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wht do we know about white adipose tissue, beside cytokine IL-6...immunology etc

Discussion in 'Cold Thermogenesis' started by chocolate, Apr 9, 2012.

  1. chocolate

    chocolate Silver

    http://www.idpublications.com/journals/PDFs/JACI/JACI_MostCited_1.pdf





    I was trying to compare my raised skin from bad allergies to an earlier ct reaction. I was thinking the brown stuff was plumping up. The white stuff harbors IL-6. Talked about the need for a controlled burn.



    "Other cytokines and chemokines

    In addition to IL-6 and TNF-a, WAT expresses and

    releases a variety of other cytokines and chemokines.

    WAT-derived IL-1 receptor antagonist is markedly increased

    in the serum of obese subjects, as is IL-18,

    although its ultimate source has not been identified.57,58

    WAT also produces chemokines, including IL-8, MCP-1,

    and macrophage inflammatory protein 1.

    CORRELATION BETWEEN ADIPOSITY

    AND IMMUNITY-INFLAMMATION

    Obesity, particularly visceral adiposity, is associated

    with chronic low-grade inflammation, as indicated by

    increased levels of the inflammatory markers CRP and

    IL-6 in the circulation of obese subjects. Although not

    completely demonstrated, the current working hypothesis

    is that adipokines, cytokines, and other factors produced

    and released by WAT are responsible for the chronic

    inflammatory state of visceral obesity. The concomitance

    of inflammation, hypertension, and dyslipidemia increases

    the likelihood of development of type II diabetes and

    CVD.59 However, the ultimate reason for increased production

    of proinflammatory factors byWATin obesity has

    not been identified. Furthermore, visceral adiposity, rather

    than simply a high body mass index (BMI; in kilograms"



    I wonder if cold is any good for inflammation?
     
  2. chocolate

    chocolate Silver

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