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Redox Rx and the EXOSOME

Discussion in 'Redox Rx' started by Jack Kruse, Nov 15, 2017.

  1. Jack Kruse

    Jack Kruse Administrator

    This article links directly to my recently released October 2017 webinar on stem cells and oncognesis. The bio-physics of the exosome is not well known yet in medical circles, but it is now clear that the immune cells in marrow and in our blood are one of the foundational steps in stem cell activation and depletion in disease associated with mitochondrial dysfunction. Mitophagy (autophagy) is a ubiquitous catabolic process in living systems, which causes cellular bulk degradation of cytoplasmic components (mitochondria) and thereby regulates cellular homeostasis through the formation of these exosomes. They travel in the blood and lymph circulation to affect other tissues energy balance. The inactivation of autophagy has been linked with many detrimental effects to cells and organisms in the literature and now the picture is becoming clear how the immune system really operates within our tissues. What is the mitochondriac viewpoint here? ??? It appears from the data that mitophagy switches from advantageous to harmful in the context of an age-associated dysfunction because of the heteroplasmy rate of immune cells. As it rises the cellular response is not the same as we see in tissues with lower heteroplasmy states. https://eurekalert.org/pub_releases/2017-10/ibri-nkr092817.php
    Brent Patrick and shiran like this.
  2. Jack Kruse

    Jack Kruse Administrator

    The functional meds docs and food guru's know very little about these mechanisms in AI's and gut issues and this is why the recylce bad info.....Once you understand why mammals concentrate DHA into cell membranes from seafood solely and not pills things become clearer to the mitochondriac. Stop buying nonsense science. Upgrade your knowledge to what makes you truly bulletproof. NATURE. http://advances.sciencemag.org/content/3/9/e1700735/tab-pdf
    Brent Patrick and shiran like this.
  3. Jack Kruse

    Jack Kruse Administrator

    Red blood cells come to the surface under the power of full spectrum of sunlight because our tissues in the skin release nitric oxide. This allows the sun to radiate our hemoglobin. We're slightly different "light collectors" than plants because we move across the tectonic plates and they don't and they also have a smaller frequency range of light they absorb because they are LESS complex than animals. Therefore they use Mg over iron because it has LESS electrons to make a DC electric current from sunlight in their nitrogen porphyrin cage as the picture shows below. The absorption spectrum of hemoglobin is 250-600nm with a sharp cut off at 600 nm for a deep bio-physical reason. RBC's have no mitochondria. They are the ONLY cell in humans that do not have a mitochondria but they are loaded with DHA sphingolipids and cholesterol. (on hemoglobin in blood, and chlorophyll in plants)
    One of the main differences between both molecules would be there’s a metal atom in the middle of each of those molecules, and in the case of plant chlorophyll it’s magnesium, which gives it a green color, and in our case it’s iron and that gives us a red color. Do biologist look at the homology the same between the two molecules? No they do not. Why? They believe the the job of the green chlorophyll is to trap sunlight (correct), and they believe the only job of our red hemoglobin is to trap oxygen or let it go. This is true but that is not all that hemoglobin does. It traps light between 250nm-600nm light to activate water in blood plasma to make an exclusion zone to create laminar flow, create proton exclusion, and to trap light energy in water too. Water has an amazing heat capacity. Animals are more complex than plants so you would think it would be obvious that RBC's would be doing more than plants but so far this has escaped basic circulatory physiology. The recent work on water has threatended this view point so to speak but it is not mainstream yet. So it should be clear that chloroplasts and mitochondria are designed to trap energy from the sun and in hemoglobin's case, also trap O2 molecules to deliver to mitochondria to drive electron flow. The solar light energy buried in the EZ of water augments the hearts pumping effect to move fluids around your body for many different functions such as gas exchange and solute exchange. Solute exchange is well understood in solid ice. During ice growth, solutes and impurities are concentrated outsied the ice crystals since they are excluded from the growing ice front. During a mild freeze, solutes excluded from ice accumulate in the matrix solution. It turns out Dr. Pollack has shown this is a general property of water when it is activated by light. Liquid water also excludes solutes down to the size of protons when the exclusion zone is built in us. It turns out red light can penetrate tissues and is the MOST effective light frequency used to build this exclusion zone in cells. When sunlight his a RBC's it generates and electromagnetic field in our vessels that actually "tickles" the artery to release the NO to bring blood to be irradiated closer to the surface of skin. We are photoelectric.

  4. Penny

    Penny New Member

  5. michael alafakis

    michael alafakis New Member

    Bonjour, je reviens sur cet article car en tant que médecin "chercheur" en Belgique, je suis très intéressé par ces exosomes.
    depuis 2017, et l'évolution des connaissances, avez-vous une autre discussion sur le sujet? comment réagir, comment sont influencés, par exemple, le message de ces exosomes avec le soleil? pourraient-ils être stimulés davantage avec l'électricité / le champ électromagnétique? la communication serait-elle alors encore meilleure? avez-vous une pensée sur tout cela? Merci beaucoup d'avance.
  6. @michael alafakis - Have you read "Cell, Gels and the Engines of Life" by Dr. Gerald Pollack
    He presents an interesting hypothesis in the section "Approaching Cell Dynamics"; in this section he pulls together his study in structured water, ions and cell potentials and takes a "dive" into an explanation of cellular - secretion and transport.
    From this, you may find a biological reasoning rather than a hypothetical evolutionary model for exosomes and their processes.

    Join me at looking to evidence when forming our beliefs; we need better perspectives when evaluating the data,
    Grandpa John
    Last edited: Apr 23, 2021
  7. JanSz likes this.
  8. Mesenchymal Stem Cell–Derived Exosomes: A Promising Biological Tool in Nanomedicine - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7944140/

    Mesenchymal Stem Cells (MSCs) are the most scientifically studied cells in regenerative medicine. They play a significant role in tissue regeneration and repair and generate local anti-inflammatory and healing signals.


    MSC-exosomes contain multiple neuroprotective proteins, which may be used as cell-free therapies to treat central nervous system disorders.


    We found that we could rescue cognitive function and also prevent abnormal neurogenesis in the brain - https://www.scientificamerican.com/custom-media/nature-outlook-extracellular-rna/inside-the-stem-cell-pharmaceutical-factory/


    Exosome therapeutics for lung regenerative medicine - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7480570/
    Modified exosomes can effectively deliver miR-124, bypassing the blood-brain barrier and inducing neurogenesis following ischaemic injury in a murine photothrombosis model.
    Last edited: Jun 2, 2021

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