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Sean's very un-optimal Journal

Discussion in 'My Optimal Journal' started by seanb4, Aug 15, 2013.

  1. JanSz

    JanSz Silver

    Good to know about desmopressin and increase of blood pressure. Thank you.

    I am going thru rather successful hack and think that it may help @seanb4
    Details are important part of it.

    After my Green Laser Prostate therapy eventually I ended up with going to bathroom about every two hours or less.
    At night that sometime can be stretched to 3 hours.
    That means that I have to go to bathroom 2 sometimes three times over my 8 hrs sleep time. Broken sleep time, ng.
    Nobody can help me with that (but me).
    Few years ago I came to think that I have to try Desmopressin.
    Asked doctor for script, he wondered by obliged.
    My hack did not worked then. One spray to the nose of Desmopressin made me bloated, I gained few pounds of weight, newer tested BP, possibly was high.
    Fast forward to March 2017.
    Different story with same Desmopressin.
    The one I was using before had 10mcg in one spray.
    Now I am dealing with
    0.83 mcg per dose or 1.66 mcg
    I am using the same Desmopressin (5 or 6 years old) but it is diluted.

    It is a work in progress.
    0.83 have not done anything.
    With 1.66 with I can sleep now 7hrs, go to bathroom then sleep my last hour.
    Eventually I will increase dose little bit more, but it is highly promising experience.

    If interested there is more details in attached file.
    There is little problem, I have new bottle of Desmopressin but use old one.
    Reason, old have a top that can be unscrewed, new does not. I have already idea on how to get it out (gracefully)
    So far the old one works so I leave that problem for latter.
    Picture shows old version.
    For the new bottle of Desmopressin I paid $40 (with insurance help)
    When the new diluted version of Desmopressin become available, called Noctivia, (10x diluted) they will likely charge more or just $40. I think I will continue asking for the old one, why spend $400 if $40 is doing the work.

    .. upload_2017-5-12_9-53-33.png

    Attached Files:

    Last edited: May 12, 2017
    seanb4 likes this.
  2. seanb4

    seanb4 New Member

    I tried about 5-10g L Glutamine yesterday and it resulted in insomnia and a worsening of palpitations. I'm sure this is caused by glutamate. Maybe getting into brain through permeable bbb. Exacerbated by COMT and MOA mutations.

    Maybe I can counter this with taurine/NAG/lithium doses however I feel this is going down the wrong, expensive path.

    @SatoriHeart What do you think of high dose bovine colostrum?

    In the meantime I will continue on with helminthic therapy and the other supplements satori had success with.
  3. You likely have expressed SNPs in GAD1, (glutamate-decarboxylase). I also had a similar reaction to Glutamine several years ago and tabled it for a long time. These days, I am able to take up to 40g without the slightest problem. My opinion is that it all comes down to the state of your microbiome. Altered levels of commensal and pathogenic microbes can change methylation patterns, silencing expression of genes such as GAD1 which converts glutamate to GABA. Glutamate excitotoxicity is already a problem for people with Pseudomonas, Citrobacter, Pylori-type GI infections. Add to that the toxic offgassing from hydrogen sulfide, and any additional glutamine would just throw oil on the fire.

    For this reason, I wouldn't recommend re-building the gut lining with a diet high in glutamine until the original problem has been resolved. And to do this properly, you need to take a stool culture. There is no shortcut. Every pathogen has its own modus operandi and requires specific handling. I, for instance, went back and looked at my last GI Map performed a couple of months ago and put focus, once more, on the high levels of Citrobacter Freundii. Looking at the array of antimicrobials I was taking, it was clear that nothing would have a profound effect on their populations. For that, we need specific antibiotics or high levels of Grapefruit Seed Extract and / or Ursa Urvi. It is vulnerable to those -- specifically.

    Helminthic therapy may very well rock your boat as well. It's hard to say without testing. Colostrum, in any case, is excellent for leaky gut.

    I would stay away from taurine until you know two things: 1) status of your CBS (cystathionine beta-synthase gene) and 2) microbiome status. If you have a strain that is producing high levels of hydrogen-sulfide (which, btw, also cause anxiety) -- then taurine... and any high-sulfur compound ... will exacerbate the problem.

    Scratch lithium orotate off your list as well. It is known to suppress thyroid function and if you have HPA-axis dysregulation, you most certainly also have a subclinical thyroid issue.

    The only way to bring your glutamate levels back into line is to bring your microbiome and immune response back into order. In the mean time, you can try L-Theanine, ~100mg daytime, 200mg nighttime. Nighttime dose can be combined with Phosphatidylserine to lower cortisol levels, but beware --- you don't want to take cortisol too low if you have a viral or bacterial gut infection. Nature has its own system of checks and balances, and having proper cortisol levels are essential until you have eradicated the offender.
    seanb4 likes this.

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