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UV Light and Stargardt's

Discussion in 'Ask Jack' started by SatoriHeart, Feb 16, 2017.

  1. Jack, what are your thoughts on the relationship of full spectrum sunlight to Stargardt's disease? I've been giving a lot of thought these days to various ailments of the eyes, and I'm intrigued by their effects on neuroendocrine function, among other things.

    The accepted etiology of Stargardt's is a defective ABCA4 gene, which is produced in the retina's photoreceptors. This defect allegedly leads to toxicity due to lower levels of N-retinylidene-PE, which "mops up" toxic substances produced by phototransduction. As a result, lipofuscin builds up in the RPE, and the rods and cones deteriorate. Brain lipofuscin, anecdotally, can be cleared using agents such as Centrophenoxine (a DMAE derivative). As far as I know, oral intake does not reach the RPE, where the problem resides... So we have to look for other options.

    More and more, you are saying that disease is less about the presence of SNPs, and more about mitochondrial health. I wonder how we can look at Stargardt's from a different angle (the mito-angle) to better understand ways to prevent or even reverse it.
  2. Jack Kruse

    Jack Kruse Administrator

  3. Jack Kruse

    Jack Kruse Administrator

  4. Jack Kruse

    Jack Kruse Administrator

    80-85% of disease is mitochondrial based. 15% is genetic.
  5. Jack Kruse

    Jack Kruse Administrator

    This disease still effects the weak covalent bond between retinol and any opsin in the eye. There are many other genes associated with variants of this juvenile macular/RPE eye disease. Ophthalmologists still recommend wearing sunglasses and hats outdoors and blue-light blocking glasses when exposed to artificial light sources with this disease because of the Vitamin defect. Tobacco smoke and second-hand smoke should be avoided because they induce mitochondrial pseudohypoxia. Animal studies also show that high doses of vitamin A can be detrimental by building up more lipofuscin toxin. We don't know if that is true in humans but I am not a supplement Vitamin A guy. Dietary non-supplemental vitamin A intake may not further the disease progression. There are 3 separate types of vitamin A's out there too.

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