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Why are some diabetics skinny and some fat if they both have leptin issues?

Discussion in 'Educating Doctors' started by Jack Kruse, Sep 15, 2022.

  1. Jack Kruse

    Jack Kruse Administrator

    Diabetics can be fat or skinny but both have leptin resistance. Can you explain why their body phenotype varies from skinny to fat?

    What causes low potassium levels in diabetics?

    Low Potassium Levels are common in Type 1 Diabetes when it is tested.

    Low potassium levels are associated with a complication of Type 1 diabetes, called diabetic ketoacidosis. It is a condition in which your body does not make enough insulin to transport glucose into the cells, so the body uses fat as an energy source.

    Type 1 Diabetics tend to be skinny & thin.

    Now, what about type 2 diabetics?

    The Link Between Potassium and Type 2 Diabetes is nuanced

    In type 2 diabetics, Potassium is generally stored in the fluid inside of the cells, but when there's too much glucose outside of the cells in the plasma (blood sugar is too high), potassium moves OUTSIDE of the cell, raising potassium levels in the blood in type 2 diabetics. When K+ moves out of the cell so does cell water. This is why type 2 diabetics urinate so much. They are getting rid of the water they no longer can structure due to their mitochondrial power loss. This K+ ion difference is a different electronic situation than we see in type 1 diabetics. Tell me now my Black Swans mitochondriacs, what do the different movements of K+ have to do with the physiologic action of water inside your cells made in mitochondria at cytochrome C oxidase? How does this affect your biological clocks in the SCN? Does water have something to do with neuronal firing?


    Biological clocks are built as flow meters for entropy inside cells. Potassium orders water molecules by hydrogen bonding network cooperation. Entropy is a measure of the disorder or chaos in a system, and the more ions present in a solution the more disorder there will be. In matter, solids have the most order and least entropy. They are held in a crystal lattice or network. Cells become liquid crystalline when K+ is added to a cell. The water molecule is quite small but the hydrogen bonds inside water are even smaller and most important to the creation of accurate biological clocks = they create an ideal periodicity = better time pieces.

    What is the stoichiometry of K+ to water in mitochondria in your SCN that is working fine in a healthy state of redox power between -300mV to -400Mv in your mitochondria?

    Experiments by Ling et al. have shown in healthy cells that each molecule of ATP in a cell controls 8,800 water molecule binding sites and 20 potassium ions to allow water to become structured inside every cell of your body. As redox varies in your matrix so does the K+ concentration and # of water molecules created by mitochondria. Melatonin, NAD+, CO2 all vary in the same way as potassium does to redox power inside a cell. Environments change redox power by varying the charge density of the hydrogen bonds in water that mitochondria create. What changes charge density most in nature? PHOTONS

    Most diabetics tend to have hypothyroidism as well. why? They lack certain parts of the solar spectrum. Leptin resistance is correlated with labs that reveal l
    ow free T3 and high reverse T3 manifests in mitochondrial phenotype in any part of the tissues/system where mitochondria have lost magnetic sense. Low T3 = a slow spinning Fo head on the ATPase. This tells us right before the ATPase at cytochrome 4 (cytochrome C oxidase) less water is being created by metabolism. Low T3 = low metabolic rate. Low metabolic rate = lowered redox. As redox varies in your matrix so does the K+ concentration inside of cells and # of water molecules created by mitochondria. What else is lowered when T3 is low? Melatonin, NAD+, CO2 all vary in the same way as potassium does to redox power inside a cell.

    Hypothyroidism shows up in environments that change redox power by varying the charge density of the hydrogen bonds in water that mitochondria create. What changes charge density most in nature? PHOTONS. A lack of UV light lowers magnetic sense the most. Excessive blue light exposure is a major factor for low T3 states and leptin resistance. Diabetics are almost always blue light toxic.

    Magnetic sense is also linked to connection to Earth (Schumann) and UV light in AM specifically for the thyroid activation via the eye where TSH sits in the pituitary gland. It also requires some IR-A too via the central retinal pathways. Where UV light exists at surfaces magnetic sense manifests in those tissues. Why? UV light has energy and momentum and is not encumbered by mass therefore energy is added to tissues in the most favorable way. This occurs ideally with purple light because it contains the most energy and momentum as it falls to earth in AM. When you don't get or assimilate it, it can't stimulate the anterior pituitary to make TSH.

    No TSH in AM = low T3 = Leptin Resistance = NAD+ = low melatonin = poor water creation in mitochondria = altered K+ inside of cells = altered structured water in cells = low redox = slower electron movements toward oxygen = hypoxia = NO production = shuts down cytochrome C oxidase = and we always see pseudohypoxia locally. Cold temperatures in an environment can augment even small amounts of UV present at high latitudes to drive the central retinal pathway to stimulate the TSH pathway to raise T3.

    Cold temps cause the Fo head of the mitochondria to spin faster to create heat in uncoupled haplotypes.
    Infrared light is released from mitochondria in response to cold. This is red light and spans from 600 nm - 1 nm wavelengths of photons. How big is that? It's from the width of a pinpoint to the size of small plant seeds. This is the type of light you release from your mitochondria at night during sleep. At a temperature of 37 degrees C, our bodies radiate with a peak intensity near 900 nm. During sleep, our CSF temperatures are designed to drop our hypothalamus temperatures in our brain where T3 and TSH are made by 2-4 degrees. This stimulates TSH & T3 release.

    Pseudohypoxia is fended off by AM UV light in any environment. Poor thyroid function and apnea present in patients are a function of where UV light exists and how cold temperatures at the surface are with O2 levels. This is the essence of how topologic insulators in cells operate at an interface with light. Since O2 is paramagnetic and is drawn to magnetic fields anywhere, and MEG data show tissues with mitochondria have them, electrons stripped from foods are loaded with photon power characterized by frequencies in the visible spectrum. O2 draws these electrons to the 5th cytochrome (ATPase) and this makes it the pacesetter of ETC speeds in mitochondria. Therefore O2 can augment the wiring diagram in mitochondria when IR-A light is present in a poor UV environment. This is why cooler water (more dense due to hydrogen bond changes) carries more O2 in it to move electric charge density for a free cost to cells. This is why people at high latitudes all have access to and eat cold pelagic fish and tend to have light skin hair and eyes. They absorb UV light more effectively via these adaptations to augment the process in mitochondria and their thyroids. It's also why those said fish in their local water have higher O2, DHA, and iodine contents and have higher vitamin D levels in their skins and eyes than we expect.

    Lacking Photons is always a diabetics problem. It is also a problem in hypothyroidism.

    Diabetics never have higher redox power of -300-400Mv. They fall way short of this power. This alters how K+ operates inside the cell.

    When their K+ levels are too low, their pancreas makes less insulin. Did you know that? Might the level of insulin made have something to do with if they are skinny or fat? When insulin varies so does blood sugar. Does glucose change the charge density of RBCs? Does this change their optics? Studies show that people with low potassium levels release less insulin, have higher blood sugar levels, and are more likely to get type 2 diabetes than those with normal potassium levels. Did you know that? Did you know blue light raises blood glucose even when you don't eat any food? Think it does anything to K+ and insulin inside of cells?


    Potassium, both serum levels and to a lesser extent dietary intake levels, has been associated with incident diabetes. Lower levels of potassium have been found to be associated with a higher risk of diabetes. Few seem to understand how this links to biological clock function in humans........Do you yet?

    Without the proof-of-work contained in the terrestrial spectrum of sunlight, you have to rely on a manufactured central authority FOR TIMING in cells ALONE. Man has done this with his created light.

    Modern life and its technologies give us the dubious consent of breaking nature's rules of engagement. Nature, not productivity, is what we need, and whether we ever admit to it or not, nature is what we crave and love. Technology renders us irrational now. We're not thinking machines, we are feeling machines that happen to think. The feelings we see are nature's waves that gently kiss our intuition daily.

    The goal of the SCN is to standardize the time/unit of hydrogen bonds in water, not joules/units when it comes to T3 thermodynamics. Joules from T3 and leptin are simply needed to verify the correct hash rate was present in hydrogen bonds in water because it took TIME to create this molecular change. That is the idea behind PoW in biological clock construction. Keeping time constant in this "hydrogen bond code" makes health costly in time. Time is an asset for cells. Time is the most valuable asset cells can create because it allows for energy transformation from sunlight with high fidelity. Nothing else matters much when you understand it from this perspective. This is how value is maintained across space/time for cells.

    Hypothyroidism is a story about thermodynamics in cells. Thermodynamics is a story about time. Time is a function of how entropy flows and entropy flows according to how heat flows in a system. Heat is created in mitochondria from environmental signals and this amount of heat alters hydrogen bond density in water that a mitochondrion creates. ALL Clocks become more accurate the higher periodicity they have. Seasonal light alters the circadian periodicity of clock genes, and that is why humans get hypothyroidism. https://www.patreon.com/posts/qt-14-methionine-19082581

    As one gets fat/larger, Leptin levels rise in the blood. What happens inside cells? Once they get high enough (around a Body Mass Index (BMI) of 20-24), Tumor Necrosis Factor (TNF) rises in several tissues. This also causes a rise in NF kappa beta and IL-6 in the brain. TNF quickly destroys normal hepatic (liver) homeostasis, which sets the stage for fatty liver disease and types two diabetes over time. This rise in TNF also biochemically changes Leptin receptor signaling and changes its quantum properties by changing its “resonance” (think of a vibration-like effect in the receptor) at the hypothalamus level. Once TNF rises, it causes the liver to make an acute phase inflammatory protein called hsCRP.

    hsCRP is an inflammatory marker. hsCRP = Inflammation

    inflammation = too many protons chasing too few electrons which inhibit the structuring of water in cells by K+ = low pH = fewer electrons being delocalized in water networks on a relative basis = lowered charge density on K+ = decreases the structured water in cells and alters hydrogen bonds in cell water = which allows respiratory proteins to spread apart = lower probability of tunneling electrons and protons = less energy made by mitochondria = less water, melatonin, NAD+ in mitochondria = pseudohypoxia = higher % heteroplasmy = emergence or disease phenotype = no nuclear gene change required to cause disease = leptin is an electron & photon light accountant protein for redox strength = leptin resistance is a lack of electrons/sunlight = not enough water creation inside your cell = and too many protons not used to make water. Simple quantum logic buried in the wiring diagram of the mitochondria

    Today realize when you're in the midst of that struggle it's hard to see why you are sick and what you really are. Finding something more important than you are and dedicating your life to it is where happiness resides. That is where your health resides.
    5G Canary, JanSz and John Schumacher like this.
  2. Jack Kruse

    Jack Kruse Administrator

    It is difficult to get modern humans to understand the implications set forth in quantum biology when THEIR addiction to screens/LEDs/tech causes changes in neurons that preclude them from understanding. https://pic.twitter.com/vnY3b4BR5F
  3. I love the blending of thoughts -
    "the Proof-of-Work contained in the terrestrial spectrum of sunlight"
    "Joules from T3 and leptin are simply needed to verify the correct hash rate was present in hydrogen bonds in water"

    Well done ;)
    Last edited: Sep 15, 2022
    JanSz and ND Hauf like this.
  4. Jack Kruse

    Jack Kruse Administrator

    The entire point of Proof of Work in Nature is that it's a REAL connection to the real-world laws of physics which are impossible to change. Human ingenuity around light creation detached our species from unchangeably neutral physics and this reintroduce human subjectivity and all of the flaws of human nature into our healthspan.
    JanSz, John Schumacher and ND Hauf like this.
  5. Jack Kruse

    Jack Kruse Administrator

    To answer the deepest questions in biology, we will have to take a closer look at the concept of time itself and how living cells handle time creation. The physics of organisms creates time for cells by acting as heat engines. We use heat dissipation in cells and water to tell time. Mitochondria acts as the clock in this system. The clock in the eye gets the information about light first and this clock must run faster than all the other clocks in the body to keep time accurate inside of cells. Hot always flows to cold and as a consequence time is created. Our molecular clocks measure this heat dissipation as a flow of entropy. Clocks measure the flow of entropy in systems. The cellular organization of atoms in our clocks/SCN creates time using the heat of mitochondria. This heat ultimately came from sunlight and dark cycles in our environment. All life on Earth gets all its energy and information from the sun. Terrestrial sunlight in your local environment sets or breaks your clock based on what happens to hydrogen bonds in water.

    Sunlight or the photons that make up the light that falls to Earth are timeless because the energy in light has not yet been converted to heat by cells. Light photons never experience time because they have to interact with matter to create heat. The heat creates entropy and this creates the illusion of time because the atoms in our cells account for it like a ledger. That LEDGER is found in our hydrogen bonding cohesiveness in water networks that our mitochondria make.

    Very soon modern quantum biology will find and report in the literature that the significance of the hydrogen bond for physiology is greater than that of any other single structural feature in human biology.

    Artificial intelligence/light is not the same as intelligence gained in Nature. Its noise will affect the periodicity of clocks. A clock is anything that undergoes irreversible that alter the flow of entropy in cells: these changes allow energy to spread out altering the flow of time by allowing more atomic particles into a broader larger area. Anytime size and shape changes occur we know thermodynamics of how entropy flows has been altered. Time is essentially a ledger for the actions of light on the atoms inside your mitochondria. Time is proof that work was done by light on atoms of water in our cells. The timekeeper or clock is our mitochondrial heteroplasmy rate in tissues because it makes the water that contains the ledger of time. A mitochondrion is the Oracle of biology.
    JanSz and John Schumacher like this.
  6. You go Dr. @Jack Kruse -
    "the atoms in our cells account for it (time) like a ledger"
    "Anytime size and shape changes occur we know thermodynamics of how entropy flows has been altered."
    " Time is proof that work was done by light on atoms of water in our cells."​
    JanSz likes this.
  7. Jack Kruse

    Jack Kruse Administrator

    I don’t think people are fully understanding the severity of what a Ministry of Truth organized by American Medical Association truly means for public health. This what Stalin and Mao used to control the narratives and their populations to get you do what they want you to do.
    What do you need to make a Ministry operate well? Make sure there is no outside feedback loop to disintermediate the Ministry’s goals. The U.S. Ministry of Truth will ask people to sign up quietly to be complicity in distributing their policy of truth.

    For this compliance, they’ll promise “protection” to erase that pesky first amendment feedback loop for you. The first amendment in medicine is the PEER reviewed literature that has been ruined by Big Pharma money and methodology by design. This "first amendment" is the feedback loop for protecting the public from the Ministry of Truth. It was broken by design to get results the paradigm needs.

    Every industrial dictatorship has a propaganda arm—a “Ministry of Truth.” Centralized medicine has now formally joined the ranks of such dictatorships with their creation of the so-called “Disinformation Governance Board = social media fact checkers”. Social media fact checkers real name is purveyors of censorship of the truth. This board was built by Big Pharma and is hidden in academic institutions and corporations linked to the the WHO/WEF/AMA who are paid to create stories of truth favorable to the Ministry and who funds them.
  8. So -> has Dr. @Jack Kruse ever brought up these subjects before? Let’s begin a review of his blog…

    In his current post on the thread Educating Doctors – “Why are some diabetics skinny and some fat if they both have leptin issues?”, he said,

    “Cold temps cause the Fo head of the mitochondria to spin faster to create heat in uncoupled haplotypes.”

    Let’s review where he may have said this before:

    “Recall UV spectrum in sunlight heats mammalian skin up the most significantly. IR light in sunlight is considered cold light energy on a relative basis but it is the initial light of the sun that builds the EZ in tissues and our blood.”

    “uncoupled haplotypes can lower their metabolic rates using COLD and UV light. This is the basis of the Cold Thermogenesis-6 blog”

    So why is TSH & T3 regulation important on the subject of diabetics? Do we just need to supplement that? What does Dr. @Jack Kruse say,

    “During sleep, our CSF temperatures are designed to drop our hypothalamus temperatures in our brain where T3 and TSH are made by 2-4 degrees. This stimulates TSH & T3 release.”

    Most of us may look at our TSH & T3 levels through a functional clinicians' perspective - that is - if its low - sell the patient some thyroid hormone(s). One of the things I've noticed on this forum are individuals who seem to rush towards equilateral-izationing levels through supplementation. This concerns me...

    However, I believe Dr. @Jack Kruse is recommending stimulation rather than supplementation.

    Question - could a potential product like a chilling pad help? - https://sleep.me/
    Last edited: Sep 15, 2022
  9. Jack Kruse

    Jack Kruse Administrator

    How can you help people with thyroid problems? Help them move H+ in the matrix to make water when the matrix is broken. The sun is how Nature does it.

    What else can help? https://pubmed.ncbi.nlm.nih.gov/8624735/
  10. Jack Kruse

    Jack Kruse Administrator

  11. Jack Kruse

    Jack Kruse Administrator

    Sunlight stimulates serotonin production and use in humans. Guess what works in this system?


    Are you seeing a trend yet?

    When NAD+ is missing MB can help but the key is understanding why it works. Lack of water production is the real mitochondrial problem in illness.

    MB helps water recycling in bad engines.
  12. Jack Kruse

    Jack Kruse Administrator

    MB can donate electrons to coenzyme Q and to cytochrome C oxidase where water is made, thus increasing cytochrome oxidase (complex IV) activity and water production while increasing oxygen consumption.

    Low dose MB can augment defective mitochondria by taking dissolved unused oxygen in the cell to form water directly without ECT operational. Did you know this?

    MB has been shown to be able to speed up the removal of damaged mitochondria (mitophagy) in damaged neurons (stroke) cell prior to cell death. In some papers it has been shown to clear amyloid plaques to = its water effect.


  13. JanSz

    JanSz Gold

    Methylene Blue
    Please describe the desirable dose.

    @Jack Kruse

    I am using MB
    in the morning, one dropper full a day

    At the end of the day, most of the time, my urine turns blue.
    Does that mean anything?

    Last edited: Sep 16, 2022
  14. Jack Kruse

    Jack Kruse Administrator

    we don't practice medicine on the internet.
    JanSz likes this.
  15. Leptin Injections don't help

    Melatonin Absence Leads to Long-Term Leptin Resistance

    We showed that Melatonin treatment reduced food intake and body weight, due to its action on the hypothalamus modulating the expression of peptides.

    It is an absence of Melatonin that leads to a progressive leptin resistance.
    Protective Effects of Melatonin against Leptin Resistance

    Melatonin: not just a sleep hormone

    The pineal gland secretes melatonin during the night (a sleep hormone) and is regulated by SCN.
    • Melatonin possesses antioxidant (rejuvenates GSH redox system), anti-inflammatory properties, stunts cancer growth and tissue repair.
    • Melatonin regenerates the
      • heart,
      • lung,
      • kidney,
      • liver, and its treatment improves liver function
      • gut and
      • bones
    Therapeutic Target Analysis and Molecular Mechanism of Melatonin - Treating Leptin Resistance

    From a wide range of pathway classes, melatonin can reduce Leptin Resistance risks by regulating the major six classes. It includes
    • signal transduction,
    • endocrine system, endocrine and
    • metabolic disease,
    • environmental adaptation,
    • drug resistance antineoplastic, and
    • cardiovascular disease.
    Last edited: Oct 31, 2022
  16. Jack Kruse

    Jack Kruse Administrator

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