1. Registering for the Forum

    We require a human profile pic upon registration on this forum.

    After registration is submitted, you will receive a confirmation email, which should contain a link to confirm your intent to register for the forum. At this point, you will not yet be registered on the forum.

    Our Support staff will manually approve your account within 24 hours, and you will get a notification. This is to prevent the many spam account signups which we receive on a daily basis.

    If you have any problems completing this registration, please email support@jackkruse.com and we will assist you.

Some Perspectives on Fish Oils and DHA

Discussion in 'Beginners Area' started by Dennis Clark, Apr 30, 2015.

  1. yewwei.tan

    yewwei.tan Gold

    Great! :p Now let's see further study to confirm that those sn-2 DHA supplements actually maintain the sn-2 until they make it to the brain, and not readily migrate to the sn-1 position as shown in other studies -- https://hal.archives-ouvertes.fr/file/index/docid/958127/filename/Lagarde_et_al._PLEFA_2013-2014.pdf

    I am not convinced that excess EPA is intrinsically bad. Clearly the EPA degradation pathways works very well -- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2785519/

    But as I noted in this comment -- https://www.facebook.com/groups/872...otal_comments=87&comment_tracking={"tn":"R9"}

    The clear answer is that production of Resolvins and Protections from EPA and DHA occur rapidly to combat inflammation --http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2785519/

    This is enzyme-mediated, specifically by the cytochrome p450 and COX2 enzymes, or the LOX enzyme -- http://en.wikipedia.org/wiki/Cytochrome_P450. Enzymatic control of this sytem likely makes for precise targeting of

    In all cases, the formation of Protectins and Resolvins require oxidation of the heme centers in the p450, COX2, or LOX enzymes. I speculate that iron-containing enzyme, being paramagnetic, are uniquely drawn to sites of high magnetic flux, which occurs due to moving charges (like inflammation is a moving positive charge). I also speculate that DHA having a paramagnetic and de-localised pi-electron cloud is naturally drawn to inflammatory sites.

    In any case, once these molecules get together (by shared resonance --http://www.i-sis.org.uk/TheRealBioinformaticsRevolution.php), I think the production of Resolvins and Protectins happen very rapidly.

    Sidenote 1: Note how the Fe3+ center has a clear Type I absorption spectrum (which is the normal case) with a peak at 390nm, which also happens to be the emission spectrum peak for many Reactive Oxygen Species. This indicates to me a highly controlled system that only activates when such biophoton emitters are present (like ROS and RNS) --http://en.wikipedia.org/wiki/File:P450cycle.svg

    Sidenote 2: that iron-bound cysteine thiol must be critically important for providing the appropriate oxidative ability of this enzymatic complex.

    The simple point after all that discussion is that excess DHA is likely used for combating excessive positive charge (inflammation) in the body, and that supports the position that excess DHA is not harmful.​

    The Cytochrome P450 pathway needs to be properly active for EPA to be "properly used" as a resolvin or protectin. To me, this says that "EPA excess" is more accurately described as "Cytochrome P450 dysfunction". The main blog goes into the many ways that Cyt P450 stops working properly.

  2. JanSz

    JanSz Gold

    @ yewwei.tan

    There are other pov.
    I am struggling to figure out how to asses the situation using blood tests.
    Could use help.

    #1 I was using fish oils, now for number of years I can't get rid of excess EPA,
    also my DHA is still very high. O6 is predictably suppressed.

    read around this sentence:
    The patients often record their fish oil (and fish intake) along with their current supplements on their medical history form. The elevated levels of EPA and DHA predominantly come from suggestions by their regular physicians
    to try fish oil. With the encouragement now coming from an authority, the over-expression of EPA and DHA has reached epidemic proportions.

    Last edited: May 9, 2015
  3. epic post, where the fuck do you find the time... :)
    Cpt.Tired likes this.
  4. Cpt.Tired

    Cpt.Tired New Member

    Maybe that's what a great redox does....? Quick processing and delivery
  5. or chocolate/candy/ricecakes/coca cola :rofl:
  6. eagerly awaiting @yewwei.tan 's epic 10,000 word+ DHA article
  7. Jack Kruse

    Jack Kruse Administrator

    Fierce Asian Tiger awakens.
  8. Considering http://tanyewwei.com/blog/ct-hormetic/ and http://tanyewwei.com/blog/ancient-civ-adv-af/ and http://tanyewwei.com/blog/kilohertz-range-emf/

    I don't think it will be something that most people here will be accustomed to hearing.

    For instance, a quote:

    "In any case, we are within the realm of anatomically modern humans, meaning that we basically evolved under a never-setting sun.

    This makes claims by Ray Peat, that “darkness is a stress because it impairs mitochondrial energy production”, actually supported by evolutionary theory - If Darkness is a stressor like Peat suggests, then Melatonin and prolactin are simply the best ways to deal with inevitable darkness, and not intrinsically good per se. Of course, today we have to deal with that inevitable darkness on a daily basis, and optimising melatonin and prolactin during times of darkness is key. I am certainly NOT an advocate of lots of artificial lighting to try and mimic an eternal sun. (at least not until we fully understand the effects of doing so) (...) Constant sunshine and constant plant growth also meant that there was an ample food supply of plant material. Proponents who argue for nutritional ketosis “because you can’t find carbs in winter today” are also not privvy to way human metabolism has worked for many thousands of years before Proto-Saturn capture (...) Should we be eating sugars through the year as Ray Peat suggests? There is compelling evidence to give it a shot. The unique ability of carbohydrates to raise NAD+ levels (through mitochondrial Complex 1 activity), produce CO2, and raise metabolic rate are benefits regardless of the time of the year.

    A high sugar, low PUFA diet is something to experiment with. Your mileage may vary, but there is good evidence to suggest that those demonised carbohydrates are the best anti-stress response to what is an evolutionarily unnatural stressor (winter)."
  9. David Baillie ND

    David Baillie ND New Member

  10. David Baillie ND

    David Baillie ND New Member

  11. David Baillie ND

    David Baillie ND New Member

    Wonder if timing is related to Traditional Chinese Meridian times when for two hours every 12 each meridian is either most active or least active. If so this peak would relate to Gall Bladder 11 to 1, while Liver is 1 - 3.

    Attached Files:

    JanSz likes this.

Share This Page