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Progesterone and pregnenolone help

Discussion in 'Adrenal Rx and Leaky Gut Rx' started by Neophyte79, Mar 5, 2017.

  1. Neophyte79

    Neophyte79 New Member

    Hi there. We are one boy and one girl from Hungary. I'd like help. English know little, help me google translator, hope everyone understands. Use simple sentences. It has been adrenal fatigue for years, stage 4 Breakfast saliva test 4-5 in the other 1.5. Girl: menstruation long time (several months) will be skipped, and now good, using progesterone cream 12 days 26 to about 30 mg per day for 2 months.. Endometrosis no. Now so good, menstruation is stable. Weight gain, hypothyroidism occurs (due to low cortisol). Work: office, it is not difficult. Weight training 2 times per week, for up to 15 minutes, quickly tired. Boy: Only low cortisol, weight gain is no longer, slightly higher cortisol. It progesterone 15 mg per day may help higher cortisol, about one month ago. Physical work every day wearing. Use of Progesterone cream helps to slightly higher cortisol, saliva test is justified, but it is still low. Pregnenolone used, quicker recovery, starting 6-8 mg, for 2 days, under the tongue. Symptom his first night sweats. Girl symptoms: palpitations, low blood sugar feeling (measured over 5, so good). Now 12 mg pregnenolone, under the tongue for a few days. Help us needed a progesterone cream? If so, how much? Pregnenolone dosage amount, time (morning, noon, evening)? Thank you very much, I hope you understand what you write.
  2. JanSz

    JanSz Gold

  3. JanSz

    JanSz Gold


    Progesterone therapy
    Progesterone is women's second important and essential hormone and a partner of estrogen. Wherever estradiol is acting in women's bodies (bone, brain, breasts, uterus, skin and everywhere), progesterone is also acting. Women have two reproductive hormonesestrogen and progesterone. Men only have one (testosterone).

    Progesterone therapy means taking natural progesterone (oral micronized progesterone) that is bio-identical. If, for cost reasons, a progestin must be substituted, medroxyprogesterone is the closest in action to progesterone (and, like progesterone, also improves hot flushes and increases bone density). Progesterone must be given at bedtime since its major "side effect" (smile) is to improve sleep; it is effective in a dose of 300 mg at bedtime daily which keeps the serum progesterone at or above the luteal phase level for a full 24-hour day.

    Cyclic progesterone, for menstruating women of any age, means progesterone for the last two weeks of a menstrual cycle or of a month. Based on a randomized controlled trial, this treatment with cyclic progesterone increases spinal bone density and provides regular flow for women who have reversible (usually stress-related) reasons their periods have stopped or are far apart. Cyclic progesterone is also an essential therapy for premenopausal women with anovulatory androgen excess (AAE)(also called polycystic ovary syndrome [PCOS]) because it prevents endometrial cancer, slows the pulse frequency of luteinizing hormone (LH) thus decreasing testosterone production, provides regular menstrual-type flow and blocks the formation of the skin hormone that causes pimples and unwanted face hair. Cyclic progesterone is also a safe and effective treatment of perimenopausal cyclic night sweats (that occur around the time of flow for women whose cycles are still regular). In perimenopause, cyclic progesterone may also (especially if ibuprofen is also taken) help decrease heavy flow. Cyclic progesterone also helps with the sleep and premenstrual symptoms in perimenopause.

    Early menopause (before age 40) can be treated with estradiol and cyclic or daily progesterone. This treatment is continued until a woman becomes age 50-52. With cyclic progesterone those women young enough to want regular flow will achieve it when estrogen is given in a long cycle (from the first to the 25th of the month) and progesterone from the 14 to the 27th. (Note—this is the only time ovarian hormone therapy is truly "replacement.")

    Progesterone (taken daily) is effective treatment of menopausal hot flushes as shown by a CeMCOR randomized trial. Daily progesterone also significantly improves sleep in menopausal women (based on three controlled trials). In short, progesterone is effective therapy for women's menstrual cycle disturbances or perimenopause and menopause-related problems.

    - See more at: http://www.cemcor.ubc.ca/resources/topics/progesterone-therapy#sthash.6M5ROEpG.dpuf


    Cyclic Progesterone Therapy
    "Cyclic Progesterone" means treatment with the natural progesterone hormone (oral micronized progesterone, Prometrium® or compounded in oil) in a way that mimics the normal pattern (14 days in the last half of the menstrual cycle) and amount (300 mg at bedtime) in the menstrual cycle. That definition may suggest this therapy would often be prescribed. But, currently, it rarely is.

    Cyclic progesterone has many potential uses. In general terms, taking cyclic progesterone is a way to prevent present or future problems (http://www.cemcor.ca/resources/preventive-powers-ovulation-and-progesterone) in premenopausal women who are otherwise healthy but for various reasons are not ovulating and making enough progesterone. These women may have hypothalamic and reversible reasons for missing, too long or irregular menstrual cycles. These menstrual cycle problems are fairly rare, most common in younger women and caused by a still "growing-up" reproductive system, plus normal life stresses and feeling alone, unloved or abused, losing weight, being ill or a combination of these. Rarely these cycle changes may be caused by some of the above stressors combined with over-activity.

    More common problems for which cyclic progesterone is good therapy are called "ovulatory disturbances," including anovulation and short or insufficient luteal phases. These ovulatory disturbances can occur within "funny cycles" that are far apart or irregular, but most often are silent or "subclinical" because they occur within perfectly regular, normal-length cycles.

    Cyclic progesterone is good therapy for "silent anovulation" which describes a normal menstrual cycle having enough estrogen but without regular ovulation, egg release or progesterone production. An even more frequent occurrence is a silent short luteal phase or silent insufficient luteal phase in which ovulation is present but progesterone is high for fewer than normal days or is made for long enough but in too little amounts. Currently mild high-side-of-the-breast soreness (without whole breast soreness) before flow or a monitored cycle by quantitative basal temperature are the only ways women can reliably tell if they ovulated.

    Rare but important reasons for treatment with cyclic progesterone include anovulatory androgen excess (also called PCOS), for improving fertility in cycles with short or insufficient luteal phases, or to prevent the rare kind of seizures that usually occur just before menstrual flow (catamenial epilepsy). Women in very early perimenopause may take cyclic progesterone for night sweats that cluster around flow, for premenstrual breast tenderness or fluid retention and sleep problems. Women in perimenopause using cyclic progesterone to treat prolonged heavy menstrual flow or anemia often need to take in a "long cycle" (for 21 days) or daily for three months.

    Currently cyclic progesterone is not officially indicated for any of these physiology-based reasons.

    - See more at: http://www.cemcor.ubc.ca/resources/topics/cyclic-progesterone-therapy#sthash.Nlgb7H0x.dpuf



    Cyclic Progesterone Therapy
    Why Might I Need To Take Cyclic Progesterone Therapy?

    Progesterone is one of two important women's hormones; estrogen is the one we usually hear about. When menstrual cycle length is irregular or cycles are long or skipped, or when egg release is absent despite regular cycles, progesterone levels are low or missing.

    Your doctor may prescribe progesterone or a synthetic called medroxyprogesterone (MPA), to control heavy flow, prevent irregular periods, acne, unwanted hair, or treat low bone density, or for perimenopausal sore breasts, sleep problems, heavy flow or night sweats. Cyclic progesterone therapy (not MPA) also helps women achieve pregnancy.
    What Medications Can I Choose?

    Oral micronized progesterone (Prometrium® or the same hormone "compounded" in oil by a pharmacist) is identical to your own hormone (or bio-identical). Because it may cause sleepiness, only take this medication on your way to bed. Three 100 mg. capsules is the dose that keeps progesterone levels in the normal range for 24 hours—it costs *$5.50 a day.

    Medroxyprogesterone (MPA) is synthetic or progestin that has been used for over 40 years. As a pill it does not provide contraception like DepoMPA, and doesn't have the same side effects while on it or difficulties when stopping it. It is stronger than progesterone so the dose that creates a progesterone-like effect is 10 mg. a day. A one-day dose costs about *Canadian $0.36.
    When Do I Take It?

    The first day of menstruation is called "day 1." If you get a period regularly and your cycles are usually 27-30+ days long, start progesterone on the 14th day after flow began and take it for 14 days or until cycle day 27. If your cycles are regular but shorter (for example, if your period starts every 21–26 days), then start cyclic progesterone/MPA on cycle day 12 and continue it for 14 days or until cycle day 25.
    View attachment 3931
    Diagram 1

    If your period starts before you have finished the 14 days of progesterone/MPA, finish the full 14 days, but start the next progesterone 14 days after the flow began. This allows for a "catch up" with your own (likely high) estrogen levels.

    Diagram 2

    If your period starts while you are still taking progesterone/MPA, always take it for the full 14 days.

    If this early flow persists, or you are in perimenopause, then you either need daily progesterone/MPA for three months or to increase the dose of cyclic therapy to 400 mg progesterone or 20 mg MPA. The early flow is a sign that your body is making high levels of estrogen that are over-stimulating the endometrium (uterus lining) and causing heavy bleeding.

    If you have not started to flow within two weeks of taking cyclic progesterone/MPA, it means your own estrogen levels are low. Stop progesterone for 14 days. After 14-days "off," start the next progesterone cycle.

    As soon as your flow returns, then start taking progesterone/MPA again, 14 days after the start of your flow, as shown in Diagram 1.
    Are There Any Side Effects?

    There are no serious negative effects from progesterone therapy—the most important is improved sleep! It does not cause blood clots, migraine headaches or increase the risk for breast cancer. In a dose of 300 mg for 14 days, it effectively prevents endometrial cancer. Pharmacy references say that progesterone causes everything shown on "the Pill" (combined hormonal contraceptives) which contain 4 times normal estrogen doses plus synthetic progestins. Prometrium® is in peanut oil; therefore those with peanut allergy must NOT take it. With MPA the major concerns are that it increases breast cancer risk in menopausal women taking estrogen therapy and should be avoided if possible when seeking pregnancy.

    You may notice some changes in your breasts, feelings of warmth and other evidences of normal progesterone action. If you get moody, feel bloated and have very sore breasts it means progesterone is temporarily stimulating your body to make higher estrogen levels. This improves after one cycle.

    Download this article in PDF format You will need the free Adobe Acrobat Reader in order to read and print a PDF version of this handout. If you don't already have the program, you can download it for free here.
    Dr. Jerilynn C. Prior, Scientific Director, Centre for Menstrual Cycle and Ovulation Research
    Cyclic Progesterone Therapy, Progesterone therapy
    Life Phase:
    Adolescence, Premenopause, Perimenopause
    Updated Date:
    November 28, 2014
    - See more at: http://www.cemcor.ubc.ca/resources/cyclic-progesterone-therapy#sthash.Sr6UhEzM.dpuf

    Last edited: Mar 5, 2017
  4. JanSz

    JanSz Gold

  5. Neophyte79

    Neophyte79 New Member

    Hi Jansz. Thank you very much for the detailed description. I would like to ask for a little help with pregnenolone use it. Thanks in advance.
  6. JanSz

    JanSz Gold

    Polak, Węgier, dwa bratanki, i do szabli, i do szklanki
    (węg. Lengyel, magyar – két jó barát, együtt harcol, s issza borát)


    Do not do strenuous exercises when cortisol is low.

    Last edited: Mar 5, 2017
  7. JanSz

    JanSz Gold

  8. JanSz

    JanSz Gold

  9. JanSz

    JanSz Gold

  10. JanSz

    JanSz Gold


  11. JanSz

    JanSz Gold

    My current understanding, may change any minute.

    If someone sleeps erratic lengths of time
    he is exposed to a jet lag.

    Artificial lighting management for a human locked in small room.

    Day length=24hrs
    Light--14 hrs
    Use minimum to no clothes 24/7
    Bed time-10PM
    At 6AM for 2-3 minutes look directly at one Solar Glow 160W
    Light 6AM-8PM using
    2-Exo Terra Solar Glow 160W
    2 of RubyLux ALL RED
    1 RubyLux Infrared Bulb NIR-A
    Light 8PM-10PM
    2 of RubyLux ALL RED
    1 RubyLux Infrared Bulb NIR-A
    No light at all, any windows blocked completely from the light
    Hand held red light similar to RubyLux ALL RED can be used on the way to the bathroom
    Use Red Sperti lamp daily
    5-15 min at first, gradual increase to desired daily exposure
    adjust time under Sperti by measuring vit D
    Vitamin D (25-Hydroxyvitamin D)(250nmol/L=100.16ng/mL)
    Minimum = 3/4 of the goal
    Maximum = 2x of the goal
    Uvex Skyper Blue Light Blocking Computer Glasses with SCT-Orange Lens (S1933X)
    2 of Exo Terra Solar-Glo High Intensity Self-Ballasted Uv/Heat Mercury Vapor Lamp
    https://www.amazon.com/Exo-Terra-Solar-Glo-Intensity-Self-Ballasted/dp/B00101JII8/ref=sr_1_sc_1?s=pet-supplies&ie=UTF8&qid=1474548267&sr=1-1-spell&keywords=exo terrra 160W
    2 of RubyLux ALL RED High Intensity LED Bulb 640 to 660nm
    RubyLux Infrared Bulb NIR-A Near Infrared Individual Bulb
    Sperti Fiji SUN Table Top Tanning Lamp

    Price:US $10.98 Free shipping
    Maximum load power: 300W
    Fit E27 light, this is a holder for a screw in light.


    Rob Hamilton, MD



    14W Black Light Spiral CFL Bulb
    Note: when I checked 12/16/2016 the link was down, but apparently the picture is still there.


    When IF, intermittent fasting, stop eating 4-6 hrs before bed time.
    time 1:02:03

    As discussed by @Dr. Mercola and @SatoriHeart here:

    Dr. Mercola said: ↑

    The Ruby Red is an excellent incandescent bulb but only 10% of the energy comes out as near IR and far less in the theraputic range of low 800s.. It is ideal for a sauna not photobiomodulation. Far better to use LEDs in the ranges I quoted as you will not generate too much heat

    Just need to know that there is a photoelectric diode that is green that turns it off during the day so you need to cover it with electrical tape so it works in the daytime. Can also remove the lens cover with an allen wrench

    CMVision IR130 198 LED Indoor/Outdoor Long Range 300-400ft IR Illuminator With Free 3A 12VDC Adaptor
    by CMVision

    Price: $66.95

    https://www.amazon.com/CMVision-IR130-Outdoor-300-400ft-Illuminator/dp/B004F9LF7E/ref=sr_1_fkmr3_1?ie=UTF8&qid=1488125922&sr=8-1-fkmr3&keywords=infrared flood light built
  12. Neophyte79

    Neophyte79 New Member

    Very useful information, thank you. Can you help us pregnenolone dosage? When and how many mg? Now 10-12 mg in the morning.
  13. JanSz

    JanSz Gold

    Desirable vit D (without vit D supplementation)
    Vitamin D (25-Hydroxyvitamin D)(250nmol/L=100.16ng/mL)
    use this lamp
    harden your skin for a month before using long exposures

    Sperti Fiji SUN Table Top Tanning Lamp

    1/day-->Super Selenium Complex, 200 mcg 100 capsules (lef.org)
    After one month on selenium
    start with one drop a day, increase every other day by 1 drop until you reach 16 drops/day.
    If you would encounter any detox problems, do not increase dose or stop all together.
    After symptoms subside, restart Lugol's again.

    1 dropperfull/day=40mg/day=16drops/day 1dropperfull=one full squeeze of rubber topper
    Lugol's Iodine Family Pack -- 6 (2 fl. oz.) bottles

    Above contains
    94% Distilled Water
    4% Potassium iodide
    2% iodine
    If you cannot get exactly the same product,
    any replacement should contain
    (iodine) and (potassium Iodide)

  14. Neophyte79

    Neophyte79 New Member

    Yes, there is a vitamin cure. But we feel that the effect is not enough. The same tired than two months ago. If you can, please help pregnenolone dose. :)
  15. JanSz

    JanSz Gold

    Pregnenolone use at wakeup time.
    Adjust dose per test results.

    Progesterone pills best at bed time.

  16. Neophyte79

    Neophyte79 New Member

    I understand. What should you watch? Side effects? Until then, raise the dosage until you feel better? What is the maximum? increased daily or weekly?

    Progesterone not tablet, cream. :)
  17. JanSz

    JanSz Gold

    I am not a doctor.
    I am 77 year old man.

    I had very low cortisol(AM) and low cortisol at other times.
    I had good results using
    Nutricology Pregnenolone 150 Mg Sustained Release Tablets,
    https://www.amazon.com/Nutricology-Pregnenolone-Sustained-Release-Tablets/dp/B000KII7CU/ref=sr_1_1_s_it?s=hpc&ie=UTF8&qid=1488725671&sr=1-1&keywords=pregnenolone 150mg

    I used it for about two years (variable doses), now do not have to and my cortisol stays ok.
    I used it in the morning at wakeup time. (Right when I get off the bed).
    I would do rather often tests of my cortisol,serum to adjust dose.
    I used dose that would give me at 7;30AM
    cortisol,serum=~20ug/dL (or only slightly less)
    on laboratory range=(6.2-19.4)ug/dL
    I wake up 6AM.

    It is important to have steady daily schedule and good exposure to light,
    that reinforces good Circadian Rhythm cycling.

    The above resulted in my somewhat elevated progesterone.
    Above should be good for
    man and postmenopausal woman

    Menstruating woman should have no problem using this system in first part of cycle (and large part of second half) (but may have to stop using it for a while to allow menstrual cycle to continue)(to allow sufficient progesterone fall).

    Healthy man and healthy menstruating woman:
    man have progesterone=1.4 ng/mL
    woman have the same progesterone level in first half of cycle.
    In second half of menstruating cycle healthy woman have very high progesterone.
    When progesterone starts falling, when it reaches level near 1.4ng/ml bleeding starts.
    And the cycle starts all over again.
    if menstruating woman would use pregnenolone (or progesterone) supplementation,
    she must manage it in such a way that would allow menstrual cycle to continue.
    IF supplementation with pregnenolone or progesterone raises serum progesterone to level higher than 1.4ng/ml she must stop using it for so many days to allow for progesterone drop.
    Both of you (boy & girl) have low cortisol,
    and are attempting to raise it using pregnenolone (or progesterone).

    This procedure, to be successful must be guided by blood tests.

    Above is just a one part of overall health maintenance.

    ...... upload_2017-3-5_10-41-46.png
    Last edited: Mar 5, 2017
  18. JanSz

    JanSz Gold

    Pregnenolone is first steroid hormone made from cholesterol.
    If you are able, pregnenolone supplementation is preferred over progesterone.
    Print chart I have given you on post #9
    hang it up in the place where you can see it very often,
    get familiar with it.

    Last edited: Mar 5, 2017
  19. Neophyte79

    Neophyte79 New Member


    Thank you for your patience and help. Monitor the situation. Breakfast salivary cortisol end 2.2 nmol / l in October. Then vitamin cure, but it did not help anything. In early January, progesterone cream and now 3.4 nmol / l in the morning cortisol in saliva. Now pregnenolone dose of 10-12 mg sublingually. We're trying to raise the dose until you feel better not. We use licorice capsule supplement. Blood pressure is fine, is not high. It was rated low. Should I use DHEA, pregnenolone or just? ask for help from you in the future? :)
  20. JanSz

    JanSz Gold

    Yes you can ask questions.
    When you are looking at test results of anything,
    make sure to post:
    exact name of the test
    what was tested (saliva, blood, urine)
    time the sample was taken
    value of result
    laboratory range
    2.2 nmol / l in October
    now 3.4 nmol / l in the morning cortisol in saliva
    can beevaluated if you post above information.

    In short, specially in very early morning you desire to have close to maximum on laboratory range.

    off hand I would say do not use
    vitamin cure
    or licorice

    instead travel and get this test:

    Micronutrient Test (MNT)
    CardioMetabolic Risk

    To find blood draw site:


    This test will tell you what supplements to take to help your adrenals, thyroid and many other.


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