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PG/E2 ratio??

Discussion in 'Optimal Labs' started by Hope, Mar 21, 2013.

  1. JanSz

    JanSz Gold

  2. JanSz

    JanSz Gold


    SHGB (Sex Hormone Binding Globulin):

    Let's look at what influences SHBG:

    Increases SHBG:
    Estrogens (particularly Estradiol)
    Progesterone (by increasing Estrogen receptors)
    Thyroid Hormone (particularly Hyperthyroidism)
    Liver Disease
    Anorexia, Starvation
    Hypoglycemia (low insulin)

    Reduces SHBG:
    Insulin (and insulin resistance)
    Growth Hormone
    Other Androgens
    Excessive Cortisol (Cushing's Syndrome or Disease)
    Progestins (such as by blocking progesterone's effects)

    Excessively high SHBG may indicate factors increasing SHBG may be in excess in thus should be addressed. For example, an excess of Estrogen to testosterone may result in high SHBG.

    Since SHBG is determined by several hormones, it is not generally a good component to address directly. Rather the influences affecting SHBG should be addressed independently of SHBG.

    Testosterone replacement alone will drive down SHBG. Low SHBG, high free testosterone but LOW total testosterone is common in diabetes.

    From my point of view, overly focusing on SHBG when trying to improve libido once total testosterone is raised to at least 650 ng/dL is a fairly narrow point of view.

    Free Testosterone is only a fraction of Testosterone signaling. Free Testosterone too often does not determine libido.

    One can use Bioavailable Testosterone as a measure of testosterone's signaling strength. I, myself, consider total testosterone more important. Testosterone which isn't free - but is bound to SHBG - also has signaling function on SHBG receptors. To take this function into account, I use total testosterone as a clearer measure of testosterone signaling.

    If one focuses on the factors that determine SHBG and focus on optimizing them or treating the disease condition involved, then one hardly needs to measure SHBG at all.

    High or low, SHBG indicates something is wrong but does not tell you what is wrong. Thus, alone, it is not a useful measure.

    SHBG within the reference range also doesn't tell if something is wrong. Factors that influence SHBG can cancel each other out, thus SHBG will be in the reference range.

    Thus, one still has to optimize each factor that influences SHBG separately.

    As a result of these considerations, SHBG is a minor player. I would look at the other issues that influence SHBG instead in their own right as more important considerations.



    Danazol is an androgen which lowers LH (Luteinizing hormone) and FSH (Follicle Stimulating Hormone) production. It is used in the treatment of endometriosis by driving estrogen production downwards. It is also indicated for fibrocystic breast disease and hereditary angioedema. Obviously, as an androgen, it can lower SHBG. Lowering SHGB and lowering LH would both reduce total testosterone. I would not use Danazol in a man or woman for that matter. There are better options for Fibrocystic breast disease (e.g. iodine) and endometriosis. However, its use in hereditary angioedema may have utility.

    mamadell likes this.
  3. JanSz

    JanSz Gold

    Iodine, Epi-paleo Rx, thyroid, and carb linkage


    Last edited: Feb 1, 2014
    Hope2Learn likes this.
  4. JanSz

    JanSz Gold

    "The Evolutionary Significance of Iodine," essential reading. Iodine is required for myelination and is the body's supreme cellular antioxidant.
    2011_Venturi_Evolutionary_Significance_of_Iodine.pdf · version 1

    Errors in Modern Thyroid Endocrinology_2017_JDach
    Link to Free Download pdf file of Power Point Presentation:
    Errors in Modern Thyroid Endocrinology_2017_JDach_A4

    Link to this article: http://wp.me/p3gFbV-5b4
    Dr Jorge D. Flechas, MD - Whole Body Iodine Sufficiency

    Published on Nov 2, 2014

    thyroid holds 50mg iodine
    whole body holds 1500mg iodine
    low iodine leads to high estrogen
    symporter may be sick

    3-4 years excess iodine to clear bromine



    Why Natural Thyroid is Better than Synthetic


    Hashimotos, Selenium and Iodine






    all AI's are associated with low Vitamin D 3



    24 Hour Urine Iodine Loading Test with Options to Add Bromide, Fluoride, and/or Chloride Analysis (+ Shipping)

    Results of
    Surya Namaskar Gold




    Not quite at iodine body sufficiency yet.
    Look at that fluoride!
    That's after installing an RO system a year or so ago and getting rid of fluoride toothpaste.
    Come to find out city water putting fluoride in - tested at 1.08 ppm. Need to avoid, even ice.
    Checked bottled spring water at work - tested at 0.22 ppm fluoride.
    Bromide also a problem; excreted above national average.

    Water test:
    Last edited: May 3, 2019
  5. Hope

    Hope Gold

    What is interesting...in the T4 to T3 list above, one that is missing is....cytokines. Though they are more inflammatory compound than medicine or nutrient. LOL
    cantweight likes this.
  6. JanSz

    JanSz Gold

    Please add cytokines.
  7. JanSz

    JanSz Gold

  8. JanSz

    JanSz Gold



    Fish is best from food not a pill!
  9. JanSz

    JanSz Gold

  10. JanSz

    JanSz Gold

    SpectraCell’s Micronutrient "Premium Package"
    they have other tests.
    Contact SpectraCell:
    my own contact (in NJ, USA) call Rene Barret (732-266-6735) ------ (732-390-0286)


    three from BodyBio.com
    BodyBio Wellness Report
    BodyBio Professional Report (Doctor's Report)
    BodyBio Fatty Acid Report (Doctor's Report)
    Contact BodyBio

    Buy this books (directly from BodyBio)(to get lattest revission):

    The Detoxx Book $34.65
    The Detoxx Book™ is a Doctors Guide to intelligently manage toxicity, and to deal with it nutritionally. It was developed to help patients safely and efficiently remove the toxic residue that is present in their body from living in today’s world. It appears that guiding patients through detoxification can be eased considerably when dietary and supplemental interventions are implemented. This book, written by doctors for doctors, will be invaluable as a text to study as it reviews, in detail, a broad coverage of the lipid scene from the double bond, eicosanoids, trans fats, dietary fats, phosphatidylserine, and the exciting subject of phosphatidylcholine. The Detoxx Book™ is a must for every doctor and every healthcare provider interested in having a safe and efficient tool to use in their effort to detoxify the body.

    Patient's Detoxx™ Book $17.35
    • The DetoxxTM Diet
    • DetoxxTM Recipes
    • Patient Prep Instructions
    for “at home” detoxification

  11. JanSz

    JanSz Gold


    What Are The Optimizing Labs?
    August 26, 2011 By Jack Kruse Comments (100)

    Readers Summary
    1. What labs might I consider with my healthcare provider?
    2. How do I start?
    3. Is the quantified self platform of testing a commitment?
    4. How long should it take before I become rockstarish?
    5. The secret sauce is not the lab data but in how they are interpreted!
    When you finally decide to take total control of you life and optimize yourself I always suggest testing. Many of you have bombarded my email and my twitter account for a blog to a list of those labs. Well, today’s post is for you. I was resistant to do this because I felt having the list of labs is a waste of time if you don’t have a physician who can decipher what they all mean for you. 7 years ago, I could not tell you what this group of labs meant at all to your optimal health. I learned it by reading and going to classes to optimize myself. After much reflection I have decided to give you what you asked for. I am fortunate because many of the PCP’s I work with understand these tests well. I may also update it as I think it needs to be updated over time.

    The first set of labs are what I call the core lab set for optimization. There are other panels I add to the core lab based upon the history, physical, and the food logs I will have patients give me. This blog is meant to be a resource for you to refer back to when the need arises. Discuss these with your doctor but don’t assume they will run out to order them because they may not know what all these tests will tell them. That part takes some time. I recommend starting the dialogue with your doctor to assess their willingness to help you. Most of my PCP doctors are awesome “helpers” to their patients with these issues. This requires a lot of work on the doctors part and the patients part. Do not be surprised if this is not covered by insurance. The time required to optimize someone is unreal. I know how long I spent optimizing myself 6 years ago. It was a tedious process but I was not going to give up because I believed my life depended upon it. For most people, 2-3 years you can expect the changes you want. If you are really in tough shape it may take longer but that should not deter you. I love patients who bring big challenges. They are the most appreciative patients I have had in the last 5 years. We can never settle for a C or D when an A is possible.

    Lab Panels
    1. VO2 Max assessment (cardio pulmonary findings lead to a work up if needed.)
    2. Initial visit DEXA with body comp. Optimization a DEXA scan to include body composition scores.
      F/U visits I use BIA assessments to monitor progress and limit radiation exposure.
    3. Neuro cognitive battery of tests to assess processing speed, response speed, memory , learning, and attention repeated annually.
    4. Chemistry 20
    5. Liver function testing
    6. Serum Iron, TIBC, Serum Ferritin and Iron % Saturation
    7. Lipid panel: VAP and/or NMR analysis
    8. Homocysteine level
    9. Complete CBC with differential and platelet count (sometimes an Ivy bleeding time)
    10. Hormone panel includes (gender specific)……serum and salivary cortisol, Total testosterone, Free testosterone, % Free T, DHT, LH, FSH, Estradiol (E2) high sensitivity, DHEA-S, PSA, IGF-1, Consider based upon history testing levels of progesterone, pregnenolone, melatonin, serum and urine Osmolarity, Prolactin levels
    11. Complete thyroid panel with antibody screening (TPO etc)
    12. Complete Urinalysis (women get beta HCG if they menstruate)
    13. Highly Sensitive CRP (Not a regular CRP)
    14. Complete Vitamin D panel
    15. Omega 6/3 serum test (for severe findings consider tissue assay)
    16. Fasting serum insulin and HbA1c assessment
    17. No panel is complete without an ASI and salivary melatonin level. Read Brain Gut 11 to understand why.
    The next set of labs are considered add ons if the patients’ history or physical require it being looked at.

    Cancer history of colon, breast, ovary
    1. CEA for colon cancer
    2. CA 125 for ovarian cancer
    3. CA 27.29 for breast cancer
    4. AFP blood test
    5. CA125, 15-3, 27.29, 19.9,
    6. BRCA 1 and 2 screen
    Previous heart disease
    1. Apo A-1 and B
    2. B Natriurietic Factor
    3. LpA status, Lp-PLA2
    4. CIMT
    5. Calcium Index Score
    Bone pathology
    1. Osteocalcin frozen blood analysis
    2. Se blood test
    3. RBC blood testing for Mg
    4. Deoxypyridinoline (DPD) Cross Link Urine Test
    5. Parathyroid Hormone assay
    Inflammatory/autoimmune panels
    1. EBV panel
    2. ANA panel
    3. Complete Cytokine Assay
    4. Candida Antibodies
    5. Helicobacter IgG panel
    6. Hep A, B and C titers
    7. Breakout of Cytokine panel
    8. ESR
    9. RA factor
    10. SLE screen
    11. T Lymphocyte helper suppressor assay
    12. IL 8, IL 1 B or TNF alpha analysis
    I also think you need to have a thorough history and physical exam. You need to retest on a quarterly or biannual basis to get feedback on your lifestyle and regimen to get things right over time.

    Once this is all correlated, you come up with a customized dietary plan, a medication/supplement plan, and exercise plan, basically a game plan for things you might consider altering for optimal health. It should be a collaboration between you and your doctor and your other health care providers.

    This is a very labor intensive task for both patient and doctor. But if you remain persistent and consistent and your relationship with your physician congruent and always focusing in on your health you can reach any goal you have for yourself. It must be adaptable but yet have some core values to it to get you to the promised land. The secret sauce is not the lab list; it is found in the interpretation of those labs and how they correlate with your epigenetic switches. That is what determines how you partition calories and what diet and exercise program are best for your current biology. You should expect this to change over time as you become optimized. Nothing stays they same in biology. I learned this on my own journey and it has proven true in those I have helped re-engineer themselves back to optimal. Enjoy!

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    Filed Under: Breast Cancer, Cancer, Colon Cancer, Epi Paleo, HCG, Leaky Gut / Grain Brain, Series: Miscellaneous, The Leptin Prescription, The Optimal Paleo Diet, Thyroid, Thyroid Cancer Tagged With: Optimized Labs

    Hope2Learn likes this.
  12. JanSz

    JanSz Gold

    Hope2Learn likes this.
  13. JanSz

    JanSz Gold

    Last edited: Mar 15, 2014
  14. Inger

    Inger Silver

    Do you take iodine JanSz?

    I am still sooo confused aboit that! I once in a while take a few drops.. and the co factors.. and then I paint my breasts and other places too like feet soles etc. but then if I get too exited about the Iodine I get bad detox!
    Then... I read a lot about the stuff... and I get only more confused? I want to get this Fluoride out of my poor bod, DARN, I had to eat fluoride pills as a kid and we had fluoride toothbrush sessions at school too... but it is ringing in my ears... Jack does not seem to be a fan of Iodine supplementation? Or is he but he wants to be cautious? Because there might be ugly detox coming? I still have (almost not noticeable though)marks on my cheek from the heavy Iodine detox pimples last spring. I guess bromide detox. And I got heavily depressed too. For a week or two.

    I want to know if Jack thinks we hurt ourselves more than we heal with the Iodine protocol, or if we just need to be careful. Maybe there is no quick fix?
    I appreciate Jacks opinion so much.. and it does not give me peace in my mind he seems not to be a fan of Iodine supplementation...
  15. Hope

    Hope Gold

    I hope someone gets back to you Inger! Jack just mentioned iodine is key for hydration....and suggests the Epi Paleo diet. Which you are doing.....

    I am wondering about SHBG...I saw JanSz' post on it and I really wonder...how to lower it. I know it's a complex thing....
  16. Jack Kruse

    Jack Kruse Administrator

    Next blog unlocks the SHBG mystery..........
  17. Josh

    Josh Gold

    Josh (Paleo Osteo) likes this.
  18. JanSz

    JanSz Gold

    Ovaries make thyroid hormone T2.
    time 5:12

    T2 can convert to T3 or T4 (time 5:35)

    women start gaining weight when ovaries fail to make T2

    T2 is available as supplement, no prescription reqd.
    Hyper T2
    By: Lecheek Nutrition

    Premium Jitter-Free Thermogenic to Bolster Thyroid Function!*
    Each capsule contains key ingredients to enhance the T2 hormone and increase metabolism which can lead to amazing results by itself or even better results.*
    http://www.amazon.com/Hyper-T2-Capsules-Lecheek-Nutrition/dp/B009K6X1W4/ref=sr_1_1?ie=UTF8&qid=1422394787&sr=8-1&keywords=Hyper T2 Lecheek Nutrition
    Hyper T2, 90 Capsules, From Lecheek Nutrition
    by Lecheek Nutrition

    Jorge Flechas - Total Body Iodine Sufficiency - AARM

    Jorge Flechas on youtube
    https://www.youtube.com/results?search_query=jorge flechas
  19. Screen shot 2015-01-28 at 12.02.32 PM.png
    interested to know how to test peroxisomal function
    from my labs:
    Screen shot 2015-01-28 at 2.09.18 PM.png
    Screen shot 2015-01-28 at 2.09.33 PM.png
  20. JanSz

    JanSz Gold

    Josh (Paleo Osteo)
    interested to know how to test peroxisomal function
    Rather than limit testing to only (C22-C26)

    Test 81369 :
    Fatty Acid Profile, Peroxisomal (C22-C26), Serum

    you may want to test (C8-C26)

    Test ID: FAPCP
    Fatty Acid Profile, Comprehensive (C8-C26), Serum

    in regard to O6 & O3
    may want to study results and decrease consumption of fats that you have in excess
    and increase consumption of those that are deficient.

    GLA /------- g-Linolenic Acid, C18:3w6
    DGLA /------- h-g-Linolenic Acid, C20:3w6

    instead of evening primrose raising mostly GLA only
    some claim that black currant would also raise DGLA

    look at middle of page #2
    and suggested supplementation to support delta 5 and 6 desaturases and elongase,

    instead of above
    one may get better indicators by doing
    Micronutrient Test


    Possibly faster way would be to get information from:

    BodyBio Inc
    Customer Service
    45 Reese Road
    Millville, NJ 08332

    Telephone: 888.320.8338 (toll free)
    856.825.8338 (outside the US)
    Fax: 856.825.2143
    E-mail: custserv@bodybio.net


    You need two tests, names below in bold.
    BodyBio Professional Report (Doctor's Report)
    BodyBio Fatty Acid Report (Doctor's Report)

    Call customer service first. They will find for you doctor, local to you, who have account with them, or ask your doctor to open account with them.
    First blood is drawn at Labcorp or similar place, per list that they will supply. When they receive results that will be input for their
    BodyBio Professional Report (Doctor's Report)

    At the same time your doctor or you will receive kit.
    Kit contains one lavender tube. Draw blood. Post process per instructions, ship overnight.
    Results should be available within 3-4 weeks from blood draw.

    You are in NZ, the testing is done in USA.
    If you arrange (and succeed) with testing and post-processing at Spectracell and or bodybio
    describe your experience
    ways to go
    specially delivering blood samples.

    There are people all over the world looking for help,
    this would be of great help.

    Last edited: Jan 28, 2015

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