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UBIQUITINATION 17 is live and speaks volumes.

Discussion in 'Mitochondrial Rx' started by Jack Kruse, Jun 9, 2015.

  1. Jack Kruse

    Jack Kruse Administrator

    best if you have a thin sheen on your skin as you will soon find out. Surface science chemistry has shown us in experiments that if you shine any kind of radiation on a metal ion, you get this big flux of low-energy electrons coming out. When those electrons come out you need something on the skin or within the skin to assimilate them. DHA and sulfated cholesterol is big on those electrons.
    Last edited: Jun 16, 2015
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  2. Penny

    Penny New Member

    thanks - really helpful -
  3. Josh

    Josh New Member

    Lissajous Curves?
  4. CoolSwede

    CoolSwede New Member

    But IIRC ketosis is stimulatory to SIRT1 and NAD+ so I assume that a high fat diet in this case ≠ nutritional ketosis? Am I missing something here?
  5. Jack Kruse

    Jack Kruse Administrator

    you are........ketosis sans DHA stimulates NAD+ alone.........SIRT1 needs some type of co morbid hormesis to exist. SIRT 1 is usually made from some from of carbohydrate naturally. Wine or grape skins being an example........if you embrace a zero carb policy you will raise NAD+ alone and destroy SIRT 1. You will have developed a half truth.
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  6. CoolSwede

    CoolSwede New Member

    That definately clears things up.

    You made the point earlier about ketosis being suboptimal without a decent DHA supply so that is a no-brainer. However, the fact that SIRT1 needs a kick in the b*tt from carbs (or other things) is interesting. That raises the question about how often that kick needs to be employed.

    During long light cycles, I guess that seasonal carbs is the answer if your context allows it. That would give you a daily kick. However, during short light cycles, when we embrace ketosis and cold, is it ok to let SIRT1 drop say between Oct and Mar? Or should we use vinegar, nicotine, XYZ or whatever means necessary to give SIRT1 a kick? How often? Daily?
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  7. Jack Kruse

    Jack Kruse Administrator

    This is why nicotine is interesting.......it increases NAD+ while very slightly raising glucose to stimulate the superoxide burst.
  8. Martin

    Martin Gold

    If one has a negative response to nicotine gum, say dizziness and nausea, push on with trying lower dose, or is it a sign of something else?
  9. CoolSwede

    CoolSwede New Member

    Thinking aloud here:

    Nicotine use in the winter feels similar to supplementing D3 in the winter. That is, it may be a nice tool in the toolbox but since the KT mammals didn't have the luxury of chewing tobacco, nicotine use can not be a long term solution. The elimination of blue light is!
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  10. Jack Kruse

    Jack Kruse Administrator

    First time it maybe the dose........and the fact that your mitochondria can't handle the increase of electron flow........does nt mean its bad........but I would go lower on dose.
  11. I did 16mg one day. Reached a limit. Took 4mg upon waking next day but took it with L-Carnatine and D-Ribose. The combo was too much.
  12. CoolSwede

    CoolSwede New Member

    Jack also mentioned D-ribose (D-R) as an alternative to increase SIRT1. I wonder if that is due to its augmenting effect on the PPP? There were many worries in the keto world that D-R would "kick them out of ketosis" (no it won't) and since it does not raise blood sugar is it the PPP itself that boosts SIRT1? Trying to tie loose ends here...
  13. Penny

    Penny New Member

    I think he said he uses d-ribose for the kick in the winter (when he goes more low carb/high fat/lots of cold) but not in summer - that would make sense because if you're eating carbs anyway in the summer, what do you need d-ribose for? Although it is a huge hit in the chronic fatigue world as I understand it - maybe if you can't handle sugar, you can't get a kick from a carb anyway 'cause cyto 1 is blown, so you might use some of these other methods to ping superoxide... I'm having great luck with the berberines... and soon, my fermented papaya will be ready for testing:) Or, it will be a total fail and unfit to eat... :)
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  14. CoolSwede

    CoolSwede New Member

    Thank you for your comment, Penny, very interesting! Blown cyto 1 = necessary to find other means to get that superoxide...
  15. RWR

    RWR New Member

    I am excited, scared, and confused. Here is why;
    In TENSEGRITY #7: BLACK HOLE SUN, HERE WE COME you say; ;" In summer, we use eNOS with the photons of UVB and IR light to make sulfated proteins to deliver cholesterol and oxygen to tissues that need it. In winter, we use eNOS to deliver cholesterol and oxygen to tissues that need it using a plasma that is more loaded with electrons. Here you can see how our SCN goes from its light switch to its cold switch that I mentioned in CT 4 and CT 6. This is the metabolic trap door of the Ancient Pathway. Calcium efflux is the key metric to the change in the metabolic sensor in seasons."
    "When your LDL cholesterol is elevated, it is a sign your skin is lacking sunlight in these specific frequencies. These frequencies occur 9-12 noon in most places on the globe. Why is this pathway critical from a quantum scale? Oxygen transport in blood is dangerous game for life. The sulfate molecule supports safe transport of O2 in blood. Nitrogen makes it much more dangerous. Cholesterol depletion in cell membranes forces cells to switch to nitrogen-based O2 transport. Normally, this only occurs in the absence of sunlight in winter. In our modern environment, it happens 24/7 while people eat a carbohydrate diet 24/7. This creates a huge problem for mitochondria. "
    In UBIQUINATION 1: Bio-hacking altitude, suicide, and loss of muscle mass you say: "This is why you should opt to be close to sea level and embrace cold as much as possible, in a modern world that now causes calcium efflux everywhere."
    "Remember, cold temperatures and strong electric currents are the only two things in the universe that increase magnetic flux". " You do not stress a body with cold environment; with cold, you are stimulating its quantum heat machines (mitochondria) to work better by releasing heat. Heat is infrared light. When you say cold is a stressor or hormetic you are announcing to the world you clearly do not understanding how mitochondria use cold to control water’s density that surrounds your mitochondria."
    "This is why you should opt to be close to sea level and embrace cold as much as possible, in a modern world that now causes calcium efflux everywhere."
    In UBIQUINATION 2: GRAVITY BENDS LIGHT AND TIME AT YOUR SCN you say; "This is an example of how surface cold thermogenesis works. This reflection of light, cools our brain skin and gut linings to increase the natural effect of cold on magnetism to allow quantum tunneling and entanglement more likely to happen in these three tissues. This is why cold thermogenesis helps our magnetic sense and builds our wellness."
    "It is too bad biologist/medicine/ancestral health do not realize how our skin, brain, and gut, use sulfur to control temperature on our tissue surface areas, where some “forms of light” is released." "Food is a variable whose context changes as the environment varies……..nothing has changed more in our modern world then our environment because of what we have created to make life easy via technology."
    In UBIQUINATION 3: THE RHYTHM IS GONNA GET YOU You say: "All ubiquination defects are associated with altered melatonin and sulfated Vitamin D levels."
    In UBIQUITINATION 4: UBIQUITIN’S CONNECTION TO LIGHT You say; "Food is a variable whose context changes, as the environment varies. " "This is why low vitamin D3 levels are always associated with low sulfate levels in the skin, gut, and brain. Today’s modern microwaved world blocks us from using the sun as our cell’s were designed. Sulfate needs a natural source of sunlight to work properly. The AM sun provides the perfect light frequencies for this photocatalysis. " "Today modern man faces globally low sulfated Vitamin D3 levels for many reasons." "Most people know that the suprachiasmatic nucleus (SCN) in the brain is where the circadian pacemaker lies in humans. It monitors this dance between darkness and light, and the seasonal cold and hot temperatures in our environment to help control and monitor our own growth and development."
    In UBIQUITINATION 6: UNCOUPLED CYCLES UNCOUPLES KNOWLEDGE You say; "The AMPK pathway is a “cross-talk” pathway between mTOR and the Insulin/IGF-1 pathway. It couples and regulates both via light activation. Activating AMPK inhibits both of these “bad” pathways. This is why fasting and drinking water, alone post workout, with Cold Thermogenesis at night is the way to go when faced with a microwaved environment. Few people seem to know that chronic cold exposure not only increases AMPK activity in brown and white adipose tissue, but that it does so via distinct signalling" pathways.
    In UBIQUITINATION 7: PALEO’s BITTER TRUTH You say; "The amount of blue light frequency we allow our mitochondria to sense is the key issue. It has a seasonal dose response curve. The dose makes the toxin, for blue light. Modern life allows for a constant barrage of blue light because of technology, TV, computer use, and indoor living. The effect is magnified when the cold is missingfrom the environment that you allow your mitochondria to sense."
    "This is why I have always maintained, in my templates and Rx’s, that carbohydrates in season, are important parts of the optimal health. Carbohydrates in summer time, slow the clock speeds in your organ clocks in relation to your SCN. This seasonal action allows you to make the required dose of free radicals your mitochondria need to signal properly to your nucleus to drive proper epigenetic signals. You need the superoxide burst at the right time of the year."
    . "Chronic cold stimulates AMPK pathways, to put an emergency brake on mTOR and IGF-1 naturally. This works even if we are uncoupled from light. 65 million years ago mammals were uncoupled from light and it worked like a charm" .
    . " AMPK slows growth and promotes survival for this reason. This is why Cold thermogenesis needs to be in your toolbox in this modern microwaved world."
    "This is why I scoffed loudly, when I heard on Robb Wolf’s podcast, multiple times, that cold is just a hormetic stressor. Anyone who understands biochemistry well, as Robb does, should know cold is not hormetic and increases survival and improves longevity because its major effect is on AMPK signaling. This is why CT 6 was written long ago. The science of AMPK signaling is clear in uncovering how chronic cold environments becomes an emergency brake for up regulation of both IGF-1 and mTOR. I assumed someone well versed in biochemistry knew this. I learned right there not to trust anyone else’s ideas. This blockade even works if you are blue light toxic!!! This is why it is critical to perform my cold thermogenesis chronically in a microwaved world. My tribe has gotten that information for 6 years now. It seems the leadership of the paleo tribe has no idea why cold works, fundamentally."
    "Cold alone puts the brakes on illness and death. How is that for irony? This is how mammals survived in a chronically cold environment and near total starvation 65 million years ago, when photosynthesis was ABSENT."
    "When you don’t fully understand something you should remain curious, and not make up some partial truth to believe in."
  16. RWR

    RWR New Member

    Here is the 2nd part of the above comment.

    " Chronic cold temperature changes water optics, because it affects water density. This is why Archimedes principle is critical to understand regarding the sea within your cells. Water density changes facilitate AMPK signaling, which then inactivate IGF 1 and mTOR pathways in one fell swoop. Cold exposure extends longevity because surface cold exposure is able, by itself, to increase AMPK and blood glucose to try to slow clock genes down. This is why the mammalian dive reflex is based upon surface changes to our face alone. It is also why it forms the basis of my CT protocol."
    In UBIQUITINATION 8: THE MAMMALIAN BATTERY You say; "Cold temperatures block metallic and ionic currents while cold increases semiconducting DC electric currents."
    In UBIQUITINATION 9: FREQUENCY AWAKENING you say; "The more electrons you collect the more electron repulsion you generate in cold water or temps so you do not suffer from cold exposure because your endogenous electromagnetic fields protect you; this is how polar bears, penguins, and fish do it. They are all linked to the marine seafood chain and the sea they swim in is called the photic zone where sun penetrates this water."
    InUBIQUITINATION 10: BIO-HACKING ROS AND RNS You say; "Why should you understand part of a quantum reversal is pressure, free diving, and the 3 quantum gases linked to the mammalian dive reflex and how Cold thermogenesis works in you? Cold is a synonym for magnetic field strength in your mitochondria."
    "A higher DC current allows you to repel cold easily from your environment in winter and photons from solar radiations in skin and fat, naturally. This is why animals tolerate equatorial sun and polar cold, because they are innately coupled to their quantum ecosystems. It is a function of the redox potential built into their cells. Wild animals are naturally coupled to the natural cycles and humans decouple themselves and fell they need adivce on food and environment. All humans need to do is get out of nature’s Rx’s."
    In UBIQUITINATION 12: NITROGEN CYCLE ECODYNAMICS you say; "This is why electrical capacitance is usually coupled with NO, cold, and ketosis with DHA tissue levels. One provides the needed electrons (in free fatty acids FFA), and the other improves the conduction of electrons so it can catalyze the reaction." See Tensegrity 5 for all of the benefits of CT.
    I started doing the morning sun when I read TENSEGRITY #7: BLACK HOLE SUN, HERE WE COME. I also stopped supplementing vitamin D3. In a short while, I had formed stools for the first time in 60 years. This was very exciting to me. I felt I could change at 74 years old. In the Spring I became constipated and could not pee until I had a BM. This was, and is, very scary. I have not figured out how to do the Summer (long light) with lots of fruits and much less fat and CT. In the quotes from the above blogs, it looks like I should do CT or Summer, but not both at the same time. I feel like I could become Optimal if I knew what to do or harm myself by not handling this power properly. This is a power that I feel and it is just waiting for me to make the right choices.
    I really need help!
  17. Jack Kruse

    Jack Kruse Administrator

    CT is good all the time because it optimizes surfaces for the interaction with light. It increases EZ. Summer time can increase EZ using IR and UV light. EZ always increases wellness..........do things to increase EZ and you'll be fine.
  18. Jack Kruse

    Jack Kruse Administrator

    Many food guru's tout acetate for turning WAT to BAT. Acetate does not turn WAT to BAT FYI. It is a substrate that tells us, if used by a mitochondria, the mitochondria are DEFECTIVE. Cells use it when their mitochondria are metabolically unfit. When they are not yoked to light and when they are not oscillating at 100Hz, when the fat globules are not perfectly aligned in the matrix adjacent to the cristae as Wallace showed in the video I linked here 100 times. Acetate has been used a radio tracer with PET scanning to image the efficiency of fatty acid synthesis and detect tumors with a Warburg metabolism. The key abnormality in tumors is their heightened dependence on glucose metabolism and avoidance of fat metabolism. Warburg observed that even in the presence of sufficient oxygen, which is an optimized micro-environment favorable for oxidative phosphorylation to burn fat. The key is th optical and mechanical arrangements in the mitochondria are not optimized for fat burning at the cristae level. April 2016 webinar speaks volumes on this issue.

    Listen 50:00 onward: https://www.youtube.com/watch?v=KwbIR2yUziw
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  19. Jack Kruse

    Jack Kruse Administrator

    Cancer is linked to a low O2 environment. What most dont realize is that low O2 microenvironment = low a quantum yield. Why? Oxygen levels in the Earth's ecosystem are always liked to the UV environment via the ozone interaction and the UVA and B levels that drive photosynthesis to make oxygen from plants and photosynthetic bacteria and algae in the sea.

    When you cannot make O2 it means your tissues are devoid of UV and it means that just distal to the ATPase where oxygen picks up electrons, ECT slows........anything that slows ECT makes death likely. So a warburg metabolism provides a survival mechanism until things change in the terroir of the cell.

    There is a lot of BS going on now in oncology and biochemistry circles now. You have people in many FB group who have zero clinical ability to dissect a paper and rip it to shreds and just read it literally and reductively. They believe bullshit in the face of reality of what nature shows us. It has become beyond pathetic. Enlightened docs who are trained to read and rip shit up........I am focusing on those who need to learn how to read papers and how to find papers that reproduce results and those that have NEVER been reproduced once.

    Most solid tumors are also characterized by a lipogenic phenotype. Cancer cells often require that fatty acids be generated de novo, regardless of their exogenous levels. Most people do not even KNOW this basic stuff.

    This requirement in cancer cells is so critical because its needed in tumors to maintain proliferation and viability. As it happens massive ELF-UV is released and mitosis is stimulated in the neighboring cells. As a result, the metabolism of fatty acids, in particular their biosynthesis becomes a critical step. In eukaryotes that are complex they cannot make the more complex lipids we need in cell membranes.........and here in lies a significant problem. This is why blue light destruction of DHA is always linked to these problems.

    Where does the quantum perspective I carry come in? Non linear optics and processing. Why? Glucose metabolism provides the precursors for numerous macromolecules, including the fatty acids we needs sans DHA. However, the transition from glucose to fatty acid is a distinctly a "non-linear process" that is coordinated through the action of numerous enzymes localized in various cellular compartments which is a nice way of saying it relies on things biochemistry is clueless about. And so are most of the critics.
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  20. Jack Kruse

    Jack Kruse Administrator

    While most glucose consumed in glycolysis is ultimately metabolized into lactate, some of the pyruvate generated during this reaction will be further metabolized into the fatty acid synthesis pathway. In order to do this, pyruvate is transported into the mitochondria and converted to acetyl-CoA through the activity of enzymes, including pyruvate deydrogenase . Acetyl-CoA can also be produced in the mitochondria from ketone bodies, such as 3-hydroxybutyric acid. Since fatty acid synthesis takes place in the cytosol and the mitochondrial membrane is impermeable to acetyl-CoA, it must first be converted into citrate. This is accomplished when the two carbon acetyl group from acetyl-CoA is condensed onto oxaloacetate by citrate synthase in the TCA pathway. It should be noted that transamination of aspartate can also serve as a source for oxaloacetate and citrate production. In non-proliferating cells, the TCA cycle generally serves to synthesize ATP from oxidizable substrates, such as amino acids. However, in rapidly dividing cells, like tumors, many of the intermediates, particularly citrate, that are generated during the cycle are effluxed from the pathway in a process termed cataplerosis. This stuff is well known but no one is connecting the dots on why some of the shit being spewed is completely wrong.

    Once citrate is shuttled into the cytosol, it is cleaved by ATP-citrate lyase into acetyl-CoA and oxaloacetate, comprising the first step of fatty acid synthesis in our cells. It's critical that the carbons utilized for the production of acetyl-CoA are derived from glucose. This is why Warburg cells use glucose. It is also why Nora Volkow found nnEMF from cell phones were associated with unregulated glucose metabolism and calcium efflux with calcium flowing into mitochondria like mad. Once within the cytosol of the cell, the acetyl-CoA is converted to malonyl-CoA via carboxylation by acetyl-CoA carboxylase. This is the rate-limiting enzyme in the fatty acid synthesis pathway in humans. The coda: fatty acid synthase catalyzes the ultimate steps of fatty acid synthesis in these solid tumor cells, yielding the 16-carbon fatty acid palmitate.

    Last edited: Apr 28, 2016
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