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Progesterone and pregnenolone help

Discussion in 'Adrenal Rx and Leaky Gut Rx' started by Neophyte79, Mar 5, 2017.

  1. Neophyte79

    Neophyte79 New Member

    Thanks. We live in Hungary, England is not good. Licorice and vitamins suggested why not? There is quite a lot of artifacts, if you are interested. Tsh, RT3, t3, t4, trak, anti-TPO, ATG, C125, vitamin d, complete blood counts (fresh).
  2. JanSz

    JanSz Silver

    Most people are low on DHEAs.
    So most should use it.
    Usually 50mg/day is first dose that many can use without testing.
    How much to use should be guided by tests.
    DUTCH test, I posted above is good test to use.

    Excess of DHEA supplementation can mess up other hormones.
    Specially, androstenedione and estrone E1.

    Usually recommended DHEAs levels on blood tests are:

    Men 350-500 μg/dL
    Women 275-400 μg/dL

    ....
    Note that good DHEAs levels can prevent
    pregnenolonme steal.
    so
    You may want to optimize DHEAs levels first (say up to the lower recommended level).
    That
    may improve
    pregnenolone
    progesterone
    cortisolAM

    If you lucky, that may be a big part of what you need.
    Add lots of light (at the right time), and that may be it.

    ..
  3. JanSz

    JanSz Silver

    Post all test that you have.
    Post the way I described above.

    ===============================
    You are doing your self disservice by not getting spectracel test.
    But it is up to you.

    upload_2017-3-5_11-9-29.png
  4. JanSz

    JanSz Silver

    Cant figure what it means, greetings??
  5. Neophyte79

    Neophyte79 New Member

    We can not go to England. But thank you for the opportunity. For now, pregnenolone supplement, DHEA is not. increased dose daily until they feel the better effect. Thank you for taking the time to devote to me to keep in touch with you. :thumbsup: I hope we will improve in the short term. :)
    JanSz likes this.
  6. Neophyte79

    Neophyte79 New Member

    Two more questions. Pregnenolone half-life can possibly? It is distributed into several parts, or right at the same time the whole thing in the morning? Thanks.
  7. JanSz

    JanSz Silver

    I do not know half-life.
    When I was using pregnenolone-MLM tabs
    I was taking it the moment I got out of bed.
    My cortisol would raise rather quickly, minutes, half hour.
    On the day that I would draw blood for test,
    got up 6:AM, took preg-MLM
    7:30AM would draw blood
    when dose adjusted the way I want, I would get
    cortisol,serum(7:30AM)=~20

    /
    At first I was guessing that I would have to get another dose of preg-MLM sometime around noon.
    Did that for a while.
    But eventually (in my case) it turned out to not be necessary.

    I would draw blood
    7;30AM
    NOON
    2:30PM
    and my cortisol profile was looking good and as expected (gradually falling).

    ..

    .
  8. Neophyte79

    Neophyte79 New Member

    Very thank you. :)
  9. Jack Kruse

    Jack Kruse Administrator

    Progesterone acts like a "competitive allosteric inhibitor" of aromatase levels in fat mass and is one proxy I use that tells me how much CO2 and water a mitochondria are capable of making. So this makes it a very interesting for adiocyte redox hacks. This give me a good insight into heteroplasmy rates of my mitochondria as well. I use this in a lot of my light mito-hacks. Very interesting and reliable marker in my hacks. I want tp know the rules by which I'm actually playing. Not the rules society thinks we're playing with.
  10. JanSz

    JanSz Silver

    @Jack Kruse
    for men current upper laboratory range for progesterone is 1.4 ng/mL
    Do you see any benefits in maintaining higher levels in men?
    Say 2-3x higher. Say 3ng/dL
    In the past (Mark's Daily Apple) I have seen you supporting higher levels for women. (continuous 15-20ng/mL for menopausal women (IIRC)
    .
    .
  11. Neophyte79

    Neophyte79 New Member

    Hello. I hope you understand what I'm writing. Very low levels of cortisol can cause weight gain? If so, why? If cortisol levels will improve, you will stop gaining weight? It is possible that due to the low cortisol hormone T3 does not penetrate into the cells?
  12. Jack Kruse

    Jack Kruse Administrator

    Low cortisol = high PVN activation = brain gut 16 blog.
  13. JanSz

    JanSz Silver

    Lets hope I understand you.
    -------------------------------------------
    We are build of cells.
    Space is divided
    outside cells
    inside cells

    nothing happens when FreeT3 is outside cells

    Metabolism depends on proper level of Free Thyroid hormone, FreeT3, inside cells.
    When we swallow thyroid hormone pills,
    the thyroid hormone is inside our body but outside of cells.
    To do its intended work, FreeT3 have to be inside cell.
    If there is not enough FreeCortisol that thyroid hormone will stay outside cells.

    It is very important
    to work on FreeCortisol levels first.
    because
    if you raise FreeT3 first it will pool and stay there (waiting for cortisol)
    when FreeT3 is not used right away its level may raise
    so
    when you latter
    raise cortisol level
    you may get excess of FreeT3 inside cells.
    That could create excessive activity.
    At certain level that may reach emergency proportions.

    ....
  14. Neophyte79

    Neophyte79 New Member

    Hi Jansz. I'd as promised. Son: 400 mg now pregnenolone (100 morning, evening 150, the other divided during the day). Definitely better, but sometimes I wake up at night to pee and hungry in the morning (low cortisol). Girl: 300 mg pregnenolone, sometimes better, sometimes worse. Not much improvement. What do you suggest? Lift the dose? Tests of blood expensive, but introspection is possible.
    Thank you.
  15. JanSz

    JanSz Silver

    https://dutchtest.com/shop/
    Get this tests.
    Results will come in PDF files.
    Attach those files to your posts.
    Describe your protocols.
    Describe your problems.

    .........


    [​IMG]


    https://dutchtest.com/resource/dutch-complete-sample-report/

    https://dutchtest.com/wp-content/uploads/2016/04/Steroid_Pathway_Jan2016.pdf

    https://dutchtest.com/2015/04/24/a-...arrie-jones-clinical-pearls-on-shbg-and-dhea/
  16. Neophyte79

    Neophyte79 New Member

    Thank you very much for your response. This test is very dear to me, hungary pay $ 400 one month. Unfortunately, this option is not good.
    JanSz likes this.
  17. Neophyte79

    Neophyte79 New Member

    Hello. The first two are the girl's blood, 3 days of menstruation. The third is the boy. What do you think? Girl is 700 mg pregnenolone, 40 mg progesterone cream for 12-24 days. Boy 500 mg prengenolon, 50 mg and d. Progesterone is a lot of blood, but no better. There are few cortisol, tired.

    Attached Files:

  18. JanSz

    JanSz Silver

    Majoros Richard
    stop using pregnenolone.
    --------------------------------------------------------
  19. Neophyte79

    Neophyte79 New Member

    Allright. What shall we do?
    Last edited: Apr 27, 2017
  20. JanSz

    JanSz Silver

    From my pov:
    1, learn English or Polish or find a friend with this abilities, pray that someone who reads this board offer translation service.
    2, describe your problems, both of you
    3, increase ability to do testing
    4, Schultz_Adrien_Judit have very high SHGB
    looking for possible reasons may be the right way to go
    ..

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