1. Registering for the Forum

    We require a human profile pic upon registration on this forum.

    After registration is submitted, you will receive a confirmation email, which should contain a link to confirm your intent to register for the forum. At this point, you will not yet be registered on the forum.

    Our Support staff will manually approve your account within 24 hours, and you will get a notification. This is to prevent the many spam account signups which we receive on a daily basis.

    If you have any problems completing this registration, please email support@jackkruse.com and we will assist you.

Mitopchondrial Lesson: Aging vs Cancer

Discussion in 'Mitochondrial Rx' started by Jack Kruse, May 16, 2013.

  1. Jack Kruse

    Jack Kruse Administrator

    Cellular Phenomena Cancer Cells Senescent Cells
    Inflammation upregulated upregulated
    Apoptosis apoptosis resistant apoptosis resistant
    Telomeres short short
    Inflammation high high
    Mitochondria damaged damaged
    Reactive oxygen species high levels high levels
    Antioxidant enzymes upregulated yes yes
    Inflammatory cytokine secretion yes – IL-6 driven yes – IL-6 driven
    Immune evasion yes –TGF-β driven yes – TGF-β driven
    Defective DNA repair yes yes
    DNA mutations present present
    Harmful epigenetic silencing yes yes
    Harmful epigenetic desilencing yes yes
    mTOR upregulated with HS CRP yes yes
    Ras/Raf pathway upregulated yes yes
    c-myc pathway upregulated yes yes
    Angiogenesis upregulated yes yes
    Extracellular matrix degradation upregulated Upregulated

    2011 publication Cellular senescence: A link between cancer and age-related degenerative disease?
    Finding Common Solutions to the Problem of Aging and Cancer – avoiding strategies with antagonistic pleiotropy effects

Share This Page