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Ming's Optimal Journal

Discussion in 'My Optimal Journal' started by MingP, Jul 25, 2018.

  1. JanSz

    JanSz Gold


    In Fat ---->> less deuterium
    In water -----> more deuterium

    ---------------------

    There is a study? (Boros, Somlyai), really one or two tables of results
    on cost ($$) effectiveness of using DDW.
    periodical flushing
    vs
    continuous use
    it seems to give an slight edge to continuous use

    -----------------------------
    The Center for Deuterium Depletion <info@cignaturehealth.com>
    Newsletter: Tuesday, July 31 2018
    The most current recommendations on body Deuterium content.
    in this video by dr Boros.


    [======MEDIA=facebook]186235958908814[/MEDIA]
    remove ======
    Watch on Facebook

    Biological Range 95-125ppm

    Recomended

    plasma
    urine
    saliva
    125ppm
    then body can do the rest

    Breath and body fluids should not contain more than
    130ppm but 125ppm is better

    ===============================================
     
    Last edited: Sep 15, 2018
    MingP likes this.
  2. drezy

    drezy Gold

    Yep Jan actually posted a Dr Boros slide earlier
    https://forum.jackkruse.com/index.php?threads/deuterium-in-foods.20423/page-2#post-228372

    Yes D is used as shorthand around here for deuterium as well as vitamin D.

    Yes all consumption in that timeframe

    So far I can only see this as a seasonal thing. I admit my bias that it would be expensive continuously. If I had cancer I'd be on it 365 or my goal was to always maintain the lowest D possible. But when I think about nature, say glacial melt water or even just fruits in spring & summer, there is a cycle/periodicity to the D depletion during a year worth considering.
     
    MingP likes this.
  3. JanSz

    JanSz Gold




    Egg yolk (bright on MRI) is lower in deuterium
    than
    egg white (darker on MRI)

    upload_2018-8-3_9-11-26.png



    upload_2018-8-3_9-13-42.png
     
    drezy likes this.
  4. JanSz

    JanSz Gold

    This study puts in question
    earlier statements where DDW use was not advised for growing humans.
    @Jack Kruse

    ================================
    https://pdfs.semanticscholar.org/e383/46c34670fd34e61b4c00a7e6448c1b9046bc.pdf

    Reproductive function and postnatal progeny development of rats in four generations treated
    with deuterium depleted water (40 ppm)
    were investigated. The targeted generations were
    parent (F0), first (F1), second (F2) and third (F3). Replacement of tap water to deuterium
    depleted water did not influence on fertility index as well as on survival and postnatal offspring
    development. Reproductive function, physical parameters and reflexes development in rats and
    pups consumed DDW was similar or more intensive in comparison with control group.

    Therefore, DDW consumption did not possess any toxic effects and may enhance general
    postnatal development.

    ====================================================
     
    drezy likes this.
  5. drezy

    drezy Gold

    Good call pointing out the fact that kids use deuterium differently.

    Also mentioned within the first 8 minutes of the Aug '18 webinar too.
     
    Last edited: Aug 3, 2018
    MingP likes this.
  6. JanSz

    JanSz Gold

    Everytime @Jack Kruse says methionine
    you check situation on homocysteine.

    upload_2018-8-3_10-49-21.png
     
  7. MingP

    MingP New. Gold. Thirsty.

    Thanks again sir.
    I presume Calcium Score = Checking for Coronary Artery Disease?

    Need to clarify:
    I need to flush these out, or I take these to flush Arterial Calcium out?

    I will research as well. But would appreciate your input and guidance as you're way ahead of the curve vs me.
    Thank you~
     
  8. MingP

    MingP New. Gold. Thirsty.

    Thanks Drezy & Jan for the Deuterium related info.
    Yet another rabbit hole to jump down.

    I've put it on my To Do List
    https://forum.jackkruse.com/index.php?threads/mings-optimal-journal.21703/#post-246973

    I also have this mammoth + webinars to go through. 0_0"
    I'll start with the basics and make sure they are firm first. Light-Water-Magnetism, Circadian Rhythm management
    https://forum.jackkruse.com/index.php?threads/what-to-consider-as-you-begin.14737/#post-165464
     
    drezy likes this.
  9. MingP

    MingP New. Gold. Thirsty.

    Sun & Vit D. 6Aug2018
    Was out in the sun yesterday. Beautiful equatorial sun. Managed to do 2 hours @ UVI 13 to 14 and my d-minder app spazzed out on me and refused to let me clock anything > 25,000IU.

    I estimate 50,000IU and slept like a log.
    Was feeling oddly under the weather from indigestion (ate too fast, in a hurry... :/ ) but the massive amount of red + IR seemed to have calmed the system.

    .
    Tan Throughs
    Using tan throughs over lunch at work has increased my sun-surface exposure from 30% to 60% which effectively will double the amount of sun I get on weekdays.

    I need to hunt for tan throughs for the lower half of my body as well.
    This should give me 100% exposure for the times I head out on weekends.
    .
    Grounding
    I've added copper tape to my flip-flops, which should keep me grounded while on the go.
    For aesthetic purposes, they're nearer to the arches, so it doesn't look too glaring. haha.

    I need to get a body voltage meter to test its efficacy... and figure out how they hell to get my hands on one or make one in the mean time.
    .
    No-Light-At-Night / Circadian Rhythm Management
    Getting myself some rash guards and long pants, dry fits during the evenings to go with my blue-blockers, in order to reduce the light exposure on skin after the sun goes down.

    With the new found importance of Melanopsin-Melatonin relations, it's the only prudent thing to do.
    .
    I need alternatives for oil lamps or candles. Incandescence?

    There's also a dimmer at home, and while I need to get it tested, it's also on my mind to switch it back to a non-dimmed version given the "usual" EMF implications of dimmers.
    Need to check and test.
     
    Last edited: Aug 7, 2018
    WalterNL likes this.
  10. Sue-UK

    Sue-UK Gold

    In diurnal humans with solar panels, the sunlight/deuterium relationship to fertility, post natal development (including frontal lobes) and immune function etc is unlikely to be the same as a furry nocturnal mammal like a rat? :confused:
     
  11. JanSz

    JanSz Gold

    Vascuzyme
    Lumbrokinase
    Nattokinase
    Serrapeptase

    Chymotrypsin
    Wobenzym N
    Boluoke

    add Cialis (10mg/day)
    ==============================================

    I need to clarify (specially for myself) about what is helpful and what is less helpful.
    For the last 18+ years I am testing and eating massive amounts of supplements (and prescription medicines of my own selection).
    I just had Calcium score done and it is better that what they have in their database.
    I had 78 birthday.
    Something is either
    fishy, they have made mistake in my test
    or
    I am doing something right.
    That list of enzymes is on the list of suspects.
    I have eaten them occasionally, now I use Serrapeptase.
    But I do not know of any particular tests which results would tell me to use any of that.

    =============================================================================
    Fibrinolytic and Proteolytic Enzymes

    https://jeffreydachmd.com/2018/06/fibrinolytic-proteolytic-enzymes-medical-use/

    Proteolytic Enzymes Dissolve Biofilms – Assist Antibiotics





    =============================================================================


    upload_2018-8-7_6-59-11.png
     
    Last edited: Aug 7, 2018
  12. JanSz

    JanSz Gold

    https://jeffreydachmd.com/2018/06/fibrinolytic-proteolytic-enzymes-medical-use/

    lumbrokinase is primarily a fibrinolytic enzyme and it possesses both direct and indirect fibrinolytic effects.
    It can activate the innate plasminogen system and also can achieve direct fibrinolysis independent of the plasminogen system (see Diagram 1). In 2004, Zhang el al discovered that lumbrokinase also inhibits PAI-1 activity and enhances t-PA activity.4 In addition to being a strong fibrinolytic agent, lumbrokinase may indirectly achieve anticoagulation by inhibiting platelet functions.

    Potential Clinical Applications
    As an oral enzyme supplement, lumbrokinase is not allowed or approved to make any therapeutic claims in North America. However, by looking into available animal and human research, it is not too hard for anyone to see the following potential applications:

    Ischemic Stroke. To further explore the traditional medical uses of earthworms in stroke, naturally one of the most intensely researched areas has been in the prevention and treatment of ischemic stroke patients. Lumbrokinase has been shown to be safe and effective for treating acute ischemic stroke by lowering blood viscosity, preventing re-perfusion damage, and reducing neural deficits.7-9 It was also shown to improve the efficacy of aspirin as a secondary prevention of stroke.10,11 In fact, for people who are resistant to aspirin (thus does not benefit from taking aspirin as a prevention), lumbrokinase appears to negate aspirin resistance and potentially help achieve the goal of cardiovascular disease prevention.12

    On a milligram to milligram basis, the fibrinolytic strength of lumbrokinase is about 300-fold stronger than serrapeptase
    On a milligram to milligram basis, the fibrinolytic strength of lumbrokinase is about 30-fold stronger than nattokinase

    Therefore, serrapeptase is not considered a strong fibrinolytic enzyme and should primarily be used for inflammation and pain association with oral/facial surgeries, sinus infection, arthritis, or chronic airway diseases. Respectively, nattokinase and lumbrokinase would be more suited for patients with mild and severe hypercoagulation or for patients with low and high cardiovascular risks.
     
  13. MingP

    MingP New. Gold. Thirsty.

    Dr K. Facebook. Sodium Bicarbonate
    "What if I told you a simple product in the store could be used to prove to you all autoimmune conditions are linked to mitochondrial damage?
    Why does it work for AI's? It fixes the "Proton problem" in mitochondria.

    Y'all ever hear of bicarb and carbonic anhydrase? The carbonic anhydrases or carbonate dehydratases enzymes are experts at moving protons to and fro form a family of enzymes that catalyze the rapid interconversion of carbon dioxide and water to bicarbonate and protons (or vice versa).

    Making water and CO2 is exactly what a HEALTHY mitochondrion does and it is exactly what an AUTOIMMUNE condition comes from. When will we learn?
    This is a reversible reaction that occurs relatively slowly in the absence of a catalyst. Baking soda is that catalyst. The active site of most carbonic anhydrases contains a zinc ion; they are therefore classified as metalloenzymes. This means nnEMF can affect this transition metal so we have another 5G mitohack."

    https://medicalxpress.com/news/2018-04-soda-inexpensive-safe-combat-autoimmune.html

    Carbonic Anhydrases:
    https://en.wikipedia.org/wiki/Carbonic_anhydrase

    The carbonic anhydrases form a family of enzymes that catalyze the interconversion between carbon dioxide and water and the dissociated ions of carbonic acid
    [​IMG]

    A zinc prosthetic group in the enzyme is coordinated in three positions by histidine side-chains. The fourth coordination position is occupied by water. This causes polarisation of the hydrogen-oxygen bond, making the oxygen slightly more positive, thereby weakening the bond.

    A fourth histidine is placed close to the substrate of water and accepts a proton, in an example of general acidgeneral base catalysis (see the article "Acid catalysis"). This leaves a hydroxide attached to the zinc.

    The active site also contains a specificity pocket for carbon dioxide, bringing it close to the hydroxide group. This allows the electron-rich hydroxide to attack the carbon dioxide, forming bicarbonate.
    [Note to Self: Wth is a zinc prosthetic group...]
    //

    Now how exactly does the above tie in from a Bio-Physics point of view?
     
  14. MingP

    MingP New. Gold. Thirsty.

    The only reason I go on facebook is to follow up on Dr K's new posts!
     
    JanSz likes this.
  15. MingP

    MingP New. Gold. Thirsty.

    Sun Powered
    Been back to the uniformed services reserves and been a tad busy.
    BUT, have also had ALOT OF EQUATORIAL SUN, to the tune of 2hrs++ per day.
    My wife says I'm glowing, and without much changes, my body composition has gotten pretty amazing.
    I'm already athletic, but wow, I just noticed that I got even more ripped without even trying!
    Nothing else has changed, minus the extra dose of sun.
     
  16. MingP

    MingP New. Gold. Thirsty.

    Notes: Vitamin K2 and The Calcium Paradox by Dr Kate Rheaume-Bleue

    https://jackkruse.com/osteoporosis-two-the-vitamin-k2-story/

    Summary:

    Get enough, Vit D, A, K2 + Magnesium.
    Vit A rich foods = Liver, Sweet Potatoe
    Vit K2 = Naato (Japanese fermented beans. Bought some. Smells like old socks....)

    //

    Published—in the prestigious British Medical Journal no less—the results of yet another calcium and heart health study. According to the study, women who supplement with calcium to prevent osteoporosis are at a higher risk of atherosclerosis (formation of calcium plaques in the arteries), heart attack and stroke than those who don’t.

    Vitamin D specifically accelerates the accumulation of arterial calcification in vitamin K2–deficient conditions.

    Vitamin K2 works by activating a number of special proteins that move calcium around the body. Specifi cally, K2 activates a protein called osteocalcin, which attracts calcium into bones and teeth, where calcium is needed. K2 activates another protein called matrix gla protein (MGP),

    which sweeps calcium out of soft tissues like arteries and veins, where the mineral is unwanted and harmful. When K2 is lacking, the proteins that depend on K2 remain inactive.


    upload_2018-8-24_11-33-19.png

    Osteocalcin (also known as bone gla protein or BGP) is a biological protein found in bones and teeth. It is the most abundant protein in bone after the collagen that forms the matrix that holds calcium.

    Together, vitamins A and D cause special bone-building cells (osteoblasts) in our skeleton to secrete osteocalcin and use the protein to draw calcium into bone tissues.

    In addition to building bone density, osteocalcin, produced by our bones and teeth, plays some unexpected roles in health. For example, new research shows that osteocalcin acts as a hormone that causes the pancreas to secrete more insulin and increases sensitivity to insulin.

    Vitamin K2–activated MGP is the strongest inhibitor of tissue calcification presently known. Its pivotal importance for cardiovascular health is demonstrated by the fact that there seems to be no eff ective alternative mechanism for preventing calcifi cation in blood vessels.13 In other words, when vitamin K2 is defi cient, the calcium plaque buildup of atherosclerosis is unavoidable—and this is where things get spooky.
    //

    Dr Weston A Price found that the diets of healthy traditional people contained at least four times more minerals and water-soluble vitamins than the standard American diet of the 1930s. What was more surprising is that the traditional fare provided at least 10 times more fat-soluble vitamins than the average industrialized diet. It was to these fat-soluble nutrients that Price turned his attention.

    [My Note: Natives also got a lot more sun, wore less clothes, and ate natural, with food in their region, and hence each had it’s own traditions for food etc, adapted to what was generationally known to be good for their people. IE: “Regional” N=1]

    //

    Vit D --> gla proteins --> Increased Vit K2 demand --> More calcium into bones/teeth, out of serum.

    Vit A --> reduces demand for Vit K2, allowing body to get by on less K2

    Retinol regulates the production of K2-dependent MGP, it seems to be at odds with the action of menaquinone. And yet, K2 content in grass-fed foods varies with the content of retinol.
    Why would K2 pairup with its apparent nemesis?
    Vitamin A promotes urinary excretion of calcium. When K2 removes calcium from arterial plaque, vitamin A disposes of it.
    Vitamin D promotes calcium absorption so K2 can guide it into bones and teeth.
    Vitamin A chaperones calcium out of the body when K2 has extracted it from soft tissue.
    This is the calcium cycle of life.

    So exactly how much A, D and K2 do we need to keep everything in balance and keep calcium in its proper place?
    Since vitamin K2 does not act like a hormone and stimulate protein production, it has no toxic effects, as you know. For that reason, K2 isn’t a limiting factor—it will activate as much osteocalcin and MGP as it finds. It’s vitamins A and D that are the limiting factors. Since they are also the nutrients with potentially toxic effects, we need to determine our relative requirements of these vitamins.

    /

    Magnesium is essential for the absorption and metabolism of vitamin D. Magnesium deficiency, thought by many health experts to be common, impairs vitamin D metabolism. In particular, a lack of magnesium limits the conversion of vitamin D to active, hormonal form.4 To reap the full benefi ts of vitamin D, and by extension vitamins K2 and A, you need magnesium.
     

    Attached Files:

    Last edited: Sep 4, 2018
  17. MingP

    MingP New. Gold. Thirsty.

    The Magnesium Miracle, Carolyn Dean
    An unacknowledged side effect of statins is that they inhibit the production of coenzyme Q10, which is a fat-soluble antioxidant found in large amounts in mitochondria

    A well-known magnesium proponent, Mildred Seeling, M.D., just before she died in 2004, wrote a fascinating paper with Andrea Rosanoff, Ph.D., showing that magnesium acts by the same mechanisms as statin drugs to lower cholesterol.

    Every metabolic activity in the body depends on enzymes. Making cholesterol, for example, requires a specific enzyme called HMG-CoA reductase. As it turns out, magnesium slows down this enzymatic reaction when it is present in sufficient quantities. HMG-CoA reductase is the same enzyme that statin drugs target and inhibit. The mechanisms are nearly the same; however, magnesium is the natural way that the body has evolved to control cholesterol when it reaches a certain level, whereas statin drugs are used to destroy the whole process. This means that if sufficient magnesium is present in the body, cholesterol will be limited to its necessary functions—the production of hormones and the maintenance of membranes—and will not be produced in excess.
    [Note: So Mg is a cholesterol regulator, not a reducer. Perhaps it's a Lipid optimizer.]

    The magnesium/cholesterol story gets even better. Magnesium is responsible for several other lipid-altering functions that are not even shared by statin drugs. Magnesium is necessary for the activity of an enzyme that lowers LDL, the “bad” cholesterol; it also lowers triglycerides and raises the “good” cholesterol, HDL. Another magnesium-dependent enzyme converts omega-3 and omega-6 essential fatty acids into prostaglandins, which are necessary for heart and overall health.
    [Note: "Low LDL = BAD". Lipid hypothesis still active in this one...]

    Seelig and Rosanoff conclude their paper by saying that it is well accepted that magnesium is a natural calcium channel blocker, and now we know it also acts like a natural statin. In their book The Magnesium Factor, Seelig and Rosanoff reported that eighteen human studies verified that magnesium supplements can have an extremely beneficial effect on lipids. In these studies, total cholesterol levels were reduced by 6 to 23 percent; LDL (bad) cholesterol were lowered by 10 to 18 percent; tryglycerides fell by 10 to 42 percent; and HDL (good) cholesterol rose by 4 to 11 percent. Furthermore, the studies showed that low magnesium levels are associated with higher levels of “bad” cholesterol and and high magnesium levels indicate an increase in “good” cholesterol.
    .
    Vit B1 (Thiamin) required for Magnesium absorbtion
    Selenium helps Magnesium stay in cells.
     
  18. drezy

    drezy Gold

    Don't forget to shower afterwards.
     
  19. MingP

    MingP New. Gold. Thirsty.

    From the trashy comments? haha
     
    drezy likes this.
  20. MingP

    MingP New. Gold. Thirsty.

    Hello @drezy @JanSz @Sue-UK,

    I'm wondering if I can get some input from you guys.
    My children's nanny who's been with my wife's family for 20yrs++ has an elevated BUN/Creatinine ratio (22). Nearly fell off my chair when I computed it.
    She's also got high blood pressure.

    So far, from my reading, to fix this,
    (1) BUN/Creatinine = Drink more water (correct?)
    (1a) Iodine, via seaweed/Iodora, to help increase intra-cellular water
    (1b) Potassium. Bananas (live in Singapore. So no circadian mismatch for bananas).
    (2) Magnesium to help lower blood pressure

    .
    She also is mildly type 2 diabetic.
    TD2 is a mitochondrial disease
    https://forum.jackkruse.com/index.p...2d-a-mitochondrial-illness.20217/#post-224427

    Rx:
    In light of this: Leptin Reset + AM and PM sun
    Reduce carbs and increase fatty meat intake
    .

    Does this make sense?
    Thank you in advance. And further reading and blogs is more than welcomed.

    I also figured this comes back to a Redox issue, ala Redox Rx, which I will implement.

    (For some reason I can't access "Ask Jack" despite having signed up for Gold. :/
    Please bear with me).
     
    Last edited: Aug 27, 2018

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