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Too much cysteine

Discussion in 'Ask Jack' started by BJK77, Nov 9, 2013.

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  1. BJK77

    BJK77 Gold

    Jack,

    Is it possible to consume too much cysteine or is there a mechanism by which a body simply cannot properly process cysteine?
     
  2. Jack Kruse

    Jack Kruse Administrator

    Cysteine is best assessed via food and not supplement form. Food provides the proper natural balance and helps you avoid the natural imbalance inherent in the use of anything out of its evolutionary package. Remember even good things can become bad because the dose makes the toxin. Food provides the best medicinal dose. You CAN NOT out supplement a bad environment or diet. Consumption of foods containing cysteine, or its precursor methionine, is not likely to cause toxicity symptoms. When you use cysteine of its precursors out of the evolutionary context, cysteine/cytosine can become brain excitoxin that can cause damage to brain cells in susceptible individuals.

    Chronic, low level exposure to toxic transition metals is an increasing global environmental problem. The symptoms associated with the slow accumulation of toxic metals are multiple and rather nondescript, and overt expression of toxic effects may not appear until later in life. The sulfhydryl-reactive metals (mercury, cadmium, lead, arsenic) are particularly insidious and can affect a vast array of biochemical and nutritional processes. These metals react with the thiols side groups of cysteine for detoxification and eventual clearance. The thiol side chain in cysteine often participates in enzymatic reactions, serving as a nucleophile. The thiol is susceptible to oxidization to give the disulfide derivative cystine, which serves an important structural role in many proteins. A nucleophile is a chemical species that donates an electron pair to an electrophile to form a chemical bond in relation to a reaction. Protein primary and secondary structure is determined by its DNA and RNA code. This is an example of how the nucleic acids act as a Maxwell Demon, meaning they do multiple things at once to save energy while lowering entropy. It turns out cysteine's side chain groups (denotes as an R group). Tertiary protein structure refers to the complete three dimensional folding of a protein. Stabilization of a protein's tertiary structure may involve interactions between amino acids located far apart along the primary sequence. These may include:

    A. weak interactions such as hydrogen bonds and Van der Waals interactions.
    B. ionic bonds involving negatively charged and positively charged amino acid side-chain groups.
    C. disulfide bonds, covalent linkages that may form as the thiol groups of two cysteine residues are oxidized to a disulfide: 2 R-SH � R-S-S-R. (R being the side chain or group on the protein backbone) This is where protein bending in all neuro immune disease (see EE 8) begin.

    Some individuals do not metabolize the amino acid correctly because of an inborn error or metabolism or chronic toxic insidious exposure, and, as a result, may be at risk for certain neurodegenerative diseases, including multiple sclerosis, amylotrophic lateral sclerosis (Lou Gehrig's disease) and Alzheimer's disease. (another EE 8 alert)

    The pro-oxidative effects of the metals are compounded by the fact that the metals also inhibit antioxidative enzymes and deplete intracellular glutathione. The metals also have the potential to disrupt the metabolism and biological activities of many proteins due to their high affinity for free sulfhydryl groups. Cysteine has a pivotal role in inducible, endogenous detoxication mechanisms in the body, and metal exposure taxes cysteine status. So BJK the key in all this science is not the cysteine.......but in the chemistry of the transition metals in reaction with normal biologic proteins.............When you begin to supplement you lose the stoichiometry of the chemistry and this pushes the biochemical reaction to either end of the spectrum where the DOSE MAKES the TOXIN. This is why you have to understand the context of things.......biology is not a science of linear thinking as most believe. Moreover, humans think linearly and not stochastically. (QB 8 alert) This is why the reality of the world rarely makes intuitive sense to people. QED works stochastically and this is why most of the counterintuitive things QED says and has proven stumps people steeped in biology.

    High doses of oral N-acetyl-cysteine, such as those given to patients with acetaminophen (Tylenol) toxicity, can cause nausea, vomiting, and diarrhea. Intravenous administration of N-acetyl cysteine can cause allergic reactions in a small percentage of people, characterized by skin flushing, a drop in blood pressure, irregular heart beat, and respiratory distress. Accidental overdose of intravenous N-acetyl-cysteine has proven to be fatal.

    Cites:http://umm.edu/health/medical/altmed/supplement/cysteine
    http://www.ncbi.nlm.nih.gov/pubmed/18973429
    http://jn.nutrition.org/content/136/6/1652S.full
     
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