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Progesterone and pregnenolone help

Discussion in 'Adrenal Rx and Leaky Gut Rx' started by Neophyte79, Mar 5, 2017.

  1. Neophyte79

    Neophyte79 New Member

    Thanks. We live in Hungary, England is not good. Licorice and vitamins suggested why not? There is quite a lot of artifacts, if you are interested. Tsh, RT3, t3, t4, trak, anti-TPO, ATG, C125, vitamin d, complete blood counts (fresh).
  2. JanSz

    JanSz Silver

    Most people are low on DHEAs.
    So most should use it.
    Usually 50mg/day is first dose that many can use without testing.
    How much to use should be guided by tests.
    DUTCH test, I posted above is good test to use.

    Excess of DHEA supplementation can mess up other hormones.
    Specially, androstenedione and estrone E1.

    Usually recommended DHEAs levels on blood tests are:

    Men 350-500 μg/dL
    Women 275-400 μg/dL

    Note that good DHEAs levels can prevent
    pregnenolonme steal.
    You may want to optimize DHEAs levels first (say up to the lower recommended level).
    may improve

    If you lucky, that may be a big part of what you need.
    Add lots of light (at the right time), and that may be it.

  3. JanSz

    JanSz Silver

    Post all test that you have.
    Post the way I described above.

    You are doing your self disservice by not getting spectracel test.
    But it is up to you.

  4. JanSz

    JanSz Silver

    Cant figure what it means, greetings??
  5. Neophyte79

    Neophyte79 New Member

    We can not go to England. But thank you for the opportunity. For now, pregnenolone supplement, DHEA is not. increased dose daily until they feel the better effect. Thank you for taking the time to devote to me to keep in touch with you. :thumbsup: I hope we will improve in the short term. :)
    JanSz likes this.
  6. Neophyte79

    Neophyte79 New Member

    Two more questions. Pregnenolone half-life can possibly? It is distributed into several parts, or right at the same time the whole thing in the morning? Thanks.
  7. JanSz

    JanSz Silver

    I do not know half-life.
    When I was using pregnenolone-MLM tabs
    I was taking it the moment I got out of bed.
    My cortisol would raise rather quickly, minutes, half hour.
    On the day that I would draw blood for test,
    got up 6:AM, took preg-MLM
    7:30AM would draw blood
    when dose adjusted the way I want, I would get

    At first I was guessing that I would have to get another dose of preg-MLM sometime around noon.
    Did that for a while.
    But eventually (in my case) it turned out to not be necessary.

    I would draw blood
    and my cortisol profile was looking good and as expected (gradually falling).


  8. Neophyte79

    Neophyte79 New Member

    Very thank you. :)
  9. Jack Kruse

    Jack Kruse Administrator

    Progesterone acts like a "competitive allosteric inhibitor" of aromatase levels in fat mass and is one proxy I use that tells me how much CO2 and water a mitochondria are capable of making. So this makes it a very interesting for adiocyte redox hacks. This give me a good insight into heteroplasmy rates of my mitochondria as well. I use this in a lot of my light mito-hacks. Very interesting and reliable marker in my hacks. I want tp know the rules by which I'm actually playing. Not the rules society thinks we're playing with.
  10. JanSz

    JanSz Silver

    @Jack Kruse
    for men current upper laboratory range for progesterone is 1.4 ng/mL
    Do you see any benefits in maintaining higher levels in men?
    Say 2-3x higher. Say 3ng/dL
    In the past (Mark's Daily Apple) I have seen you supporting higher levels for women. (continuous 15-20ng/mL for menopausal women (IIRC)
  11. Neophyte79

    Neophyte79 New Member

    Hello. I hope you understand what I'm writing. Very low levels of cortisol can cause weight gain? If so, why? If cortisol levels will improve, you will stop gaining weight? It is possible that due to the low cortisol hormone T3 does not penetrate into the cells?
  12. Jack Kruse

    Jack Kruse Administrator

    Low cortisol = high PVN activation = brain gut 16 blog.
  13. JanSz

    JanSz Silver

    Lets hope I understand you.
    We are build of cells.
    Space is divided
    outside cells
    inside cells

    nothing happens when FreeT3 is outside cells

    Metabolism depends on proper level of Free Thyroid hormone, FreeT3, inside cells.
    When we swallow thyroid hormone pills,
    the thyroid hormone is inside our body but outside of cells.
    To do its intended work, FreeT3 have to be inside cell.
    If there is not enough FreeCortisol that thyroid hormone will stay outside cells.

    It is very important
    to work on FreeCortisol levels first.
    if you raise FreeT3 first it will pool and stay there (waiting for cortisol)
    when FreeT3 is not used right away its level may raise
    when you latter
    raise cortisol level
    you may get excess of FreeT3 inside cells.
    That could create excessive activity.
    At certain level that may reach emergency proportions.


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