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Photodynamic therapy (PDT) vs LLLT and PBM.

Discussion in 'Redox Rx' started by Jack Kruse, Feb 8, 2019.

  1. Jack Kruse

    Jack Kruse Administrator

    Photodynamic therapy (PDT) is a treatment that uses special drugs, called photosensitizing agents, along with light to kill cancer cells. The drugs only work after they have been activated or “turned on” by certain kinds of light. PDT may also be called photoradiation therapy, phototherapy, or photochemotherapy.

    In PDT, the exogenous photosensitizers are introduced into the cells and then irradiated with wavelengths of visible or near infra-red (NIR) light to produce elevated amounts of ROS that are lethal to the cells. In LLLT or PBM, light is absorbed by endogenous cellular photosensitizers such as cytochromes, flavins, porphyrins and NAD+/NADH.

    Since the amount of endogenous cellular photosensitizers is relatively small, low concentrations of ROS are generated. and this usualy stimulate healing and regeneration.

    This insight should help you understand now why the blue light hazard is associated with elevated cancer risk. the Blue light hazard makes a lot more ROS than PBM or solar exposure does, so when you chronically live in blue light you are giving cells the proliferation signal without the regeneration signal to buffer the creation or ROS in the mitochondrial matrix. Abeerant light frequencies are able to usurp the control function of creating ELF-UV from ROS and oxygen signaling in the mitochondria.

    Richelle Jones likes this.
  2. Jack Kruse

    Jack Kruse Administrator

    Here is an article that really explains why we are losing the battle for cancer: Oncologist and PhDs keep looking in the nuclear genome for the cure for cancer when the cure is going to be found in the molecular interactions between the circadian mechanisms and how the mitochondria matrix responds to the circadian signal stimulus.

    Why is curing cancer so hard.......the answer is not what most think. When you look in the wrong genome and spend 99% of your research budget looking around in this genome you are apt to miss the real cause in the other genome linked to the circadian clock mechanism of man that is turned on and off by light frequencies.


    These type of papers should change the imbalance of how we spend research money in cancer, but you can bet the professional scientist and oncologist making careers in the nuclear genome research won't let that happen. Big Pharma oncology drug paradigm will reinforce the bad decisions because the creation of cancer drugs is big business. 10-25K a month for these drugs is now normal. It is ironic when you think about the cost of sunlight and natures real vaccine for this disease. https://newatlas.com/cancer-circadian-clock-experimental-drug/58182/
    Richelle Jones and drezy like this.
  3. Jack Kruse

    Jack Kruse Administrator

    Then there is this: My experience is that in modern science peer review is poor, even if it independent. If a paper conforms to conventional wisdom, it will eventually get published in some journal because this supports Big Pharma advertising. If it is too unorthodox it is too easy to reject and this is why PhDs stay away from new areas of research that are deemed the leading edge of science. Their jobs depend upon publishing ANYTHING to keep their job via grant money.
    Richelle Jones and drezy like this.
  4. Jack Kruse

    Jack Kruse Administrator

    RED LIGHT THERAPY: All matter is ultimately composed of charged particles such as sub-atomic particles, electrons, protons etc. When electromagnetic radiation impinges on matter in our patients, the charged particles will absorb energy leading to oscillations depending on the energy of the individual photons (wavelength). Visible light is generally absorbed by electrons in molecular orbitals, while IR energy is generally absorbed by bonds within molecules leading to increased vibrational modes such as twisting, stretching, and bending. Both kinds of energy may transform and dissipate into other molecular vibrations in the form of increased thermal energy (temperature).

    How are we to distinguish between NIR and FIR absorption that interacts with different elements the tissue structure (water, proteins, amino acids, lipids, etc.). It’s an interesting question for quantum medicine now because we cannot AND SHOULD NOT assume that the optical characteristics of the radiation remain the same all the time. Yet, when you read the PDT or PBM/LLLT literature you see this mistake made a lot. I believe every hour and ever season our tissues optical windows change to match to the solar changes. This is a radical new idea. I believe this because light changes the optical characteristics with matter. It is a physical fact yet in medicine. we do not appreciate the dynamism. We falsely believe that the matter we all have come to know is unchanging in light. It is just not true based upon what physics teaches us.

    Physics tells us that NIR and FIR could be absorbed and re-radiated as different electromagnetic wavelengths by the tissue chromophores within a very short period of time. It is quite possible that the final photobiological result originates from a variety of sources, including the original incident light photon absorption, the different re-radiated electromagnetic waves arising from cellular structural molecules, and induction of electromagnetic fields that affect energy metabolism within the cells. All of these things are uncontrolled for in ALL MEDICAL STUDIES. This is why I am a skeptic of the entire literature of medicine. Until we design proper light controls into methodology we just cannot say with any certainty that we know what we need to know to solve our patient's issues.

    Tissue optics describes mathematical modeling approaches to analyze how photons of different wavelengths interact with tissue. Photons can either be absorbed or scattered either inelastically or elastically, according to modern photonics. On the macroscopic scale, the Monte Carlo simulation tool has been applied for studying the light penetration and absorption in human skin during LLLT.

    LASER THERAPY uses the endogenous chromophores to turn visible spectrum sunlight into coherent laser light. LLLT bypasses this step built by nature. I believe healthy tissue, not disrupted or destroyed by a lowered mitochondrial redox is incapable of generating a PBM or PDT response. This is why laser therapy helps those with poor redox in my opinion

    Nasouri et al. simulated laser propagation through a three-layer human skin model in the spectral range from 1000 to 1900 nm. Remember that sunlight goes from 600-3100nm This type of analysis is necessary to design parameters to maximze the depth of light penetration into tissue, without any risk of causing thermal damage to the upper layers of the skin. Additionally, the beam profile of the laser spot, which can be uniform or Gaussian can increase the local volumetric dosage, and is important when selecting wavelength and laser power in LLLT.
    GavinH and Richelle Jones like this.

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