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Mitochondrial cytochrome efficiency in obese diabetics isn't good

Discussion in 'Mitochondrial Rx' started by Jack Kruse, Sep 12, 2022.

  1. Jack Kruse

    Jack Kruse Administrator

    No surprise.

    Participants in both groups were of a similar age, weight and BMI. Mitochondrial respiration rates were markedly reduced in diabetic vs non-diabetic patients.
    There were no differences in fatty acid (octanoyl carnitine) supported respiration, leak respiration or isolated activity of cytochrome c oxidase.
    In the muscle of diabetic patients, blue native gel electrophoresis revealed a striking decrease in complex I, III and IV containing ETC supercomplexes.
    Conclusions/interpretation: These findings support the hypothesis that ETC supercomplex assembly may be an important underlying mechanism of muscle mitochondrial dysfunction in type 2 diabetes mellitus.

    Non obese diabetics will have a different thermodynamic footprint methinks.
    John Schumacher likes this.
  2. The potential for OXPHOS inhibitors shows significant profitability for medical science.
  3. JanSz

    JanSz Gold

    Why skinny people develop diabetes type 2?

  4. Jack Kruse

    Jack Kruse Administrator

  5. JanSz

    JanSz Gold

    John Schumacher likes this.
  6. JanSz

    JanSz Gold

    @Jack Kruse
    Thank you for your answer.
    I will re-formulate my question.

    Describing someone as a Skinny is not precise, sorry I did that.

    There are people who have low BMI, and overall, not much fat.
    But most fat that they have is visceral fat.
    Visceral fat is fat that wraps around your abdominal organs deep inside the body.

    How to reduce the amount of that fat?



    Last edited: Sep 14, 2022
  7. JanSz

    JanSz Gold

  8. Jack Kruse

    Jack Kruse Administrator

    Tell me JanSz what is the relationship between K+ and diabetics?
    When their K+ levels are too low, their pancreas makes less insulin. Did you know that? Might the level of insulin made have something to do with if the are skinny or fat? When insulin varies so does blood sugar. Does glucose change the charge density of RBCs? Does this change their optics? Studies show that people with low potassium levels release less insulin, have higher blood sugar levels, and are more likely to get type 2 diabetes than those with normal potassium levels. Did you know that?

    Potassium, both serum levels and to a lesser extent dietary intake levels, has been associated with incident diabetes. Lower levels of potassium have been found to be associated with a higher risk of diabetes. Few seem to understand how this links to biological clocks........Do you yet?

  9. JanSz

    JanSz Gold

    low fasting insulin, 4 -5
    Serum potassium in the middle of the laboratory range

    @Jack Kruse

  10. Jack Kruse

    Jack Kruse Administrator

    What causes low potassium levels in diabetics?

    Low Potassium Levels in Type 1 Diabetes

    Low potassium levels are associated with a complication of Type 1 diabetes, called diabetic ketoacidosis. It is a condition in which your body does not make enough insulin to transport glucose into the cells, so the body uses fat as an energy source.

    Type 1 Diabetics tend to be skinny

    Now, what about type 2 diabetics? they tend to be fat
    The Link Between Potassium and Type 2 Diabetes

    Potassium is generally stored in the fluid inside of the cells, but when there's too much glucose outside of the cells (blood sugar is too high), potassium moves OUTSIDE of the cell, raising potassium levels in the blood. Tell me JanSz what does this do to water inside your cells? How about your biological clocks?
  11. JanSz

    JanSz Gold

    low fasting insulin, 4 - 5
    Serum potassium in the middle of the laboratory range ( Comprehensive Metabolic Panel (CMP 14)

    @Jack Kruse
  12. Jack Kruse

    Jack Kruse Administrator

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