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Why sunlight always trumps food: The details.

Discussion in 'Educating Doctors' started by Jack Kruse, Jul 22, 2018.

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  1. Jack Kruse

    Jack Kruse Administrator

    Everyone knows that UV light is purple.....but few know how UV light acts in cells. It is the most variable frequency in a day and it acts in non-linear fashion 100% of the time with living systems. So as you watch the video and read the following words about how the sun builds its code you might begin to realize there is a lot you really do not know and there are many pieces you don't understand how they fit into the Quilt of your life. My website can change that for you.......Another possible explanation for why observations in a day on Earth don’t match predictions is that humans aren’t very observant about the mosaics of light around us.

    Watch the piano and the purple light and as you do imagine what you are seeing is the morse code in light instructing your cells how to make melatonin and dopamine using UV A light. Watch the keys and see the diurnal variation..........is there an order you failed to sense?

    Beautiful mosaics are made of broken or torn material. Your sight is made from broken down colors in light to bring you a unique reality. In every sound, the hidden silence sleeps. Life is a series of adversities: It's a strong wind tearing away from us all but the things that cannot be torn and ripped, so that we see ourselves as we are now. Food is also an electromagnetic mosaic of light but few humans realize it because of how they perceive food. They got this idea from food gurus. Food is an electromagnetic barcode mosaic of seasonal power densities. We're all mosaics of many things design to fall apart under the forces of nature so we do not come fully come undone. Pieces of light, love, history, stars; cemented together with love, music, and ideas.

    The key is transforming the environmental energies/information to something different and new..........

    We are all made up of broken pieces of sunlight, called food substrate, and our mitochondria were built by nature to collect the parts of this mosaic and make sense of the waveforms grown by the photosynthetic process of the sun. Mitochondria are the glue that makes life with mitochondria work with photosynthesis ..........and that is heteroplasmy in a nutshell...
  2. Jack Kruse

    Jack Kruse Administrator

    Bart Wolbers posted an interesting blog: https://www.naturebuildshealth.com/blog/iron

    My answer:

    Iron's toxicity is mediated by sunlight and few people seem aware of it. the first steps of heme synthesis begin in the mitochondria in humans. Simcox JA, Mitchell TC, Gao Y, et al. Dietary iron controls circadian hepatic glucose metabolism through heme synthesis. In a series of elegant studies, they show that higher iron intake, and consequently higher hepatic iron, was associated with the change in the circadian rhythm of glucose and gluconeogenesis mediated by the repression of key gluconeogenic enzymes, PEPCK, and glucose-6-phosphatase (G6Pase).

    The effects of iron were mediated by increased oxidative stress, resulting in increased peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) transcripts and protein levels; induction of aminolevulinic acid synthase 1 (ALAS1), the first enzyme for heme synthesis; and an increase in total heme and heme B in the liver. The mechanism of the repressive effect of iron was shown to be the requirement of heme for nuclear receptor subfamily 1 group d member 1 (Rev-Erbα) to bind nuclear receptor corepressor 1 (NCOR) to form a repressor complex without any change in its protein levels, instead of increasing hepatic heme by administering aminolevulinic acid, thus bypassing ALAS1 or by feeding heme repressed gluconeogenesis. Here is more food for thought: an endogenous ligand of Rev-erb is heme (the iron-binding element in red blood cells). RBC's have a serious diurnal cycle. Heme is degraded into bilirubin. Elevated levels of bilirubin cause jaundice in kids born from parents who germlines are blue light toxic. The older treatment for jaundice was exposure to UV light but today's treatment of neonatal jaundice is now exposure to blue light in NICU's. This has been associated with pigmented skin and higher risks of skin and ocular melanomas as the kids get older because of the stimulatory effect of blue light on melanocytes. Blue light is a major regulator of circadian rhythms and Rev-erb is an executive-level player in this game. When heme is degraded carbon monoxide (CO) is made. CO prevents Clock/Bmal1 from binding to DNA. This binding Inhibits this process and throws off numerous other circadian rhythms in the liver. This is why blue light exposure is causative in most cases of diabetes. When you add in the melanopsin issue it is no surprise why diabetes is now explosive globally. In humans, there is reciprocal regulation of carbon monoxide and the circadian clock mechanism. (Klemz et al., 2016)

    Bart seems very worried that eating more iron means more diabetes. That science has also been done and it is not true. The study by Simcox et al. underscored an important feature of chronobiology. A change in dietary iron did not perturb the periodicity of the chronome and it only impacted the amplitude of expression. The periodicity of expression of transferrin receptor, ferritin, PGC-1α, ALAS1, PEPCK, or G6Pase did not change and peaked at zeitgeber time (ZT) 10 and is likely related to activity and food intake. The key is the LIGHT that food was eaten under. If you eat that TOMAHAWK steak at 10 PM under LED light then being a carnivore could be an issue, not because of the steak but because of the effect of light. Most human-carnivore prior to 1879 never had to worry about this because we have no artificial light. I'm glad Bart post this because I hope he slays this dragon of bullshit because it once again shows my thesis light always trumps food nutrients in chronobiology always exists. Food is not the primary driver in anything. It just appears this way when you are missing the key data as this post points out.

    The sequence of peak expression of ALAS1 at ZT10, followed by heme concentration at ZT12 and of heme oxygenase 1 (HO1) at ∼ZT18 ensures the tight regulation of the cellular concentration of heme at the mitochondrial level. People keep forgetting that heme is a mitochondrial process and blue light causes melanopsin dysfunction and destroys iron-based photoreceptors. High dietary iron was associated with higher peak expression of PGC-1α, ALAS1, HO1, and the total heme in the liver, but it never causes a problem unless the toxic light is present. The antioxidants (SOD1 and catalase) peaked at ZT6. These data point to the exquisite regulation of diurnal rhythm by central oscillators tied to LIGHT, not the diet.

    What has Uncle Jack always said in his Leptin Rx?

    SUNLIGHT and food in the morning are most wise and let endogenously produced CO from heme breakdown rhythmically tune the clock in the evening. This is why ALAN has to be absent!!!!! ALAN = artificial light at night.
  3. Jack Kruse

    Jack Kruse Administrator

    Leland's premise is correct in this article. Let us dissect why: food is only needed as an electron and proton source to create the smallest current/force we need to remain alive to keep subatomic particles moving from cytochrome 1 to oxygen. For those how don't know death occurs when this motion STOPS. When it stops we die = what cyanide does to CCO (cytochrome 4). This is why I say mitochondria really are a Turing machine. Here is the real important point......This action is the see-saw of life. You need the quantize balance of both actions to get Optimal outcomes. Sunlight SLOWS the flow of ECT via UVA and UVB light - the VDR and NO actions on CCO.
    So what is nature saying? When you live in sun you'll need seasonal food but you won't need a lot of you are in my sun.......If you are not.....you'll eat a lot more out of the sun or further from the equator which is why I made uncoupled haplotypes.
    This is Mother Nature's message nobody seems to get in the food guru world. https://medium.com/@StillmanMD/who-will-win-the-diet-wars-aa7d16ec7de6
    livevitae, Corey Nelson and JanSz like this.
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