I want to share my best biohack of 2022. If you have mild presbyopia, and you hate using glasses like me, you can use pilocarpine 1,25% eyedrops, one drop on each eye, twice a day, and you won´t need to use glasses, at least for some years.
Use it or try it only if you have mild emmetropic presbyopia. There are very expensive eyedrops, FDA approved, that costs a lot of money, but you can buy very cheap pilocarpine 2% eye-drops, and dilute them with physiological saline solution. It works, and costs nearly nothing, at least here in Argentina.

 

Your clear lens sits inside the eye behind your colored iris. It changes shape to focus light onto the retina so you can see. When you are young, the lens is soft and flexible due to fibroblasts optimizing the collagen in the lens and the motor function of the ciliary muscles, to easily change the shape of the lens. This lets you focus on objects both close-up and far away. After age 40, the lens becomes more rigid. It cannot change shape as easily. This makes it harder to read, thread a needle, or do other close-up tasks. Pilocarpine is a Cholinergic agonist. The combination of red light combined with blue light over several hours, as it is in the sun's terrestrial light, has massive cholinergic effects on cells because of how it stimulates fibroblasts to function better.

A solely cholinergic = increase of HRV, and decrease of heart rate might be achieved by PBM alone or chronic time spent in terrestrial light. I believe both can be used.

Centralized healthcare currently believes there is no way to stop or reverse the normal aging process that causes presbyopia. I reject that as a decentralized MD. I think PBM is a better choice. Standard centralized treatment today of presbyopia is done now with eyeglasses, contact lenses, or surgery. All these have serious collateral effects. People who have trouble seeing both near and far may benefit from progressive lenses, which also have serious collateral effects. In the future, presbyopia may be treated by centralized MDs with cholinergic eye drops but in my view, that is not the best-decentralized choice. If you do not correct presbyopia, you may be bothered by headaches and eye strain and be set up for mitochondrial disease.

Light is a ubiquitous environmental stimulus and energy source for all species living on earth. Our organism reacts to diurnal and seasonal light fluctuations with complex mechanisms and elaborated adaptations, which developed during the evolution of human beings. Although we are mostly not able to perceive the non-visual effects of light, the latter can indeed initiate a number of complexes and so far only partially explored mechanisms by centralized healthcare. Specifically, an effect of light on the autonomic nervous system (ANS) and cardiovascular system is evident and the biochemical signal transduction of light impulses in specific brain areas has recently been discovered: After entering via the retina and the retinohypothalamic tract, light impulses are mainly processed in the nucleus suprachiasmatic (SCN), which is also considered as the “endogenous master pacemaker”. This center subsequently triggers autonomic pathways, located in the hypothalamus, to regulate body temperature, wake-sleep-rhythm, blood pressure, respiration, digestion, lipid metabolism, hydration, as well as body growth.

The effects of light are not exclusively explained by its intensity but likely also depend on its spectrum or mix of spectra as the day evolves and seasons evolve.
Litscher and colleagues found in a small cohort of healthy volunteers that blue light leads to decreased HRV.
Since the effects of blue light are dose-dependent, light intensity likely makes a difference in the more pronounced light effects observed in the autonomic nervous system. The retinohypothalamic pathway regulates the autonomic nervous system, lending support to the notion of a central nervous effect on light in our environments.

 

https://www.sciencedirect.com/science/article/abs/pii/0309165187901238