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What parameters would you recommend consideration for Cold Hypothermic Therapy?

Discussion in 'Ask Jack' started by John Schumacher, Mar 17, 2021.

  1. We know cold therapy is "good for you". There many benefits.
    upload_2021-3-17_16-11-26.png

    Application of therapeutic hypothermia in the intensive care unit – https://link.springer.com/article/10.1007/s00134-003-2151-y Hypothermia can be used to protect the brain from post-ischemic and traumatic neurological injury.
    • lowers metabolic rate
    • decreases the adenosine tri-phosphate (ATP) demand
    • raises lactate acid levels and increases membrane stability
    • decreasing permeability of cellular membranes, blood-brain barrier and blood vessel walls
    • protective against neurological injury by decreasing accumulation of neurotransmitter glutamate
    • enhances immunity
    • increase insulin sensitity
    The initial induction of mild hypothermia increases myocardial oxygen demand. Mild hypothermia decreases cardia output by about 25%, leading to an increase of vascular pressure. A potential reason for a decrease in the T wave amplitudes from mild hypothermia is that -> Leptin decreases heart rate associated with increased ventricular repolarization via its receptor - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666984/

    Adding to the story of Leptin - https://academic.oup.com/edrv/article/41/2/232/5644230 Leptin acts in the brain to suppress food intake. However, Leptin has no thermogenic effect. It does not activate BAT-dependent thermogenesis, as is evident from the absence of an effect on energy expenditure. Leptin does not lead to thermogenic recruitment of BAT, but there are indications that leptin can affect sympathetic nerve growth and activity, thereby regulating lipolysis.

    Clinical application of mild therapeutic hypothermia after cardiac arrest - https://journals.lww.com/ccmjournal...inical_application_of_mild_therapeutic.7.aspx - Therapeutic hypothermia is feasible and can be used safely and effective

    Hypothermic therapy modifies the transmural repolarizing gradient by reducing the amplitude of the T wave - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6931437/
    upload_2021-3-17_16-27-14.png
    The simulated activation sequence and action potential duration (APD) distribution under normothermia (38 °C) and hypothermia (32 °C). A, normal APD distribution; B, APD endo were increased proportionally to APD epi; C, APD endo were increased by 50% less than APD epi; D, APD endo were not increased. The transversal and frontal views of the model are presented. The schematic of APD gradients calculation is depicted by arrows. APD = action potential duration; RT = end of repolarization times; endo = endocardial; epi = epicardial.

    • Note: the Body surface potential distribution (BSPD) inversion under hypothermia (implying changes not only in the amplitudes of the T wave, but also the T wave polarities in the majority of leads) is the experimentally documented inversion of epicardial repolarization time (RT) gradients. Therefore, the transmural RT gradient does not play a predominant role in hypothermic BSPD inversion. At the same time, the magnitude and direction of the transmural RT gradient contribute to the amplitudes of the inverted hypothermic T waves: the normal transmural gradient (RTendo > RTepi) decreases the T wave amplitudes, while the inverted transmural gradient (RTendo < RTepi) amplifies the T wave amplitudes, with greater inverted transmural gradient causing greater T wave amplitudes.
    There have been hundreds of studies on hypothermic therapy.

    Including: Adult Hippocampal Neurogenesis Can Be Enhanced by Cold Challenge - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411820/ The effects of cold challenge increased hippocampal neurogenesis (AHN) and hippocampal gene expression. The Cold challenge (6 ± 2°C) for 4 weeks caged mouse study.

    who wants to live in continual 6 degrees C for the winter.
    NeuroAthletics reported: https://www.neuroathletics.com.au/cte-/concussion/coldthermogenesis -
    • One Hour At 57F Degrees Increases Norepinephrine Levels By 530% And Dopamine Levels By 250%.
    • Norepinephrine Has Anti-Inflammatory Properties At High Concentrations (Pongratz, 2014).
    • The Norepinephrine Signalling Pathway Also Plays An Extremely Important Role In The Regulation Of Hippocampal Function, Which Is Important For Memory And Learning.
    What Temperature And Duration Are Required in this report?
    • Starters: Taking A Cold Shower, Jump Into A Cold Pool, Lake, River, Seas For At Least 2 To 5 Mins A Day Is A Good Way To Start.
    • Real Therapy: Cold Water Immersion for One Hour At 57F (14C) Degrees Increases Norepinephrine Release By 530% (Sramek, 2000).
    My practice has been ->
    Water immersion at 50 to 55 degrees F submerged up to my chin, covering the back of my neck as well. If the water is moving, which I prefer a river -> it has a higher voltage potential and its continuous movement cools all the "warm" parts, including where the large blood vessels go from your torso down into your legs, arm pits and the blood to your head. I spend at least 20 minutes minimum; sometimes I have time to spend 50 minutes; at this point, hopefully, I will get a good chill/shiver going which could last an hour or more after the therapy session; this shiver is in itself therapeutic; it sends your heart-rate-variability into a strong parasympathetic zone.

    Thank you Dr. @Jack Kruse for your CT reasoning & "protocol" - https://jackkruse.com/the-evolution-of-the-leptin-rx/ & https://jackkruse.com/cold-thermogenesis-easy-start-guide/
    upload_2021-3-18_16-53-10.png

    Knowing the right parameters, understanding your own N=1 redox value, human haplotype, medical diagnosis are just some of the variables to take into consideration.


    What parameters would you recommend consideration for Cold Hypothermic Therapy?

    The Nordic Morning Routine - Ice bath


    Eisbaden in zugefrorenen See

     
    Last edited: Mar 19, 2021
    Braden M likes this.

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