#biophysics #LeptinRx #mito #mitochondriac The take home of the paper below: Eat less live longer. Funny how that Leptin Rx thing works with that device in the sky, huh? Seems my LpetinRx now close to 15 years old is still winning the battle of data and natural wisdom. https://www.sciencedaily.com/releases/2018/08/180831130131.htm

 

More Leptin Rx wisdom data with support. When you fix the light cycle Kreb's bicycle begins to do things the food gurus cannot explain. Black Swans can. We repair the engines and do not worry about the fuels. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786199/

 

Brown adipose tissue controls satiation! Yes. Really. (I know what you think => read on. brown fat is stimulated by cold and by sunlight into action to burn your fat away. This is the basis of the Leptin Rx and Cold Thermogenesis Rx on my website. This is also why nature put leptin in our subcutaneous fat with melanopsin. We have both a light and cold detector system in our fat to tell the brain which system needs to be active as the seasons vary. As seasons vary, so does the electromagnetic footprint of the sun as Earth revolves, and this is how your colony of mitochondria know what program to use during the correct time of the year. https://buff.ly/2zX39IS

 

Another win for the Leptin Rx.........2019 style.
"It is now becoming clear that our circadian rhythms are intimately connected to our digestion and metabolism in many other ways, through the body’s intricate signaling pathways – a new understanding that could explain the long-term effects of jet lag and shift work." http://www.bbc.com/future/story/20190304-how-meal-timings-affect-your-waistline

 

Modern humans are starved for darkness? 4 nights of short sleep ramps up the body’s endogenous production of cannabinoids. A new mechanism (alongside leptin & ghrelin) explaining why a lack of sleep = excessive food intake, and the link between short sleep & obesity? https://pubmed.ncbi.nlm.nih.gov/26612385/

 

The same key can open the doors to heaven or hell. The environment it occurs in or the redox time stamp of the gut when it occurs decides which outcome you experience is the take home. Stop blaming food for what you environment is causing. Lesson is here. https://www.nature.com/articles/s41586-022-04408-7

 

Later circadian timing of food intake is associated with increased body fat = more data that my Leptin Rx is spot on. https://pubmed.ncbi.nlm.nih.gov/28877894/

 

Big lessons in today's post. Have you learned them yet?https://www.facebook.com/drjackkrus...62983165042222&notif_t=feed_comment&ref=notif

 

https://www.facebook.com/drjackkrus...ta1nb3ctiUGXCcVqTLbF2h5ryHx1Nvsxphx2RqjvsMQdl

 

The take home from the paper: The timing of eating controls energy use in nocturnal mammals = another win for the Leptin Rx.
https://www.science.org/doi/10.1126/science.ade6720

What is the Leptin Rx for diurnal mammals?

To regain Leptin Sensitivity (LS) follow an Epi-Paleolithic diet using daily sunrise.
To see an outline of a strict Epi-Paleolithic diet, read my book The Epi-Paleo Rx =
https://www.amazon.com/Epi-paleo-Rx-Prescription-Disease-Reversal-ebook/dp/B00BIUAZUQ


When you eat is more important than what you eat.

• Try to eat as soon as possible upon rising in the morning, ideally within 30 minutes of waking. Make sure that breakfast has little to no carbs (less than 50 grams), and has a lot of protein and fat. Protein is best because obesity is associated with mitochondrial reductive stress = low NAD+. I use as a general rule 50-75 grams of protein with most patients. Some patients can use less and some need more. The key point of knowing how much is right for you is your hunger later in the day during the solar day. If you remain ravenous throughout the day, you need to eat more protein in the morning. If you can hold off eating until dinner you probably are at homeostasis for yourself. If you can skip both meals you likely are overdoing it at breakfast. As for sources, I suggest pastured or organic eggs first, served with leftover dinner scraps of seafood, grass-fed meats, and cheeses. A third option, although less ideal, would be whey protein or protein shakes.
• Try to limit carb intake to 25 grams if you are overweight by more than 30 lbs. If you are fit and have a small amount of weight to lose, (less than 30 lbs.) you can titrate up your carb loads. Even then, I do not advocate potatoes or rice as some Paleo diets allow for. You will be able to eat them eventually, but try to avoid starches until you have mastered your cravings and hunger. Do not count calories; it is not needed at this point. Any time I eat carbs, I use liberal amounts of butter, heavy cream, coconut, or palm oil. The season determines my fat choices. I do not recommend other oils (MUFA) initially such as olive oils or industrial seed oils (omega 6,9). I would also avoid all nut oils at the initial stages. My personal favorite is coconut oil because of the great metabolic effects of MCT, and how it helps heal the guts of LR folks (due to liver use).

How and when you eat your fuel is more important than any other factor, including the food itself.

• Eat only when the sun is out! Never snack at all. This is meant initially and forever. Snacking completely stresses the liver’s metabolism and is just not recommended. Your liver needs to re-learn how to use gluconeogenesis normally again when you are asleep and awake in a solar day. Snacking just destroys the timing and circadian clocks that work in unison with Leptin.
• Try to eat three meals a day initially; but as your hunger and cravings fade you can adapt to two a day.
• Try to eat breakfast as early as possible from rising.
• Do not work out before or after breakfast.
• Try to allow 4-5 hours between dinners and sleep time. Eat dinner as a pauper before sunset
• If you decide to incorporate working out, do it after 5 PM.
• Within an hour of sunset try to make your surroundings as dark as possible.
• If you have trouble falling asleep I suggest 3-5 minutes of body weight exercises right before bed (pushups or air squats are fine, but avoid this if your evening cortisol is high).
• If you’re inclined to, try becoming mindful when you first lay down. I use transcendental meditation techniques to help me clear my mind and concentrate on improving my thinking. I use cold environments that are dark to master it. (Optional, but this is awesome if your evening cortisol is high). Most people who are overweight have flattened cortisol, low melatonin, and very low Vitamin D levels on all 3 vitamin D associated labs

Most people will notice a change in their cravings and hunger within 4-6 weeks.
Another change I advise some of my patients with visceral obesity is to supplement with prescription-grade fish oils. This is not for everyone! The dose depends upon their HS CRP, mitochondrial water production, melatonin levels, and salivary cortisol levels.

Signs that you are becoming Leptin Sensitive (LS) again

• Men will notice quicker weight loss than women due to DHA biology. People with myopia also will take longer time to lose weight. Darker skin also slows weight loss
• Women will notice mood changes first (calmer/sleepy) and their sleep will improve (huge clue). Their clothes will fit differently but their weight may not change drastically initially because of the effects on the pituitary. This will change too if they continue moving forward.
• You will notice a change in your sweating pattern. This is a vagal response.
• You will notice you have a better recovery from exercise and your energy levels seem to have risen.
• Your hunger is gone and so are your cravings.
• When you awaken you will feel very refreshed as you slept well.
• Generally when the signs are all present, I then really push HIIT exercise with heavy weights.

(Quilt Survivability) = (Total Energy – Growth and Immunity Expense) x (Resources) x (Efficiency) x (Awareness of our solar environment).