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Mitopchondrial Lesson: Aging vs Cancer

Discussion in 'Mitochondrial Rx' started by Jack Kruse, May 16, 2013.

  1. Jack Kruse

    Jack Kruse Administrator

    Cellular Phenomena Cancer Cells Senescent Cells
    Inflammation upregulated upregulated
    Apoptosis apoptosis resistant apoptosis resistant
    Telomeres short short
    Inflammation high high
    Mitochondria damaged damaged
    Reactive oxygen species high levels high levels
    Antioxidant enzymes upregulated yes yes
    Inflammatory cytokine secretion yes – IL-6 driven yes – IL-6 driven
    Immune evasion yes –TGF-β driven yes – TGF-β driven
    Defective DNA repair yes yes
    DNA mutations present present
    Harmful epigenetic silencing yes yes
    Harmful epigenetic desilencing yes yes
    mTOR upregulated with HS CRP yes yes
    Ras/Raf pathway upregulated yes yes
    c-myc pathway upregulated yes yes
    Angiogenesis upregulated yes yes
    Extracellular matrix degradation upregulated Upregulated

    2011 publication Cellular senescence: A link between cancer and age-related degenerative disease?
    Finding Common Solutions to the Problem of Aging and Cancer – avoiding strategies with antagonistic pleiotropy effects
     

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