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Red light therapy and gut healing after radiation......

Discussion in 'Redox Rx' started by Jack Kruse, Mar 24, 2022.

  1. Jack Kruse

    Jack Kruse Administrator

    PBM describes the use of low levels of visible or near-infrared (NIR) light to heal and stimulate tissue, and to relieve pain and inflammation. In recent years, PBM has been applied to the head as an investigative approach to treat diverse brain diseases such as stroke, traumatic brain injury (TBI), Alzheimer's and Parkinson's diseases, and psychiatric disorders. Also, in recent years, increasing attention has been paid to the total microbial population that colonizes the human body, chiefly in the gut and the mouth called the microbiome. It is known that the composition and health of the gut microbiome affect many diseases related to metabolism, obesity, cardiovascular disorders, autoimmunity, and even brain disorders. It turns out you can recover the gut and the microbiome after radiation damage. That is how powerful red light therapy is for healing.
    "Photobiomodulation Enhances the Angiogenic Effect of Mesenchymal Stem Cells to Mitigate Radiation-Induced Enteropathy"
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429482/
     
    John Schumacher, Elk and Alex97232 like this.
  2. Jack Kruse

    Jack Kruse Administrator

    In consideration of the known effects of PBM on metabolomics, and the now demonstrated effects of PBM on the microbiome, as well as other effects of light on the microbiome, including modulating circadian rhythms, the present perspective introduces a new term “photobiomics” and looks forward to the application of PBM to influence the microbiome in humans.

    It has been recognized in recent years that the gut microbiome is inextricably linked with health and disease. The gut microbiome (whether healthy or not) has a profound effect on inflammation and cytokine production, production of metabolites, and direct vagal nerve stimulation. It is also recognized that there is a complex communication between the body and the various microbiomes within the body. It is my contention that light, and specifically photobiomodulation (PBM), can alter the microbiome, possibly through quantum thermodynamic communication.

    Light can affect the microbiome indirectly through the daily circadian rhythm. The metabolome is intimately associated with chronobiology and hence with ambient light, with the circadian clock regulating levels of metabolites, including those from the microbiome, which in turn can affect metabolome. The effect of the circadian rhythm on the microbiome has been demonstrated and the bacteria responsible for decreased gut integrity and increased lipopolysaccharide transport are upregulated in mice after disruption of the sleep/wake cycle. In addition to circadian rhythm, light also has an indirect effect on the microbiome through vitamin D, produced by the action of sunlight on keratinocytes. Vitamin D is known to boost immune function by the induction of antimicrobial peptide genes and the regulation of tight junction proteins in the epithelial layer of the intestine and to maintain microbiome homeostasis and protect against colitis in mice, possibly by controlling inflammation. Vitamin D deficiency has been linked with such conditions as irritable bowel disease, obesity and diabetes, proinflammatory cytokines, intestinal barrier disturbance, and gut dysbiosis, and has been suggested to influence immune-mediated disease. Similarly, contaminants in food, such as fertilizers, pesticides, and herbicides, can have their toxicity increased by sunlight, which may also have an adverse effect on the microbiome.
     
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  3. Jack Kruse

    Jack Kruse Administrator

    It is generally accepted that the single most important chromophore in the red and NIR regions of the spectrum is cytochrome c oxidase (CCO), which is unit IV of the mitochondrial respiratory chain. When CCO absorbs light, the enzyme activity is increased leading to increased electron transport, more oxygen consumption, higher mitochondrial membrane potential, and increased ATP production. Signaling molecules are produced, including a brief burst of reactive oxygen species (ROS), nitric oxide, cyclic AMP, and movements in intracellular calcium. These signaling molecules result in the activation of a host of transcription factors, and changes in the expression of a multitude of gene products, including structural proteins, enzymes, and mediators of cell division and cell migration.

    In addition to the proposed action of PBM on CCO, and the consequent signaling, other mechanisms operate at a cellular and tissue level, including nonvisual phototransduction cascades involving opsins (OPN 1–5). Recent evidence has shown that blue (415 nm) and green (540 nm) light are absorbed by opsins that then trigger the opening of transient receptor potential (TRP) calcium ion channels.
     
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  4. Jack Kruse

    Jack Kruse Administrator

    There is recent evidence that melanopsin (OPN4), found in the eye, is also present in adipocytes, throughout the brain, in skin cells, and in blood vessels. Melanopsin is a tri-stable switch that can absorb in the red spectrum. This might surprise some until you read this paper.

    Emanuel AJ, Do MTH. Melanopsin tristability for sustained and broadband phototransduction. Neuron 2015;85:1043–1055

    Light penetrating the skull (sunlight and PBM) can alter melanopsin function. In this way, PBM can reverse blue light toxicity. The 380 nm light is also absorbed by neuropsin (OPN5) in the skin, retina, and nervous system, and light is absorbed in hair follicles by OPN2 and OPN3. Absorption by opsins results in downstream nonvisual phototransduction cascades, which in turn presumably influence protein conformation at the cell membrane and possibly cytoskeleton modulation cascades.

    PBM also has an effect on brain oscillation patterns, with changes to alpha, beta, gamma, delta, and theta EEG waves in both mice and humans and effects on the default mode network. When the gut is disrupted usually the gut barrier becomes permeable and affects the BBB and the brain. This is why PBM can help gut-brain axis issues.
     
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  5. Jack Kruse

    Jack Kruse Administrator

    PBM has a pronounced effect on inflammatory processes by reducing oxidative stress, reducing proinflammatory cytokines, and changing macrophage phenotype. The local effect of PBM on inflammatory pathways most probably has systemic consequences. It is possible that circulating immune cells (mast cells, macrophages, etc.), stimulated by PBM, could transduce protective signals from distal tissues to sites of injury such as the brain, heart, or gut.
     
    Elk likes this.
  6. caroline

    caroline New Member

    We have been wondering if we can get a redlight delivered to ES?
     
  7. Jack Kruse

    Jack Kruse Administrator

    The main communication pathways between the microbiome and the body are through the immune response, redox signaling, the endocrine system, and the enteric/vagus nerve pathway.

    One of the major known effects of the microbiome is the release of short-chain fatty acids (SCFAs), such as butyrate, acetate, and propionate, produced by fermentation of undigested polysaccharides or proteins. SCFAs influence the integrity of the gut mucosa by increasing epithelial integrity and production of mucus and influence the body's energy balance, inflammatory response, and protect against cancer.
     
    John Schumacher, Elk and caroline like this.
  8. JanSz

    JanSz Gold

  9. caroline

    caroline New Member

  10. JanSz

    JanSz Gold

    Let me try it.

    I have sent them the question.
    If they reply I will let you know the answer.
     
    caroline likes this.
  11. JanSz

    JanSz Gold

    They are quick.
    Kris is fast.

    upload_2022-3-25_9-11-14.png
     
    ND Hauf likes this.
  12. caroline

    caroline New Member

    I emailed them a few times and never an answer.

    So they deliver to El Salvador?
     
    JanSz likes this.
  13. JanSz

    JanSz Gold

    upload_2022-3-25_15-19-51.png
    That is what he wrote me back.
    Your experience may wary.
    Have you tried to buy stuff from him already?
    Try it.
    See what happens.
    -------------------------------------

    Note;
    It is easy to get clutter.
    Are you already in the place that you will stay little longer?

    ...................
     
  14. caroline

    caroline New Member

    Not yet ….we are still homeless
     
    JanSz likes this.
  15. For those following this thread, we have been posting on this subject for sometime. Please see:
    Well, well, oxygen just may be a big part of the mitochondria story
    https://forum.jackkruse.com/index.php?threads/aging-is-not-a-disease-damn-it.25242/page-28#post-311209

    The mechanism of action contributing to the protection and increased function of synapses seen in our study is increased function of the synaptic mitochondria. The 600–1000nm wavelength spectrum of the NIR light has been shown to optimally photostimulate cytochrome c oxidase, a key enzyme in the electron transport chain that is believed to result in an increase in ATP production. Cytochrome c oxidase contains 2 copper centers and 2 heme iron centers. When photostimulated, the copper centers are unable to bind nitric oxide, an inhibitor of respiration, resulting in an increase of oxygen consumption and ATP formation. Several previous studies have investigated the dysfunction of mitochondria in AD.
    Why is this oxygen story is important, because it gives evidence that it is not through the "transient receptor potential (TRP) calcium ion channels" by which the reactions occur. I encourage our readers to study, "Cells, Gels and the Engines of Life" by Dr Gerald Pollack.

    We must have a better understanding of "quantum biology".
     
    Last edited: Mar 26, 2022
  16. This article is part of the back drop we have been working up on this forum. That is, radiation damaged cells can be treated with "quantum treatment". Please note the experiment in this study regenerated these radiation damaged cells with mesenchymal stem cells (MSC) plus Photobiomodulation (PBM). Also note the treatment time of PBM for optimum results was one hour.

    upload_2022-3-26_7-31-57.png
    Photobiomodulation (PBM) enhances the proliferation and self-renewal of mesenchymal stem cells (MSCs). (A) Cell proliferation assays using MSCs treated with or without PBM at the indicated light parameters. As an irradiance of 7.12 mW/cm2 and a fluence of 1 J/cm2 were considered most beneficial to stimulate MSC proliferation, the following experiments were conducted using this condition.

    upload_2022-3-26_7-33-23.png

    Hematoxylin and eosin staining of the small intestinal tissue in control (CON), irradiation with vehicle treatment (IR), irradiation with MSC treatment (IR+MSC), and irradiation with PBM-preconditioned MSC treatment (IR+PBM-MSC) groups at Day 10 post-irradiation. Scale bar = 100 μm for main images; 1 mm for inserts.
    What this means is -> a "quantum clinician" now has the tools to solving squamous cell carcinoma and basal cell carcinoma.
     
  17. Dr. @Jack Kruse may I suggest looking into the gut-brain axis through the lens of amyloid peptides.

    Amyloid beta: structure, biology and structure-based therapeutic development
    https://www.nature.com/articles/aps201728
    Amyloid beta peptide (Aβ) is produced through the proteolytic processing of a transmembrane protein, amyloid precursor protein (APP), by β- and γ-secretases. The Aβ peptides are cleaved from the much larger precursor APP. APP has been implicated as a regulator of synaptic formation and repair, anterograde neuronal transport and iron export9.​
    Cellular processing of β-amyloid precursor protein and the genesis of amyloid β-peptide


    Intra-gastrointestinal amyloid-β1–42 oligomers perturb enteric function and induce Alzheimer's disease pathology
    https://physoc.onlinelibrary.wiley.com/doi/full/10.1113/JP279919
    We found that enteric Aβ oligomers induce an alteration in gastric function, amyloidosis in the CNS, and AD-like dementia via vagal mechanisms. Our results suggest that Aβ load is likely to occur initially in the GI tract and may translocate to the brain.​

    Aβ caused cerebral and vagal beta-amyloidosis
    Explanations could be that:
    (1) the memory impairments of the GI model might not result from hippocampal degeneration, as the MWM task depends heavily upon the hippocampus;
    (2) because of the stress of the MWM task itself, subjects might respond individually or differently in the memory acquisition session​
    Αβ delivery to brain via the vagus nerve
    We observed Αβ deposits in the vagus with loosely arranged vagal fibres, consolidating our hypothesis that axonal transportation via vagal nerves is one available route to facilitate migration of enteric Αβ to the brain, much as in prion and Parkinson's diseases.​
    So why may this amyloid perspective be important on this thread - ttps://forum.jackkruse.com/index.php?threads/red-light-therapy-and-gut-healing-after-radiation.26923?

    Because -> Near infrared light decreases synaptic vulnerability to amyloid beta oligomers

    NIR light had decreased Aβ binding at the concentrations of Aβ oligomers.
    As a "quantum clinician", it is important to understand the reason for the mechanism of action.
     
    Last edited: Mar 26, 2022
  18. Jack Kruse

    Jack Kruse Administrator

    Hydrogen is not a source of energy. Hydrogen is a carrier of energy, better thought of it as a battery that life uses in mitochondria. Energy is defined by quantum field theory. Hydrogen & electricity are a store of energy buried in a quantum field awaiting conversion by cells. The conversion of energy is linked to E=mc^2 relationship. In quantum field theory (QFT), quantum fields aren't generated by matter. Instead, what we interpret as "matter" is itself a quantum field of energy that can be used. How you extract the energy from this field is what life has evolved to do.

    WHY IS 43% of the sun’s light red?
    Watch this video carefully at the 3:56 minute pt and realize what he says about H+ in the sun. When H+ gas is ionized it becomes an electric plasma & it makes RED LIGHT. H+ is the most common element in the sun, so this is why the key things in biology are built around red light. Hydrogen atomic spectrum is that reason. The H+ in the sun is special. It's a proton stripped of its electron and it is light hydrogen. This light massively changes the capabilities of water on Earth.

    The red light emitted from ionized Hydrogen is capable of stimulating, healing, regenerating, and protecting tissues that have either been injured, are degenerating, or else are at risk of dying. Our tissues are defined by ideas based on Quantum field theory.

    The inception of QFT is usually dated 1927 with Dirac's famous paper on “The quantum theory of the emission and absorption of radiation” (Dirac 1927). Here Dirac coined the name quantum electrodynamics (QED) which is the part of QFT that has been developed first. The paradox of the Lamb Shift in hydrogen was not predicted by the Dirac equation, which posited that the excited and ground states of hydrogen should have the same energy. Lamb found they did not. This opened the door to quantum field theory that got science closer to understand what life is. We still not have progressed past this idea in 2022.

    Quantum field theory (QFT) is a theoretical framework that combines classical field theory, special relativity, and quantum mechanics. QFT is used in particle physics to construct physical models of subatomic particles and in condensed matter physics to construct models of quasiparticles. Water irradiated by red light becomes a quasiparticle described by QFT. The Heisenberg uncertainty relation means that a quantum field cannot sit still. Instead, it froths and boils, a bubbling soup of particles and anti-particles, constantly created and destroyed. This soup is the recipe in cells and tissues.

    When energy (an EMF) is absorbed from the field/environment, particles of matter will begin to oscillate between two configurations, the ground state, and an excited state. In particular, all particles in water coupled to the same wavelength of the fluctuations will oscillate in phase with the EM field of Earth and begin to exhibit quantum coherent behavior in all the water on Earth. This organizing principle is how the Schumann resonance made water on Earth quantum coherent before any life was present on Earth. This is why every living thing has an alpha wave of 7.83 Hz on their EEGs. How is this possible? Understanding the Lamb shift of hydrogen and what it does was key to making sense of why the Schumann resonance made life possible on Earth because the Schumann EMF plus water was the QFT blueprint 4.6 billion years ago for mitochondria. It took life 3.95 billion years to get the creation of mitochondria right to match what water and the Schumann resonance showed at Earth's surface.

    The fluctuations in the electric and magnetic fields associated with the QED vacuum perturb the electric potential due to the atomic nucleus hydrogen. This perturbation causes a fluctuation in the position of the electron, which explains the smallest energy shift. This effect was first measured in 1947 in the Lamb–Retherford experiment on the hydrogen microwave spectrum and this measurement provided the stimulus for renormalization theory to handle mathematical divergences. This "shift" lead to the genesis of quantum field theory and quantum electrodynamics. The Lamb Shift was the harbinger of modern quantum electrodynamics developed by Julian Schwinger, Richard Feynman, Ernst Stueckelberg, Sin-Itiro Tomonaga, and Freeman Dyson.

     

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