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UBIQUITINATION 17 is live and speaks volumes.

Discussion in 'Mitochondrial Rx' started by Jack Kruse, Jun 9, 2015.

  1. Jack Kruse

    Jack Kruse Administrator

    Do you know the gears of your "eye clock"? Do you know how wellness is really built. Strap in for this monster. http://ow.ly/O5ydb
    rlee314 likes this.
  2. nonchalant

    nonchalant Silver

    I agree that the skin is also a source of photic input to the SCN. If I am sleepy in the morning, though the sun is rising, all it takes is for me to remove the sheet, at least from my arms. If the window shade is open, the sunshine on my skin wakes me up promptly. Suddenly I actually want to get up. If I stay burrowed in, I'll often fall back asleep for a few minutes.
  3. From the blog "I have mention David Sinclair name many times on my blogs. What David Sinclair and colleagues from both Harvard and Australia showed in a recent publication late in 2013, that supplementation with a NAD+ precursor could reverse this mitochondrial dysfunction and it’s associated “Warburg” metabolic state in mice in one week. That shocked many in the science world, but not me"

    Sort of raises the question what would example of NAD+ precursors be? Is nicotine an example? Would they 'work' in humans and would you recommend?

    I am sure I have some "Warburg" going on and wonder..............though there never is a miracle drug/supplement!
  4. nonchalant

    nonchalant Silver

    nicotine, niacin, niacinamide
  5. Nonchalant - Dr K seemed to say niacin was 'bad' but nicotine is 'good'...............vastly over-simplyfied
  6. nonchalant

    nonchalant Silver

    Oh. Curious. Perhaps processed niacin?
  7. nonchalant

    nonchalant Silver

    As the sunshine approaches noon, and the natural blue light increases, do our mitochondria slow down (from the uncoupling of SIRT1 and NAD+)? But that's ok because of the tremendous amount of energy in the sun's light, charging our water batteries to the max. Then as the afternoon wears on, the mitochondria come back online, and some DHA breaks down to resolvins, protectins, and maresins to repair UV damage. By nightfall, when it's cooler and dark, the mitochondria are humming along, producing ATP and lots of IR light to rebuild our water batteries?

    I think I've left something out.
  8. Lahelada

    Lahelada New Member

    Explains porenant woman's need for dill pickles,my mother being one of them. I only speedread so far but the vinegar caught my attention. Both my mother and me could never get enough of vinegar.
    Guess I started the quest for optimal early,huh...:p
    Bad mitos in at least 2 generations- who would have thunk.
  9. Jack Kruse

    Jack Kruse Administrator

    it doesn't raise the question........it gives you the answer.......nicotine is a huge benefit to someone with a ubiquitin problem.
    Penny, rlee314 and Josh like this.
  10. Jack Kruse

    Jack Kruse Administrator

    no all niacin.........because it LOWERS SIRT 1.

    Hey Pat wine increases SIRT 1.

    So does chocolate, nuts, olive oil, and nuts........remember that January webinar bio hack on resistant starch?

    mamadell and rlee314 like this.
  11. It is pretty safe to say I have an ubiquitin problem. So maybe nicotine would be of use. I think right now I use occasional carbs to give the Super Oxide burst to help with mitochondria. I mean I wouldn't say I 'crave' carbs and mostly I avoid but it seems deep down I always 'want' them even if mostly I don't actually. But I have 1/2 bagel pretty much most mornings and even after a 'healthy' meal I do kind of 'crave' like a slice of pizza or chocolate or something sweet.
  12. Jack Kruse

    Jack Kruse Administrator

    Nicotine might wean you from that.........
  13. Josh

    Josh New Member

  14. nonchalant

    nonchalant Silver

    Yeah, even though it's not winter here, nicotine gum is really tempting. Guess I'll finish reading the blog before I rush out and get some...
  15. Valerie

    Valerie New Member

    Dr Kruse....awesome blog...hits home for my N-1. Still rereading
  16. Jack Kruse

    Jack Kruse Administrator

    Valerie the key to the blog is understanding that the NAD/NADH ratio = your redox potential. The ratio is NOT determined by dietary intake, your supplements or any fake IV bullshit. It is enzymatically controlled. All enzymes work via proton tunneling. That enzyme is called “NAD(P)H dehydrogenase, quinone 1. It is activated by light. Cancer up regulates that gene and aging reduces it.

  17. Jack Kruse

    Jack Kruse Administrator

    Photodynamic therapy (PDT) is a clinically approved and rapidly developing cancer treatment. PDT involves the administration of photosensitizer (PS) followed by local illumination with visible light of specific wavelength. In the presence of oxygen molecules, the light illumination of PS can lead to a series of photochemical reactions and consequently the generation of cytotoxic reactive oxygen species (ROS). PS, like bok choy can increase NAD+ by increasing NAD(P)H dehydrogenase (quinone 1)
    Brent Patrick likes this.
  18. Bill1

    Bill1 New Member

    how do you know if you have a ubiquitin problem ?
  19. Jack Kruse

    Jack Kruse Administrator

    Read the end ubiquitination 4. top ten reasons are there.
  20. Jack Kruse

    Jack Kruse Administrator

    DCA can be sued to increase NAD+. Human use is interesting in the heart........Dichloroactetic acid, a simple, cheap chemical that is well absorbed orally, induces a “metabolic switching” of cardiomyocytes from the utilization of fatty acids to the utilization of glucose. This glucose utilization is NOT aerobic glycolysis (i.e. the Warburg effect), but instead is true “glucose oxidation” in the mitochondria. This increases the amount of ATP that can be generated and reduces the workload of the heart to generate ATP. The dose is relatively high (50 mg/kg body weight in humans). This means for an average person, they would need to take 3-4 grams of DCA.

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