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Omega-3 fatty acids (DHA, EPA, and ALA) are not essential???

Discussion in 'The Epi-Paleo Diet' started by Johan Lindstrøm, Jan 9, 2022.

  1. Linz

    Linz Gold

    :)
     
  2. Sue-UK

    Sue-UK New Member

    https://twitter.com/davidasinclair/status/1214885266877505537?lang=en-GB

    https://www.cell.com/molecular-cell/pdf/S1097-2765(19)30894-9.pdf
    Lipid Droplet-Derived Monounsaturated Fatty Acids Traffic via PLIN5 to Allosterically Activate SIRT1
     
  3. Sue-UK

    Sue-UK New Member

    Or does dysfunction cause us to (biologically) age? This makes me think that maintaining youthful levels of SIRT1 could for example extend childbearing age, and/or delay menopause.

    https://www.mdpi.com/2072-6643/12/5/1271
    Elevated Glucose and Insulin Levels Decrease DHA Transfer across Human Trophoblasts via SIRT1-Dependent Mechanism
    "The suppressed SIRT1 expression and the resultant decrease in placental DHA transfer caused by high glucose and insulin levels suggest new insights of molecular mechanisms linking GDM to fetal DHA deficiency."

    Then there's omega 3s as an upregulator of the sirtuins

    https://pubmed.ncbi.nlm.nih.gov/33810216/
    Omega-3 Fatty Acids Upregulate SIRT1/3, Activate PGC-1α via Deacetylation, and Induce Nrf1 Production in 5/6 Nephrectomy Rat Model


    https://pubmed.ncbi.nlm.nih.gov/23806688/
    Docosahexaenoic acid improves vascular function via up-regulation of SIRT1 expression in endothelial cells
     
    Johan Lindstrøm and JanSz like this.
  4. I found this when I searched Ray Peat. Interesting thread from Jack about DHA:

    "Everything Peat says are studies linked to supplemental form of DHA. I advocate seafood not a damn pill. I have told you this many times on the forum over and over. Seafood not a pill. Why? The fish oil used in most studies is not in triglyceride form and is in ethyl ester form which increases inflammation. This means it cannot be in the SN-2 position in our body. And the SN-2 is required to get into the CNS and PNS. What good is the pill or studies that use this. There is another problem. DHA in the TG form or the ethyl ester form outside of its other chemicals photo-oxidizes. This means the light the study is done in is critical. Peat never mentions that how the experiments are done affects the results. He made his living doing these flawed studies as a Phd so he never thought to control for them himself. And HE NEVER thinks about how that lack of light control affect the results, the data and what he believes. I do. The study would have to be done in the cold and dark to have any scientific power AT ALL. There are good quality SN-2 natural triglyceride fish oils, granted eating clean seafood is always optimal over supplementation. Just say the studies are a weak basis of that because they use ethyl ester.

    My forum and website are not a magnum opus as some believe, it is preliminary, and not absolute and designed to be subject to change as data and ideas evolve our perceptions of human biology. This was outlined in the Quilt, which is an adaptable document. That was the origin, but the destination is determined by the redox potential of new material brought to bear on older ideas. In this way it becomes a a creative common for the biophysical sciences. In this way I breaks through academia’s and peer reviews current limitations of journals and the scientific mentality of the day. Academia must engage the aberrant and far from equilibrium ideas that challenge their present draft as a finished project. and they won’t, because they do not want to subject themselves to this scrutiny because it is a blow to itself. Therefore, we must do it for them. We need to realize we observe things through the lens we see them. We need to begin to examine that lens as we collect data that puts a haze on that lens of understanding.

    https://forum.jackkruse.com/index.p...using-killer-ray-peat-says.17123/#post-182111"
     
    John Schumacher and Linz like this.
  5. Nature has the answer. And Jack says in brain-gut 3-5 that this is not based on science, but based on nature.

    "DHA has been present for 600 million years in the eukaryotic tree and NEVER REPLACED EVEN ONCE. If this lipid is bad in anyway, as Peat advocates, just by chance alone you'd expect something else to have been naturally selected for to replace it."

    An interesting dr.
     
    Last edited: Jan 21, 2022
    John Schumacher likes this.
  6. Both blood thinners and vitamin D3 are used as rat poison ...
     
    John Schumacher likes this.
  7. Sue-UK

    Sue-UK New Member


    "To have a 50% chance of killing a rat with vitamin D3 would require 100,000 IU (international units) of D3. That’s the amount required to have a 50% death outcome of a 0.5 lb rat.

    The equivalent of that would be about 4,000,000 IUs (4 million IUs) given to a human. According to research, that amount could endanger your health, but not kill you."

    https://www.rootcausemedicalclinics...n uses cholecalciferol,and the rat bleeds out.
     
    JanSz, ND Hauf and Johan Lindstrøm like this.
  8. Thank you for searching out this reference @Johan Lindstrøm ;)
     
  9. Let's go exercise outside in the snow

    upload_2022-1-20_9-50-20.png
    How much you bet he'll catch her?

    upload_2022-1-20_9-49-46.png
    We may not be getting "vitamin" D exposure, but we maybe getting another kind of stimulation ;)
     
    ND Hauf and Johan Lindstrøm like this.

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