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Discussion in 'The Epi-Paleo Diet' started by Jack Kruse, Jan 23, 2019.

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  1. Jack Kruse

    Jack Kruse Administrator

    How does a defective circadian mechanism in enterocytes lead to alterations in the microbiome? The light environment causes it. This allows bacteria to moderate active vitamin A levels in the intestine to control its fidelity, protecting or harming the microbiome from an overactive immune response. http://bit.ly/2PRUbmn
  2. Jack Kruse

    Jack Kruse Administrator

    What doesn't this guy know? Light in the primate zoo is very similar to light in the hominid zoo and the results are the same. It is painfully obvious what he is missing. How long do you think it will take for him to get around and reach Jeff Leach's work in Science on this topic? Light at the equator does not vary and no matter what you did to the Hadza their microbiome there was rock solid. Wild primates and wild humans have a lot in common. The most interesting thing is the zoo humans have no idea they have a lot in common with the confined primates because they are being forced to live indoors under blue light. The very same light stress environment we see in US zoo humans in neighborhoods. #mitochondriacwisdom https://www.youtube.com/watch?time_continue=1&v=FW3198J83RQ
  3. Jack Kruse

    Jack Kruse Administrator

  4. Jack Kruse

    Jack Kruse Administrator

    When the gut and brain are disordered by electromagnetic pollution is suicide a likely outcome? Is this why we are so bad at helping those with mental illness in the USA? Is it because we have no Earthly idea it is tied to our use of the spectrum?
    Is this why food cannot solve the quantum problem?
    Food did not solve this young lady's problems as we traveled from SF to NYC over the last decade, at all did it? Condell listed her “favorite things in life” as “food, helping people, and science,” according to the bio". If you cannot help yourself you won't help anyone else. The key is understanding the less wisdom you obtain from your sensory afferent abilities from nature, the more human bias you acquire and believe and this can lead to diseases of thinking you did not expect and is difficult to track back to the original source. Mental illness is a fundamental electromagnetic problem. I hope we get to this level of understanding soon because this suicide wave I predicted in 2005 is becoming a tsunami in 5G cities now illuminated with artificial light. https://nypost.com/2019/01/31/young...st-hanged-herself-after-posting-suicide-note/
  5. Jack Kruse

    Jack Kruse Administrator

    Since I've established for you that the gut lumen below the LES is anoxic and this helps bacteria live well, so they can create 5000 times the amount of ELF-UV that our own cells would do........have you ever stopped to ask yourself what this set of circumstance means for NO production in the gut lining?

    Does it mean MASSIVE amounts of NO is likely made in the gut?

    We know that the blood volume to the gut is INDUCIBLE. When we eat blood flow into the mesenteric arterial system rises......This is helped by local NO production.

    What does off the chart NO production the gut mean for the viscera? It means oxygen will be shunted from the surfaces of the gut to deeper levels because NO inhibits CCO in the gut surface. So when we eat the evolutionary blueprint of the gut is to make itself quite hypoxic and this would lower NAD+ and age the gut lining really quickly. Why would Nature try to raise the age of the gut lining?

    Because it is designed to be replaced every 24-72 hours to get rid of deuterium the enterocytes collect from foods.

    The shunting of paramagnetic oxygen goes to the liver via the portal circulation where cells contain massive amounts of catalase and CCO and inducible heme enzymes called the P 450 system. These enzymes are all under the CYP SNP's on your 23andme data when you run your raw data. This tells us that NO production is critical in optimizing phase one and phase two detox pathways.



    IS THIS WHY FUNCTIONAL MEDICINE AND THE GUT EXPERTS LIKE ZACH BUSH truly are marketing snake oil salesmen?



    Who packs your medical parachute? In this podcast, you are lead to believe you are hearing groundbreaking ideas on neurodegeneration. I am going to tell you-you are not hearing anything truly worthwhile if you're a Black Swan. Why do I give this scathing criticism?

    What do most clinicians and biochemists understand fail about the biophysics of nitric oxide(NO) production and physiology?

    How light and NO work in us. Share this with your clinicians to upgrade their knowledge so they can help you get to optimal. Nitric oxide and LLLT are interesting bedfellows. Light-mediated vasodilation was first described in 1968 by Furchgott, in his nitric oxide research that leads to his receipt of a Nobel Prize thirty years later in 1998. Later studies conducted by other researchers confirmed and extended Furchgott's early work, and demonstrate the ability of light frequencies to influence the localized production or release of NO, and to stimulate vasodilation through the effect NO on cGMP. This finding suggests that properly designed illumination devices may be effective, noninvasive therapeutic agents for patients who would benefit from increased localized NO availability. However, the wavelengths that are most effective on this light-mediated release of NO are different from those used in LLLT, being in the UV-A (320-400 nm) and in some cases light frequencies present in the low blue range just above UVA.

    UVA light also marks the time of the day where PER1 gene is transcribed and found in its HIGHEST CONCENTRATION in the blood plasma to affect all tissues ability to tell time well. Without this frequency of sunlight, PER1 activity is poor in the plasma and cannot turn out the proper endogenous cycles in the cytoplasm of cells to optimize the timing of metabolic pathways in biochemistry. Just knowing the pathway matters little in this situation because you need to understand what is controlling its kinetics because altered kinetics come from bad circadian timing in cells. This = broken circadian mechanism = poor redox state = poor solar exposure. This is why food gurus and biochemists continue to trip over the dogma.

    Some wavelengths of light are absorbed by hemoglobin, and that illumination can release the NO from hemoglobin (specifically from the nitrosothiols in the beta chain of the hemoglobin molecule) in red blood cells (RBCs) Since RBCs are continuously delivered to the area of treatment, there is a natural supply of NO that can be released from each new RBC that passes under the light source and is exposed to the appropriate wavelength of photon energy. Since the half-life of the NO released under the area of illumination is only 2 to 3 seconds, NO release is very local and focal, preventing the effect of increased NO from being manifested in other portions of the body. Vasodilation from NO is based on its effect on the enzyme guanylate cyclase (GC), which forms cGMP to phosphorylate myosin and relax smooth muscle cells in the vascular system. Once available levels of GC are saturated with NO, or once maximum levels of cGMP are achieved, further vasodilation through illumination will not occur until these biologic compounds return to their pre-illumination status. This system is designed to feedback upon itself. Again, the wavelengths that have been shown to mediate this effect tend to be in the UV-A and blue ranges, not the red and NIR wavelength ranges that are mainly used for LLLT.

    Many people are unaware that cytochrome c is a heme related protein. This is critically important in understanding how light and mitochondria work at the most fundamental level. The activity of cytochrome c oxidase is inhibited by nitric oxide (NO). This was a surprising discovery to those who do understand how mitochondria work with light and sleep. They found it 'shocking' that the body could and would poison one of its own enzymes; in fact, it was initially shrugged off as an imperfection of experiment, but a few years later, several groups reported that mitochondria produced an enzyme that synthesizes NO, that was identified as the neuronal isoforms of NO synthase.

    It was proposed that evolution crafted cytochrome c oxidase to bind not only oxygen but also to use the NO as a braking mechanism for electron flow and power in the mitochondria. The effect of slowing respiration and electron flow in some locations was to divert oxygen elsewhere in cells and tissues. Since O2 is paramagnetic and drawn to magnetic fields, O2 will naturally flow without much effort of extra needed energy to move toward mitochondria where magnetic fields are generated due to good redox power.

    Since NO blocks respiration in the endothelial cells lining blood vessels, and this helps to transfer oxygen into smooth muscle cells in these vessels where it is needed and required by physiologic demands. This effect is very misunderstood in the etiology of PAD and atherosclerosis damage. A lack of sunlight with UVA light is the FIRST STEP in these diseases. This is why most people with PAD and atherosclerosis have low Vitamin D status and poor redox.

    This inhibition of mitochondrial respiration by NO can be explained by direct competition between NO and O2 for the reduced binuclear center CuB/a3 of cytochrome c oxidase and is reversible. Many people do not even realize that cytochrome c is inducible. Details matter in quantum biology. It was later proposed that laser irradiation could reverse the inhibition of cytochrome c oxidase by NO by photodissociating NO from its binding sites. Because this coordinate binding is much weaker than a covalent bond, this dissociation is possible by visible and NIR light that has insufficient energy to break covalent bonds. This ability is used in optogenetics. This ability is also used in PBM.

    The dissociation of NO from COX will thus increase the respiration rate ("NO hypothesis"). The experiment has now proved, light ALONE can indeed reverse the inhibition caused by NO binding to cytochrome oxidase, both in isolated mitochondria and in whole cells. Most clinicians are unaware of this ability of UV and IR light. This is incredibly important in CAD, PAD, atherosclerosis sand all neurodegeneration because this is HOW THEY ALL BEGIN. when you do not get out in the sun in nature it alters the redox state of the arterial wall and the RBCs in the artery. This ruins the peroxiredoxin heme proteins in the RBC's and they lose their DHA, Vitamin C, and ability to induce the COX enzyme. All of these things age the blood cells faster and lower their ability to carry oxygen and CO2 while keeping the innate immune system activation status in the blood plasma active. This ruins how Toll receptor proteins work and also can lead to autoimmune conditions like Crohn's disease. You should no longer be surprised how effortless nature really is below your level of understanding. Light can also protect cells against NO-induced cell death. These experiments used light in the visible spectrum, with wavelengths from 600 to 630 nm. NIR also seems to have effects on cytochrome oxidase in conditions where NO is unlikely to be present. This is why parabiosis studies show the effects they do. These are the things we do for our clients at Kruse Longevity Center. https://peterattiamd.com/franciscogonzalezlima/
  6. Jack Kruse

    Jack Kruse Administrator

    So a simplified gut flora really means what to a Black Swan? = you are not able to mount enough NO to allow the gut to work properly. This tells you why appendectomies and gallbladders get removed so often yet show no macroscopic disease.

    You cannot see NO or UVA light and the surgeon has no way to assess these quantum mechanisms during surgeon. So when in doubt......they take them out.

    That is the reality you see when you train as a surgical resident.
  7. Jack Kruse

    Jack Kruse Administrator

    Leland's premise is correct in this article. Let us dissect why: food is only needed as an electron and proton source to create the smallest current/force we need to remain alive to keep subatomic particles moving from cytochrome 1 to oxygen. For those how don't know death occurs when this motion STOPS. When it stops we die = what cyanide does to CCO (cytochrome 4). This is why I say mitochondria really are a Turing machine. Here is the real important point......This action is the see-saw of life. You need the quantize balance of both actions to get Optimal outcomes. Sunlight SLOWS the flow of ECT via UVA and UVB light - the VDR and NO actions on CCO.
    So what is nature saying? When you live in sun you'll need seasonal food but you won't need a lot of you are in my sun.......If you are not.....you'll eat a lot more out of the sun or further from the equator which is why I made uncoupled haplotypes.
    This is Mother Nature's message nobody seems to get in the food guru world. https://medium.com/@StillmanMD/who-will-win-the-diet-wars-aa7d16ec7de6
    Richelle Jones and Tanya McGowan like this.
  8. Jack Kruse

    Jack Kruse Administrator

    5G is going to ruin sulfation and nitrosylation of your skin, gut, and eye because it will affect surfaces first because of how these waves ruin the topology of these surfaces. It is a prediction I made about the engineered 5G RF portion of the wavefronts because of its pulse rate and polarization. Now we have more data why this prediction was made.

    Sulfated-Nitrosylation is the covalent attachment of a nitric oxide group (-NO) to cysteine thiol within a protein to form an S-nitrosothiol (SNO). Sulfated-nitrosylation has diverse regulatory roles in bacteria in the microbiome, yeast, and plants and in all mammalian cells. This process is almost always associated with massive liberation of molecular hydrogen in the gut when this process occurs. The process of parsing H+ from deuterium in the microbiome controls the growth of species in the human gut because of the effect of deuterium to control the growth of the microbiome.

    This process is run by three gasotransmitters thus operates as a fundamental mechanism for cellular signaling across phylogeny and accounts for the large part of NO bioactivity in the human gut. This would have been the topic I was going to speak about in Vermont 2019 but I changed plans and instead am heading to Munich Germany for Flowfest July 5-7, 2019.


    How do you heal a gut in an electromagnetic polluted city using this basic science? Might it be wise to eat seasonal foods with nitrates (Epi-paleo Rx) and then get in the sun to boost your exercise performance?

    Maximal nitrates come from seasonal vegetables only grown in the SUN and not in artificial light. It also is found in meats made in many of the countries of Europe.

    This is why charcuterie is a staple for me because nitrites added to meat are not damaging but quite helpful if you go outside. When you don't go outside in the sun, that's when you have problems with nitrates.

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