However, in recent years there has been a riff in the fabric…

• Serum total cholesterol and risk of cardiovascular and non-cardiovascular mortality in old age - https://bmcgeriatr.biomedcentral.com/articles/10.1186/s12877-017-0685-z

• The mean age of the 3090 participants was 73.3 (standard deviation, 10.4) years and 63.7% were women. The competing risk regression models revealed that the reduced all-cause mortality was associated with high total cholesterol.

​

• Paradox of hypercholesterolaemia in highly trained, keto-adapted athletes - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173254/

• Ultra-endurance athletes habitually consuming a very low-carbohydrate/high-fat diet for over a year showed unique cholesterol profiles characterized by consistently higher plasma LDL-C and HDL-C, less small LDL particles, and lipoprotein profiles consistent with higher insulin sensitivity. There may be a functional purpose to the expansion of the circulating cholesterol pool to meet the heightened demand for lipid transport in highly trained, keto-adapted athletes.

​

• Lack of an association or an inverse association between low-density-lipoprotein cholesterol and mortality in the elderly: a systematic review - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908872/ High LDL-C is inversely associated with mortality in most people over 60 years. This finding is inconsistent with the cholesterol hypothesis (ie, that cholesterol, particularly LDL-C, is inherently atherogenic). Since elderly people with high LDL-C live as long or longer than those with low LDL-C, our analysis provides reason to question the validity of the cholesterol hypothesis. Moreover, our study provides the rationale for a re-evaluation of guidelines recommending pharmacological reduction of LDL-C in the elderly as a component of cardiovascular disease prevention strategies.

• The Highs and Lows of Cholesterol: A Paradox of Healthy Aging? - https://agsjournals.onlinelibrary.wiley.com/doi/full/10.1111/jgs.16302

• It is well established that cholesterol for many body functions including nerve conduction, intracellular transport (eg, for the fat‐soluble vitamins A, D, E, and K), as a precursor for important molecules (eg, sex and steroid hormones), and as a part of all cell membranes.

​

• Effects of Step-Wise Increases in Dietary Carbohydrate on Circulating Saturated Fatty Acids and Palmitoleic Acid in Adults with Metabolic Syndrome - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4240601/

• Lipoprotein Insulin Resistance Index: A Lipoprotein Particle–Derived Measure of Insulin Resistance - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4175429/

• https://www.uptodate.com/contents/hypertriglyceridemia

• https://www.gbhealthwatch.com/dna-based-diet-for-high-triglycerides.php

• People with a particular FADS1 gene risk variant do not efficiently convert plant-based polyunsaturated fats to the bioactive forms found in animal fats. This deficiency limits our body’s ability to utilize fat as energy.

​

• https://www.gbhealthwatch.com/Science-Fat-Metabolism-101.php Triglycerides are synthesized in many tissues including the gut, liver, adipose tissue, mammary glands and muscle.

• "Triglycerides" are one type of blood fat that your body uses for energy. High levels of triglycerides can raise risks for heart disease in younger adults. However, we don't know as much about the risks to adults aged 80 and older, or whether high levels of triglycerides can affect their risks for disability or even death. - https://www.sciencedaily.com/releases/2019/02/190204142313.htm

• Higher triglyceride level was linked to a lower risk of cognitive decline, less of a reduction in the ability to perform daily tasks, less frailty, and lower risk for death.

​

• The triglyceride paradox in the mortality of coronary artery disease - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343235/ This study found an inverse association between TG levels and mortality risk in CAD patients, which suggests that the “TG paradox” may exist in CAD patients. A total of 3061 patients with CAD were included in the study. The average age was 64.4 ± 10.7 years.

• Our study revealed that low triglyceride levels were associated with worse stroke as assessed by NIHSS on presentation. - https://www.hindawi.com/journals/neuroscience/2013/870608/

• https://www.nature.com/articles/s41598-020-63825-8

• https://speciality.medicaldialogues...erides-better-for-elderly-concludes-new-study
• https://www.healthinaging.org/blog/...terol-treatment-for-adults-aged-80-and-older/
• The triglyceride paradox in the mortality of coronary artery disease - https://sci-hub.se/10.1186/s12944-019-0972-0
• Oxidized cholesterol as the driving force behind the development of Alzheimer’s disease - https://www.frontiersin.org/articles/10.3389/fnagi.2015.00119/full
• Oxidized cholesterol is the driving force behind the development of AD and that oxysterols play a fundamental role, by enhancing inflammation, Aβ generation and accumulation, and neuron death. High LDL-C is shown to be protective
• Relationship between Lipoprotein (a) and cognitive function – study - https://www.nature.com/articles/s41598-020-66783-3
• https://www.researchgate.net/publication/283309595_Brain_cholesterol_in_normal_and_pathological_aging
• C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162187/
• C‑reactive protein and cardiovascular disease – https://www.spandidos-publications.com/10.3892/etm.2020.8840 The increase in CRP in the body affected endothelial nitric oxide synthase activity and led to endothelial cell dysfunction
• Low-density lipoproteins cause atherosclerotic cardiovascular disease? - https://academic.oup.com/eurheartj/article/41/24/2313/5735221 Oxidized LDL initiates a sterile inflammatory response by activating endothelial cells to up-regulate adhesion molecules and chemokines that trigger the recruitment of monocytes—typically inflammatory Ly6Chi monocytes—into the artery wall. As a result, efferocytosis becomes defective and resolution of inflammation, which is mainly driven by modified LDL, is impaired. Under such conditions, apoptotic cells accumulate and undergo secondary necrosis, promoting the release of several DAMPs that further propagate inflammation. Impaired clearance of apoptotic cells results in the formation of necrotic cores that contribute to unstable plaques and plaque rupture. Arterial calcification is an established marker of atherosclerotic disease, and the severity of coronary artery calcification is a strong predictor of cardiovascular morbidity and mortality.
• Inflammation, not Cholesterol, Is a Cause of Cardiovascular Disease – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986484/
• Of course, HDL is good for you - https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.120.050808
• https://pubmed.ncbi.nlm.nih.gov/33811580/
• Steroidogenesis entails processes by which cholesterol is converted to biologically active steroid hormones - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365799/
• https://link.springer.com/article/1...ign=BSCN_1_DD01_CN_springer_article_paid_XMOL
• Low apoA-I is associated with insulin resistance in patients with impaired glucose tolerance: a cross-sectional study - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379622/#:~:text=Low apolipoprotein A-I (apoA-I,cause of atherosclerotic cardiovascular disease.
• https://www.apollohealthco.com/dr-bredesen/
  
  • 
    
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5486142
  
  

 

Ok, so there’s a riff in the fabric of cholesterol reporting. But that doesn’t change the hypothesis that cholesterol is associated with cardiovascular disease. -> Right?


We know cholesterol is on the first line of defense against inflammation as it serves as an antioxidant within our cells as well as external of our cells. All antioxidants whether it is vitamin E or other antioxidant become damaged as they try to fix the inflammatory issue through the bio-chemical redox process. How many studies now show vitamin E has been associated with cancer? https://cancerpreventionresearch.aacrjournals.org/content/5/5/701 https://news.cancerconnect.com/head...y-be-harmful-in-head-and-neck-cancer-patients “Vitamin E supplements may raise lung cancer risk” -> https://www.medicinenet.com/script/main/art.asp?articlekey=87525 Why is that? -> oxidative damage of the vitamin E lipid molecule.

Name the study, antioxidants become damaged and must be shuttled out of the body just like ox-LDL. Does that make antioxidants bad? -> No

Those publishing the riff in the fabric of cholesterol reporting are being very careful not to cut off their funding support from the pharmaceutical industry. They use words like: Paradox, “We currently don’t know the mechanism of action”, but they also putting in the important qualification: “We know cholesterol is associated with cardiovascular disease.”

So since we are on the thread Educating Doctors, what’s a clinician to do with her CVD patients? -> Glycation

It’s the low hanging fruit and it’s the easiest to work on.

Although food is not the end-all, it can help. Specifically, a low carbohydrate vegetable diet with lots of cold-water fish, typically has a low inflammatory response for most people. Of course, a good food sensitivity iGg test will provide better specifics. A good set of antioxidants to help out the anti-inflammatory action of cholesterol can include: Astaxanthin.

Endothelial dysfunction can be assisted with both a Coronary Calcium score and an Ultrasound Bilateral Carotid Arteries analysis. If these are issues, Chelation and/or Pulsed Ultrasound therapies have proven to be successful. https://pubmed.ncbi.nlm.nih.gov/26578361/ However, when these oxidated molecules are broken loose, it is important to provide binders to collect, clean up and help transport them out of the body. These can include: charcoal and chlorella.

Blood pressure is primarily managed by the renin-angiotensin-aldosterone system (RAAS) system. A Renin Activity and Aldosterone lab analysis will show where in the RASS system it maybe misfunctioning. https://www.aacc.org/science-and-re...aboratory-medicine/2020/aldosterone-and-renin

Secondarily, high blood pressure can be managed by two endothelial mechanisms for vasodilation -> eNOS and prostaglandin-endoperoxide synthase (PTGS), which is an enzyme that is responsible for formation of prostandoids, such as prostacyclin from arachidonic acid.

So, when is it time to lower cholesterol?
According to recent journal studies -> the higher the cholesterol the better the outcome.

 

[QU OTE="John Schumacher, post: 300691, member: 23768"]Ok, so there’s a riff in the fabric of cholesterol reporting. But that doesn’t change the hypothesis that cholesterol is associated with cardiovascular disease. -> Right?


We know cholesterol is on the first line of defense against inflammation as it serves as an antioxidant within our cells as well as external of our cells. All antioxidants whether it is vitamin E or other antioxidant become damaged as they try to fix the inflammatory issue through the bio-chemical redox process. How many studies now show vitamin E has been associated with cancer? https://cancerpreventionresearch.aacrjournals.org/content/5/5/701 https://news.cancerconnect.com/head...y-be-harmful-in-head-and-neck-cancer-patients “Vitamin E supplements may raise lung cancer risk” -> https://www.medicinenet.com/script/main/art.asp?articlekey=87525 Why is that? -> oxidative damage of the vitamin E lipid molecule.

Name the study, antioxidants become damaged and must be shuttled out of the body just like ox-LDL. Does that make antioxidants bad? -> No

Those publishing the riff in the fabric of cholesterol reporting are being very careful not to cut off their funding support from the pharmaceutical industry. They use words like: Paradox, “We currently don’t know the mechanism of action”, but they also putting in the important qualification: “We know cholesterol is associated with cardiovascular disease.”

So since we are on the thread Educating Doctors,
what’s a clinician to do with her CVD patients? -> Glycation

It’s the low hanging fruit and it’s the easiest to work on.

Although food is not the end-all, it can help. Specifically, a low carbohydrate vegetable diet with lots of cold-water fish, typically has a low inflammatory response for most people. Of course, a good food sensitivity iGg test will provide better specifics. A good set of antioxidants to help out the anti-inflammatory action of cholesterol can include: Astaxanthin.

Endothelial dysfunction can be assisted with both a Coronary Calcium score and an Ultrasound Bilateral Carotid Arteries analysis. If these are issues, Chelation and/or Pulsed Ultrasound therapies have proven to be successful. https://pubmed.ncbi.nlm.nih.gov/26578361/ However, when these oxidated molecules are broken loose, it is important to provide binders to collect, clean up and help transport them out of the body. These can include: charcoal and chlorella.

Blood pressure is primarily managed by the renin-angiotensin-aldosterone system (RAAS) system. A Renin Activity and Aldosterone lab analysis will show where in the RASS system it maybe misfunctioning. https://www.aacc.org/science-and-re...aboratory-medicine/2020/aldosterone-and-renin

Secondarily, high blood pressure can be managed by two endothelial mechanisms for vasodilation -> eNOS and prostaglandin-endoperoxide synthase (PTGS), which is an enzyme that is responsible for formation of prostandoids, such as prostacyclin from arachidonic acid.

So, when is it time to lower cholesterol?
According to recent journal studies -> the higher the cholesterol the better the outcome.[/QUOTE]
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One of the functions of your adrenal glands is to produce a hormone called aldosterone that plays an active role in your blood pressure. It does this by maintaining the balance of sodium, potassium, and water in your blood.
--------------------


@DrEttinger
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Inflammation, not Cholesterol, Is a Cause of Cardiovascular Disease
////////

Homocysteine
Histamine



Lets attack homocysteine first




Thorne Research - 5-MTHF 15 mg Folate - Active Vitamin B9 Folate Supplement - 30 Capsules

//////////////////////

 

https://dutchtest.com/shop/

Available everywhere where mail can be sent too.
Lots of instructional videos.
It is the only place where you can take one set of samples and get a whole body one time shot at your
Steroid Hormone Panel.

Spectracell does a similar deal with what they test, but the problem is in delivering test samples.


Spectracell is available in the USA only, (I think).
The website is worth studying.
https://www.spectracell.com/patients-home

 

May I underscore their DUTCH Cycle Mapping Complete - https://dutchtest.com/wp-content/uploads/2016/02/Cycle-Mapping-Complete-Sample-Report-Ref020121.pdf



It includes:

Why DUTCH? ->
Reliability of a dried urine test for comprehensive assessment of urine hormones and metabolites - https://bmcchem.biomedcentral.com/articles/10.1186/s13065-021-00744-3

 

Bringing the subject back to statins again . . . . . .

Further research into pleiotropic effects of Atorvastatin.
- Reduce inflammation
- Reduce clotting
- Reduce oxidative stress/damage

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2733023/

Changes in parameters of pleiotropic effects
Figure 2 shows the changes in the parameters (hs-CRP, PAI-1 and 8-OHdG levels) of the pleiotropic effects of atorvastatin. Atorvastatin significantly decreased serum hs-CRP levels only at the higher dose (10 mg/day). Both 5 mg and 10 mg doses of atorvastatin significantly decreased the serum PAI-1 levels compared with baseline values, although the decreases were comparable between the two treatment regimens. Of the three parameters, only 8-OHdG concentrations were significantly decreased dose-dependently by atorvastatin, with values at 5 mg and 10 mg doses of atorvastatin significantly different. No significant correlations were observed between the extent of reduction in the LDL-C levels and either the hs-CRP or PAI-1 levels. There was a significantly positive correlation between the extent of reduction in the LDL-C concentrations and that in the 8-OHdG concentrations (n=30, r=0.37, P<0.05).



My next step may be to reduce from 40mg/day down to 5 or 10mg/day thus keeping these pleiotropic effects which are still present at much lower doses and maybe lessening the negative effects of PCSK9 up-regulation and lower CoQ10 levels/slowing metabolism.

In defense of my GP - it was he who emphasized the pleiotropic effects and downplayed the importance of LDL-C when I discussed this with him. It would seem that these other benefits are still present at very low doses.

 

And just for balance - the negative pleiotropic affects.

Dr. Nadir Ali - 'Do statins prevent or cause heart disease? Should LDL be called "bad" Cholesterol?'

 

I'm seeing a pattern where statins replace or substitute the exogenous for the endogenous.

While I would always prefer endogenous, in my case something endogenous wasnt working very well or I wouldn't have had a heart attack, aye. The search for root causes continues . . . .

 

https://forum.jackkruse.com/index.php?threads/pg-e2-ratio.6427/page-9#post-289952

..
https://www.excelmale.com/forum/threads/one-more-reason-to-take-nac-it-may-dissolve-plaque.11696/

One More Reason to Take NAC: It May Dissolve Plaque

....

 

https://forum.jackkruse.com/index.php?threads/pg-e2-ratio.6427/page-9#post-290197

 

Since @Da-mo would like to stay on the subject of statins - Shall we...

Dr. @Jack Kruse has "taught" his tribe -> Statins are a mitochondria toxin.
https://www.linkedin.com/pulse/why-do-statins-cause-diabetes-jack-kruse/

As described in https://forum.jackkruse.com/index.php?posts/300689 <- Cholesterol – what is it, what does it do? An investigation into the mechanism of action of cholesterol in the human biological function.

Dr. @Jack Kruse states "Statins affect the cataplerosis and anaplerosis pathways in the urea and TCA cycle. That is what Quantum Thermodynamics blog #8 on Patreon is all about."

• https://optimalklubs.com/qt8-krebs-bicycle/
  
• https://forum.jackkruse.com/index.p...r-the-tca-and-urea-cycle-is-not-simple.21360/

Gaining an understanding as to why employing a toxin into the mitochondria may not be a good option for health, specifically for patients who have cardiovascular disease.

• The triglyceride paradox in the mortality of coronary artery disease - https://sci-hub.se/10.1186/s12944-019-0972-0
• Bottom line - the higher your cholesterol the higher your probability of survival from a heart attack - https://forum.jackkruse.com/index.php?posts/300690

Since you are a Gold member, have you posted your thoughts on statins to ask Jack? The authors of the articles, @Da-mo posted, believe the side-effects of atorvastatin therapy are "worth it".

 

Thanks for the links

 

My cholesterol is sky high. HDL is the highest my doctor had seen, but LDL is very high too, triglycerides are low. So last week I had a TV crew filming here again and we went to the doctor and he checked my arteries and thyroid, and my bloodvessels were crystal clear, zero plaque.

He was very impressed.
Also my thyroid was very healthy.
And i have smoked for many years (not anymore, since several years) and had lots of stress.

My grandma dies of heart attack and my grandpa of stroke. I am trying to avoid that.

I still think one can get heart attack from other reasons though.. like... psychological reasons... or radiation. Such things.

 

If you believe psychological stress is an issue, have you looked into heart-rate-variability? https://www.heartmath.com/

 

Make sure to check your
potassium RBC
newer mind potassium serum

Thre is, there must be a potassium conspiracy, not smaller than Statins, GERD, or covid conspiracies.
I had an unbelievable wakeup call after seeing my (potassium RBC), and an even bigger wakeup after I started taking potassium bicarbonate.

http://charles_w.tripod.com/arthritis3.html


https://forum.jackkruse.com/index.php?threads/pg-e2-ratio.6427/page-9#post-291201



NOTE

There is some kind of obsession with potassium.
I see supplements, they do not have more than 99mg potassium per dose.
While the need for supplementation is 1000-3000 mg/day

...

 

arteriosclerosis
stenosis
restenosis
Restenosis is a renarrowing of an artery after a PCI procedure
------------
Butyrate, glutathione GSH, zinc, NAC
------------------------------------------------------------------
https://tahomaclinic.com/Private/Ar...vascular smooth muscle cell proliferation.pdf

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N-acetylcysteine Restenosis
https://www.bing.com/search?q=N-ace...&aqs=edge..69i57.1664j0j1&FORM=ANSPA1&PC=HCTS



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https://jeffreydachmd.com/2019/03/coronary-calcium-score-paradigm-shift-podcast-jeffrey-dach-md/

https://jeffreydachmd.com/wp-content/uploads/2018/11/Heart_ICIM_Philli-2019_JDach_PDF_M6.pdf



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https://jeffreydachmd.com/2018/06/fibrinolytic-proteolytic-enzymes-medical-use/

keywords
This entry was posted in arthritis, atherosclerosis, Biofilms, Blood Clot, coronary artery disease, dementia, Enzymes, fibrinolytic enzymes, Heart Disease, infection, jeffrey dach, NSAIDS, sprained ankle and tagged enzyme, fibrinolytic, lumbrokinase, nattokinase, serrapeptidase, sprained ankle by Jeffrey Dach MD
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Atherosclerotic Plaque as Infected Biofilm
https://jeffreydachmd.com/2015/06/atherosclerotic-plaque-as-infected-biofilm/


.......
“Biological evidence supporting infection-based model of atherogenesis.

https://jeffreydachmd.com/2019/03/atherosclerotic-plaque-infection-electron-microscopy/

...........

The three major enzymes are
1) Serrapeptidase,
2) Nattokinase and
3) Lumbrokinase.

---------------------



Find Lumbrokinase, Nattokinase and Serrapeptidase on Amazon

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It is relatively easy to make/raise earthworms.
Wonder how to extract lumbrokinase from them.
Or
how much lumbrokinase is in one pound of earthworms?
Possibly having hamburger made from earthworms is in our future.

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