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The Silica thread

Discussion in 'The Cave' started by Sue-UK, Sep 21, 2020.

  1. Sue-UK

    Sue-UK Gold

    Possible I suppose but when humans weren't disrupting the ecosystem with agricultural practices that don't put silica back in the soil, there would probably have been no need. Even carnivores like lions and polar bears would have a source of silicon from internal organ structure, entrails, blood etc ... and polar bears would likely have less exposure from aluminium, plus the cold. With silicon's relationship to protecting both male and female fertility, lowered silicon chronically = less favourable breeding ability= aging? Perhaps acutely low silicon is the starvation signal, certainly for a female who gives up her silicon to her fetus and in breastmilk.

    Another possibility is that something like aluminium could interfere with biological transmutation, via something like ROS, or the light emitted when a photon hits it .... Would a chicken be able to transmute silicon into calcium if they were also fed a pathological dose of aluminium?
     
  2. Sue-UK

    Sue-UK Gold

    I think its a half truth that giraffe's evolved long necks to get to higher leaves. There's visual benefits, and another protective mechanism is for the brain against TBI. The giraffe neck is effectively a chimney to rebreathe some of its expelled CO2. In many species, head butts are a major part of defence, or for males to demonstrate reproductive fitness. This starts off about woodpeckers but giraffes feature nearer the end. :)
    [/QUOTE]
     
    JanSz likes this.
  3. Sue-UK

    Sue-UK Gold

    Adding this

    Dennis Crouse has written: The APOE-e4 gene increases the concentration of beta-amyloid peptide in the brain and has been linked to a higher risk of AD. The e4 allele of the APOE gene was introduced into the human population at least 1.5 million years ago. The reproductive advantage of carrying the e4 allele was to promote human fertility in highly infectious environments in spite of its adverse effects on late onset diseases (i.e. an example of antagonistic pleiotropy). Because of this reproductive advantage the e4 allele frequency slowly increased during the last 1.5 million years with currently approximately 14% of the worldwide population carrying the e4 allele.

    So would there have been any reproductive advantage to the APOE 4 without this....?

    https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0136149 Aquaporins Mediate Silicon Transport in Humans.

    This ties with a female giving up her silicon stores to the fetus and through breast milk, and the links of aluminium to male infertility. (Blue zone book). Then there's this .....

    https://www.sciencedirect.com/science/article/abs/pii/S0946672X17300974
    The role of lysosomes in the phenomenon of concentration of aluminum and indium in the female reproductive system. An ultrastructural study

    Abstract

    The female reproductive system is one of the most complex systems in the body taking into account the hormonal fluctuations associated with ovarian and uterine menstrual cycles. The purpose of this work was to study the impact of aluminum nitrate and indium sulfate on the uterus and the ovary of a pregnant rat. The experiment was performed on adult female rats of Wistar strain weighing approximately 250 g. The Transmission Electron Microscopy (TEM) showed the presence of electron-dense material in lysosomes of both uterine cells (myometrium and endometrium cells) and in the cells of the ovary (internal theca and granulosa cells). In addition to the presence of aluminum and indium deposits in the uterine and ovarian tissue, impaired endoplasmic reticulum, mitochondria and vacuolation were also identified. We concluded that lysosomes of uterus and ovary cells had the function to extract aluminum and indium introduced into the body in a soluble form. Then, the two elements were sequestrated within these organelles in an insoluble form most probably as phosphate salts such as reported for other kind of cells; kidney, liver, bone morrow Berry, 1996 [1]. This mechanism seems to be a defense one in which the lysosome would play a central role. Our results concerning the impact of the aluminum or indium presence in the lysosome of female reproductive system will be further used in order to assess their effects on the fertility and viability of oocytes in the pregnant treated rats.

     
    Last edited: Oct 6, 2020
    JanSz likes this.
  4. Sue-UK

    Sue-UK Gold

    The lysosymes are interesting, particularly the previous study abstract and its relationship to menopause and potentially a higher risk of uterine or ovarian cancers in women. But for the organism as a whole from this comes crinophagy, and "Cellular defecation".

    https://aasldpubs.onlinelibrary.wiley.com/doi/pdf/10.1002/hep.1840100522 The Liver and Intracellular Digestion: How Liver Cells Eat!

    From figure 1, the crinophagy pic, I think the link back to silica is the Golgi apparatus, and in the female reproductive study there's mention of the endoplasmic reticulum, both linked to melanin for energy, as are the peroxisomes.
     
    John Schumacher and JanSz like this.
  5. https://forum.jackkruse.com/index.php?posts/292699
     
  6. Dan2

    Dan2 New Member

    Sue-UK:
    "Possible I suppose but when humans weren't disrupting the ecosystem with agricultural practices that don't put silica back in the soil, there would probably have been no need.

    Another possibility is that something like aluminium could interfere with biological transmutation, via something like ROS, or the light emitted when a photon hits it .... Would a chicken be able to transmute silicon into calcium if they were also fed a pathological dose of aluminium?"​


    If a new element starts interfering with a transmutation, how long would it take for the transmutation processes to adapt to that? I don't mean I expect you to know, just putting the question out.

    ____

    (https://forum.jackkruse.com/index.php?threads/biohacking-inositol.25081/#post-290517)
    "Kervran studied oil workers in the Sahara, and found "the workers ate tremendous amounts of salt (sodium chloride). Some of this was lost in perspiration and some in the feces, but a lot of it simply "disappeared". He also found that the men put out huge amounts of potassium through the sweat glands although their diet was very low in potassium. Later experiments have demonstrated that the conversion of sodium to potassium takes up heat. It is an endothermic process. This provides an explanation of how the extra heat produced in the oil workers could be removed from their bodies. It also explains how potassium can be found in perspiration during very hot weather even though ordinary salt (sodium chloride) tablets are taken.

    Kervran also found in another study that the Sahara workers excreted over 250 milligrams more magnesium every day than they ingested. This went on for 8 months, although at this rate, body magnesium reserves should have been exhausted in 8 days."


    (quote from Diet and Nutrition a holistic approach, Rudolph Ballentine MD)"

    ____

    If the transmutation of sodium to potassium was primarily to remove heat from their bodies in the desert, and people can stretch their genetic tolerance for sunlight or cold -- thermodynamic intensity -- like with slowly building a strong solar callus and slowly adapating to cold thermogenesis...

    And there are some exceptions to thermodynamics laws for biology...
    (https://jackkruse.com/quantum-biology-1-the-zero-entropy-system/
    https://jackkruse.com/reality-2-can-life-skirt-uncertainty-principle-second-law-thermodynamics/)

    ...I don't know how to lead to the question well, I'm just thinking vaguely: could something to do with the exceptions to the laws of thermodynamics in biology mean the transmutations could evolve more quickly than normal evolutionary timescale?
    And if so, could the interaction of amounts of a new element (like aluminum) with thermodynamics in the body be the signal for that quicker-timescale adaptation of transmutation to affect the new element so that new element doesn't imbalance the thermodynamics; like the thermodynamics is the mediator between which elements transmute how much, and a new element can be removed, by transmutation of other elements into something that can remove it, for the sake of the thermodynamics maintaining the thermodynamics? And could something about thermodynamics exceptions in biology that I don't understand affect how quickly people could adapt with that ability?

    ____


    (https://forum.jackkruse.com/index.php?threads/biohacking-inositol.25081/#post-290523)
    "...sunlight can be turned directly into matter based upon what the cell needs when it needs it. Lavoisier has established a mass conservation law which is valid in chemistry. Now we know that it is NOT true when nuclear reactions are involved. The review of more than two centuries of research demonstrates that this is not true in biology. It appears that all living organisms can under some circumstances produce nuclear reactions. However, there is an important need of finding an adequate theory to explain these results. It is highly probable that such a theory should also be capable of explaining Cold Fusion, or more generally, nuclear reactions in condensed matter. Another point is the irreproducibility of some experiments. Probably, in order to produce significant transmutation of an element, it is necessary that another element be missing. This is why taking calcium, magnesium, selenium, and boron may do more harm than good when heteroplasmy rate is very high. It seems that nature has a tendency to find ways to transmute an element into another to provide the necessary ingredients for the healthy growth of the four kingdoms of bacteria, fungi, plants and animals, including human beings. http://www.e-catworld.com/wp-content/uploads/2015/09/JCMNS-Biberian.pdf It appears most pictures of mito needs to be updated for this abilities now."

    (That link doesn't go through anymore.
    https://forum.jackkruse.com/index.php?threads/winter-survival-guide.24178/page-6#post-283143
    Biological transmutations by Jean-Paul Biberian, 2015
    https://www.currentscience.ac.in/Volumes/108/04/0633.pdf)

    ____

    Or to rephrase that big font bolded part: could a thermodynamics imbalance from excess of an element, that could be fixed by more of another element that would react with it (making that fixer, effectively for the thermodynamics balancing, like it's missing) make the thermodynamics affect the transmutation into the missing fixer so the excess element is reduced and the thermodynamics balance is improved? Like thermodynamics balancing thermodynamics as mediated by transmutation. And from my paragraph above, "like the thermodynamics is the mediator between which elements transmute how much"... so thermodynamics mediated by transmutation balancing thermodynamics, and transmutation balancing reactions of elements mediated by thermodynamics? So, element reactions are subject to transmutation, and transmutation is subject to thermodynamics?

    ____

    @Sue-UK , I have Arturo Solis-Herrera's "Human Photosynthesis" book slowly making its way to a local bookstore. I should be able to start reading it in about two weeks. It'll probably be too complicated for me to contribute much to the forum from reading it. But the transmutation and melanin stuff you've posted got me interested in reading the book. I'm also interested in how it relates to hydrogen gas and Brown's Gas therapies, which I've posted some about recently.
     
    Last edited: Oct 6, 2020
    Sue-UK likes this.
  7. @Dan2 - I think you may appreciate what Dr. Kruse wrote: "random hydrogen bonding of one-state water". Think about your hydrogen water DIY project. Hydrogen is a negatively charged very small molecule which can diffuse easily through the skin, and lungs. Since cells can begin to "heal" once their voltage is -50mV or greater; Dr. Jack Kruse recommeds -125mV, then finding pathways into increasing this voltage has shown to be therapeutic.

    I believe Dr. Jack Kruse started to get this "right" with: "Veljko Veljkovic, first proposed that molecular interactions are electrical in nature, and take place over distances that are large compared with the size of molecules. Then his graduate student Irena Cosic later introduced the idea of dynamic electromagnetic field interactions. This implies that molecules recognize their particular targets and vice versa by electromagnetic resonance as their sole signal. This means the resonance is the key to understanding how biochemical reactions work in the electromagnetic field they exist in."

    When we follow the design Nature placed into electromagnitizm, I believe we will have found the "right" pathway.

    @Dan2 - You may find that hydrating your body with Mg first will help the flow of electrons from your hydrogen "water & air" therapy.
     
    Last edited: Oct 7, 2020
    JanSz likes this.
  8. Sue-UK

    Sue-UK Gold

    Last edited: Oct 11, 2020
    John Schumacher likes this.
  9. Sue-UK

    Sue-UK Gold

    https://www.frontiersin.org/articles/10.3389/fpls.2015.00994/full#F1
    Silicon as Versatile Player in Plant and Human Biology: Overlooked and Poorly Understood

    "The presence of Si increases the absorption and utilization of other mineral elements such as magnesium and copper (Emerick and Kayongo-Male, 1990; Kikunaga et al., 1991). Additionally, Henrotte et al. (1988) suggested that Si plays a role in regulating the cell cycle of lymphocytes which ultimately affect the immune and inflammatory response. As in plants, Si is involved in signal transduction because it binds to hydroxyl groups of proteins (Rezanka and Sigler, 2007). It may be assumed that similar mechanisms of action improve mental health, immune and inflammatory response, and gene expression of factors involved in osteoblastogenesis and osteoclastogenesis."

    https://link.springer.com/article/10.1385/BTER:89:3:251
    Silicon deprivation decreases collagen formation in wounds and bone, and ornithine transaminase enzyme activity in liver

    https://en.wikipedia.org/wiki/Ornithine_aminotransferase
     
  10. Sue-UK

    Sue-UK Gold

    Another enzyme link
    https://www.cmijournal.org/article....18;issue=4;spage=312;epage=316;aulast=Prabhoo
    Choline-stabilized orthosilicic acid and bone health

    "Silicon and collagen synthesis

    Silicon positively influences endogenous collagen synthesis by stimulating activities of certain enzymes involved in the process of collagen synthesis. Collagen type-I synthesis is a series of closely harmonized physiological process. Adequate silicon concentration is required for the activation of prolyl hydroxylase that catalyzes the proline residues of collagen chains which is a critical step in collagen type-I synthesis and its secretion into the extracellular space. Prolyl hydroxylase enzyme gets activated by silicon in osteoblast cytoplasmic granular endoplasmic reticulum followed by bone formation and mineralization."


    https://en.wikipedia.org/wiki/Proco...oxygenase, commonly known,Fe2+, and ascorbate.
     
  11. JanSz

    JanSz Gold

    Allantoin
    https://pelledolce.com/allantoin-organic/
    In skin care products, allantoin helps to moisturize and soften skin and acts as a keratinolytic. Keratinolytics soften keratin, a tough, inflexible protein found in the outer layer of the skin called the epidermis. By softening keratin, allantoin allows skin to hold onto water better. This makes it moister, softer and better hydrated.
    @DrEttinger
    I am at the end of second bottle of BioSil, using 40 drops/day
    Initially my body water was 56.9% (9/10/2020)
    Today it is 57% (10/24/2020)
    Variations from day to day are significant, 56.4% - 57.2%
    But, since the goal is to have water above 60%, there is practically no progress as of to date.
    I will keep using BioSil, what do you think about the current dose?
    The Allantoin
    you presented may be helpful in increasing my body's water content.
    https://www.essentialwholesale.com/product/1197/allantoin
    Today I got one pound of Allantoin powder.
    Today will eat the first teaspoon.
    How to think about dosing it?
    As far as my kidneys they could use some help. note (When I started supplementing with creatinine my eGFR fell below 59)
    I think my liver is ok.

    upload_2020-10-24_10-13-5.png

    https://supplementpolice.com/allantoin/
    upload_2020-10-24_9-49-10.png
    -------------------------------------------------------------------------------
    @Sue-UK
    @DrEttinger
    @John Schumacher
    https://forum.jackkruse.com/index.php?threads/post-finasteride-ed-problem.25249/page-3#post-292916
     
    Last edited: Oct 24, 2020
    John Schumacher likes this.
  12. DrEttinger

    DrEttinger Choice, the only thing we control

    Based on your labs it looks like the need is in rehabbing HCl production (protein below 6.9 with elevated BUN 21), not the kidney.

    I take 10 drops Biosil and 1 tsp of allantoin with 1 tbsp beet root powder.
     
    JanSz likes this.
  13. Sue-UK

    Sue-UK Gold


    https://www.tandfonline.com/doi/abs/10.1080/10715760000300241
    Is allantoin in serum and urine a useful indicator of exercise-induced oxidative stress in humans?

    From the wiki page "Since uric acid is the end product of the purine metabolism in humans, only non-enzymatic processes with reactive oxygen species will give rise to allantoin, which is thus a suitable biomarker to measure oxidative stress in chronic illnesses and senescence."

    https://search.proquest.com/openvie...370e974a58e/1?pq-origsite=gscholar&cbl=105775
    Allantoin improves methionine-choline deficient diet-induced nonalcoholic steatohepatitis in mice through involvement in endoplasmic reticulum stress and hepatocytes apoptosis-related genes expressions

    "Allantoin is one of the main compounds in many plants such as yam, Nymphaea nucifera rhizome, sugar beet, and leguminous ..."
    The "many plants" might be a clue to the wholefood plant based diet .....


    Yam and sweet potato also a good source of silica if its unpeeled (93mg/100g versus peeled 0.37mg/100g).
    Then there's more allantoin in the skin ...
    https://www.sciencedirect.com/science/article/abs/pii/S0308814605000099
    Quantitative analysis of allantoin and allantoic acid in yam tuber, mucilage, skin and bulbil of the Dioscorea species
     
    JanSz likes this.
  14. JanSz

    JanSz Gold

    Last edited: Oct 25, 2020
  15. JanSz

    JanSz Gold

    Results: Allantoin administration decreased
    serum alanine aminotransferase (ALT),
    cholesterol,
    low-density lipoprotein (LDL),
    hepatic lipid accumulation,
    and liver tumor necrosis factor (TNFα) level.

    Also, treatment with allantoin
    down-regulated the gene expression of glucose-regulated protein 78 (GRP78),
    activating transcription factor 6 (AFT6),
    TNFα,
    sterol regulatory element binding proteins 1c (SREBP1c),
    fatty acid synthase (FAS),
    Bax/Bcl2 ratio,
    caspase3,
    and P53.

    On the other hand,
    peroxisome proliferator-activated receptor alpha (PPARα),
    apolipoprotein B (Apo B),
    and acetyl-coenzyme acetyltransferase 1 (ACAT1) gene expression
    increased after allantoin injection.

    Conclusion: This study indicated that allantoin could improve animal induced NASH by changes in the expression of endoplasmic reticulum stress-related genes and apoptotic pathways.
     
  16. Sue-UK

    Sue-UK Gold

    On its own I'm not sure it has a lot of value, for example, I'm not sure how any test differentiates between allantoin produced as a result of oxidative stress and dietary allantoin. I'm doing a hack that increases dietary silica, but its also increasing my intake of allantoin ........... A blue zone resident might have high allantoin levels from diet, yet have little oxidative stress. Presumably you would need to not exercise and possibly fast overnight, or at least not eat allantoin containing foods prior to the test?

    "daily sun while trail running or surfing" ..... acute oxidative stress resulting in allantoin for humans ...? The exercise challenged part of me likes the idea of a allantoin supplement instead of exercise, but I'm not going there ......:D In terms of say a mammal that produces it as part of the uric acid cycle, the exercise thing is interesting .........A lion may have to go like stink to try and catch its prey, but probably only be successful one or two times in ten .... But being able to endogenously produce allantoin from an exhausting chase may be protective, particularly as a carnivore with little dietary allantoin ........
     
  17. JanSz

    JanSz Gold

    Bottom line, how to live longer, better.

    Ok, so let's forget any allantoin measurements.
    Oxidative stress.
    Take two people. One lives in the blue zone and the other in NYC (New York City on Manhattan).
    How would you select those people to make the comparison logical?
    What would you measure in them? Use metrics available to everyday pedestrians (and useful in daily life planning).
    .
    Note:
    I live 30 miles from NYC for almost 50 years.
    I and my family benefited greatly (numerous times), from high-quality (and promptly delivered) surgical type health care. Most recent one 95 days ago. Without them, I probably would already be gone for a while, instead of being preoccupied fighting for more pleasant and frequent orgasms.
    .
     
    Last edited: Oct 26, 2020
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  18. Sue-UK

    Sue-UK Gold

    Because I don't do it for myself, I wouldn't measure anything .... But in daily life planning, if someone was living in NYC, Manhattan, theoretically their exposure to environmental causal factors for oxidative stress would likely be far greater than someone living rurally in a blue zone. Manhattan's an extreme environment to hack, but I'm assuming where you are is less extreme in terms of population density and nnemf exposure? Then there's the starting point - is there already a disease profile? Let's assume not at this point for either where you are or a blue zone resident. A resident where you are may on paper seem to be at a disadvantage, but may also have a stronger maternal mitochondrial heritage, good social bonding network, and mitigate or block a lot of any negatives, (CT, regular trips to the sun, reducing aluminium load, blue blocking, magnetico, good diet, etc ) and do better than someone with a weaker maternal mitochondrial heritage, lonely, being zapped with self inflicted nnemf and artificial blue light, and eating junk food in a blue zone.....

    I think the trick is can I make where I live now an n=2 (DH and me) blue zone ... if not, or if the environment changes in the future, then it may mean creating another blue zone somewhere else ... :D
     
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