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SIBO, GERD, or IBS? Ubiquitination 12 is live.

Discussion in 'Adrenal Rx and Leaky Gut Rx' started by Jack Kruse, May 7, 2015.

  1. Jack Kruse

    Jack Kruse Administrator

    To know a person's library is, in some measure, to know their mind. There is a great difference between knowing and understanding: you can know a lot about something and not really understand it. Let Nature guide you. An unnatural point of view can be a dangerous luxury when substituted for real insight and understanding. Don't let modern reality, get in way of your insight. It is a barrier to scale. The strength of your obstacle determines the weight of your potentials. Your potential to use nature will provide the power to destroy today's reality.

    rlee314 and David Limacher like this.
  2. yewwei.tan

    yewwei.tan Gold

    Now this is the kind of blog that I like :D. Major details laid out here. As usual, I make notes to understand the blogs -- http://qhwiki.com/excerpts:jk-ubiquitination-12

    Lots of hanging thoughts, which I think I'll eventually get to, but I'll post the ones at the top of my mind first. Hopefully the thoughts are somewhat coherent.


    This blog comes at a time when I have just literally yesterday experienced a bit of gut issues. Ate some fermented cabbage and pickled onions, and immediately felt bloated with some gut pain over the course of the day. No change to bristol score today, but the pain is clearly explained in the blog:

    Pain in these syndromes will vary, but pain will be associated with mismatched blood flow in the mesenteric plexus with the uncoupled production of nitrogen gases are made in the lumen of the gut and plasma of the mesenteric plexus.

    Essentially, it's a problem of too much nitrogen (high Ubiquitination), likely from a combination of nitrates in said vegetables, and too much ammonia production. Lately, I've been eating a bit more protein too, and this may not be a good idea.

    The blog mentioned the Ammonia -> Ubiquitination link, and would also explain another mechanism of how dietary protein can increase Ubiquitination rates. Earlier in the series, we see Protein intake stimulating mTOR, and now we see how excess ammonia can result from protein intake if de-nitrifiers cannot perform their job in an oxygen-rich gut environment.


    Now, fixing a bad gut basically comes down to decreasing Oxygen concentrations in the gut, while increasing oxygen concentrations in the rest of the tissues.

    Somehow I feel nicotine can do this by increasing blood flow to the tissues surrounding the gut lumen, while potentially increasing NAD+. This assumes of course, that the GALT has enough DHA already in place to allow for the light-mediated reactions to happen. Not 100% on the details, and my own research is in progress.

    Hydrogen-infused water sounds like a straightforward solution, since both the H+ and H- are useful. From the blog:

    This should also point out why now reverse osmosis water or supercooled water build health. It provides a huge army of protons without any food added in this process. This helps you maintain a diverse flora best with small risks and low O2 levels in the gut.
    I don't have access to that sort of water now, but I suspect that Sodium Bicarbonate is a cheap fix as well. The Bicarbonate ion could potentially deliver more protons to the gut flora. Another stray thought I have is that the similar electric configurations of the bicarbonate ion and Nitrates can help with Nitrogen-Carbon balance.

    I also wonder how drinking stuff like vinegar would help? This could again be another proton source, but I may have my facts confused. Anecdotally it's thought to be a remedy to SIBO. Hmmm, maybe I should experiment with some apple cider vinegar + higher dose sodium bicarbonate. :rolleyes:

    Higher fat intake and lower protein intake is probably wise.


    When there is oxygen in your gut, I don't know what adding fermented foods to "re-populate the gut with good bacteria" would do. It could provide more bacteria to get rid of the oxygen, or it could makes your condition worse by making more ammonia to further accelerate ubiquitination rates.


    Why am I experiencing these symptoms now, and not earlier this year (where my gut was basically bulletproof)? It obviously has to do with the change in seasons, with simultaneous reduced light and reduced magnetism

    Sidenote: one of the downsides of being in the Southern Hemisphere is that there are larger variations in solar output even when you're closer to the Equator like I am (16.5deg south). There is 7% more in Solar Radiation in December compared to June, meaning that you get diminished magnetism in Southern Hemisphere winters in addition to diminished sunshine. Summers here are also more light-dominant as a result.​

    The "tropical Australian" climate will still present major variations in Nitrogen cycling as a result. Anecdotally, I'm not seeing that many green vegetables out in the farmer's markets, though fruit like pineapples and papayas are present.


    Like I said, more to come over the next few days, this was a hectic blog post (just the way I like it :p)

    Last edited: May 7, 2015
    Danny, seanb4 and David Limacher like this.
  3. Lots to digest here...
  4. Quote from the blog "Today, about 60% of the total fixed nitrogen is produced industrially using the Haber-Bosch process. The Haber-Bosch process (manmade) now matches the entire nitrogen-fixation output of the oceans and exceeds the microbial fixation on land"

    I find that pretty shocking. I really under-estimated how much we have interfered with Nature. I grew up on a farm and we used Nitrogen - sparingly. We were aware it was 'artificial' and at all times preferred to use cow manure for example. It was well known that the use of artificial Nitrogen 'weakened' the soil over time and was seen as something to be used as little as possible. But that was an older tradition for example we had no tractors of any kind, all 'work' was done by horses and people. Over time people get so disconnected from the land and tradition they jettison all their old beliefs and wisdom in favor of the 'new'. That's a reason I don't resonate so well with all this business about jettisoning 'old ideas' some of them are very good................a lot better than a lot of the so called 'new' ideas................
  5. Dr Kruse, I find the parallels of the bacteria in the soil and in our gut very interesting. But would it be correct to think that though there are many similarities the function is also quite different? The bacteria in the soil is fixing Nitrogen out of thin air so to speak...............in the gut it seems a part of their job is 'disposing' of Nitrogen. I suppose a bit like the difference/similarity of chloroplasts and mitochondria? Similar but different. Does this mean there are literally different 'species' of bacteria in both realms or is it a case of different 'behavior' . For example do bacteria in the soil ALSO 'release light'................sorry I am such a 'beginner' here any light released on this topic would be of interest to me.............
  6. kovita

    kovita Gold

    now why I have been drinking vinegar during the last few months like crazy? I crave it soooo much, diluted in water it tastes like the most heavenly juice to me. Never had any SIBO or other digestive issues. I love sauerkraut and can eat tons of it without any "side effects". Many people I know eat sauerkraut and "cannot digest it well". Some points ypu raised here to think about well...
  7. kovita

    kovita Gold

    and one more note. I do experience more sensitive digestion in the transition seasons - late autumn and early spring.
  8. yewwei.tan

    yewwei.tan Gold

    Yeah, only at times like this ;). I like the taste of vinegar too, though probably not a craving. I do want less carbs and protein though ;). In your case, must be baby looking for more proton flows :p

    On top of that 4 days ago we had a >7.0 magnitude earthquake in New Guinea, which is pretty close to where I'm at. 2 days ago, we had another >7.0 magnitude earth in New Guinear o_O -- http://www.abc.net.au/news/2015-05-07/earthquake-strikes-off-png-local-tsunami-alert-issued/6453462

    Ben Davidson talks about how Solar Activity (specifically solar holes) is primarily responsible for causing Earthquakes. I'm awaiting his talk in late June for details, but it sounds like quick shifts in the Sun's activity (like flipping of it's magnetic field) very literally tug on the tectonic plates, and make earthquakes likely. Obviously, that tugging affects us to, which makes this Autumn transition particularly stressful for the folks down in the South Hemisphere. Even @Josh (Paleo Osteo) is seeing some stress on his lab results :eek:

    Josh and Josh (Paleo Osteo) like this.
  9. yewwei.tan

    yewwei.tan Gold

    They look pretty similar to me -- http://aem.asm.org/content/79/1/2.full

    Picture below of plant rhizosphere from wikipedia -- http://en.wikipedia.org/wiki/Rhizosphere

    From the blog:

    Symbiotic nitrogen-fixing bacteria such as Rhizobium usually live in the root nodules of legumes (such as peas, alfalfa, and locust trees). Here they form a mutualistic relationship with the plant, producing ammonia in exchange for carbohydrates.

    This same relationship exists between your gut microbiome and you in your intestines. Because of this relationship, legumes will often increase the nitrogen content of nitrogen-poor soils. Our microbiome is capable of doing this when oxygen is present to excess.

    In your gut, your microbiome increases the ammonia content to liberate nitrogen for you to use for your ubiquitination pathways. The more simplified your gut flora is the more nitrogen you liberate to drive cell growth.

    An anaerobic microbiome restricts decomposition of nitrogen in plant soils and your microbiome to limit growth. Aerobic decomposition unleashes nitrogen and facilitates decomposition. This drives growth and the amount of CO2 consumed by roots of plants and expired in the guts of mammals.​


    Josh (Paleo Osteo) likes this.
  10. Josh

    Josh New Member

    Saturated soil=maximum amount of structured water that can be held by that soil ecosystem. Exceeding this limits nutrient and energy flows by sursurrounding parts of the system with bulk water. Dehydration and mishydration in living organisms where there is not enough charged surface to structure water and create necessary flows is analogous. Altering isotope ratios that change atomiic mass, density and buoyancy has profound implications related to this As it alters the convection gradients.
    nonchalant likes this.
  11. Jack Kruse

    Jack Kruse Administrator

    Yew said give it......so I have.
  12. Valerie

    Valerie New Member

    It seems to me that uncoupling of the nitrogen cycle would manifest in your BUN/Creatine ratio?

    "When the gut flora is more diverse, the less ammonia you liberate, and cell growth is controlled and constrained because ubiquination pathways are tightly coupled to this mechanism in soils and our guts. This is ubiquitous across all living things, hence where is name came from. This is why ammonia is liberated in the guts of people with liver and kidney disease and they develop brain symptoms like asterixis. Most ammonia in the body forms when protein is broken down by bacteria in the intestines. The liver normally converts ammonia into urea, which is then eliminated in urine."
    seanb4 likes this.
  13. Jack Kruse

    Jack Kruse Administrator

    Not always.........why? hydration can co-opt the effect. This is why those with uncoupled biology drink a lot of coffee or water.
    rlee314 and Penny like this.
  14. I have so many other questions about this Nitrogen, ubiquination etc ( sample: is the condition of a bad gut analogous to the 'dead zones' in the ocean, excessive nitrogen 'run off' ? how EXACTLY is nitrogen tied into ubiquination, does it have something/a lot to do with the 'excessive' Nitrogen we pump into the land to boost crops, could we say there is literally too much "N" in the food web and that 'speeds' up ubiquination?? or not or if so exactly how. Ubiquination is a 'light story' but "N" is also connected how exactly. I already asked about the similarity/difference of gut bacteria and soil bacteria. I can or could think of more but the one I already asked is ignored anyway (except for Yew to give him his props at least tried to answer it)

    It is not only this.................last week I asked a question about the big temperature drop from being inside to womb to being born................I thought it was interesting especially as possibly it might have some possible tie in to CT and all the rest of it..............again just 'ignored'. Now I understand Dr Kruse is very busy and I have often wondered where he gets the time, there are many others with questions too, I understand all that but it seems to me something has changed or is it only directed at me. But if it is well maybe let me know somehow...................if I don't know it just feels 'embarrassing' to keep on asking questions and being ignored. You know the next step is I STOP asking questions and the next is I leave the blog and the community all together. This is not some kind of lame 'threat' just being honest and open about it. I would miss it greatly but sometimes painful decisions have to be made.............

    Anyway and I am just being 'honest' here...................I find it discouraging to be just ignored, gives me the message to just stop asking questions which is how I learn, how else can I learn? They are maybe not 'great' questions they are basic questions of someone who is curious and wants to know and I can only imagine others might have very similar questions. Any progress I make come through the process of questioning not giving 'likes' all over the place or constantly 'agreeing' and giving 'booms' to each other to me that does not involve learning more self assurance and self congratulations.

    I really don't think I have a 'bad attitude' but I believe in being 'honest'as best as I can. I for example don't share Neil's high regard for Ayn Rand I have said this before and no need to re-iterate but I hope people here maybe even Dr K might think this I have some 'oppositional disorder' to use the kind of latest psychological jargon. I am a big boy and I think of Neil as the same no need to that to cause any ripples of unease it just a difference of opinion and I think the blog might be 'healthier' for that. Am I wrong?

    I don't want to make too much of this and maybe I am (making too much of it) but right now I am considering cancelling my passage on the Cruise Sometimes I no longer find the 'atmosphere' that inspiring..............I am not happy to feel this way I have had a lot of hope and belief in what I see here and of course of Dr K but something feels 'off' now.............
  15. Jack Kruse

    Jack Kruse Administrator

    I think youre wrong to feel that way, but that decision is yours Pat.
  16. Jack Kruse

    Jack Kruse Administrator

    any temp drops help life because it lowers ubiquitination. I thought this was second nature now that we are 4 years past CT series. Cold directly lowers mTOR and IGF 1 activation. Even half a degree lower than your body temp helps.......4 Nitrogen atoms surround the core atom in chlorophyll. They deliver the photon to the reaction center called an exciton. 4 Nitrogens also surround iron in hemoglobin......If you read Tensegrity 7 and 8 you would see AM sunlight electrifies the blood plasma 8-11 AM in sunlight to increase the zeta potential. Nitrogen is the atomic portal of how sunlight is first transduced to energy we can use.
    rlee314 likes this.
  17. Jack Kruse

    Jack Kruse Administrator

    And I was in Colorado since thursday doing a TV show.......I have a life too so I cant always be plugged in here 24/7. Eventually I get around to it.
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  18. Josh

    Josh New Member

    Really??? Do you have any idea how hard it is to find anyone who has a clue about this stuff, let alone someone who will talk about it EVER...let alone when you want them to?
    rlee314, seanb4 and David Limacher like this.
  19. Jack Kruse

    Jack Kruse Administrator

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  20. Josh

    Josh New Member

    Pat, I am looking forward to meeting you and having a good laugh about the absurdity of arguing with people you have never smelled, seen or broken bread with over the internet...:)
    Penny likes this.

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