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Statins: The real info you need to grasp.

Discussion in 'Educating Doctors' started by Jack Kruse, Nov 2, 2013.

  1. JanSz

    JanSz Gold


    What are the names of antibiotics used?

    John Schumacher likes this.
  2. Da-mo

    Da-mo Gold

    Effects of statins on mitochondrial pathways

    Besides the well-known beneficial effects in primary and secondary prevention of CVD, statins may induce adverse effects, like myopathy. Mitochondrial dysfunction is likely to play an important role in the pathogenesis of these adverse reactions due to CoQ10 depletion, inhibition of ETC complexes, depletion of mevalonate pathway end products, membrane depolarization and induction of intrinsic apoptosis, dysregulation of calcium metabolism, and fatty acid oxidation. Chronic statin treatment has been associated with increased risk for T2DM and cognitive impairment. The beneficial effects of statin treatment are not questionable; however, the widespread usage of these drugs and the considerable prevalence of side effects require the underlying pathological mechanisms to be carefully studied.
    John Schumacher and JanSz like this.
  3. Statins increases: Coronary Artery Calcium Score, promotes vascular calcification, and the plaque get harder

    Just as Dr. @Jack Kruse has "taught" his tribe -> Statins are a mitochondria toxin. - https://forum.jackkruse.com/index.php?posts/300862
    Richard Watson and JanSz like this.
  4. JanSz

    JanSz Gold

    Wonder what is your levelof E3, Estriol.Measured in urine.
    If less than in the middle of laboratory range, maybe worthwhile to get it up.

    More on this and few posts after that one.
    E3 looks like a jack of all trades since it is about the parietal (which is the lining behind any bodily surface)
    Including vascular (so heart or arteries too).


    Last edited: Aug 21, 2021
    John Schumacher likes this.
  5. Da-mo

    Da-mo Gold

    Thanks for that @JanSz. I'll look into it as I am showing some signs of autoimmune - dermatitis. I'm considering a multi-day fast to attempt to counter it using autophagy etc.
    John Schumacher likes this.
  6. Da-mo

    Da-mo Gold

    So - back in August my lipid panel, particularly LDL, was the worst it has ever been despite 6 months of Atorvastatin 40mg daily.

    I subsequently reduced the statin to 10mg and implemented intermittent fasting one meal a day for 4 straight days on every 8 day cycle.

    2 weeks ago I went in for echocardiogram and cardiologist consultation. The cardiologist told me I had made a miraculous recovery. My ejection fraction was now >55 (previously 45) and the full movement had returned to the affected heart muscle. You would think she would have asked me what I did to recover, right? She didn't. She wasn't very happy about me reducing the statin either.

    I put this recovery down to going fairly keto and intermittent fasting. IF is such a powerful tool and Autophagy Rocks!!!
  7. caroline

    caroline New Member

    Great news!
  8. Sue-UK

    Sue-UK New Member

    Congratulations! :)

    I'm down the citrus bergamot rabbit hole for different autophagic reasons, having read Naomi Whittel's book Glow 15 (and as a covid avoiding/protective strategy). But there seems to have been a fair bit of research on cardiovascular health, this article has a few link references you might be interested in.

    IIRC from youtube, I think some doctors are using supps along with lower doses of statins for those that can't tolerate normal doses.
    Although it mentions aged mice hearts, not human, this paper is interesting
    Antioxidant and antisenescence effects of bergamot juice.

    I think there's more to it that concerns light ... citrus bergamot essential oil on the skin can blister in strong sunlight, so maybe its also what the fruit does with light internally ......:confused: Musings. :)
    Last edited: Dec 22, 2021
    John Schumacher and caroline like this.
  9. Sue-UK

    Sue-UK New Member

    Dr Brewer has a few youtube videos on citrus bergamot, and in one IIRC he wasn't sure if it had anti inflammatory effects.
    Found this down the rabbit hole ...:D

    Flavonoid Fraction of Bergamot Juice Reduces LPS-Induced Inflammatory Response through SIRT1-Mediated NF-κB Inhibition in THP-1 Monocytes

    Anne V and John Schumacher like this.
  10. Jack Kruse

    Jack Kruse Administrator

    Statins are mitochondrial toxins because of their effect on CoEnzQ10. There are many ways in which they increase coronary artery calcification. One way is depletion of Vitamin K2 from the gut, another is lack of sun to control calcium flows, and another is direct arterial melanopsin damage liberating Vitamin A to cause intimal damage and a loss of arterial NO.

    Sufficient production of vital biochemicals such as Geranylgeraniol (GGPP) is required to maintain endotoxin tolerance in macrophages in our arteries once the damage occurs. Macrophages are the hallmarks of CVD/Atherosclerosis, contributing to plaque development, inflammation, and the promotion of thrombosis. Geranylgeraniol is downstream of Mevalonate in the cholesterol synthesis pathway, and GGPP synthesis is inhibited by Statins, as is CoQ10 and K2. Vitamin K2 is the cofactor for matrix Gla-protein activation, which PROTECTS arteries from calcification.

    Statin use is independently associated with increased calcification in patients, & using an animal model of hypercholesterolemia, we present a molecular mechanism whereby statins promote the calcification of atherosclerotic plaque. https://www.ahajournals.org/doi/10.1161/ATVBAHA.119.313832
  11. JanSz

    JanSz Gold

    Is Red Yeast Rice
    in that category?


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