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TRPM8 and TRPV1 - simultaneous activation

Discussion in 'Cold Thermogenesis' started by JakZ, Jan 24, 2021.

  1. JakZ

    JakZ New Member

    For some time I've been struggling with enormous shivering during CT and by accident found a possible shortcut - after having a hot (capsaicin-rich) meal an hour before the cold water immersion I got rid of any shivering.

    It turns out that capsaicin turns off the shivering thermogenesis via TRPV1 receptor:
    https://sci-hub.do/10.1152/ajpregu.00296.2013

    At the same time it promotes browning of the WAT and activates the non-shivering thermogenesis in BAT, so it works synergistically with what TRPM8 does via cold exposure:
    https://sci-hub.do/10.3945/ajcn.111.018606
    https://www.frontiersin.org/articles/10.3389/fphys.2019.01380/full

    After few tries with capsaicin and CT I feel much better, I'm not shivering and have no energy drop after longer CT sessions.
    Did any of you have similar insights? Any possible drawbacks of such method?
     
    MITpowered26 and John Schumacher like this.
  2. MITpowered26

    MITpowered26 New Member

    I haven't but I am excited to explore this. Have you tried capsaicin directly to skin as a cream for example? Hmm...
     

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