1. Registering for the Forum

    We require a human profile pic upon registration on this forum.

    After registration is submitted, you will receive a confirmation email, which should contain a link to confirm your intent to register for the forum. At this point, you will not yet be registered on the forum.

    Our Support staff will manually approve your account within 24 hours, and you will get a notification. This is to prevent the many spam account signups which we receive on a daily basis.

    If you have any problems completing this registration, please email support@jackkruse.com and we will assist you.

The melatonin and leptin connection 2018

Discussion in 'The Leptin Rx' started by KalosKaiAgathos, Jan 26, 2019.

  1. KalosKaiAgathos

    KalosKaiAgathos New Member

    Surprise, surprise:

    Melatonin Absence Leads to Long-Term Leptin Resistance and Overweight in Rats.
    Melatonin (Mel), a molecule that conveys photoperiodic information to the organisms, is also involved in the regulation of energy homeostasis. Mechanisms of action of Mel in the energy balance remain unclear; herein we investigated how Mel regulates energy intake and expenditure to promote a proper energy balance. Male Wistar rats were assigned to control, control + Mel, pinealectomized (PINX) and PINX + Mel groups. To restore a 24-h rhythm, Mel (1 mg/kg) was added to the drinking water exclusively during the dark phase for 13 weeks. After this treatment period, rats were subjected to a 24-h fasting test, an acute leptin responsiveness test and cold challenge. Mel treatment reduced food intake, body weight, and adiposity. When challenged to 24-h fasting, Mel-treated rats also showed reduced hyperphagia when the food was replaced. Remarkably, PINX rats exhibited leptin resistance; this was likely related to the capacity of leptin to affect body weight, food intake, and hypothalamic signal-transducer and activator of transcription 3 phosphorylation, all of which were reduced. Mel treatment restored leptin sensitivity in PINX rats. An increased hypothalamic expression of agouti-related peptide (Agrp), neuropeptide Y, and Orexin was observed in the PINX group while Mel treatment reduced the expression of Agrp and Orexin. In addition, PINX rats presented lower UCP1 protein levels in the brown adipose tissue and required higher tail vasoconstriction to get a proper thermogenic response to cold challenge. Our findings reveal a previously unrecognized interaction of Mel and leptin in the hypothalamus to regulate the energy balance. These findings may help to explain the high incidence of metabolic diseases in individuals exposed to light at night.​

    No emphasis given on any line because they're almost all gold. No further comment...

    b.pezzia likes this.
  2. Jack Kruse

    Jack Kruse Administrator

    Surprise to who? People not following the melanopsin thesis I am laying out huh?
  3. Jack Kruse

    Jack Kruse Administrator

    Brown adipose tissue controls satiation! Yes. Really. (I know what you think => read on. brown fat is stimulated by cold and by sunlight into action to burn your fat away. This is the basis of the Leptin Rx and Cold Thermogenesis Rx on my website. This is also why nature put leptin in our subcutaneous fat with melanopsin. We have both a light and cold detector system in our fat to tell the brain which system needs to be active as the seasons vary. As seasons vary, so does the electromagnetic footprint of the sun as Earth revolves, and this is how your colony of mitochondria know what program to use during the correct time of the year. https://buff.ly/2zX39IS
    CjHedberg likes this.

Share This Page