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Rotavirus (gluten is mimicker) and Blood Type A

Discussion in 'Adrenal Rx and Leaky Gut Rx' started by chocolate, Apr 20, 2012.

  1. chocolate

    chocolate Silver


    Surprise finding

    "We wondered how this genotype of rotavirus recognized a cellular glycan," said Prasad. "With colleagues at Emory (University School of Medicine), we did a glycan array analysis to see which glycans interacted with the top of the virus spike (called VP8*)."

    The only type of glycan that interacted with VP8* was type A histo-blood group antigen, he said.

    "That was surprising," he said. "We thought it had to be a glycan with sialic acid."

    The histo-blood group antigen A does not have sialic acid.

    However, when Dr. Liya Hu, a post-doctoral researcher in Prasad's laboratory, determined the structure of the VP8* domain, she found that the type A glycan bound to the rotavirus spike protein at the same place as the sialic acid would have in an animal rotavirus. Histo-blood group antigens are known to promote binding of norovirus and Helicobacter pylori cells to intestinal cells, but this had never been demonstrated in rotavirus.
  2. chocolate

    chocolate Silver


    All Health Bioscience Physical Science Environment Space Tech Life Origins Misc

    Press Release

    Legumes give nitrogen-supplying bacteria special access pass

    Tuesday, December 20, 2011

    A 125-year debate on how nitrogen-fixing bacteria are able to breach the cell walls of legumes has been settled. A paper to be published on Monday by John Innes Centre scientists reports that plants themselves allow bacteria in.

    Once inside the right cells, these bacteria take nitrogen from the air and supply it to legumes in a form they can use, ammonia. Whether the bacteria breach the cell walls by producing enzymes that degrade it, or the plant does the work for them, has been contested since an 1887 paper in which the importance of the breach was first recognised.

    "Our results are so clear we can unequivocally say that the plant supplies enzymes to break down its own cell walls and allow bacteria access," said Professor Allan Downie, lead author from the John Innes Centre, which is strategically funded by BBSRC
  3. janagram

    janagram New Member

    chocolate, what does the first article mean to you? In layman's terms. Cuz I'm interested.
  4. chocolate

    chocolate Silver

    I think it means that a special (sugar) glycan A type only, accommodates the rotavirus. If I had to WAG, and really that's all it would be, we adapted to allow the virus in. The virus has to do something for us. We give up resources, so it has to be mutual benefit. Plus, we consummate, it is automatic? I don't know if that glycan is there all the time. I know the lacto keep the gates closed, probably all winter. And lacto is a treatment for rotovirus. But sugars open the gate.....inside or out.
  5. chocolate

    chocolate Silver

    I think it would have to be in a dish of each kind of gut bacteria, lacto and e choli. Then see what happens. and both temperatures. The other blood types seem to accept it regardless. A's solicit.
  6. chocolate

    chocolate Silver


    Lectins that make sialic acid more diverse

    Lectins that recognize sialic acids are categorized into three groups, pathogenic lectins towards glycoconjugates from vertebrates, endogenous lectins in vertebrates, and exogenous lectins from other organisms such as insects and plants. Plants have lectins that recognize sialic acids and the plant lectins are powerful tools for the detection of sialic acids. Because plant itself does not have sialic acids, plant lectins are considered to function in protecting itself from foreign enemies that have sialoglycoconjugates. Alternatively, the real ligands for these lectins may be mimetic molecules different from sialic acids.

    The binding specificities of these lectins are different according to the sialic acid species and linkages, and may be the result of frequent encounters with endogenous lectins. In brief, the more diverse the sialic acid structure becomes by species, substitution of the hydroxyl group with sulfation, or methylation by adding more sialic acids toward sialic acids and by changing the structure of inner glycan chains, the more liable the endogenous lectins are to be multifunctional and beneficial to the organism.
  7. chocolate

    chocolate Silver


    Designer Probiotics Could Reduce Obesity

    The same group of researchers previously found that microbially produced CLA was able to reduce the viability of colon cancer cells by 92%. "It is possible that a CLA-producing probiotic may also be able to keep colon cancer cells in check. All our findings to date demonstrate that the metabolism of gut bacteria can modulate host cell activity in ways that are beneficial to the host," explained Dr Stanton. "We need to further investigate the effects of CLA-producing bacteria on human metabolism, but our work so far certainly opens up new possibilities for the use of probiotics for improvement of human health."
  8. chocolate

    chocolate Silver

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