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THE HYPOXIA OF C19 MIMICS AN EXTRAVASCULAR HEMOLYTIC ANEMIA

Discussion in 'Educating Doctors' started by Jack Kruse, Apr 6, 2020.

  1. Jack Kruse

    Jack Kruse Administrator

    THE HYPOXIA OF C19 MIMICS AN EXTRAVASCULAR HEMOLYTIC ANEMIA

    The next blog in the hypoxia series is now live. HYPOXIA #7: WHAT MAKES COVID HYPOXIA UNIQUE?
    From my initial post mortem of data, I have gathered from my contacts on the front line in New York and New Orleans this virus is hijacking hemoglobin's ability to carry oxygen to tissues. The lung tissue then responds to this insult to mimic pulmonary hypertension as we see in high altitude sickness. This idea implies how we treat COVID19 must change. It also implies Trump might be correct about his push to use drugs and Fauci might be wrong. These ideas are supported by laboratory and imaging studies ER docs are seeing on the front lines in New Orleans and NYC. Have a look at this very clinical blog that links the viral illness to quantum biologic processes we know are happening globally to mankind in the modern world.
    Unless you are prepared to give up something valuable you will never be able to truly change at all because you'll be forever in the control of things you can't give up.......don't be afraid of life's chaos. Embrace it. What we call chaos today are just patterns we haven't recognized yet. This blog lays out a new pattern based upon new data from the front lines.
    https://www.patreon.com/posts/35702264
     
    Glenn A and Katherine B. like this.
  2. Susan Tyson

    Susan Tyson New Member

    Thanks for the insight... A 40,000 ft view from Dr. Shiva ...
     
    Glenn A likes this.
  3. Summer

    Summer New Member

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  4. Inger

    Inger Silver

    Interesting.
    Friday, I donated blood, and there were tons of people donating!
    I wonder of they have read about high iron being not so good when there is a virus around? Hmmm.

    I have read various articles about malaria risk and high iron. Women with anemia have less risk for malaria. Iron supplementation seems to increase maraia risks.

    If people with iron overload, and lots of nnEMF, are at increased risk for issues with corona?
    Seems plausible to me.
    I wonder if Boris Johnson have iron overload..could be very possible, as lots of people of his ancestry are genetically predisposed to it. The add all the nnEMF in England. Uh :(
     
  5. Penny

    Penny New Member

    You really knocked it out of the park on corona virus - unholy cool blog thanks!
     
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  6. Glenn A

    Glenn A New Member

    Summer -

    A really good explanation in your link of the dangers of free toxic iron and what's happening in the lungs. I'll add another link or two to explain why vitamin C treatment, even oral ascorbic acid, is needed, plus plenty of zinc, B vitamins, etc.
    So I agree that SARS CoV-2 needs to be understood as an attack on the circulatory system. There are other treatments though that are essential besides those mentioned in your link.

    In this link notice it's not just the iron from the hemoglobin, but once it's oxidized that causes the cascade. Also notice that not only are high levels of ascorbic acid necessary, but in conjunction with Melatonin.

    https://www.townsendletter.com/arti...ell-free-hemoglobin-ascorbic-acid-connection/

    Notice also that the article goes on to defend the great ability of ascorbic acid to regenerate it's potency, yet all IV vitamin C is sodium ascorbate, and a good argument made for oral doses of ascorbic acid which can be put in the blood sooner and in higher potentcies, and with higher persistence than IV sodium ascorbate which has minimal regeneration capability.

    This video explains that Chloroquine is effective as a zinc ionophore, facilitating it's entry through membranes to allow it's intracellular action.



    Here's a paper on how zinc acts within the cell to inhibit Coronavirus.

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2973827/

    Zinc is important in thousands of ways, but this study shows that in insufficient levels, Zinc can turn on an inflammatory response, but then without Zinc, the inflammatory response cannot be turned off, stabbing the subject in the back with excessive inflammation.
    https://www.sciencedaily.com/releases/2014/07/140715084928.htm

    This link shows how Melatonin can be a more potent free-radical scavenger than even glutathione. Check the final section of the article.

    http://cescos.fau.edu/observatory/lightpol-melatonin.html

    All this just to mention that Chloroquine is not the complete answer to any virus attack. Don't let even the more "alternative" sector of the mainstream media fool you. We still need to get back to light (Melatonin) and optimum nutrition, even use of supplements like ascorbate, B vitamins, plus minerals.

    Edit: I forgot to mention that I mostly write about nutrients as preventive solutions. Start the "treatment" today and avoid most illness and chronic conditions for life! Tell others it's not to late. I also usually mention that you are never going to hear this preventive strategy from the mainstream, so guide people to forums where they can get educated. And let's do it this time BEFORE we have to suffer through the first round of worldwide mandatory innoculations! I feel it's coming for sure. COVID-19 is just the aria before the curtain is raised on the grand scheme.
     
    Last edited: Apr 8, 2020
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  7. Jack Kruse

    Jack Kruse Administrator

    Reading can seriously damage ignorance on the internet........some people are more interested in short cuts than nature's methods.

    Perspective time on HCQ: Did NASA have RCT evidence to save the Apollo astronauts when they were dying in space? The Lunar Module did not have enough CO2 scrubbing canisters to make air breathable for 3 men. In their time of death, the astronauts had to build a crude adapter using spare parts on board, to make use of canisters meant for the command module. During a pandemic, you do what you can to save life...............

    I am under no obligation to make sense to people. My epistemology is to elevate their thinking above where it is now. And by elevating your knowledge, I need you to sink to the quantum scale to make the leap to optimal.

    My thoughts were clearly laid out in this blog. How about you actually READ IT?

    https://www.patreon.com/posts/35702264 Then we can talk about why the leftist globalist media does not want people woke. HCQ is a zinc ionophore. When are people going to open a biochem book and realize the first and last step in heme synthesis require Zn as the co-factor: C19 and malaria destroy heme, and slows new heme synthesis that is needed for a C19 recovery in both the RBC's and cytochrome c oxidase heme proteins in mitochondria (COX) = no energy made = why hypoxia happens

    ECCG and Quercetin also are Zn ionophores but HCQ is a different animal.
    The amount of Zn each provides as a cofactor to both enzymes in heme synthesis is not equivalent. HCQ produces the most on a per unit basis and that is why it helps prior to a massive infection and in the recovery phase to make new heme. ECCG/quercetin availability on a per unit basis in comparison to HCQ is like pissing in the "Zn lake" so to speak, so it makes no sense to use it when HCQ is way more effective

    If you are living with a co-morbidity and you contract a virus that makes you so sick that you die. Your primary cause of death is that virus not the comorbidity
    Glad we cleared that up for the myopic. This is why the cause of death is counted as it is.
     
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  8. Glenn A

    Glenn A New Member

    Summer, reading through your link one more time, I read:

    "How does chloroquine work?" .... proceeding to say "The reason chloroquine works for malaria is the same reason it works for COVID-19 — while not fully understood, it is suspected to bind to DNA and interfere with the ability to work magic on hemoglobin."

    Notice the ""while not fully understood"? and "suspected"?

    That put me back to reading my reference previously posted, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2973827/
    on how Zinc acts within the cell, where I found statements such as the following that seems to clearly explain how an ionophore such as chloroquine works:

    "Zinc ions and zinc-ionophores, such as PT and PDTC, have previously been described as potent inhibitors of various RNA viruses. We therefore investigated whether PT-stimulated import of zinc ions into cells also inhibited the replication of nidoviruses in cell culture."

    "The inhibitory effect of Zn2+ on the replication of picornaviruses appeared to be due to interference with viral polyprotein processing. In infections with the coronavirus mouse hepatitis virus (MHV), Zn2+ also interfered with some of the replicase polyproteins cleavages"

    I think it needs to be stressed that while Chloroquine is offered as a solution, as an ionophore for Zinc, it is only as effective as the Zinc that is available. It's Zinc that has the action on coronavirus, and Chloroquine only speeds entry to the cell for whatever Zinc is available. No Zinc, no effectfrom Chloroquine. OR that seems to be the case. So this begs the question, what results would the doctors achieve if they provided some Zinc along with the Chloroquine?
     
  9. Jack Kruse

    Jack Kruse Administrator

    A lot but most docs do not remember one damn thing about heme synthesis nor do they know about Zn being a cofactor in the rate-limiting step or the last step nor that both steps occur INSIDE the mitochondria which also contains another heme protein in cytochrome c oxidase. When the mitochondrial damage is happening HCQ loses its therapeutic efficacy.
     
  10. Michael CULLEN

    Michael CULLEN New Member

    Covid symptoms are caused by 5G.
     
  11. ElectricUniverse

    ElectricUniverse New Member

    I see you are one of those sharp people who 'get it' about why Vitamin C is a go-to 'drug' to combat COVID-19. I think this disease could bring the therapeutic antiviral action of Vit C into the mainstream once and for all.

    While we still may not understand all the mechanics of why Vit C is so deadly to viruses (but only in sufficiently high mega doses) it is refutable, decades of literature is replete with clinical evidence that it works nonetheless (it works whether you debate it is effective or not-- actual results trump beliefs and biases every single time!).

    Vit C supplements seem in short supply everywhere now (or at least last time I checked) because people are snapping it up-- the time to stockpile it seems to be past. Still, wherever you can find it be advised to get it.

    There are many forms of C, but the most recommended form is sodium ascorbate (powdered form is cheaper for mega doses, vs more pricey capsules that you have to swallow in large amounts). Avoid brands that use calcium ascorbate-- all that calcium is ultimately toxic in any but minute amounts.

    Don't worry about the sodium in sodium ascorbate-- it does not really raise blood pressure because it is not in sodium chloride form (i.e. salt). And no, as a rule it does not cause stones.

    The secret to winning with oral C is to increase your dose (taken in divided doses throughout day, not in one large bolus) until you reach what is called 'bowel tolerance' (stage where you experience gas or discomfort or diarrhea). At that point in time, you have reached full saturation with C and can back off a bit. In good health, that can vary from a few grams to a dozen or more grams (varies widely with individuals). An acute viral infection can require up to 100 grams (100,000 milligrams) /day or more to reach bowel tolerance (yes, you read that right).

    Once symptoms/signs are relieved and you feel good again, it is advised to continue high doses for 48 hours or more-- this reduces chance that virus might rebound and infection return.

    IV C is more expensive (requires clinical setting) but it is effective. Liposomal C seems to be the king of all C supplements-- it is the most biovailable and it is conserving for your body's energy budget because all other forms, (incl. oral and IV) require precious energy to get C into cells where it is needed.
     
    Last edited: Apr 8, 2020
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  12. Glenn A

    Glenn A New Member

    Jack,

    I don't argue that Azythromycin, as you mention in Hypoxia #7, isn't effective or other points in your article. It's all well explained. I'm merely adding some information via my links, that the cause of a disease state with COVID-19 is not just the destruction of RBCs as the virus takes over and kicks out the heme, or uses these toxic free hemes to protect itself while total oxygen capacity is reduced.

    The Townsendletter link seems to point out how any heme escaping from the RBC after the virus attack may becomes a great oxidative threat. The "Cell-free heme" itself threatens inflammation when not contained by the virus. It describes how, when cell-free hemoglobin attaches to heme-acceptors, they initiate a cascade of free radical chain reactions, such as lipid-peroxidation, and how ascorbate can prevent or reduce the formation of cell-free hemoglobin. I think consideration of the help from ascorbate and zinc is still of value.
     
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  13. Glenn A

    Glenn A New Member

    Update --

    I was happily knocked off my feet when Trump, during the press conference last night, in one sentence mentioned Azthromycin and Zinc as worthy of investigation. Not surprised that not a single question arose about that remarkable utterance.

    Could he finally be taking on the beast and daring to mention nutrition as prevention? At least he's threatening. If the political/medical collusion doesn't start talking nutrition, he can blow it all apart at this point. The word Zinc in a press conference is very telling to those of us who understand what a thin thread by which the whole debate on health hangs.

    Wondering where the President could be getting his thoughts, I happened to go back to Jacks "Hypoxia #7 and read the comments. There I found Jack's comments on the damage caused by toxic cell-free Heme and how it happens in a C-19 attack if there's a shortage of "vitamin C and other things" (like Zinc).

    He had another comment mentioning Zinc.

    Also the same day Jack added those comments to Hypoxia #7, (just 2 days ago on April 7, 2020) there was a great article by Bill Sardi on LewRockwell.com that strongly mentioned the obvious nutrient solution to the virus:

    https://www.lewrockwell.com/2020/04...a-decade-ago-but-failed-to-put-into-practice/

    Sardi is no friend of those touting the "Wait for the vaccine" solution. One statement from the paper:

    "treatment protocol includes oral zinc, chloroquine as a zinc ionophore and an antibiotic (azithromycin)".

    Results: Supposedly 100% success treating SARS-CoV-2. Whatever that means, but it can't be considered a failed test of the treatment protocal.

    I hope the mention of Zinc in a nationally covered press conference is the foot in the door that most of us here would love to see fully opened by the president. He's obviously getting some good information from his staff and just needs more encouragement to proceed.

    Discrediting vaccine solutions to obvious nutrition deficiencies could not come too soon by my thinking.
     
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  14. JanSz

    JanSz Gold

    https://www.lewrockwell.com/2020/04...a-decade-ago-but-failed-to-put-into-practice/

    Why China does not post this? (Answer, they want eunuch for the next USA President)

    Modern Medicine HAVE NOT failed.
    They are about making $$ and not about making lemings healthy.

    [​IMG]
    upload_2020-4-9_7-45-20.png

     
    Last edited: Apr 9, 2020
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  15. Glenn A

    Glenn A New Member

    JanSz,
    I'm with you, but your signature says produce medical stuff first, and I lean toward sharing info on light and nutrition first. The 5% already know it, and only the brightest 10% of the lemmings will get interested and apply the knowledge. It's not a waste of time to talk about nutrition. MSM would have to hammer the nutrition mantra daily for years to get it to take effect on the majority. There's just so much waste in encouraging the likes of General Motors and Boeing to produce masks and ventilators. And yes, that gives real solid reality to the medical-only solution.
     
  16. JanSz

    JanSz Gold

    I agree with you.
    nutrition=food
    For important reasons, @Jack Kruse decided to eliminate discussion about food as an important input to our bodies.
    But the man can't live on oysters and bacon alone. Survival Soup also has limitations.
    It is time to figure out how to introduce apples to our diets as a very important part road to survival (possibly even when not in synch with latitude and seasons).
    upload_2020-4-9_10-4-20.png

    upload_2020-4-9_10-14-8.png

    upload_2020-4-9_10-27-41.png
     
    Last edited: Apr 9, 2020
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  17. JanSz

    JanSz Gold

  18. Glenn A

    Glenn A New Member

    Thanks for the Quercetin info. I'd encountered something about it before but didn't realize it might function as does Chloroquine.

    OK, found the reference and yes, functions also as ionophore.

    https://pubs.acs.org/doi/abs/10.1021/jf5014633
     
    JanSz likes this.
  19. Inger

    Inger Silver

    Quercetin...??
    I have stumbled upon that in my research about Iron overload!
    I have learned, it works as an inhibitor of absorbtion of non heme iron when taken with wood, or in food :)

    Onions sauteed gently for 3-4 minutes is a great source of Quercetin BTW! I eat 1-3 onions that way about every day to help my iron overload.

    Cool stuff :) :)
     
  20. JanSz

    JanSz Gold

    Inger;
    I have noted your new avatar.
    I have trimmed it so it is square now.
    It may make a better fit. Jack's captain's hat would be fully visible, if you would use it.

    upload_2020-4-10_17-44-36.png
     
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