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Post Finasteride ED problem

Discussion in 'Meet and Greet' started by bugrahan, Sep 30, 2020.

  1. DrEttinger

    DrEttinger Choice, the only thing we control


    FYI ONLY! This is not a recommendation. I like it though :)

    Cliff Note version. You know me. In my quest to find every possible epigenetic hack to optimize human biology, I researched and put this together, and have put it to the test. 1 tsp of Allantoin, 1 Tbsp of Beet Root Powder, daily sun while trail running or surfing = increased NO, testosterone, 4 am erection and ejaculate.

    Allantoin Alleviates Male Sexual Dysfunction in Diabetic Rats through Augmenting the Level of Testosterone

    Beet Powder
    JanSz, John Schumacher and Pablo like this.
  2. Pablo

    Pablo New Member

    @John Schumacher a lot of things there!! :)

    Next week I´ll have home this photobiomodulation device: https://emr-tek.com/products/firewave
    No flicker and seems good for low price

    I´ll try the behind scrotum thing. In the past I´ve focused on genitals "from the front", so to speak. But it seems interesting to try the light behind scrotum, basically between balls and anus, especially since finasteride has effects on the prostate. I´m thinking right now on the best position... a bit of acrobatics will be needed!!
    John Schumacher likes this.
  3. JanSz

    JanSz Gold

    No Obligation, 15 Minute, Phone Consultation*
    714-639-4360 or info (@) advancedhealing (.com)
    I’ve helped people locally and around the world
    or anybody else.

    About Red Beet Root Powder.
    It tastes ugly. I am using it after my last consultation with you.

    I was raised on borsht. It is made from (fermented) red beets roots.
    Fermentation happens when you take sliced beetroots add water, add a slice of bread (and also a good amount of garlic).
    I am doing (hopefully) one better.
    I run beets thru the juicer. Take juice only no water, add bread and garlic.
    After about a week juice is fermented and most importantly it is delicious.
    Would this kind of juice do the same work as a powder from red beets?

    Beet roots are cheap. $0.75 per pound.
    At this moment I just got 2 gallons of freshly fermented juice.


    Last edited: Oct 17, 2020
    John Schumacher likes this.
  4. JanSz

    JanSz Gold

    I have this light. Watch out, it operates at high temperature.
    Pablo and John Schumacher like this.
  5. Nice product -> 3 watt diodes are the best LlyEDs current; depending on the quality of soldering, the flicker can be minimized. It looks like its dimensions are around 12 inches square and 4 inches wide.
    I would stand, straddled over it, and let it my underside all day long, while working in my home office.
    Products like these are investments -> good for you!
    Pablo and JanSz like this.
  6. Thank you for the advice.
    Do you use an external fan to keep things cooler?
    JanSz likes this.
  7. Thank you for the source reference links.
    JanSz likes this.
  8. Thank you @DrEttinger
  9. JanSz

    JanSz Gold

    IIRC that red light have a nod from Jack. It is low or no flicker.
    No I keep it 3 feet away from my head.
    I also have 3 Exo Tera 160W lizard lamps there.
    John Schumacher and Pablo like this.
  10. JanSz

    JanSz Gold


    Allantoin is a major metabolic intermediate in most organisms including animals, plants and bacteria.

    Allantoin has been shown to improve insulin resistance when administered to rats and increased lifespan when administered to the nematode worm

    Allantoin is present in botanical extracts of the comfrey plant and in the urine of most mammals.

    a soft lotion with 5% allantoin ameliorates the wound healing process,

    It is frequently present in toothpaste, mouthwash, and other oral hygiene products, in shampoos, lipsticks, anti-acne products, sun care products,

    Biomarker of oxidative stress
    Since uric acid is the end product of the purine metabolism in humans, only non-enzymatic processes with reactive oxygen species will give rise to allantoin, which is thus a suitable biomarker to measure oxidative stress in chronic illnesses and senescence.[21][22]

    How to measure allatonin in the human body?
    What it means when it is high,
    what does it mean when it is low?


    When allatonin is given to rats it improves their insulin resistance.
    Should we expect the same in humans? Remember that they do not have metabolic pathway mentioned in the picture above.


    John Schumacher likes this.
  11. JanSz

    JanSz Gold

    @John Schumacher
    Post Finasteride ED problem

    While searching for reasons and remedies for Post Finasteride ED problem
    it may possibly help in overall understanding reviewing my situation.

    I have been thru using
    Overal for close to 10 years possibly more.
    Propecia I think when my hair started thinning.
    Propecia was quickly replaced by Proscar and Avodart per my urologist scripts when trying to slow down my prostate growth.

    Overall that use has not affected my ability to have erections.
    But possibly I am affected anyhow since my sensitivity is much lower than in heydays, and it is really hard to get an orgasm.

    Pablo and John Schumacher like this.
  12. @DrEttinger & @JanSz -> I must confess; I have a mental handicap; When studying medical “sciences”, I have found it not just primitive but fundamentally lacking. Medical study, including its alternative i.e. integrated medicine, has been a prosecute of minimizing or eliminating the symptom response as the primary outcome of intervention. What is not understood is what makes a functional system for building optimal human health. Our understanding in chemistry and the periodic table are based on laboratory finds of what we think are complex synthesis based on what we think had been fundamental experimental outcomes. Cellular biology has tried to the do the same; placing a cell in a saline petri dish, determining cellular phase transitions. We have advanced a bit by placing dyes into the mixture and used molecular fluorescent microscopes to “see” the reaction. When the prosecuted objective is identification of disease states and the influence chemical “interventions” have along each stage of the disease process, we at best may find ways to meet the medical objective -> minimizing or eliminating the symptomatic response.

    My handicap is that I too am limited to this “science” -> a dysfunctional paradigm and view at human function.

    As you know, there are many others before us who prosecuted alternative methods for intervention to symptom outcome reduction, who are now die. Example: Charles Poliquin, strength coach inventor of BioSignature Modulation, had a supplement for everything, tying symptoms and processes together, like methylation, thyroid functioning, sexual hormone management, etc. Dr. Jack Kruse warned him to stop working out inside. How did he suddenly die at 57? -> Vascular Endothelia Dysfunction.

    Despite my handicap, my prosecute is in the identification of two things -> 1) How does optimal human health function? 2) How, without creating a different issue, do we best restore dysfunction?

    There are hundreds of ways available to "improve a situation" by a simple search. i.e. pumps - https://restorecanhelp.com/product/restore-ed-pump/ , injections, etc.

    My attention, for these two gentlemen, is on how best do we restore what seems to be two dysfunctions: vascular health and hormone regulation.
    Last edited: Oct 17, 2020
    Pablo and JanSz like this.
  13. DrEttinger

    DrEttinger Choice, the only thing we control

    It is strange how elevated allantoin urine metabolite can = endogenous oxidative stress, but exogenous supplementation can = such amazing benefits.

    I will always defer to evolutionary biology and/or the creation theory in the book of Genesis. Every answer is there. That said, supplementing back in what we can use to become superhuman, is an amazing adventure.
    John Schumacher and JanSz like this.
  14. Pablo

    Pablo New Member

    @John Schumacher

    I actually own one of those "dick pumps", though only used it a few times, a couple years ago: https://bathmatedirect.com/products/bathmate-hercules

    Yeah, there are many random ways to improve erection dysfunction out there. Actually there is a whole community dedicated to exercise their dicks for getting them bigger, more rigid or both. https://www.pegym.com/forums/forum.php

    And they seem to have some good results with different exercises.

    Actually this other guy has invented a free protocol with different exercises which people are saying it is amazing, curing their erectile dysfunction and/or growing their dicks bigger.

    I did this for a while and I think it works in the sense that I noticed my member more "vascular", more blood into the vessels, but not necesarily more rigid/better erections. Maybe I just didn´t do it enough time, but I really sense people with PFS need to fix their androgen receptors/hormones first.

    Actually I also went last year to an urologist in order to have "shock waves" in my dick, but the guy (which I didn´t trust much but was the only provider around) said, after analizing my dick with some scaner, that blood flow was good. He insisted I didn´t need that, but also didn´t offer any other solution neither seemed to know what DHT was. I didn´t show again to any doc, and began focusing more on Jack´s protocols.



    Dr. Jack Kruse
    8 de diciembre de 2016 ·
    "Question asked by a member: In the finasteride forum, recently a fellow former user showed up stating he was diagnosed with PAIS, after finasteride usage. I think he ran what seemed like a Reverse Transcription Polymerase Chain Reaction exam on his androgen receptor RNA and turns out the resulting DNA was that of a mutant Androgen Receptor in Exon1. Exon1 encodes the ligand binding domain and the dimer binding domain of the receptor.

    Such diagnostic would make sense seeing as everyone has some degree of impairment of androgenic effects in the body. So this would mean that post finasteride users could suffer from a form of Androgen Insensitivity Syndrome, either MAIS or PAIS.

    We know by studies done on the drug that it isn't mutagenic. So I am assuming it is safe to say that there is a change at the epigenetic level, or am I reading wrong into this?

    I've been reading and found out that the Heat Shock Protein 90 , HSP-90, is responsible to the ligand binding affinity to the ligand elements of the receptor, in this case i'm interested in DHT as most of us can create muscle no problem, but the androgen effects are just not there.

    I would like to know if @Jack Kruse talks about Heat Shock Proteins, particularly HSP90 in his blogs? Is this HSP affected by cold exposure? Could the induction of HSP90 be contributing to the optimal hormones after cold adaptation? MY ANSWER: Ubiquitin is the key heat shock protein and this is how receptors are modified.........when the redox is lowered at the same time as it is in this scenario then protein folding is altered. That is covered in the OSF series of how it happens. when the protein side chains are changed the protein function changes. Remember that the first two folds are controlled by the DNA code. The last two are controlled by the cells/tissue redox potential. As the last two change this affects the Faraday effect of the side chains to work optically and magnetically properly. Here is the good news..........the DNA is rarely changed in this scenario. So if you fix the redox potential then you can re-mark the defective receptor with ubiquitin and get rid of it...........and then the DNA make new good receptor.........and the cell redox is improved so the last two folds occur properly...........and you can recover. What is the key to rebuilding the redox of these tissues?

    Sunlight, water, and magnetic effects from grounding to direct the DNA to do it right by having more energy available in the cell. http://www.oecd.org/chemicalsafety/testing/37880949.pdf"
    John Schumacher likes this.
  15. JanSz

    JanSz Gold


    Are you able to open the file you posted there?
    If you do, scan each page and post it here.
    Make sure to post all pages.
  16. I'm impressed - well done @Pablo
    Energy in Motion -> How to we raise the potential net negative charge of our cells such that their redox quotient is sufficient to "reproduce" successfully?
    And why the hell don't nutraceuticals just fix the problem, if in the chemical pietri dish it seems to work?
    However, nutraceuticals do produce results. It's a fun and challenging journey.
    Last edited: Oct 19, 2020
  17. JanSz

    JanSz Gold

    Vascular Abnormalities <- is a big deal.
    Cialis=Tadalafil ---- I use half of 20mg pill every day for more years than I can count

    Serrapeptase -I use 3 daily


    Fibrinolytic and Proteolytic Enzymes

    Find Lumbrokinase, Nattokinase and Serrapeptidase on Amazon

    John Schumacher likes this.
  18. @bugrahan @Pablo @DrEttinger @JanSz - Gentlemen, Let us pick up where we left off:

    We are focusing on three elements for increasing your cellular "Energy" quotient

    • Photoelectric force
    • Biochemical-electrical force / signaling
    • Piezoelectric force
    I have briefed photoelectric force; now let’s move our attention to Biochemical-electrical force or signaling.

    The selection criterion of a nutraceutical will include:

    • Does it energize the cells?
    • Does it improved proliferation?
    • Does it inhibit inflammation?
    • Is it readily available, local to every cell no matter where the cell(s) maybe located in the human body?

    Since our focus is Post Finasteride Syndrome, hypotrophic blood vessels need to be on our agenda. Thus, may I draw your attention to prostaglandins.

    When addressing vascular health, Dr. Jack Kruse wrote about dopamine and nitric oxide - https://optimalklubs.com/cpc-28-is-obstructive-sleep-apnea-protective/. However, he didn’t tell you about prostaglandin-endoperoxide synthase (PTGS), which is an enzyme that is responsible for formation of prostandoids.

    Let’s compare eNOS to PTGS –
    Nitric oxide is a potent vasodilator, reduces platelet aggregation and leukocyte adhesion, and quenches oxygen-derived free radicals. The actions of NO are mediated by increasing levels of cyclic guanosine monophosphate (cGMP), which is derived from guanosine triphosphate (GPT) in target cells, in contrast to prostaglandin, which act by increasing intracellular cyclic adenosine monophosphate (cAMP), which is a derivative of adenosine triphosphate (ATP). https://www.annalsthoracicsurgery.org/article/0003-4975(96)00498-5/pdf

    Prostaglandins are generated from arachidonate by the action of cyclooxygenase (COX) isoenzymes.
    https://www.yourhormones.info/hormones/prostaglandins/ - Unlike most hormones, which are produced by glands and transported in the bloodstream to act on distant areas of the body, the prostaglandins are produced at the site where they are needed. Prostaglandins are produced in nearly all cells and are part of the body’s way of dealing with injury and illness.
    Prostaglandins act as signals to control several different processes depending on the part of the body in which they are made. Prostaglandins are made at sites of tissue damage or infection, where they cause inflammation, pain and fever as part of the healing process. When a blood vessel is injured, a prostaglandin called thromboxane stimulates the formation of a blood clot to try to heal the damage; it also causes the muscle in the blood vessel wall to contract (causing the blood vessel to narrow) to try to prevent blood loss. Another prostaglandin called prostacyclin has the opposite effect to thromboxane, reducing blood clotting and removing any clots that are no longer needed; it also causes the muscle in the blood vessel wall to relax, so that the vessel dilates. The opposing effects that thromboxane and prostacyclin have on the width of blood vessels can control the amount of blood flow and regulate response to injury and inflammation.

    Ok – so what are we comparing:

    • eNOS consumes ATP to create cAMP which was derived from GPT which was derived from cGMP.
    • PTGS creates ATP for the surrounding cells through cyclooxygenase (COX) isoenzymes <- explanation to come.

    There are four principal bioactive prostaglandins generated in vivo: prostaglandin (PG) E2 (PGE2), prostacyclin (PGI2), prostaglandin D2 (PGD2) and prostaglandin F2α (PGF2α). They are ubiquitously produced – usually each cell type generates one or two dominant products - and act as autacrine and paracrine lipid mediators to maintain local homeostasis in the body. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3081099/

    Prostanoid biosynthesis pathway -> The enzyme phospholipase A2 (PLA2) hydrolyzes arachidonic acid (AA) from the phospholipids of the extracellular membrane. Arachidonic acid is modified by the cyclooxygenase (COX) enzymes (COX-1 and COX-2) to form the intermediate precursor prostaglandin G2 (PGG2) via the addition of two oxygen (O2) molecules. Prostaglandin H2 (PGH2) is subsequently formed by the actions of peroxidase enzyme, which releases a single oxygen (O2) molecule. Prostaglandin E2 is a potent anti-inflammatory agent capable of inhibiting neutrophil chemotaxis, aggregation, and superoxide production, while thromboxane A2 is a proinflammatory mediator that activates platelet aggregation and clotting.

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3081099/ - Prostaglandin production (Figure above) depends on the activity of prostaglandin G/H synthases, colloquially known as COXs, bifunctional enzymes that contain both cyclooxygenase and peroxidase activity and which exist as distinct isoforms referred to as COX-1 and COX-2 (2). COX-1, expressed constitutively in most cells, is the dominant source of prostanoids that subserve housekeeping functions, such as gastric epithelial cytoprotection and homeostasis. COX-2, induced by inflammatory stimuli, hormones and growth factors, is the more important source of prostanoid formation in inflammation and in proliferative diseases, such as cancer. However, both enzymes contribute to the generation of autoregulatory and homeostatic prostanoids, and both can contribute to prostanoid release during inflammation.

    Bottomline -> Prostacyclin is released by vascular endothelia cells is a pathophysiological mediator providing both proliferation and anti-inflammatory functions. It meets the criterion of a targeted nutraceutical:

    • It energizes all the cells it come in contact with
    • It improves proliferation of cells
    • It inhibits inflammation in and around cells
    • It is readily available, local to every cell no matter where the cell(s) maybe located in the human body
    Nice, now what? -> Prostaglandin-endoperoxide synthase (PTGS) is an enzyme that is responsible for formation of prostandoids, such as prostacyclin from arachidonic acid.

    As mentioned above, cyclooxygenase (COX) enzymes are how PTGS make their ATP. So how do we upregulate COX? -> There are naturally occurring bioflavonoids are up to 29 times more efficacious in stimulating the COX activity. Myricetin as an example, its stimulatory effect on COX -mediated formation of various AA metabolites, such as PGF2a, PGE2, PGD2, and 12-HHT. Myricetin (at 200mM) had the highest efficacy, increasing the formation of PGF2a, PGE2 ,PGD2, and 12-HHT by 549%, 924%, 677%,and 680%, respectively. In addition, bio-flavonoids have been reported to inhibit the LOX activity. This inhibitory effect has often been used as a mechanistic explanation for their chemopreventive effect against certain types of cancer. https://www.jlr.org/content/49/12/2557.full.pdf We also know that - Endothelium-mediated control of vascular tone: COX-1 and COX-2 products - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195913/ Prostacyclin: A Vascular Mediator is stimulated by myricetin - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1566141/

    Ok, myricetin stimulates prostacyclin which is a prostandoid. What do we know about myricetin? It has been studied as “A Dietary Molecule with Diverse Biological Activities” - A compound exhibits a wide range of activities that include strong anti-oxidant, anticancer, antidiabetic and anti-inflammatory activities as well as protects against Parkinson’s and Alzheimer’s. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772053/

    Nice, now how do I get my hands on this stuff? -> Dihydromyricetin is a form of myricetin. What do we know about it? Dihydromyricetin improves glucose and lipid metabolism and exerts anti-inflammatory effects in nonalcoholic fatty liver disease: A randomized controlled trial - https://www.sciencedirect.com/science/article/abs/pii/S1043661815000936 (150 mg) twice daily for three months Ampelopsis grossedentata, a medicinal and edible plant, has been widely used in China for hundreds of years, and dihydromyricetin is the main active ingredient.

    Recent Update on the Pharmacological Effects and Mechanisms of Dihydromyricetin - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209623/ The detailed mechanisms may be associated with several different molecules involved in cellular apoptosis, oxidative stress, and inflammation, such as AMP-activated protein kinase (AMPK), mitogen-activated protein kinase (MAPK), protein kinase B (Akt), nuclear factor-κB (NF-κB), nuclear factor E2-related factor 2 (Nrf2), ATP-binding cassette transporter A1 (ABCA1), peroxisome proliferator-activated receptor-γ (PPARγ)

    Different pharmacological effects of DMY. DMY exhibits powerful cardioprotection on atherosclerosis, myocardial ischemia reperfusion (I/R) injury, myocardial remodeling, adriamycin-induced cardiotoxicity, arrhythmia, pulmonary artery hypertension (PAH) and diabetic cardiomyopathy (DCM). DMY protects against liver I/R injury, chemical liver injury, alcoholic liver disease (ALD), non-alcoholic fatty liver disease (NAFLD), hepatic insulin resistance and acute liver failure. DMY has been shown to protect against Alzheimer disease (AD), Parkinson’s disease (PD), depressive disorder, hypoxia injury and fetal alcohol exposure induced brain injury. DMY is also indicated to suppress hepatocellular carcinoma (HCC), non-small cell lung cancer (NSCLC), osteosarcoma, ovarian cancer, acute promyelocytic leukemia (APL) and gastric cancer. DMY is beneficial for skin depigmenting, melanoma and UVA-induced skin damage. And DMY was applied for the treatment of anti-bacterial infection, osteoporosis, asthma, kidney injury, nephrotoxicity and so on.

    Doesage: As with all studies, the researches are insane. In a hypertension studies, the oral doses of 100 and 300 mg myricetin/kg body weight (80 kg = 175 lb). So 80 times 100 -> 8 grams. And by the way - I do not recommend this dosage!

    As with all nutraceuticals, please start slow and titrate up. May I suggest two to three 300mg capsules of dihydromyricetin twice daily without food. Where to purchase - https://www.amazon.com/gp/product/B0767N448Q/ref=ppx_yo_dt_b_asin_title_o03_s00

    Grandpa John

    Last edited: Oct 21, 2020
    JanSz likes this.
  19. JanSz

    JanSz Gold

    The prostaglandins are a group of physiologically active lipid compounds called eicosanoids having diverse hormone-like effects in animals. Prostaglandins have been found in almost every tissue in humans and other animals. They are derived enzymatically from the fatty acid arachidonic acid.

    Following @Jack Kruse
    one works toward increasing DHA (that already may be very high).

    Increased DHA suppresses AA (arachidonic acid).
    That is my beef with Jack since before he made this site available.
    I asked him about this many times, at first when he was posting on Marks Daily Apple.

    Jack referred me to Patricia Kane.
    the reason I am asking these questions is that Patricia Kane has made me aware of this situation before I posed my questions to Jack.

    So, it looks like any eventual progress with PFS and many oter problems
    be made without at least basic fatty acid analysis
    but better when
    using Krieger laboratory.

    Last edited: Oct 21, 2020
    John Schumacher likes this.
  20. It is my understanding that Arachidonic acid is found mainly in the fatty parts of meats and fish (largely red meat).
    I have not covered it yet on this thread - Meals containing fatty bone broth with the heart from pasture raised grazing animals should be part of a well balanced diet. The bone marrow is one of the most important ingredients of a good broth.
    Dr. Jack Kruse has a recipe for Bone Broth in his “Optimized Cooking” book. This broth is then used in a soup, like: French Onion Soup. I look forward to covering these topics.

    In your opinion, should someone supplement arachidonic acid if they also supplement with DHA?

    As you know, eicosanoids are under attack by our current medical paradigm. Most all seek and rescue functions of our body (neutrophils, eicosanoids, etc., etc., etc.) are viewed as “bad” innate functions out of control and must be medically suppressed with NSAIDs, anti-immune drugs, etc.

    I believe this approach is barbaric and shows the primitive thought process of scientists’ seeking funding from the next pharmaceutical investor.

    I hate pain just like anyone else and I have used “pain medicine” because the “ice therapy” just didn’t cut it. However, I’m under the believe that the body needs energy for the cells to heal. When we deliberately robe our cells of this reparative net negative potential, then healing may never come.
    Last edited: Oct 21, 2020
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