory proteins do a poor job of this, because they are separated a further atomic distance away from the neighbors, NAD+ levels drop, oxygen levels have to drop to lower ROS risk, and SIRT 1 ratio is the result in cells.

    How does ketosis fit into this scenario? If you read my book, The Epi-Paleo Rx on Amazon, you will see that ketosis is a “small critical part" of reversing most diseases, and not the be all end all. Ketosis works best when you have sunlight beaming on your skin, eyes, and gut because the UV light stimulus affects the VDR receptors in the inner mitochondrial membrane to slow ECT no matter how many electrons are fed into the system.

    If you don’t understand my blogs on this topic well, you will think I have just contradicted myself in my book. I have not. Ketosis can change the flow of electrons, but it has zero effect on the electron spin or state of this subatomic particle, moreover, it has no effect on the size of the ECT protein components nor the distance between them. That angstrom distance is CRITICAL in comprehending what is really going on.
    Ironically where ketosis works of us, is by narrowing the distance between the respiratory proteins in the mitochondrial electron transport that ultimately determines the speed of flow of electrons. Ketosis only augments the flow of electrons. If the electrons are in the singlet state is this a good thing? Nope. It means you build a body faster than falls apart sooner. Ketosis is an accelerator pedal of electrons only. Wellness is not based solely on electrons' quantity or its speed to get to oxygen. In fact, the fraction of oxygen that never gets the electrons is what creates the free radical signal in a mitochondrion that controls the genome.

    You cannot recapitulate the quantum coherence just by quickly TUNNELING electrons !!!!! It will sustain life until you get every detail correct. This is why you will always hear me say, you can never reverse a disease if you do not alter the environment you got ill within. The environment determines the state the electrons are in and your diet choices control the flow from cytochrome 1 to oxygen. Wellness is not linear it is non-linear and far from equilibrium. Ketosis is only a tool in reversals to buy you some time to fix your light environment your body is being forced to endure.

    Fake light (unopposed blue) causes your mitochondria ECT to slow because the respiratory proteins enlarge and the distance between then GETS larger. This slows electron tunneling by a factor of ten with each Angrstrom of increased distance! It also creates new singlet state electrons which alters the free radical message. So….…..when ECT slows, you up-regulate carbohydrate metabolism by way of AMPK pathways. You need environmental UV light from the sun to offset this free radical risk. Nature built us to work this way. All this occurs just from the change in frequency of light on your surfaces. The brain can not tell sunlight from blue light, only your mitochondria can because it is what gives electrons its spin. Moreover, alternative and ancestral clinicians are unaware of this. You no longer can afford to be.

    You think Uncle Jack is wrong? Here ya go.....more data that you don't have it all down, food gurus.........Ketones and lactate fuel tumor growth and metastasis - in epithelial cancer cells!!!! https://www.tandfonline.com/doi/full/10.4161/cc.9.17.12731 a "reverse Warburg effect" Oops.......just when you thought the science was settled........here comes Uncle Jack with more truth bombs.
    DebraGM, mrc and caroline like this.
  5. Jack Kruse

    Jack Kruse Administrator

  6. Jack Kruse

    Jack Kruse Administrator

    Elevated melatonin while eating decreases glucose tolerance. Elevated melatonin while fasting increases b-cell recovery.
    When is your melatonin elevated?
    Moral of the story?
    Eat when the sun is shining not at nighttime.
    This also implies just how dangerous ALAN is for modern humans as well. ALAN/blue light all increase glucose metabolism/AMPK/and insulin levels.

  7. Jack Kruse

    Jack Kruse Administrator

  8. Jack Kruse

    Jack Kruse Administrator

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