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Taurine - Light - GABA efflux in the retina... this explains a lot:-)

Discussion in 'The Cave' started by Penny, Aug 12, 2017.

  1. Penny

    Penny New Member

    Effects of Taurine and Light on Retinal GABA Content and the Efflux of 14C-GABA and 14C-Aspartate from Frog Retina
    • Jasmine E. Haroutounian
    • Andranik M. Petrosian
    Chapter
    Summary
    GABA content of isolated, dark adapted frog retina was found to be 3.15 ± 0.28 mM. After 30 minutes of exposure to intense light (200 1x), retinal GABA levels increased about 70%. Interestingly, incubation of dark adapted retina for 30 minutes with medium containing 0.4 mM taurine also led to a 70% increase in GABA levels. Since the light-induced elevation in GABA content was reduced over 50% by a simultaneous injection of 0.02 mM strychinine, it is likely that the light-induced GABA change is partly mediated by the release of taurine from the retina seen after light exposure. However, incubation of isolated retina with medium containing increasing concentrations of taurine (1, 2 and 20 mM), caused a progressive rise in 14C-GABA efflux from retina that was preloaded with 2.2 μM GABA and exposed to dim light (0.05 1x). It was also shown that taurine (1 and 5 mM) dramatically reduced 14C-aspartate efflux from retina preloaded with radioactive aspartate and exposed to dim light conditions. By comparison, intense light stimulation (40 1x) reduced basal 14C-aspartate efflux while dark exposure increased 14C-aspartate loss from the isolated retina. We found that taurine depressed the b-wave signal of frog retina, with the maximum effect occurring at a concentration of 1 mM. Addition of strychnine (0.4 mM) reversed the taurine effect on the b-wave, indicating that taurine receptors must be present in the inner retina. By contrast, taurine (0.1 – 20 mM) had no effect on the P111 component of the ERG initiated by either aspartate or cobalt. However, taurine exerted a modest depressant activity on P111 initiated by glutamate. The significance of these data relative to the putative neurotransmitter function of taurine in the inner retina is discussed.
    https://link.springer.com/chapter/10.1007/978-1-4899-0117-0_51
    Alex97232 likes this.
  2. Alex97232

    Alex97232 Gold

    Thank you, Rabbit, for this and all of your posts. I know this is important, but not sure I follow: Can you translate this to non-geek? TIA.
  3. Da-mo

    Da-mo Gold

    Id like to know too - especially with many of the energy drinks these days containing Taurine.
    https://news.cornell.edu/stories/2008/02/scientists-close-taurines-activity-brain
    Alex97232 likes this.
  4. Da-mo

    Da-mo Gold

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3630960/
    Alex97232 likes this.
  5. Da-mo

    Da-mo Gold

    http://nootropicgeek.com/taurine-review/
    Alex97232 likes this.
  6. Penny

    Penny New Member

    Alex97232 likes this.
  7. Penny

    Penny New Member

  8. Penny

    Penny New Member

    And I used to think they put taurine in energy drinks to prevent heart attacks... :) I also used to think that the gurana was a less jittery jolt, but it seems to me that the taurine modulates the caffeine if done in the correct ratio - might be an interesting hack actually:)
    Alex97232 likes this.
  9. Alex97232

    Alex97232 Gold

  10. Da-mo

    Da-mo Gold

    Yes, thanks Penny for bringing this to light. Interesting that Taurine has positive effects for both eye health and diabetes - since they are strongly linked.
  11. WalterNL

    WalterNL New Member

    Lahelada likes this.
  12. Lahelada

    Lahelada New Member

    We want more GABA? When do we want more GABA?
    If and when we do this might help too.
    Ruhr-Universitaet-Bochum
    Summary:
    Instead of a sleeping pill or a mood enhancer, a nose full of jasmine from Gardenia jasminoides could also help, according to researchers in Germany. They have discovered that the two fragrances Vertacetal-coeur (VC) and the chemical variation (PI24513) have the same molecular mechanism of action and are as strong as the commonly prescribed barbiturates or propofol.
    https://www.sciencedaily.com/releases/2010/07/100708104320.htm
    http://www.jbc.org/content/285/31/23985.full

    [​IMG]
    Alex97232 likes this.

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