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Pineal Calcification, Melatonin Production, Aging, Associated Health Consequences and Rejuvenation o

Discussion in 'The Cave' started by Penny, Jun 25, 2020.

  1. Penny

    Penny New Member

  2. Melatonin genesis in the human eye stimulated by sunrise UV therapy (depending upon latitude & time of season -> beginning of its rising to 10am).

    The melatonin rhythm phase advancement caused by exposure to bright morning sun light -> Benefits of Sunlight: A Bright Spot for Human Health https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2290997/

    Phosphorylated AANAT (pAANAT) associates with 14-3-3 proteins, which activate and stabilize the enzyme resulting in increased conversion of serotonin to N-acetylserotonin, and ultimately to melatonin. -> Melatonin: An Underappreciated Player in Retinal Physiology and Pathophysiology https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3462291/

    Dr. Jack Kruse believes melatonin is a powerfully protective antioxidant for mitochondrial DNA.

    Melatoninergic antioxidative system - neutralize a wide range of ROS and reactive nitrogen species. It modulates UV-induced apoptosis, hydroxyl radicals, involvement in keratinocyte proliferation and protection, and fibroblast health.

    Since the Pineal gland has its own melatonin receptors, is it possible this is its mechanism of action for self-repair?
    Last edited: Jun 25, 2020
  3. Penny

    Penny New Member

    Like methylene blue, it shleps electrons across the mito - and makes more heme proteins, (it's a zince ionophore) one of which is COX C - which of course means more and better mito and more production of water... and if you read the latest post on Patreon, he really dives into it - ionophore:
    a substance which is able to transport particular ions across a lipid membrane in a cell.
    "calcium ionophores" - maybe it gets rid of the calcium because it is an ionophore? Dude, I am no doctor... this is just a wild guess on my part... :)


    Effect of calcium on melatonin secretion in chick pineal gland I
    Author links open overlay panelMarta I.PablosM.TeresaAgapito
    ReginaGutierrez-BarajaRussel J.ReiterJose M.Recio

    https://doi.org/10.1016/0304-3940(96)13101-3Get rights and content
    Melatonin is the neurohormone which is synthesized by the pineal gland and secreted rhythmically. The role of calcium in the activation of melatonin production remains unknown. In this study, we demonstrated that calcium input participates in the regulation chick pineal gland. Pineal glands from Gallus domesticus were perifuse with Krebs medium (controls) or with Krebs medium plus drugs (ethylene glycol tetraacetic acid (EGTA) or calcium ionophore A23187). When EGTA was added to the perifusion medium, free extracellular calcium concentrations were dramatically decreased and melatonin synthesis was decreased. On the other hand, when the calcium ionophore A23187 was added to the perifusion medium, chick pineal glands exhibited a marked increase in secretion of melatonin. No effects were observed when chick pineal glands were treated with drugs during or after the time of the natural peak levels. We propose that calcium input from extracellular medium and output from intracellular calcium reserves are primary mechanisms in the activation of melatonin synthesis in the chick pineal gland.
    Sheddie and John Schumacher like this.
  4. I prefer to look at human bio-chemistry from an electromagnetic-chemical reaction point of view. Most researchers do not understand the reason why chemical reactions occur "the way they do", because their paradigm is focused on a chemical-theory-calculation & transformation potential, and as such, many scientists do not agree on the process.

    I am looking forward to the day when the waveform of light and electron charge potential are calculated into human-bio-chemical-transformation.

    Grandpa John
    Sheddie and Penny like this.
  5. Penny

    Penny New Member

    Hydroxychloroquinone - the pills used to shlepp zinc so the mito can make blood faster -
    Tim Enright likes this.
  6. JanSz

    JanSz Gold

  7. DrEttinger

    DrEttinger Choice, the only thing we control

    Calcium vs Silica is the story. Read this at your leisure and you will better understand calcification. This article is no longer available on the net - why? Download and save a copy.

    • Silica is the second most abundant element on earth. It is an essential element of living matter and humans have a critical need for this element.
    • We are born with an abundance of silica and relatively low amounts of calcium. Then with every advancement in chronological age, the amount of calcium increases, and the amount of silica decreases within the body.
    • Silica enhances the function of iron, calcium, magnesium, potassium, and boron, and is essential for bone development and growth.
    • Silica is also one of the most important constituents of the body’s connective tissue, including cartilage, vascular lining, tendons, and ligaments. It is found in the thymus gland, the adrenal glands, the liver, the spleen, the pancreas, and in considerable quantity in the hair.
    • It is known to play a part in the integrity of the bones, arterial walls skin, teeth, gums, hair, and nails, and has been used to alleviate eczema and psoriasis.
    • The average adult body requires the maintenance of about 20 grams of silica to promote good health. However, the body metabolizes and secretes about 10-40 mg. of silica per day through urination, hair loss, and nail trimming.

    JanSz and Sue-UK like this.
  8. JanSz

    JanSz Gold

    Thank you @Sue-UK for your persistence in highlighting silica.
    barley and millet, both rich in silica
    Last edited: Sep 8, 2020
    Tim Enright likes this.
  9. @JanSz What are the best non-grain methods for increasing silica levels in the body?
  10. Sue-UK

    Sue-UK New Member

    Molecular basis for defining the pineal gland and pinealocytes as targets for tumor necrosis factor

    "The presence of TNF-R1 in pinealocytes strongly indicates that TNF directly affects melatonin production. We have observed previously that incubation of cultured rat pineal glands with TNF inhibits the noradrenaline-induced transcription of Aanat and the synthesis of N-acetylserotonin, the immediate precursor of melatonin (Fernandesetal.,2006). These in vitro observations were corroborated by clinical data that show a suppression of the nocturnal melatonin surge in patients with high levels of circulating TNF, such as in the presence of sepsis (Mundigler eta l., 2002), myocardial stroke (Domínguez-Rodríguez et al.,2002), and mastitis (Pontesetal.,2006). In addition, an analysis of the levels of TNF and melatonin in mothers whose infants were delivered by cesarean section, a condition that induces an acute inflammatory response, has shown that the daily melatonin rhythm was recovered only in mothers with no circulating TNF (Pontes et al., 2007). Therefore, the hypothesis that activation of TNF-R1 triggers a transduction pathway that inhibits noradrenaline-induced melatonin production is supported by experimental and clinical findings."

    "In conclusion, this study provides mechanistic evidence for considering the pineal gland a key participant in the innate immune response. Understanding how the synthesis of melatonin is suppressed to permit the proper mounting of an inflammatory response is the initial step in evaluating why the daily rhythm of melatonin is not restored in some, but not all, chronic diseases. "

    So perhaps as part of an anti inflammatory protocol, HCQ might have a role in reducing the TNF suppression of melatonin production, which in turn might benefit the pineal gland's own melatonin receptors?
    John Schumacher likes this.
  11. JanSz

    JanSz Gold

    How about comfrey?
    Either directly
    feed the pigs with comfrey and then eat the pigs.


    Last edited: Sep 8, 2020
    Tim Enright likes this.
  12. Sue-UK

    Sue-UK New Member

    His book, Silica Water the secret of healthy blue zone longevity in the aluminum age, would probably help answer your question. :) Another person on youtube worth a listen to is Professor Chris Exley - I've done the AD protocol for reducing the body burden of aluminum using silica rich water. Followed it for 8 months, and still drink a litre a day, I just don't do the blood saturation technique any more.

    In his book, he discusses the blue zones of Okinawa, Japan, Villagrande in Sardinia, Ikaria, Greece, the Nicoya Peninsula in Costa Rica, and Loma Linda California. Different local diets, but all contain staples that have skins or husks high in silica. Not all of that is bioavailable, but can be protective against aluminium in the gut. But they also have good amounts of bioavailable silica in their drinking water. :)
    Tim Enright likes this.
  13. Sue-UK

    Sue-UK New Member


    Aluminum and Glyphosate Can Synergistically Induce Pineal Gland Pathology: Connection to Gut Dysbiosis and Neurological Disease

    Section 8) "As we have previously stated, the pineal gland also tends to bioaccumulate aluminum more easily than other parts of the brain. Aluminum gains entry into cells as a calcium mimetic, and it binds calmodulin with a ten-fold higher binding strength than calcium. So it can be expected that aluminum will have a severe adverse effect on sulfate synthesis and melatonin synthesis in the pineal gland."
    John Schumacher likes this.
  14. DrEttinger

    DrEttinger Choice, the only thing we control

    Most effective and easy delivery. I use a different company that you would not be able to purchase. The ingredient is the same, choline stabilized silica. I take 10 drops per day with some MSM and Great Lakes Collagen Hydrolysate. - https://www.iherb.com/pr/BioSil-by-...vanced-Collagen-Generator-1-fl-oz-30-ml/23158
    John Schumacher likes this.
  15. JanSz

    JanSz Gold

    I can grow comfrey in my backyard garden.
    Eat it instead of green salad.
    I assume fresh green should be better during growing season and latter on dried could be used.
    Would not it be better than pills or drops?

    Thinking of your feta-walnut-salad:
    John Schumacher likes this.
  16. For detox, I've used fermented chlorella - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4094164/
    Since we are very similar to pig, it has made sense to me to look at studies done on them. They get many of the same diseases as we; they have the same issues as we with mold toxicity. The problem is often the disease pathology maybe slow as it is in humans.

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