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Why does melanin photolysis not damage DNA?

Discussion in 'Ask Jack' started by John Schumacher, Oct 24, 2020.

  1. There are hundreds of papers stating: “visible light damage melanocytes through melanin photosensitization and singlet oxygen generation, thus decreasing cell viability, increasing membrane permeability, and causing both DNA photo-oxidation and necro-apoptotic cell death. UVA (355 nm) and visible (532 nm) light photosensitize singlet oxygen with similar yields, and pheomelanin is more efficient than eumelanin at generating singlet oxygen and resisting photobleaching.” Example: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0113266
    Articles like this dominate the literature.

    We believe sunlight is our friend not our foe.

    Please help us understand - Why does melanin photolysis not damage DNA?
  2. Jack Kruse

    Jack Kruse Administrator

    Because melanin absorbs all parts of the spectrum.
    John Schumacher and JanSz like this.

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