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Study - Combo Vit C and Vit K act as redox modulators

Discussion in 'The Cave' started by Vervaina, Aug 28, 2019.

  1. Vervaina

    Vervaina New Member

    IV Vit C is being given with IV Vit K3


    The anticipated end result is restoration of ox phos and aerobic glycolysis and eliminating a hypoxic environment. Sounds intersting...

    Here is one study about VIT C with VIT K:

    https://www.sciencedirect.com/science/article/pii/S2213231718300934

    A bit of summary-

    Vitamin K plus C acts as a powerful redox-system, which forms a bypass between mitochondrial complexes II and III and thus prevents mitochondrial dysfunction, restores oxidative phosphorylation and aerobic glycolysis, modulates the redox-state of endogenous redox-pairs, eliminates the hypoxic environment of cancer cells and induces cell death.

    The redox-cycles of vitamins C and K are cross-linked and both vitamins can serve as associated redox-modulators (a redox-shuttle). The combination vitamin C&K can serve as a bypass between complex I (or complex-III) and cyt. c of mitochondrial respiratory chain and to donate electrons (directly or indirectly) to cyt. c, passing from reduced to oxidized form. Both vitamins can be also converted into reduced forms, consuming NAD(P)H and/or GSH. These processes are accompanied by an increase in ATP synthesis and accumulation of high levels of NAD(P)+ and GSSH, which restores oxidative phosphorylation and aerobic glycolysis and eliminates the hypoxic environment.


    (I think they are using the menadione (k3) form to reach a higher dose K than with other forms ?- I wonder if it also has something to do with it being water soluble?)
     
    JanSz likes this.

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