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MODY1 and RAISED SHBG ARE LIGHT DISEASES

Discussion in 'Adrenal Rx and Leaky Gut Rx' started by Jack Kruse, Jan 5, 2019.

  1. Jack Kruse

    Jack Kruse Administrator

    Are omega 6's PUFA really the boogey man for disease food gurus tell you?

    Nope. They remain ignorant of the circadian cycle around this story and you Black Swans have to get it right and let them keep going on their wrong path. At this point it is becoming comical how wrong they have been for decades.

    The data is piling up now how light dysruption leads to a broken circadian mechanism and mtDNA destruction.

    How so?

    HNF4A gene product protein represses the operation of CLOCK and BMAL1, which act as key molecular cogs that drive the circadian rhythms in mammals.


    Inside the cell, the cogs of the clock are universal, but the hands of the clock are specific to each organ, so how the clock does its work in each cell is different.

    Jack can you give us an example of how this protein works in humans?


    This protein from the HNF4A gene also plays a pivotal role in the expression and synthesis of SHBG. SHBG is raised when this protein is not controlled by light cycles. It is an important glycoprotein made primarily in the liver, which in addition to lowering insulin-resistance also serves in reducing levels of free Estrogen as-well as prolonging the half-life of Testosterone. It also causes problems in the kidney and intestine. This protein is also associated with MODY1 diabetes. I believe it is one of the key links to melanopsin dysfunction in the guts of many people.

    Jack is this why people with gut diseases like Chrohn's can get colon cancers? Is this why young people now are getting both diseases at record rates? YEP.


    We now know increased amplification of hepatocyte nuclear factor 4 alpha has been observed in colorectal cancer.


    In humans, there are two isoforms of HNF4: they are HNF4α and HNF4γ, encoded by two separate genes HNF4A and HNF4G respectively.

    The food gurus like to blame omega 6's like LA for diseases but too few of them seem to know about the circadian control of this mechanism by HNF4.


    HNF4 was originally classified as an orphan receptor that exhibits constitutive transactivation activity apparently by being continuously bound to a variety of fatty acids like linoleic acid (LA).

    The existence of a cellular ligand for HNF4 has been somewhat controversial, but linoleic acid (LA) has been identified as the endogenous ligand of native HNF4 expressed in mouse liver. It turns out the binding of LA to HNF4 is reversible and it linked to the repression of CLOCK and BMAL1. So LA in foods really has bystandier effect here when the light cycles are dysrupted. Once again, the food gurus turn up WRONG.

    How does your internal organ clocks run? New research identifies a circadian network in the liver which is linked to diabetes and liver cancer. The liver is the key organ in the gut!!! Disruption of the circadian rhythm may be a risk factor for several age-related chronic diseases. No shocker to any clinician here.

    https://www.sciencedaily.com/releases/2018/12/181211161519.htm
     
    kris90, recoen and Inger like this.
  2. kris90

    kris90 New Member

    I assume this is not always bad? When you say SHBG is raised when the protein is not controlled by light cycles, could that mean when one is cold adapted in low light cycles?

    I'm sure SHBG rises in those who are light-mismatched, but want to make sure it can also be part of the cold-adapted pathway when one is properly adapted in winter at high latitudes?
     

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