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The Emerging Link Between Hypogonadism and Metabolic Syndrome

Discussion in 'Adrenal Rx and Leaky Gut Rx' started by chocolate, Apr 26, 2012.

  1. chocolate

    chocolate Silver

    The Emerging Link Between Hypogonadism and Metabolic Syndrome


    From the Center for Sexual Function/Endocrinology, Lahey Clinic, Peabody, Massachusetts, and Harvard Medical School, Boston, Massachusetts.


    Correspondence to: Dr André Guay, Lahey Clinic Northshore, One Essex Center Dr, Peabody, MA 01960 (e-mail: andre.t.guay@lahey.org).

    Received for publication June 13, 2008; accepted for publication August 29, 2008.


    The metabolic syndrome (MS) is comprised of various medical conditions that confer increased risk of diabetes and cardiovascular disease. The pathophysiologic components of MS include glucose abnormality, obesity or increased waist circumference, increased blood pressure, and hyperlipidemia. There is an increased risk of hypogonadism in men with MS and its individual components, including insulin resistance, considered by some to be at the core of MS. Hypogonadism may even predict MS. These factors are interwoven and impact overall health, including sexual dysfunction. One interesting and important question is whether treating hypogonadism with testosterone replacement will ameliorate the pathological components of MS.

    Key words: Low testosterone, insulin resistance, cardiovascular risk, obesity
  2. chocolate

    chocolate Silver


    Testosterone replacement therapy improves insulin resistance, glycaemic control, visceral adiposity and hypercholesterolaemia in hypogonadal men with type 2 diabetes.



    Low levels of testosterone in men have been shown to be associated with type 2 diabetes, visceral adiposity, dyslipidaemia and metabolic syndrome. We investigated the effect of testosterone treatment on insulin resistance and glycaemic control in hypogonadal men with type 2 diabetes.


    This was a double-blind placebo-controlled crossover study in 24 hypogonadal men (10 treated with insulin) over the age of 30 years with type 2 diabetes.


    Patients were treated with i.m. testosterone 200 mg every 2 weeks or placebo for 3 months in random order, followed by a washout period of 1 month before the alternate treatment phase. The primary outcomes were changes in fasting insulin sensitivity (as measured by homeostatic model index (HOMA) in those not on insulin), fasting blood glucose and glycated haemoglobin. The secondary outcomes were changes in body composition, fasting lipids and blood pressure. Statistical analysis was performed on the delta values, with the treatment effect of placebo compared against the treatment effect of testosterone.


    Testosterone therapy reduced the HOMA index (-1.73 +/- 0.67, P = 0.02, n = 14), indicating an improved fasting insulin sensitivity. Glycated haemoglobin was also reduced (-0.37 +/- 0.17%, P = 0.03), as was the fasting blood glucose (-1.58 +/- 0.68 mmol/l, P = 0.03). Testosterone treatment resulted in a reduction in visceral adiposity as assessed by waist circumference (-1.63 +/- 0.71 cm, P = 0.03) and waist/hip ratio (-0.03 +/- 0.01, P = 0.01). Total cholesterol decreased with testosterone therapy (-0.4 +/- 0.17 mmol/l, P = 0.03) but no effect on blood pressure was observed.


    Testosterone replacement therapy reduces insulin resistance and improves glycaemic control in hypogonadal men with type 2 diabetes. Improvements in glycaemic control, insulin resistance, cholesterol and visceral adiposity together represent an overall reduction in cardiovascular risk.
  3. chocolate

    chocolate Silver


    Zinc megadose gives 40 percent more free testosterone

    Zinc supplements enhance testosterone levels. If you give athletes a daily dose of 3 mg zinc sulfate [appr. 1 mg elemental zinc] per kg bodyweight, after four weeks they’ll have 40 percent more free testosterone in their blood. Researchers at the Selcuk University in Turkey discovered this when they did an experiment with 10 male wrestlers.

    In the previous posting we wrote about this Turkish zinc research. In those studies, mice and physically inactive students made more testosterone when they were given hefty doses of zinc. In this study, the researchers looked at the effect of zinc on highly-trained wrestlers. The subjects had an average age of 19 and had been training five days a week for at least six years.

    The wrestlers did weight training once a week, cross training once a week and wrestling-specific training on the other three days.

    Before and after the four-week period of zinc supplementation, the researchers got their test subjects to cycle until they reached the point of exhaustion. Before and after the test, the researchers measured the concentrations of thyroxine and testosterone in the subjects’ blood. Under normal conditions, heavy physical exertion lowers the concentration of these hormones. The figure below shows how the zinc supplements prevented this from happening. The supplements also resulted in a 40 percent increase in the amount of free testosterone before the exhaustion test.

    The same effect was also seen on the concentrations of thyroxine and free T3 and T4 in the blood.

    Many enzymes use zinc in the processes of hormone production and of generating energy from fats or carbohydrates. Physical exertion requires large amounts of zinc, the researchers believe. Such large amounts that zinc supplements can help athletes to improve their performance. "Physiological doses of zinc supplementation can prove beneficial to performance", they write.

    If you weigh 80 kg and you want to use zinc in similar doses to those used by the Turkish wrestlers, you’ll need to take 240 mg zinc sulfate a day [appr. 80 mg elemental zinc]. Long-term use of such high doses of zinc is not safe. Researchers have reported side-effects from much lower intake levels. According to Chinese researchers, a daily dose of 50 mg zinc leads to higher cholesterol levels in humans within a couple of weeks. [Wei Sheng Yan Jiu. 2004 Nov;33(6):727-31.] The American epidemiologists Walter Willett and Ed Giovannucci discovered that zinc supplements at doses higher than 100 mg per day increased the risk of prostate cancer by a factor of 2.2. [J Natl Cancer Inst. 2003 Jul 2;95(13):1004-7.]


    Neuro Endocrinol Lett. 2006 Feb-Apr; 27(1-2):247-52.


    It really works – zinc is a T-booster 13.11.2009

    Animal study: copper chloride is T-booster 23.07.2009

    Calcium raises T-levels in athletes 08.04.2009

    Study: ZMA does not raise testosterone levels 07.04.2009

    Combination of selenium and NAC raises testosterone levels 18.01.2009

    More magnesium, more free testosterone 11.11.2008

    Body Builder sight, but it's supposed to help with t3 and t 4 also.
  4. chocolate

    chocolate Silver

    Combination of selenium and NAC raises testosterone levels

    A cocktail containing high doses of selenium and the amino acid N-acetyl-cysteine increases the sperm cell production and testosterone levels. Researchers at the Shahid Beheshti University in Iran discovered this after doing a trial with nearly five hundred men. Just how relevant the results are for well fed athletes or life extensionists in the affluent West we don't know.

    The men were experiencing fertility problems. Doctors had already determined that they had a low sperm count or that they had low quality sperm cells.

    The men were given a supplement to take daily for six months: 26 weeks. The placebo group were given a fake pill, the Se group took a daily dose of 200 micrograms of selenium, and the NAC group took 600 milligrams of N-acetyl-cysteine. The Se+NAC group took both supplements.

    The supplements had a positive effect on the sperm quantity, motility and the number of sperm cells. The latter effect is shown in the graph below.

    The supplements also reduced the number of subnormal sperm cells. The magnitude of the effects was approximately the same: the graphs are almost identical.

    The researchers also noticed an effect on the testosterone level. After taking the supplements for six months, the placebo group had a testosterone level of 17.4 nanomols per litre. In the Se and the NAC groups the level had risen to 20.1 nanomols per litre, and in the Se+NAC group it was 20.9 nanomols per litre. See the graph below.

    The FSH and LH levels, on the other hand, went down. The men’s pituitary glands apparently reacted to the rise in testosterone level by becoming less active.

    The researchers think that the supplements may have an antioxidant effect in the testes. Selenium is needed for the detoxifying enzyme glutathione peroxidase. This is an enzyme that renders peroxides harmless. NAC is a precursor of the detoxifying enzyme glutathione.


    J Urol. 2009 Feb;181(2):741-51.


    Do cranberries boost testosterone? 05.12.2008

    Not Tribulus terrestris, but Tribulus alatus 21.11.2008

    Mucuna pruriens: more testosterone, more LH, less prolactin 19.11.2008

    More magnesium, more free testosterone 11.11.2008

    African pepper raises testosterone level 17.10.2008

    Animal study: pomegranate juice increases testosterone level and sperm quality 02.10.2008

    Astaxanthin supplement raises testosterone level 07.09.2008
  5. primat

    primat Silver

    +1 thanks for posting
  6. allen001

    allen001 New Member

    Low testosterone patient also complaints about brain fog or depression too.
  7. chocolate

    chocolate Silver


  8. Jack Kruse

    Jack Kruse Administrator

    Here is another brick in the wall for the higher testosterone is good story........given that this month's webinar (Nov 2012) is on prostate CA I thought it would be quite good to link this paper here.


    In the webinar you heard how now modern urology is now linking bad prostate CA prognosis and "low testosterone" and no longer blaming high testosterone on prostate cancer. This paper shows the metabolic link.

    The Neuronal Androgen Receptor regulates hypothalamic insulin signaling by repressing nuclear factor-κB (NF-κB)–mediated induction of protein-tyrosine phosphatase 1B. Hypothalamic insulin resistance leads to hepatic insulin resistance, lipid accumulation, and visceral obesity. What throws off the cellular signaling? Low Mg, low CoEnzQ10, low intracellular levels of all the chemicals that restore optimal ATP function. Optimal ATP fxn = Leptin Sensitivity. Non Optimal ATP fxn = LR= IR= NF kappa beta increasing = oncogenesis.
  9. Jack Kruse

    Jack Kruse Administrator

    The hypothalamus is the key player in signaling gone wild. These findings suggest that in men with Prostate Ca undergoing Androgen Deprivation Therapy, reduction of Androgen Receptor function in the brain may contribute to insulin resistance and visceral obesity.
  10. Jack Kruse

    Jack Kruse Administrator

    With androgen depletion "therapy" insulin resistance starts in the brain.

    Scientists from the University of Rochester Medical Center believe they have found a mechanistic explanation for the increase in diabetes and metabolic disease among men who undergo androgen deprivation for prostate cancer.
  11. Jack Kruse

    Jack Kruse Administrator

    low T is just another sign of low EPi -paleo RX nutrients......Se, Zn, and glutathione are lowered and this depletes ATP resources and if ischemia is there then it gets worse.......and oncogenesis ensure because of ATP, ADP, and AMP deficits that further diminish xanthine and hypoxanthine which are the intracellular building blocks with D Ribose to replenish the Phosphate rings of ATP. Once you lost xanthine and hypoxanthine the cell can replenish ATP because the D ribose system is slow acting.....10 days to recover. This is precisely why we see reperfusion injury in the heart and stroke when ischemia is chronic. Chronic decreases in blood flow is a primordial state for oncogenic transformation......once it happens then the immortal cell controls the glycolytic pathways to secure energy for growth of the cancer cells in the prostate.
  12. chocolate

    chocolate Silver

    It really does come down to the brain fighting for its life. So simple once it comes down to that. The sprints and cold water are so doable. I'm lucky enough to have my legs and the ability to use them.

    I deleted that comment about my tooshie getting rock hard. And not taking the d- ribose everytime I should.

    It's coming down to the point that I'm going to have to wear expensively cut jeans for everyday. I've always been able to wear dude jeans.
  13. Jack Kruse

    Jack Kruse Administrator

    I can bend a quarter between my ass cheeks now........just sayin'
  14. chocolate

    chocolate Silver

    Its amazing how strong your back is by default when that happens, huh? LOL
  15. Jack Kruse

    Jack Kruse Administrator

    kettlebell swings will give the the most amazing ass and posterior chain.............
  16. caroline

    caroline Moderator

    sorry - But - once again - I need pictures! What can I say - I am a visual learner!!
  17. nonchalant

    nonchalant Silver

    Caroline, if you eat more oysters, your imagination skills should improve...


  18. caroline

    caroline Moderator

    I will go to the fish market tomorrow for sure - but you do have to admit that pictures would be very fun!
  19. caroline

    caroline Moderator

    just saying........
  20. nonchalant

    nonchalant Silver


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