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Research Shows Carbs Fuel Brain Diseases Fat Helps Heal Brain

Discussion in 'The Leptin Rx' started by Thor, Nov 14, 2012.

  1. Thor

    Thor Banned


    Yet another reason not to eat carbs - research shows carbs cause brain disease:

    Carbs & Sugars Raise Risk of Alzheimer’s Disease

    Nov. 14, 2012


    Previously, studies suggest that high caloric intake associates with an increased risk of cognitive impairment. Rosebud O. Roberts, from Mayo Clinic (Minnesota, USA), and colleagues analyzed data collected on 1,230 men and women, ages 70 to 89 years, who were surveyed on their dietary patterns of the previous year. At that time, their cognitive function was evaluated: only the roughly 940 who showed no signs of cognitive impairment were asked to return for follow-up evaluations of their cognitive function. About four years into the study, 200 of those 940 were beginning to show mild cognitive impairment, problems with memory, language, thinking and judgment that are greater than normal age-related changes. The subjects who reported the highest carbohydrate intake at the beginning of the study were 1.9 times likelier to develop mild cognitive impairment, as compared to those with the lowest intake of carbohydrates. Participants with the highest sugar intake were 1.5 times likelier to experience mild cognitive impairment , as compared those with the lowest levels.

    The team also determined that the subjects whose diets were highest in fat -- compared to the lowest -- were 42% less likely to face cognitive impairment, and those who had the highest intake of protein had a reduced risk of 21%. When total fat and protein intake were taken into account, people with the highest carbohydrate intake were 3.6 times likelier to develop mild cognitive impairment. The study authors urge that: “A dietary pattern with relatively high caloric intake from carbohydrates and low caloric intake from fat and proteins may increase the risk of [mild cognitive impairment] or dementia in elderly persons.â€￾

    Go Fat :) woooo another win.....
  2. nonchalant

    nonchalant Silver

    Worse than sugar?!

    It would be good to remember that there are no essential carbs.
  3. chocolate

    chocolate Silver

    Quote:The molecule, called extracellular signal-regulated kinase (ERK), becomes hyperactive both in the brains of Alzheimer’s patients and in the mice at a disease stage corresponding to mild cognitive impairment in human Alzheimer’s. This excessive activity leads to improper synaptic transmission between neurons, interfering with learning and memory.

    Rosiglitazone brings ERK back into line by activating what’s known as the peroxisome proliferator-activated receptor gamma (PPARγ) pathway, which interacts with genes that respond to both PPARγ and ERK.

    “Using this drug appears to restore the neuronal signaling required for proper cognitive function,†said UTMB professor Larry Denner, the lead author of a paper describing this work now online in the Journal of Neuroscience. “It gives us an opportunity to test several FDA-approved drugs to normalize insulin resistance in Alzheimer’s patients and possibly also enhance memory, and it also gives us a remarkable tool to use in animal models to understand the molecular mechanisms that underlie cognitive issues in Alzheimer’s.â€

    ERK dysfunction in the Alzheimer’s mouse model was discovered several years ago by UTMB associate professor Kelly Dineley, senior author of the Journal of Neuroscience paper. But putting together the protein, gene and memory pieces of the puzzle required a multidisciplinary translational research team including animal cognitive neuroscientists, biochemists, molecular biologists, mass spectrometrists, statisticians and bioinformaticists.

    PPARs are expressed in fat cells, cells of the liver, muscle, heart, and inner wall (endothelium) and smooth muscle of blood vessels. PPARγ is expressed mainly in fat tissue, where it regulates genes involved in fat cell (adipocyte) differentiation, fatty acid uptake and storage, and glucose uptake. It is also found in pancreatic beta cells, vascular endothelium, and macrophages.[9] Rosiglitazone is a selective ligand of PPARγ and has no PPARα-binding action. Other drugs bind to PPARα.

    Rosiglitazone also appears to have an anti-inflammatory effect in addition to its effect on insulin resistance. Nuclear factor kappa-B (NF-κB), a signaling molecule, stimulates the inflammatory pathways. NF-κB inhibitor (IκB) downregulates the inflammatory pathways. When patients take rosiglitazone, NF-κB levels fall and IκB levels increase.[10]

    Rosiglitazone may also benefit patients with Alzheimer's disease who do not express the ApoE4 allele.[11] This is the subject of a clinical trial currently underway.[12]

    Rosiglitazone may also treat mild to moderate ulcerative colitis, due to its anti-inflammatory properties as a PPAR ligand.[13]

    A clinical trial has suggested these agents may be of use in treating malaria.[14]

    “We were extraordinarily lucky to have this diverse group of experts right here on our campus at UTMB that could coalesce to bring such different ways of thinking to bear on a common problem,†Denner said. “It was quite a challenge to get all of these experts communicating in a common scientific language. But now that we have this team working, we can move on to even more detailed and difficult questions.â€

    this article seems to fit here. the drug uses fat cell stuff
  4. Jack Kruse

    Jack Kruse Administrator

    Chocolate re read the opening paragraph from Brain Gut 5:

    GEEKS: The implications of Brain Gut 4 mean that to develop a brain seafood is required part of the program to maintain it. Nutrients and many other environmental factors have also been found to influence epigenetic programing of our DNA either directly or indirectly via metabolic sensors. Peroxisomal proliferator-activated receptors (PPAR’s), the vitamin D receptors, and the retinoid X receptors (RXR), and the retinoic acid receptors (RAR) are all examples of the nuclear receptors that interact with the brain cell membranes to control inflammation and metabolism all over our bodies. It turns out that PPAR’s are the receptors that are at the crossroads of where inflammation and metabolism actually cross. These are specialized lipid sensors that pay attention to our balance of omega 6 and 3 levels. 3% of the human genome is directly or indirectly controlled by the endocrine functions of the Vitamin D system. This shows you how environmental signals are intertwined into the expression of DNA in humans. The Epi-paleo Rx controls inflammation at a hormonal level in the brain better than the more famous paleo diet.

    NON GEEKS: What we eat is really damn important when you have 3 lbs of lipid in your head called a brain. If you eat outside our design you get sick.

    It is there. Here is the link: http://www.jackkruse.com/brain-gut-5-paradigm-drifts-paradigm-shifts-epi-paleo/

    In the Quilt PPAR has its own levee too........

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