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Possible Nonclassic Congenital Adrenal Hyperplasia ?

Discussion in 'Optimal Labs' started by Chipdouglas, May 7, 2019.

  1. Chipdouglas

    Chipdouglas New Member

    We see eye to eye about PRL and elevated progesterone.

    What you shared about those two subtypes of DHT is very interesting. This is new to me.

    Assuming one has higher 5b-DHT relative to the 5a-DHT subtype, what can one do to shift the balance towards 5a-DHT ?
     
  2. Chipdouglas

    Chipdouglas New Member

    Regarding the sub-optimal PRL hypothesis. PRL was done thrice ; one test came back below mid-range, another was low and one was high normal. So the question is : is my PRL sub-optimal most of the time ? In light of what I wrote below, it seems the answer is : yes.

    In order to test the above, I bought a vitamin E supplement containing all 8 isomers (i.e. AOR brand). Without going in much details, I'm glad to report it made a significant difference. Libido went up to a noticeable extent and both the refractory period and erectile function markedly improved - these last cannot be ignored.

    Now, a few years ago a study came out linking vitamin e supplements with increased all-cause mortality - I'm sure you heard about it then : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1479533/

    However, a subsequent and more recent meta-analysis shows no such risk : https://www.ncbi.nlm.nih.gov/pubmed/25398301

    I brought this up because I consistently want to weigh the risk to benefit ratio of anything I plan on taking long term.
     
  3. JanSz

    JanSz Gold

    First I have learned about different DHTs is from Jonathan Wright site.
    upload_2019-5-13_10-41-7.png

    time flies
    upload_2019-5-13_10-41-43.png

    Or rather from his tahoma clinic web page.
    http://tahomaclinic.com/
    https://www.meridianvalleylab.com/
    https://www.meridianvalleylab.com/resources/

    I have put lots of info on that on dr John Crisler board
    http://www.allthingsmale.com/
    now not working

    I just noted this there:
    As a patient, what tests may I order myself?
    Any test can be ordered by a patient except for 24-hour and dried urine hormone tests.
    That sucks. Previously you could do it your self.
    Back to DUTCHtest.


    Ok, way back then, dr Wright had some ideas on that topic.

    As it is now, from what I remember, you would try Proscar or Avodart.
    Avodart is stronger and (supposedly) last longer (months), so go easy with it.
    Some are saying that Avodart inhibits 5ar and 5bR, other are saying something else.
    I am not really clear on Avodart.
    Proscar is (supposedly) only 5aR inhibitor.

    Anyhow, to anybody who reads this.
    If you are not high on DHT and use proscar, welcome to PFS, (PostFinasteideSyndrome).

    And many guys fail to that trap because for hair loss they used lighter version of proscar ---->Propecia.
    ..............

    There is another place with a trap.
    One can pretty much erase his steroid hormones by using
    ketoconazole
    friendly shampoo.

    steroidogenesis inhibitor, also known as a steroid biosynthesis inhibitor,
    ...
    Cholesterol synthesis inhibitors

    https://en.wikipedia.org/wiki/Steroidogenesis_inhibitor
     
    Last edited: May 13, 2019
    Chipdouglas likes this.
  4. JanSz

    JanSz Gold

  5. JanSz

    JanSz Gold

    Chipdouglas likes this.
  6. Chipdouglas

    Chipdouglas New Member

    Dr. Jonathan Wright is a top-tier MD. I can recall Dr. Romeo B. Mariano thinking highly of him.

    In other news, I emailed Precision Analytical inc. Their tests are available to Canadian residents.
     
  7. JanSz

    JanSz Gold

    Circadian Rhythm
    DUTCH
    Spectracell Micronutrient analysis
    fasting insulin
    homocysteine
    vit D
    Fatty acids analysis(c8-c26)

    lots of lugols and just right selenium (per spectracell)

    this are the basics
    .....
    after you good with above
    start asking questions

    ..
     
    drezy likes this.
  8. Chipdouglas

    Chipdouglas New Member

    JanSz likes this.
  9. JanSz

    JanSz Gold

    This paper describes problem.
    It does not propose solution.
    If this paper is about you,
    try the best thing that we have around here.
    Get @Jack Kruse involved.

    First make thread in Ask Jack.
    Attach link to that paper there, (and very very short) description of what you are going thru (or better, what bothers you the most).
    Ask him for help,
    or possibly first ask him if he knows of ways to help you.

    ....................................................................................................
    Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21-OHD)

    ..
    https://en.wikipedia.org/wiki/Congenital_adrenal_hyperplasia_due_to_21-hydroxylase_deficiency

    Long-term_management_of_CAH
    https://en.wikipedia.org/wiki/Conge...xylase_deficiency#Long-term_management_of_CAH
    ..
     
    Last edited: May 15, 2019
    Chipdouglas likes this.
  10. Chipdouglas

    Chipdouglas New Member

    JanSz :

    The research paper I posted does describe me (i.e. wrt OCD - I don't have a textbook case of OCD, but I clearly am obsessive - in addition to lifelong issues coping with stressors, which has nearly destroyed quality of life). So that paper, backs up what that MD diagnosed me with to a reasonable extent. While it doesn't provide any solution per se, I was happy to find a research paper making use of 24-hour UFC, in addition to describing my case almost to a T - or at least accounting for a very significant part of my case.

    To me, understanding my case or what's going on under the hood is just as important as solutions. That is, it's part and parcel of the healing process.

    I also found this paper to be interesting : http://medical-case-reports.imedpub...elevated-serum-17ohprogesterone.php?aid=20632

    I'll go ahead and ask for Dr. Kruse's perspective.
     
  11. JanSz

    JanSz Gold

    So supplementation with vit D helps a lot.
    But
    think how much more you can be helped if you get good vit D level in natural way.

    I try to maximize my outdoor time (that is 100% natural information coming from sun)
    and also I use RED SPERTI
    16 minutes/day, standing, half front, half back
    touching lamp distance
    middle of the lamp is at my navel level.

    upload_2019-5-15_9-55-56.png
    upload_2019-5-15_10-3-29.png

     
    Chipdouglas likes this.
  12. JanSz

    JanSz Gold

    Chipdouglas likes this.
  13. Chipdouglas

    Chipdouglas New Member

    I absolutely agree with you about getting vitamin D from the sun. Living up North near Montreal sucks - seriously. Only reason I'm staying is because of family.
     
  14. JanSz

    JanSz Gold

    Agreeing aside.
    As long as you are where you are,
    get that lamp and use it
    also
    add any vit D on top as need.

    ........
     
    Chipdouglas likes this.
  15. drezy

    drezy Gold

    To say the least.
     
    JanSz likes this.
  16. drezy

    drezy Gold

    Last edited: May 15, 2019
    Chipdouglas and JanSz like this.
  17. JanSz

    JanSz Gold

    https://jackkruse.com/brain-gut-16-adrenal-fatigue-rx/

    Trouble for your hormone panel down the road is always signaled first in the fast acting eicosanoid system.
    Alterations in leptin signaling is the first clue something is a miss.
    ---------------------------------------------------------------------------------------------------------------------
    eicosanoid system------->>>>is important
    what is eicosanoid system
    https://www.google.com/search?safe=...0..0.0.0.......1......gws-wiz-img.MIF-bwC66gg

    upload_2019-5-16_7-59-34.png


    upload_2019-5-16_8-1-24.png

    What do I see on picture above ------>>I see more than one fatty acid

    None of those fatty acids is is more important then the other.

    If you have too much of the "important" one,
    you will be sorry about the same
    as if you were missing on it.


    Emphasize balance, do not support one against the other.

    ///////////////////////////////////////////////////////////

    My conclusion,
    after reading the quote above from Adrenal-Fatigue Rx.

    After you see altered cortisol pattern on you 4xcortisol + DHEAs test
    do
    detailed
    Fatty Acids Analysis
    Fatty Acid Profile, Comprehensive (C8-C26), Serum
    then decide
    if you want to eat seafood or something else

    that on top of
    seeing sunlight hours and hours a day

    ..................................

    The next important sentence
    after the quote above is:
    These things are rarely checked by any practitioner because few even know about how it integrates into the hormone panel and is coded for in the brain.

    It is your life, help you doctor in helping you.

    .................................

    DHA and iodine are hugely important


    Yes, orgasm (oxytocin release) can help heal adrenal fatigue
    .............................
     
    Last edited: May 16, 2019
    Chipdouglas likes this.
  18. Chipdouglas

    Chipdouglas New Member

    This is the most interesting and comprehensive AF article I've read to this day. I'd long been aware AF wasn't an adrenal issue per se, but a brain issue (i.e. involving the PVN) , but the perspective of a neurosurgeon puts a very different spin on it. Such in-depth knowledge is mind-boggling. Very interesting stuff !!
     
  19. drezy

    drezy Gold

    Glad to point you to it.

    I have a creeping suspicion that Dr Jack Kruse is a smart guy.

    For what it's worth, I think it would be worth your time to hang out here some more and pick up what you can.

    As much as my wife and I have improved our health here (and it's been significant), I think the best thing I've learned is to ask better questions.
     
    Chipdouglas likes this.
  20. Chipdouglas

    Chipdouglas New Member

    A very smart MD with two specialties once told me : '' two of the most important questions to ask are why and how.''
     
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