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PoW is the circadian clock of a monetary network.

Discussion in 'The Kruse Longevity Center' started by Jack Kruse, Nov 13, 2021.

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  1. Jack Kruse

    Jack Kruse Administrator

  2. Jack Kruse

    Jack Kruse Administrator

    BITCOIN AND YOUR SCN

    The Bitcoin network is also a clock. Think about Bitcoin as the hour hand on a wristwatch. Think about the Lightning Network as the minute hand on a wrist watch . The second hand on the writwatch is the difficulty adjustment in BTC code. Taproot is the clockmaker changing out gears to make the clock have a finer fidelity in periodicity to allow for more complexity on this monetary network. It is an evolution of money. Just as cells had no idea what the extra 10% of UV light was capable of, most investors of BTC have no idea what Taproot means. I think Uncle Jack, and Mr. Jack do. Then you’ll begin to understand why all clocks that are improved upon become better flow meters of how entropy flows within a system to lead to higher valuation because their use case rises for the financial system.

    This is a step in make BTC uncorrelated with the fiat market and it is why when the CPI number came out at 6.2% Bitcoin hit 69000. It is the first time I can remember where the BTC network responded to a failing mechanism in the fiat system.

    As per Glassnode data, within two hours of Bitcoin hitting its all-time high around $69,000, long BTC positions worth $64 million were liquidated and the bitcoin whales are now using this profit-booking to augment their positions.
     
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  3. Jack Kruse

    Jack Kruse Administrator

    In mid October 2021, $31 billion of value settled on the bitcoin network in a single day. This is an all-time high for a single day of settlement value. The global, decentralized payment system continues to become more dominant. After Taproot takes hold Bitcoin dominance will continue to rise more quickly than most investors inspect. This is additive to the halving cycle because Taproot is a new gear added to the BTC clock that has never been accounted for in the halving cycle price changes. The four year system is shrinking daily now.
     
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  4. Jack Kruse

    Jack Kruse Administrator

    What will better clock management do for the Bitcoin network?

    The Bitcoin network is presently doing ~$190k per second. Compare this to $130k per second by Visa for US customers and $55k per second for Mastercard. The value carried on the price per second is going to create unrecognizable change in the economic system of the world.

    The Cambrian period is when practically all major animal phyla started appearing in the fossil record. It resulted in the divergence of most modern metazoan phyla. This means nothing before it looks the same as life did after it. This means after Taproot what you thought was DeFi will no longer exist. Improving Bitcoin clock is akin to The Cambrian explosion event where life changed quickly and irreversibly (direction of the arrow of time) which accompanied by major diversifications in other groups of organisms as well. Taproot is going to change the look and feel of finance.

    Before the Cambrian explosion,most organisms were relatively simple, composed of individual cells, or small multicellular organisms, occasionally organized into colonies. As the rate of diversification subsequently accelerated, the variety of life became much more complex, and began to resemble that of today. Almost all present-day animal phyla appeared during this period. The fiat system represent what life looked like 3.8 billion years ago. Two domains, bacteria and archea, there was no mitochondria or chloroplasts on Earth to take advantage of the sun.

    Got it?

    Better buy that BTC soon.

    [​IMG]
     
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  5. Jack Kruse

    Jack Kruse Administrator

    Post Cambrian explosion and post Taproot are equivalent events because of their effect on clock management: Everything has become different, and everything we thought would happen changed in an instant. Bitcoin and life gained a powerful set of thermodynamic tools that nothing else had at their respective times. This drove the evolution of life and it certainly will change the rules of finance.

    -Black Swan Mindset
     
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  6. Jack Kruse

    Jack Kruse Administrator

    Energy and information are the currency that the living state uses. The same thing is true with Bitcoin. What is different is how both use them to create a timing mechanism. As soon as cells use artificial light, cells atoms rearrange and time paranoia begins in cells.

    [​IMG]
     
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  7. Jack Kruse

    Jack Kruse Administrator

    Health is proof of work. Health is a process. The process requires energy, computation (high frequency problem solving), and has a set of hardcoded rules (laws of nature) that you can’t cheat. Medicine is fiat based like the stock and bond market. Opt out. Start mining health with Bitcoin and the sun. It improves your timing mechanism.
     
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  8. Jack Kruse

    Jack Kruse Administrator

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  9. Jack Kruse

    Jack Kruse Administrator

    Two things I carry with me daily: Death is certain, but life is not.


    Red light slows time because of what it does to clock periodicity. Cold slows time for the same reason. UV light rebuilds and replenishes time in a complex dance that begins in your eye & skin. Blue light speeds up time and your life is lived like a blue straggler star. Your time burns quick and bright.

    Over supplemented comes from being undereducated about light.


    Light has weight. The shorter its wavelength the more momentum is has. As light travels close to anything with mass, it seems to become heavier because light has momentum. Light moving away from mass allows light to “get lighter” because it loses its purple power and shifts to red. Gravitational lensing is a redshift effect that shows this unique ability. Red light is capable time dilation via its neuro-photobiologic ability to regenerate things with heme proteins in the body but it especially induces time dilation changes in mitochondria. These proteins have specific absorption spectra for sunlight in the UV/IR


    Science is dangerous when all scientists agree and seek consensus, as in the case with modern medicine. Why? Because they are paid with the same centrally backed fiat currency. Fix the money, fix the world.
     
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  10. Jack Kruse

    Jack Kruse Administrator

    Taproot will improve the periodicity of the Bitcoin network's clock timing mechanism. Taproot was built by core BTC developers to improve the Bitcoin timing mechanism. Its added complexity is fuel on the BTC barnfire. In 1948 Claude Shannon paper showed that entropy also inversely tracks with information. This means when the core developers improve the complexity of the clock timing mechanism in ANY way, Bitcoin price will go up. How will this work with Bitcoin's blockchain Uncle Jack?

    Jevons Paradox occurs when technological progress increases the efficiency with which a resource is used, but the rate of consumption of that resource rises due to increasing demand.

    As the Bitcoin protocol continues to advance technologically (SegWit, Schnorr, Taproot, OpCTV, DLCs, assumeutxo, Erlay, etc.), individuals will be able to do more creative things with their UTXOs, which should stoke demand for UTXOs, driving up fees. Once block rewards go aways fees are going to be how miners get paid.


    What Is UTXO? The term UTXO refers to the amount of digital currency someone has left remaining after executing a cryptocurrency transaction such as bitcoin. The letters stand for unspent transaction output. Each bitcoin transaction begins with coins used to balance the ledger.


    We're only talking about technological innovations at the protocol level at this point. We haven't even mentioned how Taproot will improve the second layer tech like the Lightning Network and Liquid, which also increase the utility of UTXOs.

    Why is Taproot like the Cambrian explosion?

    It will drive complexity in the Bitcoin ecosystem.


    As these particular second layer solutions mature and become more useful to bitcoin users, this will also stoke demand for UTXOs that can be locked up and leveraged in more unique ways, driving up fees.

    On top of this, it would be incredibly naive to think that these will be the only second layer technologies that come to market over time. One needs to factor in solutions that haven't even been thought up yet into their long-term Bitcoin security models.

    We haven't even touched on the future dynamics of mining, which provides the long-term security that people are so worried about.

    As oil and gas companies continue to wake up and realize they can use all of the FREE gas they are currently wasting on their fields to mine bitcoin, this will severely reduce the price at which your average miner can mine profitably. An externality that many are blind to at the moment.

    When you combine all of this, it is incredibly stupid to claim with any sense of authority that Bitcoin's long-term security is at risk. The number of things one can do with a UTXO is increasing at an incredible rate. This utility will drive demand, and create a fee market.

    Many critics crypto believe Bitcoin's monetary policy is flawed because its security will depend on a healthy fee market one day.
    Critics are not very forward thinking, in my opinion, because they are ignorant of things they don't know. They chose to stay ignorant usually because they want to pump their ETH bags.


    Their argument revolves around a perceived need for a "minimum viable issuance" [read: constant inflation rate] to incentivize miners to mine the chain in lieu of a sufficient block subsidy. This is some very high quality concern trolling that aims to position Ethereum as having a "superior monetary policy" because no one can truly know what will happen once the block subsidy falls below a certain point.

    Newsflash, bitcoin was invented to provide the world with a scarce information space that can be used as a sound monetary good. A "minimum viable issuance rate" is against the whole ethos of the protocol and the fight for sound money in the Digital Age. Bitcoin is a bold affront to the conventional thinking on monetary policy that has consumed the world for quite some time now. Those who think constant inflation is necessary are thinking anachronistically. The times are changing, freaks. And this is a good thing.


    As the central bankers and politicians of the world continue to erode the confidence of the populaces they rule over, more people will come to value the utility that Bitcoin provides. This will cause more people to use bitcoin and the nature of bitcoin's scarce information space will force a healthy fee market to develop. From these small additions in code, more periodicity comes and as it comes it allows for more Bitcoin complexity.

    The BTC UTXO is a commodity that become more efficient with Taproot activation. Moreover, because it makes BTC more efficient it increases the amount of utility it provides the market and demand for that commodity increases alongside that utility increase. It's a paradox because many would believe that as things become more efficient, people use them less. It isn't true. They will be used more.

    Why specifically does Taproot mimic the Cambrian explosion?


    The Taproot activation enables bitcoin users to leverage the benefits of Schnorr signatures and gives code developers the ability to write create more expressive scripts that can enable more complex transactions.

    This will create a base from which to build better privacy enabling tech in the future, while ushering in material improvements to transaction data efficiency and the functional utility of bitcoin UTXOs. These improvements represent massive jumps that will increase the amount of things a bitcoin UTXO can do. Over time, as developers build out the software necessary to tap into these capabilities, we could see an explosion in on-chain activity as users take advantage of the new utility.

    [​IMG]


    When this situation comes to fruition in the BTC ecosystem, we should expect the fees to send an on-chain transaction to increase. The follow thru effect here is to drive the bottom line of future BTC miners who are working to secure the network by ordering transactions.
     
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  11. Jack Kruse

    Jack Kruse Administrator

    In this way, Bitcoin miners will mimic Mother Nature's thermodynamic pathway of building complexity to make energy and information transfer more efficient too. This is the wand of Bitcoin evolution.
    Bitcoin miners are ALWAYS on a quest like Mother Nature was to find the cheapest energy sources that they possibly can so that they can mine as profitably as possible. This leads miners to far-off places with stranded energy sources that aren't being utilized. Mother Nature was led to the light of our nearest star to get a cell's PoW concept up and running. My thorium blog should stir you now. How about a volcano BTC mine? How about a nuclear power plant? The sun is the solar system's nuclear power plant. A volcano is a nuclear power plant on Earth.

    Up to this point in BTC evolution, BTC miners have leveraged information asymmetry to build out infrastructure and utilize stranded energy to build profitable businesses. As time elapses and the BTC clock timing mechanism improvements continue, energy producers, will begin to wake up to the fact that Bitcoin can help them become more efficient. If politicians really ram green energy down our throats, We The People should use fossil fuels they refuse to use to create value in making BTC.

    This is another way to short governments and the WEF ideas.
     
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  12. Jack Kruse

    Jack Kruse Administrator

    How do I see BTC evolution?

    As Bitcoin's dominance begins to increase and as the power of the global central banking cabal begins to wane, energy producers will begin to replace central banks as the source of money distribution; fundamentally shifting the dynamic of finance and human organization in the process. The source of money will be in oil fields, at nuclear power plants, at solar generation farms, and hydroelectric dams, among other sources. It will no longer be centralized in stuffy boardrooms and manipulated by sociopaths.


    At the Cambrian explosion cells became able to use UV light as never before in evolutionary history. Go look for yourself what became of like 650 million yrs ago. It went from single cell organisms like bacteria and archea to humans.

    That is complexity 101.

    For Bitcoin's evolution I believe it will gain the ability to take wasted energy at ANY source it can be found and turn it into the hardest money that humans have ever encountered has never existed.

    Humans do not look like bacteria. In fact humans enslaved bacteria inside mitochondria while plants did it in chloroplasts to become masters of information and energy. This was endosymbiosis. This process made new complex life look completely different than the old living ecosystems.

    My bet, in the future, the sources of our money will be much more distributed, its distribution will be built on hard (proof of) work and risk, and they will connect the physical and digital worlds in the most efficient way we can currently conceive. This will lead to a financial system that looks very different than the one we are currently subjected to. The same thing that happened to life post Cambrian explosion will happen to BTC as well.

    Why?

    The decentralized network is the archetype in Nature, and as such, because it is so thermodynamically efficient, it will lead to massive structural change.

    [​IMG]
     
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  13. Jack Kruse

    Jack Kruse Administrator

    When you stumble upon a time machine, and learn how to use it, then you can become a trillionaire of seconds or value. This is true in money (BTC), and in health (mitochondria).
     
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  14. Jack Kruse

    Jack Kruse Administrator

    Those who are convinced that the Central Banks of today will exist in the future are wrong in my opinion. Those who think Central Banks will adapt and adopt bitcoin are sorely mistaken. These institutions are being obsoleted in real time and they will be replaced by energy producers. My understanding in biology is my intuition in my educated guess.
     
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  15. Jack Kruse

    Jack Kruse Administrator

    ^^^^This is why organizations like the WEF and BIS want green energy so bad........it creates a reliance on Central bankers.

    It is also why they helped propagate agenda 21 and COVID.

    Reject their Bullshit any time you sense it.
     
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  16. Jack Kruse

    Jack Kruse Administrator

    If you carefully read the Bitcoin white paper, Nakamoto tells us in his own words that Bitcoin is a clock. This fact hides in plain sight.

    Satoshi said, "In this paper, we propose a solution to the double-spending problem using a peer-to-peer distributed timestamp server to generate computational proof of the chronological order of transactions."

    Satoshi Nakamoto (2009)

    Out of the eight references in total, three are about timestamping.
     
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  17. Jack Kruse

    Jack Kruse Administrator

    BIP (Bitcoin Improvement Proposal).

    Here are the main ones that could be integrated into the Bitcoin protocol shortly because of Taproot.

    BIP 118 — SIGHASH_NOINPUT
    In the original Lightning Network whitepaper, Joseph Poon advocated the use of SIGHASH_NOINPUT to be able to create the first commitment transaction that references the txid of the funding transaction without actually signing the funding transaction.

    This document was written before the implementation of Segregated Witness (SegWit). Currently, the Lightning Network, therefore, operates without SIGHASH_NOINPUT as a new hash flag signature. This does not seem to be a necessity at the moment.

    However, Christian Decker has since proposed the eltoo payment channel construction. The latter would get rid of the penalty-based construction that is currently used and thus significantly reduce the overhead of maintaining the channel state since the state becomes symmetric for all participants. In particular, multiparty channels and channel factories would become easier to use.

    Eltoo depends on the implementation of SIGHASH_NOINPUT because the channel state is encoded as a chained list of update transactions that, in case of a protocol violation, are skipped from the point of violation to the current channel state, which requires SIGHASH_NOINPUT.

    All Lightning Network developers agree that Lightning channels would benefit from being built via eltoo. For this to happen, BIP 118 will need to be implemented within the Bitcoin protocol. Like Taproot, it’s not the development itself that is most anticipated, but what it will enable next.

    BIP 119 — OP_CHECKTEMPLATEVERIFY
    BIP 119 aims to incorporate a new opcode that will be used for transaction congestion control and payment channel instantiation primarily. The opcode OP_CHECKTEMPLATEVERIFY is one of the technical approaches being considered for the implementation of covenants.

    Covenants are restrictions on how a corner can be spent beyond key ownership. Covenants can be useful in the construction of smart contracts. They can also be used to further boost the scalability of the Lightning Network in the future.

    Complex to implement and comes with a risk of introducing discriminating fungibility, covenants remain in the draft stage for now and have never really been seriously considered for inclusion in the Bitcoin protocol. One technical approach being considered for covenants is based on the opcode OP_TAPLEAF_UPDATE_VERIFY.

    Drivechains
    If you’re interested in the cryptocurrency world, you’ve probably already heard of the concept of “Sidechains”. This is a feature that has long been proposed to be added to Bitcoin. These are additional blockchains that can be pegged to Bitcoin. Some of these sidechains could be used to test new experimental technologies that Bitcoin has not yet implemented.

    One can think here of a feature similar to zk-SNARKs used by the Zcash privacy coin. This feature offers Zcash users more privacy than Bitcoin currently offers its users. Users could lock up their Bitcoin to use this new coin in a sidechain.

    In addition to the BIP 300 and BIP 301 that he carries, researcher Paul Sztorc has implemented with other developers a working version of this sidechain idea under the name Drivechains.

    Nevertheless, “Drivechains” represents a very controversial idea within the Bitcoin developer community, because some developers say that it could give too much power to the miners of the Bitcoin network. So this feature is not for tomorrow, but it’s good to know that it is one of the ideas that are mentioned from time to time in the Bitcoin world.

    Cross-input signature aggregation
    The activation of Taproot paves the way for a whole bunch of new developments on top of the Bitcoin blockchain. This is the case with cross-input signature aggregation (CISA). Digital signatures are a crucial part of Bitcoin. When a user wants to send Bitcoin, he has to sign his Bitcoin using his private keys to prove that he is the owner of that Bitcoin.

    Taproot introduces Schnorr signatures, which allow multiple signatures to be combined into one, making transactions a little cheaper while boosting scalability.

    Above Taproot, the CISA feature allows signatures in a single transaction to be aggregated. The main consequence of CISA is that it would make CoinJoin transactions cheaper. Used via the Wasabi and Samurai wallets, CoinJoin is a method to boost the privacy of users’ transactions.

    With CISA, CoinJoin transactions would become less expensive, which would encourage more users to use them. This would greatly enhance the privacy of the Bitcoin network. CoinJoin would no longer be something you have to pay more for, but the norm.
     
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  18. Jack Kruse

    Jack Kruse Administrator

    Whoever owns your time creates your tyranny. Medical tyranny is an obscenity. Obscenity is not synonymous with pornography, as most pornography is not legally obscene based on the SCOTUS reviews of 1st Amendment precedence. Medical obscenity is always legally obscene and this is why you mustn't comply with it. Not complying means you reserve your time.

    Cash isn't a safe investment today. It will be taxed by inflation. Inflation is also a clock. It is a clock that measures the flow of time the government steals from taxpayers using monetary policy. Bitcoin is an "all-weather portfolio" by itself because it reserves your time for you.
     
  19. Jack Kruse

    Jack Kruse Administrator

    When you stumble upon a time machine and learn how to use it, then you can become a trillionaire in seconds in your life or value of your money. This is true in money (BTC), and in health (mitochondria).

    Vitamin D3 is also an mtDNA clock that tells about solar exposure and mitochondrial risk to viral disease. D3 will hold up against COVID variants, unlike what the big yellow bird is pushing! "A highly significant, positive correlation was found between lower death rates and a country's proximity to the equator". https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319635/

    Proof Vitamin D is a clock:
    1. https://pubmed.ncbi.nlm.nih.gov/23435299/


    The silencing of the Vitamin D receptor (VDR) in different healthy, non-transformed, and cancer cells initially decreased cell growth and modulated the cell cycle. Research now demonstrates that, in silenced cells, increased respiratory activity is associated with elevated reactive oxygen species (ROS) production and increased aging and disease = low NAD+ = lowered delta psi = lowered ox/phos = higher heteroplasmy
    2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032156/


    When your vitamin D is lowered, your ability to create new engines via autophagy in mitochondria is altered. This is why disease and death come earlier and sooner. With COVID this was exceptionally true. Mitochondrial dysfunction leads to an impaired autophagic response is associated with mortality in sepsis cases. COVID diseases are one such example.
    Vitamin D is shown to upregulate NOD2 which is linked to the efficiency of autophagy. This explains why low vitamin D levels are linked to poor sleep and a higher risk of disease. Autophagy regulates innate immunity via inhibition of mitochondrial DNA (mtDNA) release via by the inflammasome. Circulating plasma mt-DNA is a robust predictor of mortality in ICU patients. I look for this link in every KLC client I see. The peripheral smear, NO testing, and MRIs give huge insights that their 25(OH)D levels are associated with circulating mtDNA levels. This correlates well with their disease risk and should direct their treatment.
    3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4798011/

    Think about the November 2021 Q & A I did and the first question I was asked about NO, Vitamin D, and blood pressure. How did I answer it?

    What should you the tribe have thought about? The lessons on clock management I have been teaching you about for 15 years.

    All land based vertebrates express the proopiomelanocortin protein (POMC is a clock too) that gives rise to adrenocorticotropic hormone (ACTH is a clock too) which then stimulates the secretion of glucocorticoids. ACTH has long been closely associated with other signaling molecules, such as CRH, vasopressin, biogenic amines (epinephrine and norepinephrine), steroids such as cortisol and aldosterone, cytokines, such as IL-1β, and nitric oxide. All of these are clocks for cells as well. All of these substances are crucial to adaptation to stressors in your environment. So if they are defective, where you choose to live is deforming space and time around you to steal your time. It is remarkable that the gene DNA sequences for these molecules have not only been conserved over hundreds of millions of years in mammals but also continue to serve closely related adaptive functions of modern humans I see at the FARM. I hope some of them see why I say what I do to them when we do monthly consults.

    1,25-dihydroxyvitamin D (1,25(OH)2D3) is known to suppress NF-κB activity to decrease inflammation and protect mitochondrial DNA from higher heteroplasmy. Vitamin D up-regulates IkappaBalpha levels by increasing mRNA stability and decreasing IkappaBalpha phosphorylation. The increase in IkappaBalpha levels reduces the nuclear translocation of NFkappaB and thereby downgrades its activity. Since NFkappaB is a major transcription factor of inflammatory mediators. NF-κB was incorporated into this ancient signaling pathway more than 420 million years ago (200 mya the Cambrian explosion), and has been shown to play independent roles in vertebrate and insect lineages. This tells us that Vitamin D improved the periodicity of the clock timing mechanisms in living things to increase their ability to defend from inflammation using their new innate immune systems. Why? Life began in the oceans. UV light from the sun cannot penetrate ocean water well. What happened when ocean life became land life with amphibians? Life adapted by using sunlight to create vitamin D from its surface proteins.
    Following the Cambrian explosion, about 450 million years ago, when multicellular organisms—originally formed in water environments—life slowly began to colonized the land physiological homeostatic changes emerged because of sunlight's difference in water and land to allow survival. These corrective changes were essential to mammalian species evolution and emerged to solve a frequent conflict between environmental changes and preservation of the individual allowing survival and, hence, reproduction. These alterations permitted progression to future generations. This is how clock management leads to complexity.

    Stop think of food as hormone information, or as a metabolic fuel. Food is an electromagnetic barcode that tells your mtDNA how time should flow in the space you live in. It is how you experience time travel on Earth. Think of the Epi-paleo template as human jet fuel for the human nervous system because it increases the periodicity of your clock management.

    We also know today, that epigenetic modifications in mtDNA usually involves activation of NF kappa beta at some point in the biochemical pathways of life. This tells us circadian timing is key to how we transform and use energy to navigate our environments.
    The activity of 1,25(OH)2D3 is mediated by the vitamin D receptor (VDR), a member of the nuclear receptor superfamily. The classic VDR action model is that upon 1,25(OH)2D3 activation, the VDR moves into the nucleus and heterodimerizes with the retinoid X receptor (Vitamin A) from Brain Gut 5 series), which, together, bind to the vitamin D response element (VDRE) in the target gene promoter to up-regulate gene transcription to create the biological effect of time travel. Sunlight lowers inflammation and this change in mass in our cells. As mass changes, cells space/time around them deform to slow time and you live longer.
    4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3707648/
     
  20. Jack Kruse

    Jack Kruse Administrator

    Understanding clock management is the job of the Black Swan Mitochondriacs.

    So in my recent private webinar series I taught my farm members who attended this event about how the loss of negative feedback control in coupled biologic systems is the sentinel event for aging and disease generation. Moreover, I showed them what happens when you lose it in one side of the coupled time event.

    There I used predator or prey to make the point. If you alter the balance of predator or prey the result is always the EXTINCTION of both animals.

    I have taught you that in aging and neolithic disease generation that NAD+ becomes altered in relationship to NADH in mitochondria = a bad clock. The chronic loss of NAD+ is the critical sign of a loss of negative feedback control of the ubiquitin cycle = proxy for excessive protein synthesis = more growth. Growth is expensive to mitochondria. Therefore we do not want it if we don't need it. Altered space/time relations always lead to bad protein synthesis issue. Think of my analogies with Home Depot when arrival and delivery's come on the same day. Not bueno.

    Now for how this scales to your molecular circadian clock and your peripheral clock genes (CCG's) is the key to being a good clock manager.

    The current model of the mammalian circadian clock includes two interlocking transcription-translation feedback loops comprised of several so-called “clock” genes and their protein products, which ultimately regulate the transcription of “clock-controlled” genes. These feedback loops consist of positive and negative components. The positive components include the basic helix-loop-helix-PAS domain transcription factors, CLOCK and BMAL1. These transcription factors heterodimerize, translocate from the cytosol to the nucleus, and bind to circadian E-box promoter elements that enhance the transcription of genes encoding the negative components PERIOD 1 & 2 and CRYPTOCHROME 1 & 2.

    The CRYPTOCHROME and PERIOD proteins feedback inhibit the transcription of the Cryptochrome and Period genes by blocking CLOCK/BMAL1-mediated trans-activation. All these gears are used to signal a deformation in the space/time continuum you live in for cells. Amazing how complex cells became after the Cambrian explosion, no? Can you imagine what Bitcoin will look like 25-50 years from now with respect to your money or value?


    The second feedback loop involves the trans-activation of the Rev-Erbα and Rora genes by CLOCK/BMAL1. The protein products of these genes compete for binding to RRE elements in the Bmal1 promoter, driving a daily rhythm of Bmal1 transcription and closing the second feedback loop. Rhythmic expression (HERE IS THAT PERIODICITY ISSUE) of these clock gene products produces circadian clock outputs by regulating transcription of clock-controlled genes (CCGs).

    What did I say about ideal clock management above?

    All clocks are flow meters for entropy. Anything that improves the PERIODICITY of the clock improves its ability to tell how time is flowing around you.

    Taproot will improve the periodicity of the Bitcoin network's clock timing mechanism so in a way it mimics what Vitamin D for cells.. Vitamin D was a Taproot 420 million years ago for new life moving from the sea to land. In 1948 Claude Shannon paper showed that entropy also inversely tracks with information. This means when the feedback loops in cells improve the complexity of the clock timing mechanism in ANY way, life can survive on and because cells have obtained a way to deform the space time around them to harness time in their favor. Healthspan predicts longevity and species survival. This is how clock management operates in life.

    Back to cell clocks: At least some of these CCGs, including aanat, is the gene encoding the penultimate enzyme in the melatonin biosynthetic pathway. Why is this big? Melatonin controls the process of mitochondrial recycling or replacement. It controls the clock function of mtDNA!!!!

    All of the CCGs in the melatonin pathway also contain circadian E boxes, which have a core nucleotide sequence of CACGTG and are activated rhythmically by CLOCK/BMAL1. This links them to the PERIODICITY OF LIGHT AND DARK!!!!!

    Post-translational regulation, including phosphorylation, acetylation, ubiquitinatation, sumoylation and proteasomal degradation are also important in the regulatory mechanisms generating the circadian oscillation.

    Once you SCN goes haywire it is a matter of time before your circadian clock genes in tissues the SCN controls goes haywire. What will be the ultimate result? EXTINCTION of both sides of the circadian coupling and diseases like HBP, cancer, and poor sleep result. My PSA for the day is done. It is all about clock management.

    CITES

    1. Herzog ED. Neurons and networks in daily rhythms. Nat Rev Neurosci. 2007;8:790–802.
    2. Yamazaki S, Numano R, Abe M, Hida A, Takahashi R, et al. Resetting central and peripheral circadian oscillators in transgenic rats. Science. 2000;288:682–685.
    3. Ko CH, Takahashi JC. Molecular components of the mammalian circadian clock. Hum Mol Genet. 2006;2:R271–277.
    4. Munoz E, Baler R. The circadian E-box: when perfect is not good enough. Chronobiol Int. 2003;20:371–88.
    5. Gatfield D, Schibler U. Proteasomes keep the circadian clock ticking. Science. 2007;316:1135–1136.
     
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