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Progesterone In Men

Discussion in 'Optimal Labs' started by Bill1, Jun 5, 2015.

  1. Bill1

    Bill1 New Member

    Not on any BHRT or supplements - just wondering how or why? would progesterone in a man be extremely high? Saliva testing revealed this:

    Progesterone 9899 pg/ml

    range for men on this test is: anything under 94 pg/ml

    Saliva E2 was 1.26 pg/ml - normal is anything under 2.5 pg/ml

    saliva cortisol - ok WNL

    saliva Test 153 pg/ml


    Did suffer a mild TBI a few months ago - MVA related. Any effect?

    How in the world do you lower pregesterone in men?

    Um? Very strange? Any help would be great - thanks :)
     
  2. Jack Kruse

    Jack Kruse Administrator

    that test must be repeated......its a likely lab error.
     
  3. Bill1

    Bill1 New Member

    thanks - it was repeated three times and serum was also elevated.

    My doctor uses the best lab for saliva testing - LABRIX. The only lab with the most up to date equipment.
     
  4. Bill1

    Bill1 New Member

  5. JanSz

    JanSz Gold

    Note that the hormone discussed in above article were tested in serum,
    saliva test may be good for cortisol only.

    "Serum samples (n=536) were collected for 7 days post-TBI for cortisol, progesterone, testosterone, estradiol, luteinizing hormone (LH), and follicle-stimulating hormone (FSH)."

    //
    Also get interested in

    GH
    IGF-1
    IGFBP3

    Likely all other pituitary hormone.

    ..
     
  6. Bill1

    Bill1 New Member

    no idea why it's up and how to lower it :(
     
  7. JanSz

    JanSz Gold

    Severe Traumatic Brain Injury
    may be the reason.

    .
     
  8. Bill1

    Bill1 New Member

    both saliva and serum were repeated 5 times over 3 week period. All were elevated off the charts. Any idea why? and how to fix it ??

    thanks
     
  9. Bill1

    Bill1 New Member

  10. Bill1

    Bill1 New Member

    ? thanks
     
  11. Jack Kruse

    Jack Kruse Administrator

    Ubi 19 has a key statement........how I read and decipher hormone assays is not what most think.........all tied to how light interacts with nitrogen at surfaces and inside us.
     
    Bill1 likes this.
  12. Bill1

    Bill1 New Member

    ubi 19? Did I miss that or is not posted?
     
  13. RobH

    RobH Gold

    Mine was like 49000 once but I had bit and chewed an oral progesterone the day before. I repeated it.

    RobH
     
  14. Bill1

    Bill1 New Member

    no external factor involved. possible head injury but not sure that's a factor. @Jack Kruse said something about light and labs but didn't explain it.

    .
    .
     
  15. Bill1

    Bill1 New Member

    Uni 19? is that posted yet or ???

    .
    .
     
  16. Jack Kruse

    Jack Kruse Administrator

    been posted all day
     
  17. Bill1

    Bill1 New Member

    oh - it wasn't posted the other day - *see above*.

    So why the high progesterone?
     
  18. Jack Kruse

    Jack Kruse Administrator

    The binding of progesterone to its receptor allows for a conformational change which promotes binding to chromatin, and leads to gene transcription and protein synthesis. The Ubi series shows you how incredibly important the interaction of light is on proteins. The maintenance of high levels of progesterone is also crucial for the maintenance of pregnancy primarily because pregnancy is very tied to excess protein synthesis and progesterone is critical in this process. When progesterone is low it tells me ubiquitination rates are unsustainable and the environment is toxic and the result is usually a severe dehydrated state. Dehydration and high BUN creat ratios usually are seen with low progesterone levels.

    The progesterone receptor is key to chromatin physiology. The biological importance of the progesterone receptor is that it allows for gene transcription and protein synthesis. It undergoes a conformational change with the binding of progesterone in the nucleus, that allows for chromatin binding and subsequently gene transcription and protein synthesis.

    Quote from Ubi 12, "excessive nitrogen increases ubiquitination" In humans NAD

    DNA only codes for proteins. All proteins contain nitrogen. Nucleic acids and vitamin D3 are low in nitrogen for a key reason tied to LIGHT. This makes them very sensitive to light's action. No one seems to realize this. This means the low end of the electromagnetic spectrum is critical to these two classes of biologic molecules. When your environment is loaded with higher non native parts of the electromagnetic spectrum it has dramatic affects on DNA and vitamin D levels. This is why the current low Vitamin D pandemic is a huge signal to humans. Right now they do not understand how technology is destroying our biology. In the case or proteins, molecules owe their stability to the same intermolecular forces that bind crystals that are not living. Van der Waal forces are weak electromagnetic interactions that control this process. In biotic systems, very weak forces are capable of holding DNA together. This is true of all proteins and cell membranes. The interesting part of this relationship, is because these electromagnetic forces are weak by design, it allows these structures to change conformation in order to adapt their functions based upon the environments they encounter. This is why Vitamin D and DNA have very little nitrogen. This is the essence of epigenetics built into DNA and RNA.

    Let us look at this really carefully. I am very detailed oriented in the Ubi series but people reading this series do not yet know the details or know them well. The more you realize what light and nitrogen do the more you'll understand how steroids really work. From Ubi 12 again: The link between chromatin light nitrogen and progesterone all link together. Consider when most illness begin, they are associated with excessive amounts of superoxide levels, but this happens over a short timescale; There is a huge difference between acute and chronic pseudo-hypoxia. NAD+ is where eukaryotes handle their nitrogen coupling system at cytochrome 1. NAD+ and SIRT1 availability play key roles in both acute and chronic inflammation. You need both present to regulate inflammation in a cell. In aging and illness, NAD+ is missing in action. NAD+ is the key source of nitrogen for cytochrome 1.
    In acute inflammation, chromatin departs from, and returns to, homeostasis in an orderly sequence (spatially and temporally). This sequence depends on shifts in NAD+ availability for SIRT1 activation and deacetylation of signaling proteins, which support orderly gene reprogramming (epigenetics) during acute inflammation by switching between euchromatin and heterochromatin. Remember chromatin change determine if genes are expressed or repressed. In contrast, in chronic inflammation and cancer, limited availability of NAD+ and reduced expression of SIRT1 may sustain aberrant chromatin structure and functions.
    Chronic low O2 the levels (think OSA) decay into a lack of superoxide pulses from cytochromes in mitochondria and directly alter epigenetic expression via changes in the size and shape of chromatin. This happens when mitochondria become pseudohypoxic and make little O2 from electron chain transport. Here is where David Sinclair’s paper in 2013 becomes extremely important. It links all chronic disease generation and aging to nitrogen uncoupling.

    Nitrogen atoms represent 10-15% of the dry mass of our muscles and four nitrogen atoms cradle each rust colored iron atom in hemoglobin. And people wonder why fibromyalgia is now exploding. It makes 100% quantum sense when you see how nitrogen works. Four nitrogen atoms from the chlorin surround and bind the magnesium atom in chlorophyll. Nitrogen is always close to the action that makes life happen.
     
    Last edited: Jul 19, 2015
  19. Jack Kruse

    Jack Kruse Administrator

    SIRT 1 allows for deacetylation (carbon removal) to occur to inactivate the ubiquitin marking process in proteins in cells undergoing “carbon stress” from pro inflammatory or pro growth signaling. Acetylation is a synonym for additions of carbon to a protein to stabilize it or to eventually replace it. Acetylation of proteins in our cells means ubiquitin marking will continue to occur, and as a result, will continue to cost the cell a lot of energy. Acetylation is one of the more ancient pathways used to move carbon in living things. SIRT 1 is capable of altering the flow of carbon replacement in humans. SIRT 1 gains this control by being directly coupled to NAD+ function in cytochrome 1 of your mitochondria. This links the protein synthetic machinery directly to the respiratory complexes. NAD+ function is highly dependent upon the sirtuin presence or absence.
     
  20. Jack Kruse

    Jack Kruse Administrator

    Ubi 17 has all this detail. You must assimilate it and relate it to hormone panels............Hormones tell us about the environments you allow.
     
    Bill1 likes this.

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