1. Registering for the Forum

    We require a human profile pic upon registration on this forum.

    After registration is submitted, you will receive a confirmation email, which should contain a link to confirm your intent to register for the forum. At this point, you will not yet be registered on the forum.

    Our Support staff will manually approve your account within 24 hours, and you will get a notification. This is to prevent the many spam account signups which we receive on a daily basis.

    If you have any problems completing this registration, please email support@jackkruse.com and we will assist you.

PCOS-An Ancient Disorder?

Discussion in 'The New Monster Thread' started by AnnieW, Apr 8, 2014.

  1. AnnieW

    AnnieW New Member

  2. cantweight

    cantweight Gold

    "It is likely that, as for other susceptibility alleles for modern metabolic diseases (14, 15), the origins of PCOS began in Paleolithic hunter-gatherer communities, in which environmental stressors favored the survival of those males, females and offspring with the greatest capacity for energy storage necessary to endure prolonged episodes of privation, the so-called “thrifty genotype” (16-18). If so, such a thrifty genotype may have enhanced survival during times of food deprivation, with reduced postprandial thermogenesis from insulin resistance diminishing energy expenditure as an additional evolutionary advantage (19)."

    Awesome article...Thanks Annie!
    Shijin13 likes this.
  3. AnnieW

    AnnieW New Member

    No problem. I felt it was really appropriate for us on here. Hope Dr. K will chime in with his thoughts.
    cantweight likes this.
  4. Shijin13

    Shijin13 Guest

    I Fully believe PCOS is another evolutionary mechanism. as is the link btwn High FBG (metabolic syndrome) and Thyroid issues...
  5. Shijin13

    Shijin13 Guest

    doesn't this make you feel invincible Christi? it does to me. my current condition is geared to survive the current EMF onslaught... now to figure out how to make it work for us!!!
  6. cantweight

    cantweight Gold

    It kind of makes me feel the same way I did when I learned about my hemochromatosis genes.....yay me! Oh. :confused:
    Shijin13 likes this.
  7. cantweight

    cantweight Gold

    "...with reduced postprandial thermogenesis from insulin resistance diminishing energy expenditure as an additional evolutionary advantage."

    Can someone speak to this for me....unravel that little gem if you will?
  8. Shijin13

    Shijin13 Guest

    I've downloaded this and I'll read it and see if I can decipher it in the context of the article
    cantweight likes this.
  9. they are saying that the insuliin resistant state (to conserve energy) results in a decrease in the loss of heat after eating. so they are diminishing energy expenditure as free heat, to retain energy in the system as an evolutionary advantage.
    the "thrifty genes" were amazing for that particular era, however in modern environments and in the face of modern substrates they are disasterous. APOE4 is a similar thrifty gene, or ancestral allele, when carriers live an ancestral lifestyle they are unstoppable.
    i like to see these alleles as a free pass to rockstardom, if you align your environment and diets well!
    Josh, cantweight and Shijin13 like this.
  10. fitness@home

    fitness@home Silver

    Thanks for the interpretation of that phrase. I like the way you think about those alleles!

    I'm another that also has had high testosterone & DHEA levels. Was looking at some old medical records from 12+ years ago recently and my doc at the time wrote "PCOS?" in the notes.

    Going to read the article today...
  11. Shijin13

    Shijin13 Guest

    Thanks Josh. Haven't had time to read this yet!
  12. yeww!
    Shijin13 likes this.
  13. Greenisland

    Greenisland New Member

    PCOS isn't itself isn't advantageous in any way. Thrifty genes are. Whiskers, a fat belly, acne, hair loss, lethargy? Those are all repulsive on a reproductive level, which is what drives natural selection. If no one want to "mate" with you, you lose and your genes are not transmitted. I know personally when my PCOS was raging, there were very few suitors knocking at my door. PCOS is a neolithic disease state.

Share This Page