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Sean's very un-optimal Journal

Discussion in 'My Optimal Journal' started by seanb4, Aug 15, 2013.

  1. seanb4

    seanb4 New Member

    @JanSz Yes, as I say, very expensive.

    Been thinking about how cells seem to respond negatively to seemingly small amounts of excess red/IR (600-1000nm) yet the sun irradiates up with far more joules than what is said to cause overdose.

    I think it is to do with blue light balancing out some of the effects on ATP such that the net increase of ATP from red is within correct dosage range. As the light penetrates deeper, blue fades faster than red, so that even though smaller amounts of red light are entering say your thyroid/brain they are not having any decrease in ATP from blue.

    So your brain cells see, lets say 4J of red and 0J of blue. Optimal doses of a cell are something like 0.1-6J, overdose 60J. Giving a net increase of 4J ATP. Within optimal range.
    Your skin cells see something like 864J of red and 194J of blue. Should be an overdose, but if we assume that blue light slows ATP at a greater rate than red enhances it (maybe 4.4x) then the net atp would be (864-194x4.4)K = 11J ATP. Within range.

    I am just making up the numbers for how much blue negatively effects ATP production, I don't even know if this is how you don't overdose in normal sun conditions. Maybe this is one reason the quantlet contains blue...
  2. JanSz

    JanSz Gold

    disclaimer ------ I am not exactly sure if this is the company that my friend in Poland used.
    but sounds familiar

    He have highly advanced prostate cancer.
    Bought the theory they are selling.
    Spend on this stuff multiple thousands of $$.
    Have not seen absolute any progress.
    On the end they send him some stuff that was obviously not only outdated, in too high quantity, plus something else.
    When he was trying to (highly politely) straighten out this as a obvious misunderstanding, they dropped him as a hot potato.
    Highly unprofessional.

    Again, I am not saying that this are the same people, but similar topic.

    seanb4 likes this.
  3. lohd2015

    lohd2015 New Member

    Congratulations! Very good news indeed.
    Last edited: Jun 16, 2017
  4. seanb4

    seanb4 New Member

    @SatoriHeart Very pleased you are doing better, this is great news! Very, very interesting post. Yes, I think virus test results may not be reliable so no point putting too much stuck into them. I have in the past tried most of the supplements you have suggested bt never in combination and I can't remember dosages. It would be interesting to try them out.

    How were you separating the groups? Was it based on mechanism of action, or was it arbitrary, just to use process of elimination?

    That really is quite incredible. I have been using Lugols 7% 4 drops orally for about a month or so. However I have been applying butter on my skin thanks to advice from sueuk and I am now able to tolerate the sun much better. Sweating is also increased which is very good.

    I wonder how much improvement is due to Florida vs supplements.

    I have had some interesting developments this past week. A couple weeks back I decided to go for another round of Helmithic therapy. For a week now my gastroparesis has been significantly better. I do not want to put too much hope into this. It may not last, or may be the results of body increasing transit time to try kick the worms out (not digesting food right?) but I am not so sure. I have a slight growling stomach now when I go a decent time without food (never happened in last 6yrs) and I have begun eating more fat, and only 1 meal a day. I am in some discomfort afterwards but its nothing compared with before. If this sticks, it could be huge. I could go back to ketosis, my stomach won't be full at bed time (messing up sleep) and the transit time should somewhat normalise gut flora. This will mean I will have far less endotoxins and give my immune system a shot at the virus. Just really hope it lasts, so I'm not going to try anything yet that could potentially kill off the worms....
  5. Sue-UK

    Sue-UK New Member

    Update on my own hack. :) I've been experimenting with ghee and surface temperature. Yesterday the forecast was for UV 8 at solar noon. Well it didn't happen here :rolleyes:. It was overcast most of the day and windy, not particularly comfortable. I've had better days in October. So I put my ghee in an eggcup and stood it in a bowl of boiled water and went outside, and applied the melted warm ghee to my skin, including my eyelids. It was as if I'd moved further south..... It was like applying the warmth and the yellow of the sun missing beneath the clouds. I've got a 100% cotton cellular cot blanket, ghee coloured :rofl:that took some of the cold in the ground away from my back. Lay on my back, closed my eyes and it was like basking under a cloudless sky. One of the most relaxing cloud bathing sessions I have ever had. I was out to get the first light as normal this morning. It was clear blue skies, no wind but still very cool. As soon as the sun came up over the tree line, I did the same at the first piece of ground the sun hit. Turned a so-so light breakfast into delicious. :D I'm going to continue with ghee for the time being, warmed under cold and/or cloud, used cold set under a high temperature, but from October I'll be hacking butter. :D
    Jude and seanb4 like this.
  6. lohd2015

    lohd2015 New Member

    Sue-UK, this is ghee without MB, correct?
  7. Sue-UK

    Sue-UK New Member

    So far with the warming it up first, yes. With MB is next. :)
  8. lohd2015

    lohd2015 New Member

    Awesome. Keep us posted!
  9. seanb4

    seanb4 New Member

    Just a quick update.

    Been feeling better over last couple of weeks. Changes I've made.

    1/2 meal a day + ketosis:
    As my gastroparesis has lessened, I am able to do one meal a day and increase fats again. This has obvious benefits but also it has helped me identify what my problems are. I don't eat until 2-6, however if I am out in the sun before this, I tolerate the heat just fine. As soon as I eat, my symptoms ramp up, and I cannot stand the heat/sun. It's all about blood flow I think. Anything that increases blood usage causes worse symptoms. I have found that being cold after eating helps with this as less blood flow to skin.

    Restarting CT:
    I had been thinking about why CT makes my symptoms worse. It was an increase in sympathetic activity when it seems my parasympathetic activity is very weak. Reading the studies it appears that there is a strengthining of sympathetic when not cold adapted, then increase in vagus when adapted. Although I did it daily 30 mins, 6-12C, for 10 months, for whatever reason, I didn't fully adapt. I hated it, was shivering a lot, and I would have many symptoms of Sympathetic dominance. Whatever is causing me to be ill, also means I cant adapt as well. But I did also recieve benefits. So I decide to start doing it again, but this time, go way slower and only use temperatures that didn't involve shivering, as I think this is where increased sympathetic activity comes from.

    I have also brought a uv/ir light in to bathroom (have to be careful it isn't to close to tub) and shine it on my head. Both these things means my tolerance is good. I think the light warming my head should be more or less ok as it appears what is important is reducing my skin temp to activate cold receptors (torso), so my skin is still getting cold. Look foward to water getting colder and seeing how this set up holds up.

    I have increased libido, so I know it's helping my hormones howerver no longer have servere dry mouth, which I used to get after every session. This indicates my parasympathetic system isn't getting too overwhelmed.


    Been using this 1hr in the morning and 1 hr after meal for 2 weeks now. I have noticed changes in my heart pounding and overal well being.

    I now need to focus on keeping this level of improved health and building on it.
    caroline, drezy, Jude and 1 other person like this.
  10. JanSz

    JanSz Gold

    Shivering and CT.

    Using cold shower as a CT and only to the point of no shivering
    when you know that you will start shivering, open hot water valve.

    seanb4 likes this.
  11. seanb4

    seanb4 New Member

    My improvements have been maintained so far. Ketosis has been hit and miss, sleep is better however POTS symptoms get significantly worse. I figured it was just "keto flu" electrolyte imbalances. I have been in keto 1.5years ago no problem. Now it's big problem. I am eating higher fat but around 70g carbs. If I go lower for a few days I'm in trouble.

    uBiome test comes back, not sure what to make of it. Diversity percentile is good, probiotics (Lactobacillus, Bifidobacterium) is pretty bad, 20% compared to average. Nothing else really sticks out...
    Jude, caroline and WalterNL like this.
  12. caroline

    caroline Moderator

    just saying "Hi" Sean.....so happy that you are seeing improvements.
    seanb4 likes this.
  13. seanb4

    seanb4 New Member

    Since last update I have made progress in some areas, albeit small.

    Thiamine! Despite my diet having roughly enough I decided to try some transdermal allithiamine after hearing how it helps some with POTS. Instantly noticed improvement in symptoms after eating and noticed slight improvement in POTS overall. Unfortunately I have not been able to build on this, attempts at increasing dosage lead to increases in different POTS like symptoms. I am taking a B-Complex and mg, k but I still am unable to tolerate any more than slightly over the RDA.
    Thiamine helps stomach acid production, and the ANS which is how it could be helping my POTS.

    Now the question is why am I thiamine deficient since I eat lots of offal and generally get enough through diet. The obvious answer to me is poor digestion. I think the main culprit is low stomach acid possibly from screwed up ANS not letting me get into parasympathetic mode. Could also be gut bacteria eating it up.
    I have tried many times to fix my stomach acid but failed always. I can take massive amounts of Betaine HCL with no burning but then develop over symptoms from it, presumably from pushing methylation too hard.
    I think the key to fixing this issue would be fixing my ANS which would also fix my POTS and allow proper blood flow to the gut, also allow proper parasympathetic signaling to make stomach acid and increase motility. How to fix this is the million £££ question. Grounding seems to help a little, the sun light if too warm makes me more sympathetic, CT does...

    Usually I don't get ill but I got a fever 2 week ago and my heart rate was 110+ all day and night for 4 days. I had to go to the hospital as this combined with my POTS was unbearable, I stayed in for 4 days and now it's mostly gone. I am sick to death of this heart pounding, it's no good for me short nor long term however the doctors don't care.

    My vit D3 test came back at 121 nmol/L = 48ng/ml. Disappointing for saying I have spent literally all summer outside as I no longer work. I know that people who have CFS/POTS have lower vit D but I was hoping it would be higher...
  14. JanSz

    JanSz Gold

    Green bananas or green plantains should increase gut flora.
    Also inulin.

  15. laea10

    laea10 New Member

    Hi Sean, did you fix your problem with stomach acid? I mean i'm looking and looking for the answer and can't find it, maybe you solved this ? :)
  16. seanb4

    seanb4 New Member

    Hey @laea10 I am not sure my problem was particularly with stomach acid anymore. I have Dysautonomia/CFS and Gastroparesis which is secondary to this. I am pretty sure poor autonomic signaling is causing my stomach motility problems so I have revised my efforts into fixing this instead. Non of the stomach acid treatments really worked in my case but I suspect your case will be different so you may have some luck there.
  17. JanSz

    JanSz Gold

    Allithiamine is a lipid-soluble form of vitamin B₁ which was discovered in garlic in the 1950s along with its homolog prosultiamine.
    There was discussion on Marik Protocol
    sulbutiamine (goes thru blood brain barrier, BBB)
    benfontiamine(does not go thru BBB)

    Possibly you may want to try it (supposedly it wears of, so not sure about increasing doses (assuming that it would initially been helpful)

    Last edited: Jul 4, 2019
    seanb4 likes this.
  18. JanSz

    JanSz Gold

    my heart rate was 110+ all day and night for 4 days.

    or temporarily discontinue
    thyroid hormone supplementation if any.

  19. seanb4

    seanb4 New Member

    Hey JanSz, hope you've been well. The increase in HR is due to POTS which is a form of autonomic dysfunction and this + CFS I suspect is the cause of all my symptoms. No thyroid supps here.

    "Possibly you may want to try it (supposedly it wears of, so not sure about increasing doses (assuming that it would initially been helpful)"

    I did get significant initial success with allithiamine but like you said it wore off. Could you tell me more about how it wears off? I had assumed I had corrected a deficiency so I stopped gaining further benefit.

    I may as well pop on update here as it has been a long time.

    Like I said above, I feel I have a decent idea on what has been causing my all these problems, fixing it however is not so easy. My illness started September 2011 after getting Tonsilitis and a stomach ulcer. Afterwards I developed symptoms of CFS and POTS. It is very common in both these diseases for the trigger to be a viral onset. I have received official Dx of these diseases after going through a lot of ignorant doctors.

    I have been making very slow and steady progress since I hit rock bottom in 2016. I feel most of the progress I have made has been by avoiding or maneuvering around the disease as opposed to curing it. Examples include, avoiding heat!, keeping legs raised, mirtazapine, adding MCT to carbs, avoiding carbs, soft meals.

    With regards to carbs there are quite a few studies showing malfunctioning energy metabolism but particularly glucose. This rings very true in my case as my heart symptoms increase like clock work no matter the carb source after carb meals in correlation with the amount of carbs. It also follows a patern of increasing symptoms up to 1-1.5 hrs, peaking then slowly dropping to baseline over the next 4hrs.

    There is particular interested in Pyruvate Dehydrogenase Inhibition. Long story short, I thought I may be able to get around PDH inhibition by eating MCT with carbs as MCTs are metabolised straight away so the liver will have a large supply of acetyl CoA so any Pyruvate ingested will skip PDH and go through PC instead to make oxaloacetate and the TCA will keep spining.

    Anyway it seems to have worked as my symptoms are siginficantly reduced after carbs compared to before however they are still present. You may say just eat ketosis however gastroparesis then comes a big problem but I have recently managed to get keto to work by using very soft foods and relying on some excess body fat.

    Although I have no real idea what is going on I will say this is my leading theory so far. I get virus that goes into cells yet is non cytolytic. The virus then causes dysregulation in my system (cytokines, IDO, exosomes) that lead to poor energy metabolism and the resulting dysautonomia etc. This is obviously very simplified.

    Another idea is tonsilitis caused brainstem compression / CCI / etc which then caused malfunctioning autonomic system. I recently found out that ENT infections can lead to cervical spine instability, I believe it is called Grisels syndrome. There are a bunch of other reasons to suspect this.

    I have a number of other theories and things to work on. I mainly post over on phoenixrising forums now. I still do a lot of things I learnt from Kruse but I eliminate that which isn't compatible with my symptoms. For example I regularly go outside and get sun in my eyes but I do not allow myself to get hot (which is very awkward in summer), the heat causes more blood pooling in my legs and I do not sweat at all which make everything worse and absolutely kills my heart.

    So I am doing ok for the most part, still lots of things to try and optimistic I will get better however the question is how much more of my youth will be wasted before I do get better?
    Jude and JanSz like this.
  20. caroline

    caroline Moderator

    I am so happy to hear from you Sean .....and some progress.

    Have we ever talked about this book?

    The Budwig Cancer and Heart Disease Prevention Diet......by Dr. Johanna Budwig.

    Dr. Budwig believed in getting her patients out in the sun!

    There used to be a guy on the forum - a couple of years ago. I think he went by the name Ricky - from Montreal, Canada.

    He talked about this quite a lot and was implementing this diet approach.

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