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Understanding Melanoma in Australia: by way of Viagra

Discussion in 'Educating Doctors' started by Jack Kruse, Nov 24, 2016.

  1. Jack Kruse

    Jack Kruse Administrator

    Why would drugs, like Viagra, cause a cancer like melanoma? Well Viagra causes massive release of nitric oxide (NO) without the stimulus of sunlight. Most people take Viagra indoors under blue light before they want to have sex. NO is made naturally by UVA light. UV-A light is not present all the time during the day. This various by latitude, altitude, and by mitochondrial haplotypes. What happens if your cells never see UV-A light because you live and work indoors? Blue light and nnEMF cause a rise in heteroplasmy rates in mitochondria and whehn you force NO higher, blood flow will increase and since RBC's carry oxygen to tissues. When there is a "forced release" of NO, we get more free radicals from the oxygen. delivery. NO and oxygen have to have a precision or a be associated with light quanta to work properly, and when they are not yoked as they would be in a natural endogneous coupled cycle to solar light we get spikes in oxygen radicals that lead to diseases of mitochondrial flux. Melanoma is one such disease so this should not surprise anyone. Several of my MD colleagues were very surprised by this link when I showed it to them today. Nitric oxide is one of the biggest stimulators of angiogenesis in the body, and increased angiogenesis is a hallmark of the oncogenic state. Most men who use this product have poor mitochondrial function to begin with. Why? Erectile dysfunction is due to a LACK of blood flow to the penis to get erect. Where does the blood come from? The heart. The heart has one of the highest mitochondrial capacities of any tissues, so if the mitochondrial energy flux is DECREASED we should expect less blood flow from the heart to distal tissues like the pelvis. This links heart disease to erections since the erect penis gets hard from the flow of blood to the penis. A recent medical study links sildenafil, best known by its brand name, Viagra, to an increased risk of melanoma, a deadly form of skin cancer. According to study results published by JAMA Internal Medicine, Viagra may have nearly doubled melanoma risk in an estimated 45 million men who opted to take the drug since it hit the market in 1998.

    Skin cancer is the most common form of cancer in the United States, and melanoma is the deadliest form of the disease. According to the Melanoma Research Foundation, melanoma is usually, but not always, a cancer of the skin that begins in melanocytes, which are pigment-producing cells in the skin that synthesize melanin, the pigment that gives skin its color. Melanocytes are the cells responsible for the formation of moles, within which melanoma often develops. Rarely, melanoma can develop in mucus membranes or eyes, rather than the skin.
    This is what happens when one decides to use a drug that goes against how our cells work with nature and sunlight. Perhaps utilizing the sunlight as the best drug possible can stave off the cancer effects of Viagra?
    Also what happens is It also brings out all the lawyers looking for a big payday in representing Viagra users. If you know someone who uses these drugs you might want to share this with them. https://www.drugwatch.com/viagra/melanoma/
     
  2. Jack Kruse

    Jack Kruse Administrator

    Now think about OZ. What is there version of environmental version of Viagra? The donut hole allows in cosmic radiation with very high energies. The higher the energy the higher the kinetic energy that impacts the skin to release way more NO than is needed. This is why skin cancer is exploding down under. Simple physics of the kinetic energy of light. The experiment can be proven using water jugs and different size bullets being shot into them. The bullets with the most kinetic energy cannot get passed the first layer because it creates a massive shock wave. The same is true in our skin. And NO release that is unbalaced leads to higher ubiquitination rates and more skin cancer. How long do you think it will take the people down under to take their heads out of their asses too understand this? My bet is decades because their preformed beliefs of the cause will block them from reality.
     
  3. Jack Kruse

    Jack Kruse Administrator

    The kinetic energy to mke vitamin D is UVB light which is much lower than cosmic radiation so the shock wave of the cosmic radiation destroys the normal synthesis pathway in the skin. Synthesis of pre-vitamin D3 in the skin involves SPECIFIC frequencies of UVB radiation which effectively penetrates only the epidermal layers of skin at the surface. 7-Dehydrocholesterol absorbs UV light most effectively at wavelengths between 290-320nm and thus the production of vitamin D3 will ONLY occur at those wavelengths. Cosmic radiation is far more powerful than UVB light. The two most important factors that govern the generation of pre-vitamin D3 are the quantity (intensity) and quality (appropriate wavelength) of the UVB irradiation reaching the 7-dehydrocholesterol deep in the stratum basale and stratum spinosum. This is precisely what Einstein taught us about in the metal bench experiments of the photoelectric effect and kinetic energy. The parallel to Vitamin D3 production is also congruent. Another important consideration is the quantity of 7-dehydrocholesterol present in the skin during this process in OZ. Under normal circumstances, ample quantities of 7-dehydrocholesterol (about 25–50 mg/cm2 of skin) are available in the stratum spinosum and stratum basale of human skin to meet the body’s vitamin D requirements. Down under this is no longer possible because of the higher energies let in by the donut hole. Many drugs slow the formation of 7-Dehydrocholesterol. Statins are the best modern example. But it turns out nothing is worse for the precursor molecules of D3 like highly powered light above the power of UVB light.

    7-Dehydrocholesterol is the precursor of vitamin D3. Within the epidermal layer of skin, 7-Dehydrocholesterol undergoes an electrocyclic reaction as a result of UVB radiation, resulting in the opening of the vitamin precursor B-ring through a conrotatory pathway. Therefore, Cholecalciferol is synthesized in the skin from 7-dehydrocholesterol under the action of ultraviolet B light only and specificially using Einstein's photoelectric principles. Following this, the previtamin D3 undergoes a [1,7] antarafacial sigmatropic rearrangement and therein finally isomerizes to form vitamin D3. With cosmic radiation contamination it cannot occur. It reaches an equilibrium in the skin after several minutes depending on several factors including conditions of sunlight (latitude, season, cloud cover, altitude), age of skin, and color of skin.

    Cholecalciferol is then hydroxylated in the liver to become calcifediol (25-hydroxyvitamin D3). This step never happens in people in OZ because substrate is missing hence why melanoma grows like garden weeds down under.

    The next step that is block by the cosmic radiation is, calcifediol is again hydroxylated, this time in the kidney, and becomes calcitriol (1,25-dihydroxyvitamin D3). Calcitriol is the most active hormone form of vitamin D3. This is why when you order all the labs associated with D3 production in OZ doctors would find the tell tale signs of this effect as the cause of their epidemic. But in OZ they are as conventional wisdom as one can get. Patients loose when we fail to think well.
     
  4. PaulG

    PaulG New Member

    Jack

    Are you referring to the surface chemistry action of neutrinos and high energy muons as opposed to UVA? I guess it relates to hydrogen bonding articles in skin water and how they lower enzymatic energy thresholds due to lowered proton tunnelling speeds.

    Donut hole is over Antarctica (Not Australia!) but the outer edges extend over New Zealand, Tasmania, Southern parts of Australia, Argentina and Chile. It is also seasonal being largest around Sep-Nov.

    Queensland which is thousands of km away from the hole and closer to the equator has the highest incident of skin cancer worldwide. How is Queensland affected by the ozone hole?

    Argentina is affected by the hole according to the maps and people are more outdoors due to the rural economy but has relatively low rates of mortality from skin cancer compared to Australia. South Africa which is similar latitude to Queensland has low rates.

    Is this partially a haplotype/Melanin story? I am just not seeing the connection between donut hole and skin cancer rates. There are a lot of confounding variables.

    Source: http://www.worldlifeexpectancy.com/cause-of-death/skin-cancers/by-country/
     
    Last edited: Nov 25, 2016
    Richelle Jones and JanSz like this.
  5. Jack Kruse

    Jack Kruse Administrator

    Hole allows for entry and then the ionosphere and clouds of the water cycle are affected. Remember the Southern ocean is circular and is uninterupted........by any land. This brings bad water over Oz and NZ all the time. This is why Oz is essentially a dessert with an oasis present at its shores only.
     
    Richelle Jones likes this.
  6. PaulG

    PaulG New Member

    Still, doesn't make sense (to me).

    In your opening remarks you talk about the 'shock wave' of the higher kinetic energy of cosmic radiation disabling the UVB mediated vitamin-d synthesis pathways. Your analogy of the water jug made me think it is cosmic radiation hitting our skin that is the problem but you are talking about the water cycle.

    Are you saying that the oceans around Australia have higher kinetic energy cosmic radiation particles?

    This 2008 official report "The Radioactive Content of Some Australian Drinking Waters" from the Australian Government Australian Radiation Protection and Nuclear Safety Agency (ARPANSA) agency makes for interesting reading.

    "The calculated radiation doses arising from drinking the waters showed that most of the dose arises from Radium-228.

    Comparison with the UNSCEAR reference data indicate that Australian drinking waters may have considerably higher levels of radioactivity than the world-wide average and, therefore, the radiation doses arising from these waters may be considerably higher. This study indicates that a more widespread, systematic and thorough study of Australian drinking water may be necessary."
     
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  7. Jack Kruse

    Jack Kruse Administrator

    Sunlight and cosmic radiation flow to OZ via the hole. Normally only sinlight gets through. When the cosmic radiation gets through it impacts surface and unleashes the power of its wave forms kinetically in the delicate proteins and lipids in the surface of the skin that are capable of making Vitamin D3. When that ability is obliterated you get an entire population who becomes unable to make D3. This is a huge problem for obesity, auto-immunity, and cancers. This is why Oz faces what they face. It also explains why the Great Barrier reef has slowly been killed. It also explains why the oceans around Oz are dead and need people like Roy Palmer. It also explains why Oz is a island desert with an oasis at its edges.

    When you light antenna's on your skin are destroyed and you don't realize it...........diseases tied to the lack of D3 manifest. Paul........it is not that hard to understand when you understand how light works to make D3 and then realize that D3 affects 1000 humans genes. And those genes link to Vitamin A's effects.........which link to melanopsin which cause circadian diseases...........
     
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  8. Jack Kruse

    Jack Kruse Administrator

    What protects surface proteins from cosmic rays and gamma rays Paul? WATER................And that is why it is OZ problem.

    The issue is humans are not fish to protect their skin.........so they can make D3. Therefore people in Oz might have to rely on mushrooms and fish which have high D3 in the skin and eye. One problem..........OZ is now growing fish using man's ideas so to these source provide enough? Do mushrooms in Oz have the same D3 as one from France. Based upon what I said above about our skin............I doubt it.

    We have ample evidence from aquaculture and from the Great barrier reef that water in and around Oz is a realy problem because of the chronic leak through the ionosphere..........that effects the water cycle. The issue people are not aware of is how the cosmic radiationt aht gets through destory the delicate light antenna's on living things surfaces..........The fact that life in the sea is dying faster than life on land means this issue is big and why Oz is my canary in the cold mine.

    What would help? If the sun's power declined and the planet got colder............and it appears that is happening in the Southern hemisphere. (Maunder Min alert)
     
  9. Would the same apply to clomid Jack?
     
  10. Jack Kruse

    Jack Kruse Administrator

    A bit different.......
     
  11. Sebastian Coello

    Sebastian Coello New Member

    Thanks for the info, would you give the same recommendations of getting a lot of sun exposure to this part of OZ? I have heard you say that the chemistry of water down here contains much more cosmic radiation (hence the great barrier reef) , do the principles you set in the podcasts and blogs apply to OZ or is there a certain tweek or focus in our case? I bet there are numerous variables to what i just wrote although can your advice be applied to everyone?
     
  12. JanSz

    JanSz Gold

    Calling, everybody from Au or OZ

    @PaulG Denmark, Western Australia
    @Josh (Paleo Osteo) Torquay, Victoria Australia or Bendigo, Victoria
    @yewwei.tan Cairns, Australia
    @Alex Fergus Sydney, Aus (moving to NI New Zealand Nov 2016)

    Guys please post your vitamin D levels
    including note if it is supplemental or natural

    Include units.

    Vitamin D (25-Hydroxyvitamin D)(250nmol/L=100.16ng/mL)
    .
     
    Last edited: Nov 28, 2016
  13. Jack Kruse

    Jack Kruse Administrator

    Best way to Hack Oz is use water from underground sources or from Europe or Asia.
     
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  14. PaulG

    PaulG New Member

    Vitamin D (25-Hydroxyvitamin D)(113nmol/L=45.27ng/mL) - non-supplemental - April 2015
     
  15. Jack Kruse

    Jack Kruse Administrator

    This is coming out of summer in Oz........you think this is good? This is equivalent to August in Northern hemisphere. For comparison I was at 96 ng/ml Sept 3 at 28 th latitude.
     
  16. Richelle Jones

    Richelle Jones Eve Mytokondrya

     
    Last edited: Dec 5, 2016
  17. Richelle Jones

    Richelle Jones Eve Mytokondrya

    I am always confused about Australian farmed fish and whether it is worthwhile eating. Is it better than no fish? Is it better than grass fed beef/lamb? If they feed them unnatural food (derived from ruminants), antibiotics, unnatural colours, then how much DHA, iodine, selenium can they have?

    As for Australian sunlight...is there some way of protecting against the effects of the donut hole or do we really need to leave the country? Sunlight is better than no sunlight....but if I get skin cancer all the naysayers will have a field day...I am about to move up near the Great Barrier Reef...which is dying....
     
    Sebastian Coello likes this.
  18. Sebastian Coello

    Sebastian Coello New Member

    I am on the same stream of thinking as you Richelle, i have recently come back from living in Madrid and london and have seen differences in my health although did not apply any of the epi-paleo diet principles. Thankfully at Woolworths they still sell atlantic salmon anong other fish which is my main source at the moment. Water on the other hand i can only buy AUS spring water and other brands but the effect the sun has here far outweighs the amount we are probably drinking.
     
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  19. nonchalant

    nonchalant Silver

    Then other ways of increasing nitric oxide, like exercise, CT or eating, would be bad under blue light. Not just because of the lack of UV to tame the free radicals, but for the extra dose of blue.
     
  20. Jenny S

    Jenny S Gold

    Yes my family & friends will have a field day if I get skin cancer too! They already think I look like an aboriginal. Where have you decided to move to Richelle? I'm going to move a bit further north from Bribie next year but was only thinking of Tin Can Bay or somewhere just below Hervey Bay.
     

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