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What Fluoride does to the thyroid gland in pictures.

Discussion in 'Redox Rx' started by Jack Kruse, Oct 23, 2014.

  1. Jack Kruse

    Jack Kruse Administrator

  2. Jack Kruse

    Jack Kruse Administrator

  3. Jack Kruse

    Jack Kruse Administrator

    So let me ask you...........when you lose energy in your thyroid what happens? It gets bigger. See........EMF 2 has the juice.
     
    SlamSlask and (deleted member) like this.
  4. Josh

    Josh Gold

    E=MC2, Law of Mass Equivalence
     
    Shijin13 likes this.
  5. Jack Kruse

    Jack Kruse Administrator

    I told you hydrogen can also act as a group 7 halogen in Tensegrity 6. It means it can gain electrons to become a non metal. When hydrogen does this in water when it is associated with iodine it forms an ionic liquid. Ionic liquids are now receiving special attention in science, owing to their unique properties such as high ionic conductivity, non-volatility and non-flammability. This ability makes these fluids versatile alternatives to conventional solvent-based systems used to make batteries, fuel cells, and super capacitors that hold large charges. Fluoride blocks the ability to hold charges........and we lose energy and leak light from our mitochondria. That light is IR in thyroid mitochondrial cells.
     
    rlee314 and FreeRangeKiwi like this.
  6. primaledge

    primaledge New Member

    Is the information about fluoride calcifying the pineal gland accurate?

    Here in Ecuador the water is not fluoridated....BUT, the good ol' government here so lovingly declared it LAW that all salt used in restaurants, processed foods, etc is fluoridated. Several of our neighbors have health issues likely directly stemming from this - tyroid problems, anemia, etc. The obesity rates here are markedly higher among the middle aged generation than their parents.
     
    Sean Waters and SlamSlask like this.
  7. The reaction between hydrogen and fluorine is an example of an oxidation-reduction reaction:

    H2 + F2 → 2 H+ + 2 F− → 2 HF​

    Molecular Mechanisms -> Fluoride Inhibits Sodium/Iodide - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466022/
    Fluoride inhibits Na+, K+-ATPase activity.
    upload_2021-8-12_11-45-5.png
    Oxidative damage to macromolecules in the thyroid - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3542017/

    Fe2+ + H2O2 → Fe3++• OH + OH−​
     
    Last edited: Aug 12, 2021
    JanSz likes this.
  8. Iodine displacement of fluoride from thyroid gland is activated by IR-A morning sunrise light.

    A comparative study of fluoride ingestion levels, serum thyroid hormone & TSH level derangements, dental fluorosis status among school children from endemic and non-endemic fluorosis areas - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890436/

    https://pleijsalon.com/enhance-thyroid-gland-health-with-red-and-near-infrared-light-therapy/

    Thyroid Peroxidase (TPOAb) antibodies decline from near infrared therapy - https://pleijsalon.com/enhance-thyroid-gland-health-with-red-and-near-infrared-light-therapy/
    Safety and Efficacy of Low-Level Laser Therapy in Autoimmune Thyroiditis - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247385/
    upload_2021-8-15_9-39-58.png
    The general idea of what "we know" is the effects of infrared light come from the interaction with at least two main photoacceptors, including cytochrome c oxidase (unit IV in the mitochondrial respiratory chain) and intracellular water. The photons dissociate inhibitory nitric oxide from the cytochrome c oxidase, which promotes increases in electron transport, mitochondrial membrane potential, and adenosine triphosphate (ATP) concentration. There are many signaling pathways are activated through Ca2+ release from intracellular stores, which increases the concentrations of cyclic adenosine monophosphate (cAMP). These factors can induce increased expression of genes related to the synthesis or release of many molecules, such as growth factors, interleukins, cytokines, anti-apoptotic proteins, and antioxidant enzymes. These molecules are responsible for cell proliferation/differentiation, regeneration of several types of tissues, and modulation of immunological responses.

    However, fluoride toxicity can not be over come by IR-A light ->
    A few examples:
    Fluoride hazard quotient and medical geological health implications in divergent human populace -
    https://www.nature.com/articles/s41598-019-52812-3
    upload_2021-8-15_9-40-48.png
    Groundwater contamination is an enormous problem - https://www.downtoearth.org.in/coverage/indias-groundwater-is-flooded-with-fluoride-12676

    As Dr. @Jack Kruse has said -> It's your zip-code which makes the largest environmental difference on your health's potential outcome.

    In Ban Mae Toen is a small rural village in the Thai, this women has no electricity, no cell phone, no plumbing, the out-house is outside; she's a gardener. Her children experience brain damage and deaf-mutism.
    https://www.vice.com/en/article/3b74gw/a-contaminated-lake-is-poisoning-a-thai-village-855
    The picture Dr. @Jack Kruse posted at the top of this thread is the women poisoned.

    From a Thermodynamic perpective ->
    Enzymatic dehalogenation reactions - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575885/

    Glutathione S-transferase-like reductive dehalogenases

    An additional well-studied class of reductive dehalogenase is a glutathione S-transferase (GST) superfamily protein capable of dehalogenating the toxic intermediate tetrachlorohydroquinone (TCHQ)
    upload_2021-8-15_9-42-55.png
    Halogen atoms like (fluorine, bromine) can reap havoc on our health. Dehalogenating enzymes are best known for removing halogen atoms from man-made organohalogens.
    upload_2021-8-15_9-43-42.png

    Using a thermodynamics point of view as to why interspecies hydrogen transfer -
    Thermodynamic Cycle That Relates the Equilibrium and Kinetic Parameters for the Enzymic Reaction
    upload_2021-8-15_9-56-47.png
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477011/

    Balancing Kinetics and Thermodynamics -> the energy to achieve a nearly thermoneutral reaction in the enzyme is about 290 kcal/mol relative to the gas-phase reaction.

    https://www.researchgate.net/publication/40795347_Thermodynamic_Considerations_for_Dehalogenation
    The hehydrodehalogenation pathway uses nitrate or sulfate with hydrogen in reducing biochemical reactions.

    A Biochemical Study of a Cataboic Reductive Dehalogenase – https://www.research.manchester.ac.uk/portal/files/85715519/FULL_TEXT.PDF
    NAD H-driven organohalide reduction by a catabolic reductive dehalogenase

    From a Mitochondrial Perspective ->
    Is it possible to evaluate the productive energy potential of damaged mitochondria? - Not just for cellular survival but for recovery from debilitating environmental toxins? like the example of fluoride.

    Since we know the environment (zip code) has layed its impact, removal from the environment where the patient got sick maybe step one.
    However, the damage is done. Scaring of system may have found a new homeostasis for survival of the human organism (patient).
    Now what?
    We know the mitochondria need a Thermodynamic energy boost. NAD is used multiple times at each step throughout the ATP cycle. Its depletion is most likely.
    Should a physician consider NAD+ supplementation just to help the flailing beaten Citric Cycles' respiration?
     
    Last edited: Aug 15, 2021
  9. Dr. @Jack Kruse says,
    "Normally K+ is more polarizable than water, so polarization is added to the Coulomb energy in a cell. But, when fluoride or bromide are added to a cell for any reason, dielectric collapse occurs. This is precisely how the dielectric constant in water is destroyed in “floxed patients”.

    The reality is that life is really a continuum of physics built upon the sliding scale of geometry on our respiratory proteins, to create amazing diversity. Ling was the first to realize K+ ions were linked water chemistry and eventually to the ATPase. This is the sliding scale a “floxed patient” needs to pay attention too. When the ATPase slows proteins remain unfolded and water cannot bind to them to transfer energy throughout the cell.

    So when you have altered poor K+ ion and you’re dehydrated by our modern world, your cell’s interior becomes pseudo-hypoxic and NAD+ levels drop. This cause mitochondria to swell and calcium homeostasis is lost. Cells begin to leak electrons and light in the form of ELF-UV light.

    This causes a redox shift of the mitochondria cytochromes and increases the distance between the respiratory proteins. In other words, your mitochondria down shift electron tunneling speeds, by slowing their ECT flow, to protect itself from short-circuiting.

    They do this because of the lack of electrons and water. This is why ketosis is a partial fix in “floxed” patients. This becomes energy costly to a cell.

    Every stressed cell releases ELF-UV light. When this happens chronically in many tissues sequentially because of how drugs are prescribed your cells that need energy are starving for it.​


    Bottomline: How are you hydrating yourself?
     
    Richard Watson and Sara S like this.
  10. JanSz

    JanSz Gold

    @Jack Kruse
    @DrEttinger
    ----------------------------
    @John Schumacher said:
    Bottomline: How are you hydrating yourself?

    JanSz asks:

    How about changing that to:
    Bottom line: Are you tending to your K+ sufficiently?


    Dr. Jack Kruse Talks About Fluoroquinolone Toxicity - My Quin Story
    Water will come to the cell when there is enough K+.
    Last drop of fat will give its H up to make plenty of water in the cell.

    Cell water is there not because you drink it.

    .
    ......................................
     
    Last edited: Sep 15, 2021
    John Schumacher likes this.
  11. JanSz

    JanSz Gold

    @Jack Kruse
    Who are those people whose potassium is 3.5 or less?
    I suspect that they are basically goners.
    I had always "good" potassium level and that put me and my doctor to sleep for good 30+ years at least, while I had (idiopathic) leg cramps.
    I suspect that this potassium test should be taken out of
    Comprehensive Metabolic Panel (CMP 14)
    because it misleads everybody.
    When I did
    potassium RBC
    I found that I hardly have any potassium.
    One cent worth of potassium bicarbonate a day, solved my cramps, pronto.
    On top of that as a bonus, my GERD is gone too. So no need for gastric acid pills.
    upload_2021-9-15_17-35-18.png
    AVERAGE(3.5,5.2)=4.35---->>May 14/2021 I had 4.2 potassium, almost ideal, but if I would forget my evening dose of potassium bicarbonate I would have to run for it 3AM jumping of the bed, limping and crying.

    https://www.myquinstory.info/dr-jack-kruse-talks-about-fluoroquinolone-toxicity/
    upload_2021-9-15_17-37-42.png
     
    Last edited: Sep 15, 2021
    John Schumacher likes this.
  12. Fluoride Exposure Induces Inhibition of Sodium-and Potassium-Activated Adenosine Triphosphatase (Na+, K+-ATPase) Enzyme Activity -
    upload_2021-9-16_10-40-8.png

    Schematic representation of the molecular mechanisms and biological pathways by which fluoride inhibits Na+, K+-ATPase activity on plasma membranes and in thyroid follicular cells.

    Key molecular mechanisms by which fluoride inhibits Na+, K+-ATPase activity. Arrows refer to increases (↑) or decreases (↓) in regulation or expression by fluoride.
    upload_2021-9-16_10-41-34.png
    upload_2021-9-16_10-42-5.png
    Abbreviations: NKA: Na+, K+-ATPase; PKC: Protein kinase C; ATP: Adenosine-triphosphate; cAMP: cyclic adenosine-monophosphate monophosphate; Cn: Calcineurin; CaM: Calmodulin; Mn2+: Magnesium; cGMP: Cyclic guanosine monophosphate; ENO1: Enolase; NO: Nitric oxide; Pi: Inorganic phosphate; ALP: Alkaline phosphatase; TGF-β1: Transforming growth factor β 1; CT: Calcitonin; DA: Dopamine; PTH: Parathyroid hormone; PLA2: Phospholipase A2; AA: Arachidonic Acid; Prostaglandin E2; BgL: Blood glucose; Glc: Glucose; RAGE: Receptors for advanced glycation end products; OC: Osteocalcin; DA: Dopamine; PTH: Parathyroid hormone; INS: Insulin;. TSH: Thyroid stimulating hormone; TRH: Thyroid-releasing hormone.

    F− inhibition of NKA activity is complex and multifactorial. In summary, evidence is provided to show that activation of PKC, cAMP, cGMP, NO, Pi, PLA2, AA and PGE2 inhibit NKA activity and that F− upregulates PKC, cAMP, cGMP, NO, PLA2, AA, PGE2 and enhances Pi levels in systemic circulation. Furthermore, evidence is presented to show that Cn regulates NKA activity and that F− inhibits CN activity, in part, by regulating the bioavailability of manganese and Pi, as well as by altering the phosphorylation activity of CaM. In addition, evidence is provided to show that F− enhances the activation of adenylate cyclase by CaM, leading to increased levels of cAMP and further evidence is provided to show that F− inhibits the activation of phosphodiesterase by CaM, which is responsible for the breakdown of cAMP.

    Further evidence is presented to show that NKA activity is inhibited by dopamine, PTH and glucose. In addition, evidence is presented demonstrating that F− upregulates dopamine, glucose and PTH activity. Further analysis reveals that the mechanism of dopamine inhibition of NKA is via increased production of cAMP. It has also been elucidated in this study that NKA inhibition by PTH and hyperglycaemia is regulated by activation of PLA2, AA and PGE2. In addition, there is evidence demonstrating that stimulation of AGEs inhibits NKA activity and that F− inhibition of enolase results in the formation of AGEs. Again, the mechanistic pathway by which AGEs inhibit NKA enzyme activity is via activation of the PLA2 pathway leading to enhanced expression of AA and PGE2.​

    As highlighted above, there is also an association between hypothyroidism and loss of NKA activity, suggesting a negative feedback mechanism that may further decrease enzyme activity. As elucidated in this current study, this mechanism appears to be driven by increased TRH secretion and DA release which leads to inhibition of enzyme activity.
     
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