1. Registering for the Forum

    We require a human profile pic upon registration on this forum.

    After registration is submitted, you will receive a confirmation email, which should contain a link to confirm your intent to register for the forum. At this point, you will not yet be registered on the forum.

    Our Support staff will manually approve your account within 24 hours, and you will get a notification. This is to prevent the many spam account signups which we receive on a daily basis.

    If you have any problems completing this registration, please email support@jackkruse.com and we will assist you.

Should we really avoid broccoli?

Discussion in 'The Epi-Paleo Diet' started by Taylor Freeman, Sep 22, 2022.

  1. Taylor Freeman

    Taylor Freeman New Member

    According to Paul Saladino:
    “Perhaps you’ve heard of the compound sulforaphane associated with all sorts of fancy health claims from “cancer fighter” to “antioxidant hero.” This molecule is an isothiocyanate derived from the glucosinolate molecule, glucoraphanin. In this case, sulforaphane is formed when myrosinase does its enzymatic work on glucoraphanin, and out of this process come magical rainbow unicorns. While that’s the popular narrative that supplement manufacturers and many in the health space want you to believe, I’m not buying it and you shouldn’t either. Allow me to show you the dark side of sulforaphane and the whole family of these isothiocyanate molecules. Although it is true that when myrosinase acts on glucoraphanin the end result is sulforaphane, this happens only when plants are under attack and are being chewed to pieces by predatory insects and animals. Sulforaphane does not exist in a healthy, living broccoli plant. It only shows up as a defense chemical in response to damage being done to the plant cell walls. When everything is hunky-dory in broccoli’s world, glucoraphanin and myrosinase never get together to make sulforaphane. They are separated into different cellular compartments that mix only when the plant’s cell walls are destroyed as Bambi eats it for breakfast. Sulforaphane is a plant weapon. It’s a phytoalexin, a plant toxin that does not play a role in plant biochemistry, and is only employed to do its dirty work when helpless broccoli is being turned into a snack. Like a booby trap waiting to be sprung, or a highly dangerous covert operative, it’s deployed only when things get really bad. Sulforaphane is so toxic that it can’t be present in a healthy broccoli plant, or it would cause massive damage due to it’s strong capacity as a pro-oxidant. So how does sulforaphane do its dirty work? In animals, including humans, it has two main mechanisms of toxicity, a slow one and a fast one. The fast mechanism of harm is accomplished by acting as a vicious pro-oxidant, causing the formation of free radicals that damage the delicate lipids in cell membranes, proteins, and DNA. In human cell culture, sulforaphane and many other related isothiocyanates have been shown to damage DNA in the process of clastogenesis, causing chromosomal breaks.1, 2, 3–5 Trust me, damaging these cellular components is not a good thing.”
  2. Jack Kruse

    Jack Kruse Administrator

    You can do whatever you see fit. There are no rules, just tolls to pay. Many people become so obsessed with being "right" about their life that they never end up actually living it.

    I will say though you should ask yourself what might Saladino be missing.

    He called Sulphoraphanes a toxin right? Doesn't the dose make the toxin?

    Are all toxins bad? Nope. https://genesenvironment.biomedcentral.com/articles/10.1186/s41021-018-0114-3

    Sulphoraphanes are hormetic and do two main things in humans when they are subtherapeutic. They promote apoptosis (levee 19 in the Quilt) and they induce phase two detoxification enzymes in the liver that strengthen the p53 gene as the guardian of our genome.

    Now you can do your due diligence from this jumping point.

Share This Page