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Research suggests Pfizer COVID-19 vaccine reprograms innate immune responses

Discussion in 'Educating Doctors' started by DrEttinger, May 11, 2021.

  1. DrEttinger

    DrEttinger Choice, the only thing we control

    There are some interesting pieces of data in here


    - Following vaccination, innate immune cells had a reduced response to toll-like receptor 4 (TLR4), TLR7 and TLR8 – all ligands that play an important role in the immune response to viral infection.

    - Furthermore, an unexplored area is whether BNT162b2 vaccination has long-term effects on innate immune responses: “This could be very relevant in COVID-19, in which dysregulated inflammation plays an important role in the pathogenesis and severity of the disease,” writes the team. “Multiple studies have shown that long-term innate immune responses can be either increased (trained immunity) or down-regulated (innate immune tolerance) after certain vaccines or infections.”

    - Cytokine responses to certain stimuli were reduced following vaccination

    Interestingly, BNT162b2 vaccination decreased IFN-γ production following stimulation with the TLR7 and TLR8 agonist R848. The TLR7 and TLR8 ligands are key players in the immune response to viral infection.

    Vaccination also decreased production of the pro-inflammatory cytokines tumor necrosis factor-α and interleukin-1β following stimulation with either the standard SARS-CoV-2 strain or different Toll-like receptor ligands.

    In contrast, responses to the fungal pathogen Candida albicans were higher after vaccination.

    In addition, the production of the anti-inflammatory cytokine interleukin-1Ra was reduced in response to Toll-like receptor 4 and C. albicans. This also suggests a shift towards increased inflammatory responses to fungi following vaccination, say the researchers.
    Penny, JanSz and John Schumacher like this.

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