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The Leptin Rx is getting more data in the sails DAILY.

Discussion in 'The Leptin Rx' started by Jack Kruse, Jun 12, 2018.

  1. Jack Kruse

    Jack Kruse Administrator

    Another massive Leptin Rx win. It appears the food gurus like Ron Rosedale memes are getting destroyed with regularity lately. Not one food gurus predictions are holding up. The guys who follow the sun, however, are winning and winning big. Previous studies have identified a key role for mTOR in regulating photic entrainment and synchrony of the central circadian clock in the suprachiasmatic nucleus (SCN). http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1007369

  2. KalosKaiAgathos

    KalosKaiAgathos New Member

    Another one:


    While you have to read between the lines here, the collection of thousands (if not millions) of data points from different individuals of the My Fitness Pal app, eating more calories at breakfast did reduce total food consumption over the day.

    I quote:

    "While there is plenty of scatter, there is a definite trend towards eating less across the day in the people that consumed more of their daily calories at breakfast."​
  3. Jack Kruse

    Jack Kruse Administrator

    When the sun is out is when is when you are supposed to eat.
  4. Lahelada

    Lahelada New Member

    More wind. https://www.ncbi.nlm.nih.gov/m/pubmed/29861386/
    "Results reveal that the cerebral ventricles receive input from approximately one-third of MCH-producing neurons. Moreover, MCH cerebrospinal fluid (CSF) levels increase prior to nocturnal feeding and following chemogenetic activation of MCH-producing neurons. Utilizing a dual viral vector approach, additional results reveal that selective activation of putative CSF-projecting MCH neurons increases food intake"
    Brent Patrick and Phosphene like this.
  5. Jack Kruse

    Jack Kruse Administrator

    Brent Patrick, Phosphene and Lahelada like this.
  6. Jack Kruse

    Jack Kruse Administrator

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  7. Lahelada

    Lahelada New Member

    No sir, I brought this here as it is described by Nature Reviews as "a novel pathway that controls feeding behaviour". My point was that we know about this already and in more detail. Thank you for the cites. I will re-read.
    Brent Patrick and Phosphene like this.
  8. Phosphene

    Phosphene Gold (finally)

    In one of my previous careers as a grant writer I helped edit and submit the proposal for the following grant:


    Before it was awarded my health deteriorated to needing a medical leave (and then a lawsuit that I can’t discuss). I am still clawing my way out of the hole.

    I haven’t been in touch with the principal investigator for quite awhile but at some point I’d like to talk with her about how she controls for light in her studies. I remember they had a lot to do with leptin. I don’t feel well versed enough in Kruse science to tackle this yet, but I’ll get there. Can you suggest any particular blogs or webinars (beyond the obvious) that might be helpful? I would love to perhaps help set science on the right path one small researcher at a time. Thanks!
    Alex97232 likes this.
  9. Phosphene

    Phosphene Gold (finally)


    Wondering if you might have any thoughts on this since you seem well versed in leptin, and other things. :)
  10. drezy

    drezy New Member

    Susquehanna University?

    I spent the first decade an a half of my life with feet in the river of the same name and it's nearby swamps. I never had a clean pair of pants or shoes thanks to that.

    Haunting or entangled to see that name again.
  11. kris90

    kris90 New Member

    I've always had a natural preference to eat my large protein load just prior to sunset rather than at sunrise. I feel better having an empty belly during the day, and filling up my tank towards the latter half of the day. I've noticed favorable body composition with this approach.

    Then again, I always get AM sun, and use cold wisely, so for myself I don't think these details matter, because food is less important. I think when leptin sensitive, you can do without the BAB and have a nice feast at dinner instead, as long as you still eat while the sun is up.
    axel brandt, Antonis and Mitchell97 like this.
  12. drezy

    drezy New Member

    I appreciate your input. It matches my experiences. I've been experimenting, but I'm instinctively drawn back to what you describe.
  13. kris90

    kris90 New Member

    I've tried the BAB before, and in fact being summer, I'm having a lot of fun eating breakfast with the fam on days I'm home. I admit, my appetite is destroyed most of the day and I can skip lunch, but I STILL have a tendency to WANT to eat more when I eat breakfast. It's almost as if once I start, my brain wants to keep going, and I end up eating 2-3 meals versus 1-2 meals when I skip breakfast and start my feeding later in the day. Seems counterintuitive for me to purposely eat breakfast, and I find I also drink less water on those days.
  14. caroline

    caroline Moderator

    I would be interested in hearing from any females here and their experience with what Chris is saying.

    I intuitively want to do the same.......I feel much better with a bigger meal around 4-4:30pm. I do prefer to star my feeding day a little later too.

    But - Jack is saying to eat early........

    I think the optimum thing is to eat during daylight hours. Here in Oz - now winter ......I need to eat early.

    We usually walk, go to the ocean ect early and often don't get to breakfast [for various reasons] till about 10:30 am and it feels good.
    Mitchell97 likes this.
  15. Jason Coates

    Jason Coates Losing the Shade.

    Light beats food hands down in circadian entrainment, but for those of us needing to set a daily calorie deficit to lose weight a BAB assists. It is also a good tool vs dawn phenomenon. Metabolism is gimped at night and sourcing a late lunch or very early supper of note is more difficult for many of us. BAB, ftw.
  16. kris90

    kris90 New Member

    I know my wife was having success with this too. It's weird, back in 2016, I just remember we would both follow leangains and fast from about 8 PM to 12 PM the following day. We would eat a small lunch around noon (usually low-ish carbs) and a massive dinner around 7 PM that consisted of a ridiculous amount of carbs (probably 100g for my wife, and 200g for myself). I was the leanest I had ever been in my life.

    Of course I had stopped doing that when I learned about circadian rhythms and began to adopt the concepts of what is taught here, but I literally could not stop the fat from melting off my body. I was not eating clean at all, but I was on HCG for treatment of hypogonadism. Still have not been able to explain how this happened, maybe stem cell depletion? Looking good on the outside, but unfavorable effects on the inside? No idea. I do feel better now with a solid circadian rhythm, but not quite as lean as I was back then. Maybe that's a good thing?
  17. WalterNL

    WalterNL New Member

    Well this is just based on observations, but you can see some indigenous people in Africa being very lean, but are indigenous people in the high north just as lean? I would say that the farther you live north, more loosely coupled haplotypes, the more fat will help because you'll be less connected to the sun and will do more CT naturally as seasons change. Fat burning is your backup, and if you're very lean, you don't have a backup.
    JanSz likes this.
  18. kris90

    kris90 New Member

    Well, I think the problem with indigenous folks up north is that they are in an environmental mismatch because of their haplotype. They cannot uncouple well, and so they would likely hold on to fat, but a loosely coupled individual would likely get very lean because they would be dumping fat like crazy as heat.

    My experience since following circadian rhythm and seasonal eating is that I'm leaner in the cold winter than in the hot summer. The crazy thing though, is that because of how much sun I get, if I don't eat enough carbs and stay too close to ketosis, I actually become fatter. Carbs lean me out in summer. And of course winter is exactly the opposite: I eat a ridiculous amount of fat and calories but no carbs and I shed weight like crazy.
    axel brandt and WalterNL like this.
  19. Mitchell97

    Mitchell97 New Member

    I'm still trying to figure out what meal timing and frequency is best for me lol. I'm with Kris that when eating breakfast I can get satiated but I still have the urge to eat more and get hungrier as the day goes on, and I can easily hit 2000 calories at breakfast and still be hungry when dinner comes along. Wouldn't be surprised if it's my environment but when I do everything else right like making sure my circadian rhythm is on point and I do OMAD at early dinner, it's easier for me to keep a deficit and eat less. Some people are saying to eat earlier in the day and eat breakfast with an early lunch and skip dinner, and others are saying that it's better to fast for mental clarity and overall energy levels and to IF or even eat OMAD. Also the science is saying we're more insulin sensitive in the morning and to eat carbs in the morning as opposed to the evening but that would just allow me to overreat like crazy. So much info out there that it's just too confusing lol.
    Jason Coates likes this.
  20. Jason Coates

    Jason Coates Losing the Shade.

    Satiety is not "elegant sufficiency" - it is to the point where you just feel a little feedback - not vomiting but a definite "Hey there, I am full." Once you are there you learn to understand eating to satiety. Maybe a lunchtime snack of a fatty piece of meat/jerky or a pat of butter to check those hunger pangs? If they go away you know that it is not real hunger. If you are not leptin/insulin resistant the rule is simple: Eat whilst there is daylight - restrict your meals to 3 or less. OMAD can be classed as an eating disorder if it is at the wrong time and wrong type of food - that's all.

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