1. Registering for the Forum

    We require a human profile pic upon registration on this forum.

    After registration is submitted, you will receive a confirmation email, which should contain a link to confirm your intent to register for the forum. At this point, you will not yet be registered on the forum.

    Our Support staff will manually approve your account within 24 hours, and you will get a notification. This is to prevent the many spam account signups which we receive on a daily basis.

    If you have any problems completing this registration, please email support@jackkruse.com and we will assist you.

The biophysics of the microbiome: state of affairs 2015

Discussion in 'Adrenal Rx and Leaky Gut Rx' started by Jack Kruse, Aug 23, 2015.

  1. Jack Kruse

    Jack Kruse Administrator

    there are no short cuts
    lohd2015 and QuantumRadical like this.
  2. ssj3

    ssj3 Silver

    @Jack Kruse would you be able to explain some of this further...

    Mentioned that when microbiome diversity and numbers are lost, FIAF causes excess light release and obesity. But then state that when this happens optical signalling becomes simplified and FIAF rises and human host burns through fat stores? Some would see this in isolation as a good outcome... but I gather this is more complex...

    Something along the lines of a lack of varied inducers/detectors results in loss of gene transcription, cascade loss of signalling chemicals, loss of melatonin autography, circadian mismatch resulting in loss of colon anaerobic environment (ibs, sibo, gerd, etc). Excess gut oxygen lowers pH, decreases EZ. Lack of flora means that they may not consume enough protons, thus increased proton uptake leads to inflammation, then to leptin resistance and regain of initial fat loss?

    Molecular oxygen in colon is then the cause of a simplified microbiome and not the initiator?... how does the release of molecular hydrogen from IF recreate a diverse microbiome (what is the catch in this state i.e. when leptin resistant - is this a case for short term probiotics while trying to regain circadian rhythm?)
  3. Christos

    Christos New Member

    My understanding is that FIAF is made by the cells in the small bowl, muscle and liver when bacteria in the small intestine are not releasing light (ie. with no food in a fasted state). The large intestine bacteria make large amounts of fatty acids to form subcutaneous fat. FIAF allows for the oxidation of these newly formed fats. Those with SIBO would release more light in the small intestine and make less FIAF.

    Circadian dis regulation can lead to improper circadian function of the lower esophagus sphincter, resulting in oxygen release into the gut and small intestine and FIAF ceasing due the aerobic conditions (FIAF not made with oxygen present). This also simplifies the large intestine anaerobic bacteria.
    ssj3 likes this.
  4. Jack Kruse

    Jack Kruse Administrator

Share This Page